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Q8NGC4 (O10G3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 10G3
Alternative name(s):
Olfactory receptor OR14-40
Gene names
Name:OR10G3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313Olfactory receptor 10G3
PRO_0000150696

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4621Helical; Name=1; Potential
Topological domain47 – 548Cytoplasmic Potential
Transmembrane55 – 7622Helical; Name=2; Potential
Topological domain77 – 10024Extracellular Potential
Transmembrane101 – 12121Helical; Name=3; Potential
Topological domain122 – 14019Cytoplasmic Potential
Transmembrane141 – 16121Helical; Name=4; Potential
Topological domain162 – 19837Extracellular Potential
Transmembrane199 – 21820Helical; Name=5; Potential
Topological domain219 – 23820Cytoplasmic Potential
Transmembrane239 – 25921Helical; Name=6; Potential
Topological domain260 – 27011Extracellular Potential
Transmembrane271 – 29121Helical; Name=7; Potential
Topological domain292 – 31322Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation851N-linked (GlcNAc...) Potential
Disulfide bond98 ↔ 190 By similarity

Natural variations

Natural variant731S → G.
Corresponds to variant rs17792778 [ dbSNP | Ensembl ].
VAR_053274

Sequences

Sequence LengthMass (Da)Tools
Q8NGC4 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: D36D8D1B069F3C27

FASTA31335,055
        10         20         30         40         50         60 
MERINSTLLT AFILTGIPYP LRLRTLFFVF FFLIYILTQL GNLLILITVW ADPRLHARPM 

        70         80         90        100        110        120 
YIFLGVLSVI DMSISSIIVP RLMMNFTLGV KPIPFGGCVA QLYFYHFLGS TQCFLYTLMA 

       130        140        150        160        170        180 
YDRYLAICQP LRYPVLMTAK LSALLVAGAW MAGSIHGALQ AILTFRLPYC GPNQVDYFFC 

       190        200        210        220        230        240 
DIPAVLRLAC ADTTVNELVT FVDIGVVVAS CFSLILLSYI QIIQAILRIH TADGRRRAFS 

       250        260        270        280        290        300 
TCGAHVTVVT VYYVPCAFIY LRPETNSPLD GAAALVPTAI TPFLNPLIYT LRNQEVKLAL 

       310 
KRMLRSPRTP SEV 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-282.
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065893 Genomic DNA. Translation: BAC06109.1.
AF399566 Genomic DNA. Translation: AAK95051.1.
BK004525 Genomic DNA. Translation: DAA04923.1.
RefSeqNP_001005465.1. NM_001005465.1.
UniGeneHs.554581.

3D structure databases

ProteinModelPortalQ8NGC4.
SMRQ8NGC4. Positions 34-308.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117735. 1 interaction.
STRING9606.ENSP00000302437.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NGC4.

Polymorphism databases

DMDM38372665.

Proteomic databases

PaxDbQ8NGC4.
PRIDEQ8NGC4.

Protocols and materials databases

DNASU26533.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000303532; ENSP00000302437; ENSG00000169208.
GeneID26533.
KEGGhsa:26533.
UCSCuc010tmb.2. human.

Organism-specific databases

CTD26533.
GeneCardsGC14M022037.
HGNCHGNC:8171. OR10G3.
HPAHPA019766.
neXtProtNX_Q8NGC4.
PharmGKBPA31970.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44637.
HOGENOMHOG000041362.
HOVERGENHBG017625.
InParanoidQ8NGC4.
KOK04257.
OMAITVWADP.
OrthoDBEOG7Z95MR.
PhylomeDBQ8NGC4.
TreeFamTF337251.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR10G3.
GenevestigatorQ8NGC4.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR10G3.
GenomeRNAi26533.
NextBio48884.
PROQ8NGC4.

Entry information

Entry nameO10G3_HUMAN
AccessionPrimary (citable) accession number: Q8NGC4
Secondary accession number(s): Q6IET7, Q96R77
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries