Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 10G3

Gene

OR10G3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169208-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10G3
Alternative name(s):
Olfactory receptor OR14-40
Gene namesi
Name:OR10G3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:8171. OR10G3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 76Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini77 – 100ExtracellularSequence analysisAdd BLAST24
Transmembranei101 – 121Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini122 – 140CytoplasmicSequence analysisAdd BLAST19
Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini162 – 198ExtracellularSequence analysisAdd BLAST37
Transmembranei199 – 218Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini219 – 238CytoplasmicSequence analysisAdd BLAST20
Transmembranei239 – 259Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini260 – 270ExtracellularSequence analysisAdd BLAST11
Transmembranei271 – 291Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini292 – 313CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169208.
PharmGKBiPA31970.

Polymorphism and mutation databases

BioMutaiOR10G3.
DMDMi38372665.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506961 – 313Olfactory receptor 10G3Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Glycosylationi85N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGC4.
PRIDEiQ8NGC4.

PTM databases

iPTMnetiQ8NGC4.
PhosphoSitePlusiQ8NGC4.

Expressioni

Gene expression databases

CleanExiHS_OR10G3.
ExpressionAtlasiQ8NGC4. baseline and differential.

Organism-specific databases

HPAiHPA019766.

Interactioni

Protein-protein interaction databases

BioGridi117735. 1 interactor.
STRINGi9606.ENSP00000302437.

Structurei

3D structure databases

ProteinModelPortaliQ8NGC4.
SMRiQ8NGC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHDC. Eukaryota.
ENOG411199R. LUCA.
GeneTreeiENSGT00760000119161.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGC4.
KOiK04257.
OMAiITVWADP.
OrthoDBiEOG091G0CZD.
PhylomeDBiQ8NGC4.
TreeFamiTF337251.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERINSTLLT AFILTGIPYP LRLRTLFFVF FFLIYILTQL GNLLILITVW
60 70 80 90 100
ADPRLHARPM YIFLGVLSVI DMSISSIIVP RLMMNFTLGV KPIPFGGCVA
110 120 130 140 150
QLYFYHFLGS TQCFLYTLMA YDRYLAICQP LRYPVLMTAK LSALLVAGAW
160 170 180 190 200
MAGSIHGALQ AILTFRLPYC GPNQVDYFFC DIPAVLRLAC ADTTVNELVT
210 220 230 240 250
FVDIGVVVAS CFSLILLSYI QIIQAILRIH TADGRRRAFS TCGAHVTVVT
260 270 280 290 300
VYYVPCAFIY LRPETNSPLD GAAALVPTAI TPFLNPLIYT LRNQEVKLAL
310
KRMLRSPRTP SEV
Length:313
Mass (Da):35,055
Last modified:October 1, 2002 - v1
Checksum:iD36D8D1B069F3C27
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05327473S → G.Corresponds to variant rs17792778dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065893 Genomic DNA. Translation: BAC06109.1.
AF399566 Genomic DNA. Translation: AAK95051.1.
BK004525 Genomic DNA. Translation: DAA04923.1.
CCDSiCCDS32046.1.
RefSeqiNP_001005465.1. NM_001005465.1.
UniGeneiHs.554581.

Genome annotation databases

EnsembliENST00000303532; ENSP00000302437; ENSG00000169208.
GeneIDi26533.
KEGGihsa:26533.
UCSCiuc010tmb.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065893 Genomic DNA. Translation: BAC06109.1.
AF399566 Genomic DNA. Translation: AAK95051.1.
BK004525 Genomic DNA. Translation: DAA04923.1.
CCDSiCCDS32046.1.
RefSeqiNP_001005465.1. NM_001005465.1.
UniGeneiHs.554581.

3D structure databases

ProteinModelPortaliQ8NGC4.
SMRiQ8NGC4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117735. 1 interactor.
STRINGi9606.ENSP00000302437.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGC4.
PhosphoSitePlusiQ8NGC4.

Polymorphism and mutation databases

BioMutaiOR10G3.
DMDMi38372665.

Proteomic databases

PaxDbiQ8NGC4.
PRIDEiQ8NGC4.

Protocols and materials databases

DNASUi26533.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303532; ENSP00000302437; ENSG00000169208.
GeneIDi26533.
KEGGihsa:26533.
UCSCiuc010tmb.2. human.

Organism-specific databases

CTDi26533.
GeneCardsiOR10G3.
HGNCiHGNC:8171. OR10G3.
HPAiHPA019766.
neXtProtiNX_Q8NGC4.
OpenTargetsiENSG00000169208.
PharmGKBiPA31970.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHDC. Eukaryota.
ENOG411199R. LUCA.
GeneTreeiENSGT00760000119161.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGC4.
KOiK04257.
OMAiITVWADP.
OrthoDBiEOG091G0CZD.
PhylomeDBiQ8NGC4.
TreeFamiTF337251.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169208-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR10G3.
GenomeRNAii26533.
PROiQ8NGC4.

Gene expression databases

CleanExiHS_OR10G3.
ExpressionAtlasiQ8NGC4. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO10G3_HUMAN
AccessioniPrimary (citable) accession number: Q8NGC4
Secondary accession number(s): Q6IET7, Q96R77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.