ID O10G2_HUMAN Reviewed; 310 AA. AC Q8NGC3; B2RPD0; DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot. DT 23-FEB-2022, sequence version 2. DT 24-JAN-2024, entry version 151. DE RecName: Full=Olfactory receptor 10G2; GN Name=OR10G2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ARG-85; HIS-136; ARG-187; RP ARG-209; HIS-228 AND ALA-236. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ARG-85; HIS-136; RP ARG-187; ARG-209; HIS-228 AND ALA-236. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Odorant receptor. {ECO:0000305}. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE); CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10G2"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB065894; BAC06110.1; -; Genomic_DNA. DR EMBL; CH471078; EAW66374.1; -; Genomic_DNA. DR EMBL; BC137371; AAI37372.1; -; mRNA. DR EMBL; BC137382; AAI37383.1; -; mRNA. DR CCDS; CCDS32047.1; -. DR RefSeq; NP_001005466.2; NM_001005466.2. DR AlphaFoldDB; Q8NGC3; -. DR SMR; Q8NGC3; -. DR STRING; 9606.ENSP00000445383; -. DR GlyCosmos; Q8NGC3; 1 site, No reported glycans. DR GlyGen; Q8NGC3; 1 site. DR BioMuta; OR10G2; -. DR DMDM; 38372664; -. DR MassIVE; Q8NGC3; -. DR PaxDb; 9606-ENSP00000445383; -. DR PeptideAtlas; Q8NGC3; -. DR Antibodypedia; 58800; 111 antibodies from 19 providers. DR Ensembl; ENST00000542433.1; ENSP00000445383.1; ENSG00000255582.1. DR GeneID; 26534; -. DR KEGG; hsa:26534; -. DR MANE-Select; ENST00000542433.1; ENSP00000445383.1; NM_001005466.2; NP_001005466.2. DR UCSC; uc032ate.2; human. DR AGR; HGNC:8170; -. DR CTD; 26534; -. DR GeneCards; OR10G2; -. DR HGNC; HGNC:8170; OR10G2. DR HPA; ENSG00000255582; Not detected. DR neXtProt; NX_Q8NGC3; -. DR PharmGKB; PA31969; -. DR VEuPathDB; HostDB:ENSG00000255582; -. DR eggNOG; ENOG502SI7K; Eukaryota. DR GeneTree; ENSGT01050000244869; -. DR HOGENOM; CLU_012526_8_1_1; -. DR InParanoid; Q8NGC3; -. DR OMA; YYIPCIF; -. DR PhylomeDB; Q8NGC3; -. DR TreeFam; TF336512; -. DR PathwayCommons; Q8NGC3; -. DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors. DR Pharos; Q8NGC3; Tdark. DR PRO; PR:Q8NGC3; -. DR Proteomes; UP000005640; Chromosome 14. DR RNAct; Q8NGC3; Protein. DR Bgee; ENSG00000255582; Expressed in lymph node and 2 other cell types or tissues. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central. DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central. DR CDD; cd15916; 7tmA_OR10G-like; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR000725; Olfact_rcpt. DR PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1. DR PANTHER; PTHR26453:SF88; OLFACTORY RECEPTOR 10G2; 1. DR Pfam; PF13853; 7tm_4; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction; KW Transducer; Transmembrane; Transmembrane helix. FT CHAIN 1..310 FT /note="Olfactory receptor 10G2" FT /id="PRO_0000150695" FT TOPO_DOM 1..29 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 30..50 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 51..58 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 59..80 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 81..104 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 105..125 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 126..144 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 145..165 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 166..202 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 203..222 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 223..242 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 243..263 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 264..274 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 275..295 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 296..310 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 6 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 102..194 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" FT VARIANT 67 FT /note="L -> F (in dbSNP:rs10146821)" FT /id="VAR_053270" FT VARIANT 85 FT /note="L -> R (in dbSNP:rs41314525)" FT /id="VAR_053271" FT VARIANT 136 FT /note="R -> H (in dbSNP:rs10138694)" FT /id="VAR_085741" FT VARIANT 187 FT /note="P -> R (in dbSNP:rs35963889)" FT /id="VAR_053272" FT VARIANT 209 FT /note="G -> R (in dbSNP:rs12894405)" FT /id="VAR_053273" FT VARIANT 228 FT /note="N -> H (in dbSNP:rs200792644)" FT /id="VAR_085742" FT VARIANT 236 FT /note="T -> A (in dbSNP:rs41307110)" FT /id="VAR_085743" SQ SEQUENCE 310 AA; 34297 MW; 7F09580D7F31C405 CRC64; MGKTKNTSLD AVVTDFILLG LSHPPNLRSL LFLVFFIIYI LTQLGNLLIL LTMWADPKLC ARPMYILLGV LSFLDMWLSS VTVPLLILDF TPSIKAIPFG GCVAQLYFFH FLGSTQCFLY TLMAYDRYLA ICQPLRYPVL MNGRLCTVLV AGAWVAGSMH GSIQATLTFR LPYCGPNQVD YFICDIPAVL RLACADTTVN ELVTFVDVGV VAASCFMLIL LSYANIVNAI LKIRTTDGRR RAFSTCGSHL IVVTVYYVPC IFIYLRAGSK DPLDGAAAVF YTVVTPLLNP LIYTLRNQEV KSALKRITAG //