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Q8NGC4

- O10G3_HUMAN

UniProt

Q8NGC4 - O10G3_HUMAN

Protein

Olfactory receptor 10G3

Gene

OR10G3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 10G3
    Alternative name(s):
    Olfactory receptor OR14-40
    Gene namesi
    Name:OR10G3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:8171. OR10G3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31970.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 313313Olfactory receptor 10G3PRO_0000150696Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGC4.
    PRIDEiQ8NGC4.

    PTM databases

    PhosphoSiteiQ8NGC4.

    Expressioni

    Gene expression databases

    CleanExiHS_OR10G3.
    GenevestigatoriQ8NGC4.

    Organism-specific databases

    HPAiHPA019766.

    Interactioni

    Protein-protein interaction databases

    BioGridi117735. 1 interaction.
    STRINGi9606.ENSP00000302437.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGC4.
    SMRiQ8NGC4. Positions 34-306.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini47 – 548CytoplasmicSequence Analysis
    Topological domaini77 – 10024ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini162 – 19837ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini219 – 23820CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27011ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini292 – 31322CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei55 – 7622Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12121Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei141 – 16121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei199 – 21820Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei271 – 29121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44637.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiQ8NGC4.
    KOiK04257.
    OMAiITVWADP.
    OrthoDBiEOG7Z95MR.
    PhylomeDBiQ8NGC4.
    TreeFamiTF337251.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGC4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERINSTLLT AFILTGIPYP LRLRTLFFVF FFLIYILTQL GNLLILITVW    50
    ADPRLHARPM YIFLGVLSVI DMSISSIIVP RLMMNFTLGV KPIPFGGCVA 100
    QLYFYHFLGS TQCFLYTLMA YDRYLAICQP LRYPVLMTAK LSALLVAGAW 150
    MAGSIHGALQ AILTFRLPYC GPNQVDYFFC DIPAVLRLAC ADTTVNELVT 200
    FVDIGVVVAS CFSLILLSYI QIIQAILRIH TADGRRRAFS TCGAHVTVVT 250
    VYYVPCAFIY LRPETNSPLD GAAALVPTAI TPFLNPLIYT LRNQEVKLAL 300
    KRMLRSPRTP SEV 313
    Length:313
    Mass (Da):35,055
    Last modified:October 1, 2002 - v1
    Checksum:iD36D8D1B069F3C27
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti73 – 731S → G.
    Corresponds to variant rs17792778 [ dbSNP | Ensembl ].
    VAR_053274

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065893 Genomic DNA. Translation: BAC06109.1.
    AF399566 Genomic DNA. Translation: AAK95051.1.
    BK004525 Genomic DNA. Translation: DAA04923.1.
    CCDSiCCDS32046.1.
    RefSeqiNP_001005465.1. NM_001005465.1.
    UniGeneiHs.554581.

    Genome annotation databases

    EnsembliENST00000303532; ENSP00000302437; ENSG00000169208.
    GeneIDi26533.
    KEGGihsa:26533.
    UCSCiuc010tmb.2. human.

    Polymorphism databases

    DMDMi38372665.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065893 Genomic DNA. Translation: BAC06109.1 .
    AF399566 Genomic DNA. Translation: AAK95051.1 .
    BK004525 Genomic DNA. Translation: DAA04923.1 .
    CCDSi CCDS32046.1.
    RefSeqi NP_001005465.1. NM_001005465.1.
    UniGenei Hs.554581.

    3D structure databases

    ProteinModelPortali Q8NGC4.
    SMRi Q8NGC4. Positions 34-306.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117735. 1 interaction.
    STRINGi 9606.ENSP00000302437.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NGC4.

    Polymorphism databases

    DMDMi 38372665.

    Proteomic databases

    PaxDbi Q8NGC4.
    PRIDEi Q8NGC4.

    Protocols and materials databases

    DNASUi 26533.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000303532 ; ENSP00000302437 ; ENSG00000169208 .
    GeneIDi 26533.
    KEGGi hsa:26533.
    UCSCi uc010tmb.2. human.

    Organism-specific databases

    CTDi 26533.
    GeneCardsi GC14M022037.
    HGNCi HGNC:8171. OR10G3.
    HPAi HPA019766.
    neXtProti NX_Q8NGC4.
    PharmGKBi PA31970.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44637.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi Q8NGC4.
    KOi K04257.
    OMAi ITVWADP.
    OrthoDBi EOG7Z95MR.
    PhylomeDBi Q8NGC4.
    TreeFami TF337251.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR10G3.
    GenomeRNAii 26533.
    NextBioi 48884.
    PROi Q8NGC4.

    Gene expression databases

    CleanExi HS_OR10G3.
    Genevestigatori Q8NGC4.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-282.
    3. Cited for: IDENTIFICATION.
    4. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO10G3_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGC4
    Secondary accession number(s): Q6IET7, Q96R77
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3