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Q8NGC3 (O10G2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 10G2
Gene names
Name:OR10G2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 310310Olfactory receptor 10G2
PRO_0000150695

Regions

Topological domain1 – 2929Extracellular Potential
Transmembrane30 – 5021Helical; Name=1; Potential
Topological domain51 – 588Cytoplasmic Potential
Transmembrane59 – 8022Helical; Name=2; Potential
Topological domain81 – 10424Extracellular Potential
Transmembrane105 – 12521Helical; Name=3; Potential
Topological domain126 – 14419Cytoplasmic Potential
Transmembrane145 – 16521Helical; Name=4; Potential
Topological domain166 – 20237Extracellular Potential
Transmembrane203 – 22220Helical; Name=5; Potential
Topological domain223 – 24220Cytoplasmic Potential
Transmembrane243 – 26321Helical; Name=6; Potential
Topological domain264 – 27411Extracellular Potential
Transmembrane275 – 29521Helical; Name=7; Potential
Topological domain296 – 31015Cytoplasmic Potential

Amino acid modifications

Glycosylation61N-linked (GlcNAc...) Potential
Disulfide bond102 ↔ 194 By similarity

Natural variations

Natural variant671L → F.
Corresponds to variant rs10146821 [ dbSNP | Ensembl ].
VAR_053270
Natural variant851R → L.
Corresponds to variant rs41314525 [ dbSNP | Ensembl ].
VAR_053271
Natural variant1871R → P.
Corresponds to variant rs35963889 [ dbSNP | Ensembl ].
VAR_053272
Natural variant2091R → G.
Corresponds to variant rs12894405 [ dbSNP | Ensembl ].
VAR_053273

Sequences

Sequence LengthMass (Da)Tools
Q8NGC3 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 0DEF12F670594F57

FASTA31034,472
        10         20         30         40         50         60 
MGKTKNTSLD AVVTDFILLG LSHPPNLRSL LFLVFFIIYI LTQLGNLLIL LTMWADPKLC 

        70         80         90        100        110        120 
ARPMYILLGV LSFLDMWLSS VTVPRLILDF TPSIKAIPFG GCVAQLYFFH FLGSTQCFLY 

       130        140        150        160        170        180 
TLMAYDRYLA ICQPLHYPVL MNGRLCTVLV AGAWVAGSMH GSIQATLTFR LPYCGPNQVD 

       190        200        210        220        230        240 
YFICDIRAVL RLACADTTVN ELVTFVDVRV VAASCFMLIL LSYANIVHAI LKIRTADGRR 

       250        260        270        280        290        300 
RAFSTCGSHL IVVTVYYVPC IFIYLRAGSK DPLDGAAAVF YTVVTPLLNP LIYTLRNQEV 

       310 
KSALKRITAG 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065894 Genomic DNA. Translation: BAC06110.1.
CH471078 Genomic DNA. Translation: EAW66374.1.
BC137371 mRNA. Translation: AAI37372.1.
BC137382 mRNA. Translation: AAI37383.1.
RefSeqNP_001005466.1. NM_001005466.1.
UniGeneHs.554580.

3D structure databases

ProteinModelPortalQ8NGC3.
SMRQ8NGC3. Positions 114-145, 280-309.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000308821.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM38372664.

Proteomic databases

PRIDEQ8NGC3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000542433; ENSP00000445383; ENSG00000255582.
GeneID26534.
KEGGhsa:26534.
UCSCuc010tmc.2. human.

Organism-specific databases

CTD26534.
GeneCardsGC14M022102.
HGNCHGNC:8170. OR10G2.
neXtProtNX_Q8NGC3.
PharmGKBPA31969.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG147514.
HOGENOMHOG000041362.
HOVERGENHBG017625.
InParanoidQ8NGC3.
KOK04257.
OMAHPPNLRS.
OrthoDBEOG7Z95MR.
PhylomeDBQ8NGC3.
TreeFamTF336512.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR10G2.
GenevestigatorQ8NGC3.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR10G2.
GenomeRNAi26534.
NextBio48888.
PROQ8NGC3.

Entry information

Entry nameO10G2_HUMAN
AccessionPrimary (citable) accession number: Q8NGC3
Secondary accession number(s): B2RPD0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

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List of human entries with polymorphisms or disease mutations

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