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Protein

Olfactory receptor 4K17

Gene

OR4K17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176230-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4K17
Alternative name(s):
Olfactory receptor OR14-29
Gene namesi
Name:OR4K17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:15355. OR4K17.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 52Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini53 – 60CytoplasmicSequence analysis8
Transmembranei61 – 82Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini83 – 103ExtracellularSequence analysisAdd BLAST21
Transmembranei104 – 123Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini124 – 142CytoplasmicSequence analysisAdd BLAST19
Transmembranei143 – 161Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini162 – 198ExtracellularSequence analysisAdd BLAST37
Transmembranei199 – 222Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini223 – 238CytoplasmicSequence analysisAdd BLAST16
Transmembranei239 – 261Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini262 – 272ExtracellularSequence analysisAdd BLAST11
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 315CytoplasmicSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiOR4K17.
DMDMi229462954.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505591 – 315Olfactory receptor 4K17Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi100 ↔ 192PROSITE-ProRule annotation
Glycosylationi267N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGC6.
PRIDEiQ8NGC6.

PTM databases

iPTMnetiQ8NGC6.
PhosphoSitePlusiQ8NGC6.

Expressioni

Gene expression databases

CleanExiHS_OR4K17.
ExpressionAtlasiQ8NGC6. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000319197.

Structurei

3D structure databases

ProteinModelPortaliQ8NGC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJQI. Eukaryota.
ENOG4111997. LUCA.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGC6.
KOiK04257.
OrthoDBiEOG091G0CY9.
PhylomeDBiQ8NGC6.
TreeFamiTF337251.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAMKLLNQS QVSEFILLGL TSSQDVEFLL FALFSVIYVV TVLGNLLIIV
60 70 80 90 100
TVFNTPNLNT PMYFLLGNLS FVDMTLASFA TPKVILNLLK KQKVISFAGC
110 120 130 140 150
FTQIFLLHLL GGVEMVLLVS MAFDRYVAIC KPLHYMTIMN KKVCVLLVVT
160 170 180 190 200
SWLLGLLHSG FQIPFAVNLP FCGPNVVDSI FCDLPLVTKL ACIDIYFVQV
210 220 230 240 250
VIVANSGIIS LSCFIILLIS YSLILITIKN HSPTGQSKAR STLTAHITVV
260 270 280 290 300
ILFFGPCIFI YIWPFGNHSV DKFLAVFYTI ITPILNPIIY TLRNKEMKIS
310
MKKLWRAFVN SREDT
Length:315
Mass (Da):35,312
Last modified:May 5, 2009 - v3
Checksum:iF72BEFFAC1C4E2F6
GO

Sequence cautioni

The sequence DAA04848 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065891 Genomic DNA. Translation: BAC06107.1.
AL163152 Genomic DNA. No translation available.
BK004450 Genomic DNA. Translation: DAA04848.1. Different initiation.
RefSeqiNP_001004715.1. NM_001004715.1.
UniGeneiHs.553765.

Genome annotation databases

EnsembliENST00000315543; ENSP00000319197; ENSG00000176230.
GeneIDi390436.
KEGGihsa:390436.
UCSCiuc001vwo.1. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065891 Genomic DNA. Translation: BAC06107.1.
AL163152 Genomic DNA. No translation available.
BK004450 Genomic DNA. Translation: DAA04848.1. Different initiation.
RefSeqiNP_001004715.1. NM_001004715.1.
UniGeneiHs.553765.

3D structure databases

ProteinModelPortaliQ8NGC6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000319197.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGC6.
PhosphoSitePlusiQ8NGC6.

Polymorphism and mutation databases

BioMutaiOR4K17.
DMDMi229462954.

Proteomic databases

PaxDbiQ8NGC6.
PRIDEiQ8NGC6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315543; ENSP00000319197; ENSG00000176230.
GeneIDi390436.
KEGGihsa:390436.
UCSCiuc001vwo.1. human.

Organism-specific databases

CTDi390436.
GeneCardsiOR4K17.
HGNCiHGNC:15355. OR4K17.
neXtProtiNX_Q8NGC6.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJQI. Eukaryota.
ENOG4111997. LUCA.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGC6.
KOiK04257.
OrthoDBiEOG091G0CY9.
PhylomeDBiQ8NGC6.
TreeFamiTF337251.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176230-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR4K17.
GenomeRNAii390436.
PROiQ8NGC6.

Gene expression databases

CleanExiHS_OR4K17.
ExpressionAtlasiQ8NGC6. baseline.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR4KH_HUMAN
AccessioniPrimary (citable) accession number: Q8NGC6
Secondary accession number(s): Q6IF12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 5, 2009
Last modified: November 30, 2016
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.