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Protein

Olfactory receptor 10G2

Gene

OR10G2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10G2
Gene namesi
Name:OR10G2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000255582.1.
HGNCiHGNC:8170. OR10G2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 50Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini51 – 58CytoplasmicSequence analysis8
Transmembranei59 – 80Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini81 – 104ExtracellularSequence analysisAdd BLAST24
Transmembranei105 – 125Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini126 – 144CytoplasmicSequence analysisAdd BLAST19
Transmembranei145 – 165Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini166 – 202ExtracellularSequence analysisAdd BLAST37
Transmembranei203 – 222Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini223 – 242CytoplasmicSequence analysisAdd BLAST20
Transmembranei243 – 263Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini264 – 274ExtracellularSequence analysisAdd BLAST11
Transmembranei275 – 295Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini296 – 310CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31969.

Polymorphism and mutation databases

BioMutaiOR10G2.
DMDMi38372664.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506951 – 310Olfactory receptor 10G2Add BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi102 ↔ 194PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8NGC3.
PaxDbiQ8NGC3.
PeptideAtlasiQ8NGC3.
PRIDEiQ8NGC3.

Expressioni

Gene expression databases

BgeeiENSG00000255582.
CleanExiHS_OR10G2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000445383.

Structurei

3D structure databases

ProteinModelPortaliQ8NGC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHDC. Eukaryota.
ENOG411199R. LUCA.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGC3.
OrthoDBiEOG091G0CZD.
PhylomeDBiQ8NGC3.
TreeFamiTF336512.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
IPR030785. OR10G2.
PANTHERiPTHR26453:SF475. PTHR26453:SF475. 1 hit.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NGC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKTKNTSLD AVVTDFILLG LSHPPNLRSL LFLVFFIIYI LTQLGNLLIL
60 70 80 90 100
LTMWADPKLC ARPMYILLGV LSFLDMWLSS VTVPRLILDF TPSIKAIPFG
110 120 130 140 150
GCVAQLYFFH FLGSTQCFLY TLMAYDRYLA ICQPLHYPVL MNGRLCTVLV
160 170 180 190 200
AGAWVAGSMH GSIQATLTFR LPYCGPNQVD YFICDIRAVL RLACADTTVN
210 220 230 240 250
ELVTFVDVRV VAASCFMLIL LSYANIVHAI LKIRTADGRR RAFSTCGSHL
260 270 280 290 300
IVVTVYYVPC IFIYLRAGSK DPLDGAAAVF YTVVTPLLNP LIYTLRNQEV
310
KSALKRITAG
Length:310
Mass (Da):34,472
Last modified:October 1, 2002 - v1
Checksum:i0DEF12F670594F57
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05327067L → F. Corresponds to variant dbSNP:rs10146821Ensembl.1
Natural variantiVAR_05327185R → L. Corresponds to variant dbSNP:rs41314525Ensembl.1
Natural variantiVAR_053272187R → P. Corresponds to variant dbSNP:rs35963889Ensembl.1
Natural variantiVAR_053273209R → G. Corresponds to variant dbSNP:rs12894405Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065894 Genomic DNA. Translation: BAC06110.1.
CH471078 Genomic DNA. Translation: EAW66374.1.
BC137371 mRNA. Translation: AAI37372.1.
BC137382 mRNA. Translation: AAI37383.1.
CCDSiCCDS32047.1.
UniGeneiHs.554580.

Genome annotation databases

EnsembliENST00000542433; ENSP00000445383; ENSG00000255582.
UCSCiuc032ate.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO10G2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGC3
Secondary accession number(s): B2RPD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families