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Q8NGC3

- O10G2_HUMAN

UniProt

Q8NGC3 - O10G2_HUMAN

Protein

Olfactory receptor 10G2

Gene

OR10G2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 10G2
    Gene namesi
    Name:OR10G2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:8170. OR10G2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31969.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 310310Olfactory receptor 10G2PRO_0000150695Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi102 ↔ 194PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8NGC3.

    Expressioni

    Gene expression databases

    CleanExiHS_OR10G2.
    GenevestigatoriQ8NGC3.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000308821.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGC3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2929ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini51 – 588CytoplasmicSequence Analysis
    Topological domaini81 – 10424ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini126 – 14419CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini166 – 20237ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini223 – 24220CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini264 – 27411ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini296 – 31015CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei30 – 5021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei59 – 8022Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei105 – 12521Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei203 – 22220Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei243 – 26321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei275 – 29521Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG147514.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiQ8NGC3.
    KOiK04257.
    OMAiHPPNLRS.
    OrthoDBiEOG7Z95MR.
    PhylomeDBiQ8NGC3.
    TreeFamiTF336512.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGC3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKTKNTSLD AVVTDFILLG LSHPPNLRSL LFLVFFIIYI LTQLGNLLIL    50
    LTMWADPKLC ARPMYILLGV LSFLDMWLSS VTVPRLILDF TPSIKAIPFG 100
    GCVAQLYFFH FLGSTQCFLY TLMAYDRYLA ICQPLHYPVL MNGRLCTVLV 150
    AGAWVAGSMH GSIQATLTFR LPYCGPNQVD YFICDIRAVL RLACADTTVN 200
    ELVTFVDVRV VAASCFMLIL LSYANIVHAI LKIRTADGRR RAFSTCGSHL 250
    IVVTVYYVPC IFIYLRAGSK DPLDGAAAVF YTVVTPLLNP LIYTLRNQEV 300
    KSALKRITAG 310
    Length:310
    Mass (Da):34,472
    Last modified:October 1, 2002 - v1
    Checksum:i0DEF12F670594F57
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti67 – 671L → F.
    Corresponds to variant rs10146821 [ dbSNP | Ensembl ].
    VAR_053270
    Natural varianti85 – 851R → L.
    Corresponds to variant rs41314525 [ dbSNP | Ensembl ].
    VAR_053271
    Natural varianti187 – 1871R → P.
    Corresponds to variant rs35963889 [ dbSNP | Ensembl ].
    VAR_053272
    Natural varianti209 – 2091R → G.
    Corresponds to variant rs12894405 [ dbSNP | Ensembl ].
    VAR_053273

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065894 Genomic DNA. Translation: BAC06110.1.
    CH471078 Genomic DNA. Translation: EAW66374.1.
    BC137371 mRNA. Translation: AAI37372.1.
    BC137382 mRNA. Translation: AAI37383.1.
    CCDSiCCDS32047.1.
    UniGeneiHs.554580.

    Genome annotation databases

    EnsembliENST00000542433; ENSP00000445383; ENSG00000255582.
    KEGGihsa:26534.
    UCSCiuc010tmc.2. human.

    Polymorphism databases

    DMDMi38372664.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065894 Genomic DNA. Translation: BAC06110.1 .
    CH471078 Genomic DNA. Translation: EAW66374.1 .
    BC137371 mRNA. Translation: AAI37372.1 .
    BC137382 mRNA. Translation: AAI37383.1 .
    CCDSi CCDS32047.1.
    UniGenei Hs.554580.

    3D structure databases

    ProteinModelPortali Q8NGC3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000308821.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38372664.

    Proteomic databases

    PRIDEi Q8NGC3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000542433 ; ENSP00000445383 ; ENSG00000255582 .
    KEGGi hsa:26534.
    UCSCi uc010tmc.2. human.

    Organism-specific databases

    CTDi 26534.
    GeneCardsi GC14M022102.
    HGNCi HGNC:8170. OR10G2.
    neXtProti NX_Q8NGC3.
    PharmGKBi PA31969.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG147514.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi Q8NGC3.
    KOi K04257.
    OMAi HPPNLRS.
    OrthoDBi EOG7Z95MR.
    PhylomeDBi Q8NGC3.
    TreeFami TF336512.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GenomeRNAii 26534.
    NextBioi 48888.
    PROi Q8NGC3.

    Gene expression databases

    CleanExi HS_OR10G2.
    Genevestigatori Q8NGC3.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiO10G2_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGC3
    Secondary accession number(s): B2RPD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3