Q8NGC3 (O10G2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 10G2

Gene names

Name:

OR10G2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	Olfactory receptor 10G2		PRO_0000150695
Regions
	Topological domain	1 – 29	29	Extracellular Potential
	Transmembrane	30 – 50	21	Helical; Name=1; Potential
	Topological domain	51 – 58	8	Cytoplasmic Potential
	Transmembrane	59 – 80	22	Helical; Name=2; Potential
	Topological domain	81 – 104	24	Extracellular Potential
	Transmembrane	105 – 125	21	Helical; Name=3; Potential
	Topological domain	126 – 144	19	Cytoplasmic Potential
	Transmembrane	145 – 165	21	Helical; Name=4; Potential
	Topological domain	166 – 202	37	Extracellular Potential
	Transmembrane	203 – 222	20	Helical; Name=5; Potential
	Topological domain	223 – 242	20	Cytoplasmic Potential
	Transmembrane	243 – 263	21	Helical; Name=6; Potential
	Topological domain	264 – 274	11	Extracellular Potential
	Transmembrane	275 – 295	21	Helical; Name=7; Potential
	Topological domain	296 – 310	15	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	6	1	N-linked (GlcNAc...) Potential
	Disulfide bond	102 ↔ 194		By similarity
Natural variations
	Natural variant	67	1	L → F. Corresponds to variant rs10146821 [ dbSNP | Ensembl ].		VAR_053270
	Natural variant	85	1	R → L. Corresponds to variant rs41314525 [ dbSNP | Ensembl ].		VAR_053271
	Natural variant	187	1	R → P. Corresponds to variant rs35963889 [ dbSNP | Ensembl ].		VAR_053272
	Natural variant	209	1	R → G. Corresponds to variant rs12894405 [ dbSNP | Ensembl ].		VAR_053273

Sequences

	Sequence		Length	Mass (Da)
	Q8NGC3 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 0DEF12F670594F57	FASTA	310	34,472
	10 20 30 40 50 60 MGKTKNTSLD AVVTDFILLG LSHPPNLRSL LFLVFFIIYI LTQLGNLLIL LTMWADPKLC 70 80 90 100 110 120 ARPMYILLGV LSFLDMWLSS VTVPRLILDF TPSIKAIPFG GCVAQLYFFH FLGSTQCFLY 130 140 150 160 170 180 TLMAYDRYLA ICQPLHYPVL MNGRLCTVLV AGAWVAGSMH GSIQATLTFR LPYCGPNQVD 190 200 210 220 230 240 YFICDIRAVL RLACADTTVN ELVTFVDVRV VAASCFMLIL LSYANIVHAI LKIRTADGRR 250 260 270 280 290 300 RAFSTCGSHL IVVTVYYVPC IFIYLRAGSK DPLDGAAAVF YTVVTPLLNP LIYTLRNQEV 310 KSALKRITAG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065894 Genomic DNA. Translation: BAC06110.1. CH471078 Genomic DNA. Translation: EAW66374.1. BC137371 mRNA. Translation: AAI37372.1. BC137382 mRNA. Translation: AAI37383.1.
IPI	IPI00168975.
RefSeq	NP_001005466.1. NM_001005466.1.
UniGene	Hs.554580.
3D structure databases
ProteinModelPortal	Q8NGC3.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000308821.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	38372664.
Proteomic databases
PRIDE	Q8NGC3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000542433; ENSP00000445383; ENSG00000255582.
GeneID	26534.
KEGG	hsa:26534.
UCSC	uc010tmc.2. human.
Organism-specific databases
CTD	26534.
GeneCards	GC14M022102.
HGNC	HGNC:8170. OR10G2.
neXtProt	NX_Q8NGC3.
PharmGKB	PA31969.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG147514.
HOGENOM	HOG000041362.
HOVERGEN	HBG017625.
InParanoid	Q8NGC3.
KO	K04257.
OMA	HPPNLRS.
OrthoDB	EOG428226.
PhylomeDB	Q8NGC3.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR10G2.
Genevestigator	Q8NGC3.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	26534.
NextBio	48888.

Entry information

Entry name

O10G2_HUMAN

Accession

Primary (citable) accession number: Q8NGC3
Secondary accession number(s): B2RPD0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.