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Q8NGC4

- O10G3_HUMAN

UniProt

Q8NGC4 - O10G3_HUMAN

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Protein
Olfactory receptor 10G3
Gene
OR10G3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10G3
Alternative name(s):
Olfactory receptor OR14-40
Gene namesi
Name:OR10G3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:8171. OR10G3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Extracellular Reviewed prediction
Add
BLAST
Transmembranei26 – 4621Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini47 – 548Cytoplasmic Reviewed prediction
Transmembranei55 – 7622Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini77 – 10024Extracellular Reviewed prediction
Add
BLAST
Transmembranei101 – 12121Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini122 – 14019Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei141 – 16121Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini162 – 19837Extracellular Reviewed prediction
Add
BLAST
Transmembranei199 – 21820Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini219 – 23820Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei239 – 25921Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini260 – 27011Extracellular Reviewed prediction
Add
BLAST
Transmembranei271 – 29121Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini292 – 31322Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31970.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Olfactory receptor 10G3
PRO_0000150696Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Glycosylationi85 – 851N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi98 ↔ 190 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGC4.
PRIDEiQ8NGC4.

PTM databases

PhosphoSiteiQ8NGC4.

Expressioni

Gene expression databases

CleanExiHS_OR10G3.
GenevestigatoriQ8NGC4.

Organism-specific databases

HPAiHPA019766.

Interactioni

Protein-protein interaction databases

BioGridi117735. 1 interaction.
STRINGi9606.ENSP00000302437.

Structurei

3D structure databases

ProteinModelPortaliQ8NGC4.
SMRiQ8NGC4. Positions 34-306.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44637.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGC4.
KOiK04257.
OMAiITVWADP.
OrthoDBiEOG7Z95MR.
PhylomeDBiQ8NGC4.
TreeFamiTF337251.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGC4-1 [UniParc]FASTAAdd to Basket

« Hide

MERINSTLLT AFILTGIPYP LRLRTLFFVF FFLIYILTQL GNLLILITVW    50
ADPRLHARPM YIFLGVLSVI DMSISSIIVP RLMMNFTLGV KPIPFGGCVA 100
QLYFYHFLGS TQCFLYTLMA YDRYLAICQP LRYPVLMTAK LSALLVAGAW 150
MAGSIHGALQ AILTFRLPYC GPNQVDYFFC DIPAVLRLAC ADTTVNELVT 200
FVDIGVVVAS CFSLILLSYI QIIQAILRIH TADGRRRAFS TCGAHVTVVT 250
VYYVPCAFIY LRPETNSPLD GAAALVPTAI TPFLNPLIYT LRNQEVKLAL 300
KRMLRSPRTP SEV 313
Length:313
Mass (Da):35,055
Last modified:October 1, 2002 - v1
Checksum:iD36D8D1B069F3C27
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti73 – 731S → G.
Corresponds to variant rs17792778 [ dbSNP | Ensembl ].
VAR_053274

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065893 Genomic DNA. Translation: BAC06109.1.
AF399566 Genomic DNA. Translation: AAK95051.1.
BK004525 Genomic DNA. Translation: DAA04923.1.
CCDSiCCDS32046.1.
RefSeqiNP_001005465.1. NM_001005465.1.
UniGeneiHs.554581.

Genome annotation databases

EnsembliENST00000303532; ENSP00000302437; ENSG00000169208.
GeneIDi26533.
KEGGihsa:26533.
UCSCiuc010tmb.2. human.

Polymorphism databases

DMDMi38372665.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065893 Genomic DNA. Translation: BAC06109.1 .
AF399566 Genomic DNA. Translation: AAK95051.1 .
BK004525 Genomic DNA. Translation: DAA04923.1 .
CCDSi CCDS32046.1.
RefSeqi NP_001005465.1. NM_001005465.1.
UniGenei Hs.554581.

3D structure databases

ProteinModelPortali Q8NGC4.
SMRi Q8NGC4. Positions 34-306.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117735. 1 interaction.
STRINGi 9606.ENSP00000302437.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGC4.

Polymorphism databases

DMDMi 38372665.

Proteomic databases

PaxDbi Q8NGC4.
PRIDEi Q8NGC4.

Protocols and materials databases

DNASUi 26533.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000303532 ; ENSP00000302437 ; ENSG00000169208 .
GeneIDi 26533.
KEGGi hsa:26533.
UCSCi uc010tmb.2. human.

Organism-specific databases

CTDi 26533.
GeneCardsi GC14M022037.
HGNCi HGNC:8171. OR10G3.
HPAi HPA019766.
neXtProti NX_Q8NGC4.
PharmGKBi PA31970.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44637.
HOGENOMi HOG000041362.
HOVERGENi HBG017625.
InParanoidi Q8NGC4.
KOi K04257.
OMAi ITVWADP.
OrthoDBi EOG7Z95MR.
PhylomeDBi Q8NGC4.
TreeFami TF337251.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR10G3.
GenomeRNAii 26533.
NextBioi 48884.
PROi Q8NGC4.

Gene expression databases

CleanExi HS_OR10G3.
Genevestigatori Q8NGC4.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-282.
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO10G3_HUMAN
AccessioniPrimary (citable) accession number: Q8NGC4
Secondary accession number(s): Q6IET7, Q96R77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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