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Protein

Olfactory receptor 10G3

Gene

OR10G3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10G3
Alternative name(s):
Olfactory receptor OR14-40
Gene namesi
Name:OR10G3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000169208.1.
HGNCiHGNC:8171. OR10G3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 76Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini77 – 100ExtracellularSequence analysisAdd BLAST24
Transmembranei101 – 121Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini122 – 140CytoplasmicSequence analysisAdd BLAST19
Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini162 – 198ExtracellularSequence analysisAdd BLAST37
Transmembranei199 – 218Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini219 – 238CytoplasmicSequence analysisAdd BLAST20
Transmembranei239 – 259Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini260 – 270ExtracellularSequence analysisAdd BLAST11
Transmembranei271 – 291Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini292 – 313CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169208.
PharmGKBiPA31970.

Polymorphism and mutation databases

BioMutaiOR10G3.
DMDMi38372665.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506961 – 313Olfactory receptor 10G3Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi85N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGC4.
PRIDEiQ8NGC4.

PTM databases

iPTMnetiQ8NGC4.
PhosphoSitePlusiQ8NGC4.

Expressioni

Gene expression databases

BgeeiENSG00000169208.
CleanExiHS_OR10G3.
ExpressionAtlasiQ8NGC4. baseline and differential.

Organism-specific databases

HPAiHPA019766.

Interactioni

Protein-protein interaction databases

BioGridi117735. 1 interactor.
STRINGi9606.ENSP00000302437.

Structurei

3D structure databases

ProteinModelPortaliQ8NGC4.
SMRiQ8NGC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHDC. Eukaryota.
ENOG411199R. LUCA.
GeneTreeiENSGT00760000119161.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGC4.
KOiK04257.
OMAiITVWADP.
OrthoDBiEOG091G0CZD.
PhylomeDBiQ8NGC4.
TreeFamiTF337251.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NGC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERINSTLLT AFILTGIPYP LRLRTLFFVF FFLIYILTQL GNLLILITVW
60 70 80 90 100
ADPRLHARPM YIFLGVLSVI DMSISSIIVP RLMMNFTLGV KPIPFGGCVA
110 120 130 140 150
QLYFYHFLGS TQCFLYTLMA YDRYLAICQP LRYPVLMTAK LSALLVAGAW
160 170 180 190 200
MAGSIHGALQ AILTFRLPYC GPNQVDYFFC DIPAVLRLAC ADTTVNELVT
210 220 230 240 250
FVDIGVVVAS CFSLILLSYI QIIQAILRIH TADGRRRAFS TCGAHVTVVT
260 270 280 290 300
VYYVPCAFIY LRPETNSPLD GAAALVPTAI TPFLNPLIYT LRNQEVKLAL
310
KRMLRSPRTP SEV
Length:313
Mass (Da):35,055
Last modified:October 1, 2002 - v1
Checksum:iD36D8D1B069F3C27
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05327473S → G. Corresponds to variant dbSNP:rs17792778Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065893 Genomic DNA. Translation: BAC06109.1.
AF399566 Genomic DNA. Translation: AAK95051.1.
BK004525 Genomic DNA. Translation: DAA04923.1.
CCDSiCCDS32046.1.
RefSeqiNP_001005465.1. NM_001005465.1.
UniGeneiHs.554581.

Genome annotation databases

EnsembliENST00000303532; ENSP00000302437; ENSG00000169208.
GeneIDi26533.
KEGGihsa:26533.
UCSCiuc010tmb.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO10G3_HUMAN
AccessioniPrimary (citable) accession number: Q8NGC4
Secondary accession number(s): Q6IET7, Q96R77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families