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Q8NGC4

- O10G3_HUMAN

UniProt

Q8NGC4 - O10G3_HUMAN

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Protein

Olfactory receptor 10G3

Gene

OR10G3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10G3
Alternative name(s):
Olfactory receptor OR14-40
Gene namesi
Name:OR10G3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:8171. OR10G3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31970.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Olfactory receptor 10G3PRO_0000150696Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGC4.
PRIDEiQ8NGC4.

PTM databases

PhosphoSiteiQ8NGC4.

Expressioni

Gene expression databases

CleanExiHS_OR10G3.
GenevestigatoriQ8NGC4.

Organism-specific databases

HPAiHPA019766.

Interactioni

Protein-protein interaction databases

BioGridi117735. 1 interaction.
STRINGi9606.ENSP00000302437.

Structurei

3D structure databases

ProteinModelPortaliQ8NGC4.
SMRiQ8NGC4. Positions 34-306.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence Analysis
Topological domaini77 – 10024ExtracellularSequence AnalysisAdd
BLAST
Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini162 – 19837ExtracellularSequence AnalysisAdd
BLAST
Topological domaini219 – 23820CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini260 – 27011ExtracellularSequence AnalysisAdd
BLAST
Topological domaini292 – 31322CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei55 – 7622Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei101 – 12121Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei141 – 16121Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei199 – 21820Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei271 – 29121Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44637.
GeneTreeiENSGT00760000119161.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGC4.
KOiK04257.
OMAiITVWADP.
OrthoDBiEOG7Z95MR.
PhylomeDBiQ8NGC4.
TreeFamiTF337251.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGC4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERINSTLLT AFILTGIPYP LRLRTLFFVF FFLIYILTQL GNLLILITVW
60 70 80 90 100
ADPRLHARPM YIFLGVLSVI DMSISSIIVP RLMMNFTLGV KPIPFGGCVA
110 120 130 140 150
QLYFYHFLGS TQCFLYTLMA YDRYLAICQP LRYPVLMTAK LSALLVAGAW
160 170 180 190 200
MAGSIHGALQ AILTFRLPYC GPNQVDYFFC DIPAVLRLAC ADTTVNELVT
210 220 230 240 250
FVDIGVVVAS CFSLILLSYI QIIQAILRIH TADGRRRAFS TCGAHVTVVT
260 270 280 290 300
VYYVPCAFIY LRPETNSPLD GAAALVPTAI TPFLNPLIYT LRNQEVKLAL
310
KRMLRSPRTP SEV
Length:313
Mass (Da):35,055
Last modified:October 1, 2002 - v1
Checksum:iD36D8D1B069F3C27
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti73 – 731S → G.
Corresponds to variant rs17792778 [ dbSNP | Ensembl ].
VAR_053274

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065893 Genomic DNA. Translation: BAC06109.1.
AF399566 Genomic DNA. Translation: AAK95051.1.
BK004525 Genomic DNA. Translation: DAA04923.1.
CCDSiCCDS32046.1.
RefSeqiNP_001005465.1. NM_001005465.1.
UniGeneiHs.554581.

Genome annotation databases

EnsembliENST00000303532; ENSP00000302437; ENSG00000169208.
GeneIDi26533.
KEGGihsa:26533.
UCSCiuc010tmb.2. human.

Polymorphism databases

DMDMi38372665.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065893 Genomic DNA. Translation: BAC06109.1 .
AF399566 Genomic DNA. Translation: AAK95051.1 .
BK004525 Genomic DNA. Translation: DAA04923.1 .
CCDSi CCDS32046.1.
RefSeqi NP_001005465.1. NM_001005465.1.
UniGenei Hs.554581.

3D structure databases

ProteinModelPortali Q8NGC4.
SMRi Q8NGC4. Positions 34-306.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117735. 1 interaction.
STRINGi 9606.ENSP00000302437.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGC4.

Polymorphism databases

DMDMi 38372665.

Proteomic databases

PaxDbi Q8NGC4.
PRIDEi Q8NGC4.

Protocols and materials databases

DNASUi 26533.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000303532 ; ENSP00000302437 ; ENSG00000169208 .
GeneIDi 26533.
KEGGi hsa:26533.
UCSCi uc010tmb.2. human.

Organism-specific databases

CTDi 26533.
GeneCardsi GC14M022037.
HGNCi HGNC:8171. OR10G3.
HPAi HPA019766.
neXtProti NX_Q8NGC4.
PharmGKBi PA31970.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44637.
GeneTreei ENSGT00760000119161.
HOGENOMi HOG000041362.
HOVERGENi HBG017625.
InParanoidi Q8NGC4.
KOi K04257.
OMAi ITVWADP.
OrthoDBi EOG7Z95MR.
PhylomeDBi Q8NGC4.
TreeFami TF337251.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR10G3.
GenomeRNAii 26533.
NextBioi 48884.
PROi Q8NGC4.

Gene expression databases

CleanExi HS_OR10G3.
Genevestigatori Q8NGC4.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-282.
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO10G3_HUMAN
AccessioniPrimary (citable) accession number: Q8NGC4
Secondary accession number(s): Q6IET7, Q96R77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3