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Q8NGC3

- O10G2_HUMAN

UniProt

Q8NGC3 - O10G2_HUMAN

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Protein

Olfactory receptor 10G2

Gene

OR10G2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10G2
Gene namesi
Name:OR10G2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:8170. OR10G2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31969.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Olfactory receptor 10G2PRO_0000150695Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi102 ↔ 194PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NGC3.

Expressioni

Gene expression databases

CleanExiHS_OR10G2.
GenevestigatoriQ8NGC3.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000308821.

Structurei

3D structure databases

ProteinModelPortaliQ8NGC3.
SMRiQ8NGC3. Positions 114-145.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929ExtracellularSequence AnalysisAdd
BLAST
Topological domaini51 – 588CytoplasmicSequence Analysis
Topological domaini81 – 10424ExtracellularSequence AnalysisAdd
BLAST
Topological domaini126 – 14419CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini166 – 20237ExtracellularSequence AnalysisAdd
BLAST
Topological domaini223 – 24220CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini264 – 27411ExtracellularSequence AnalysisAdd
BLAST
Topological domaini296 – 31015CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei30 – 5021Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei59 – 8022Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei105 – 12521Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei145 – 16521Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei203 – 22220Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei243 – 26321Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei275 – 29521Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG147514.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGC3.
KOiK04257.
OMAiHPPNLRS.
OrthoDBiEOG7Z95MR.
PhylomeDBiQ8NGC3.
TreeFamiTF336512.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGC3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKTKNTSLD AVVTDFILLG LSHPPNLRSL LFLVFFIIYI LTQLGNLLIL
60 70 80 90 100
LTMWADPKLC ARPMYILLGV LSFLDMWLSS VTVPRLILDF TPSIKAIPFG
110 120 130 140 150
GCVAQLYFFH FLGSTQCFLY TLMAYDRYLA ICQPLHYPVL MNGRLCTVLV
160 170 180 190 200
AGAWVAGSMH GSIQATLTFR LPYCGPNQVD YFICDIRAVL RLACADTTVN
210 220 230 240 250
ELVTFVDVRV VAASCFMLIL LSYANIVHAI LKIRTADGRR RAFSTCGSHL
260 270 280 290 300
IVVTVYYVPC IFIYLRAGSK DPLDGAAAVF YTVVTPLLNP LIYTLRNQEV
310
KSALKRITAG
Length:310
Mass (Da):34,472
Last modified:October 1, 2002 - v1
Checksum:i0DEF12F670594F57
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti67 – 671L → F.
Corresponds to variant rs10146821 [ dbSNP | Ensembl ].
VAR_053270
Natural varianti85 – 851R → L.
Corresponds to variant rs41314525 [ dbSNP | Ensembl ].
VAR_053271
Natural varianti187 – 1871R → P.
Corresponds to variant rs35963889 [ dbSNP | Ensembl ].
VAR_053272
Natural varianti209 – 2091R → G.
Corresponds to variant rs12894405 [ dbSNP | Ensembl ].
VAR_053273

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065894 Genomic DNA. Translation: BAC06110.1.
CH471078 Genomic DNA. Translation: EAW66374.1.
BC137371 mRNA. Translation: AAI37372.1.
BC137382 mRNA. Translation: AAI37383.1.
CCDSiCCDS32047.1.
UniGeneiHs.554580.

Genome annotation databases

EnsembliENST00000542433; ENSP00000445383; ENSG00000255582.
KEGGihsa:26534.
UCSCiuc010tmc.2. human.

Polymorphism databases

DMDMi38372664.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065894 Genomic DNA. Translation: BAC06110.1 .
CH471078 Genomic DNA. Translation: EAW66374.1 .
BC137371 mRNA. Translation: AAI37372.1 .
BC137382 mRNA. Translation: AAI37383.1 .
CCDSi CCDS32047.1.
UniGenei Hs.554580.

3D structure databases

ProteinModelPortali Q8NGC3.
SMRi Q8NGC3. Positions 114-145.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000308821.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 38372664.

Proteomic databases

PRIDEi Q8NGC3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000542433 ; ENSP00000445383 ; ENSG00000255582 .
KEGGi hsa:26534.
UCSCi uc010tmc.2. human.

Organism-specific databases

GeneCardsi GC14M022102.
HGNCi HGNC:8170. OR10G2.
neXtProti NX_Q8NGC3.
PharmGKBi PA31969.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG147514.
HOGENOMi HOG000041362.
HOVERGENi HBG017625.
InParanoidi Q8NGC3.
KOi K04257.
OMAi HPPNLRS.
OrthoDBi EOG7Z95MR.
PhylomeDBi Q8NGC3.
TreeFami TF336512.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii 26534.
NextBioi 48888.
PROi Q8NGC3.

Gene expression databases

CleanExi HS_OR10G2.
Genevestigatori Q8NGC3.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiO10G2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGC3
Secondary accession number(s): B2RPD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3