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Protein

Olfactory receptor 4E2

Gene

OR4E2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4E2
Alternative name(s):
Olfactory receptor OR14-42
Gene namesi
Name:OR4E2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:8297. OR4E2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence analysis
Transmembranei58 – 7922Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence analysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini159 – 19537ExtracellularSequence analysisAdd
BLAST
Transmembranei196 – 21924Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini220 – 23516CytoplasmicSequence analysisAdd
BLAST
Transmembranei236 – 25823Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini259 – 26911ExtracellularSequence analysisAdd
BLAST
Transmembranei270 – 28920Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini290 – 31324CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32278.

Polymorphism and mutation databases

BioMutaiOR4E2.
DMDMi38372663.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Olfactory receptor 4E2PRO_0000150544Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGC2.
PRIDEiQ8NGC2.

PTM databases

iPTMnetiQ8NGC2.
PhosphoSiteiQ8NGC2.

Expressioni

Gene expression databases

CleanExiHS_OR4E2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000386195.

Structurei

3D structure databases

ProteinModelPortaliQ8NGC2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVIK. Eukaryota.
ENOG410YB9C. LUCA.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGC2.
OrthoDBiEOG091G0CY9.
PhylomeDBiQ8NGC2.
TreeFamiTF337251.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSLNQTRVT EFVFLGLTDN RVLEMLFFMA FSAIYMLTLS GNILIIIATV
60 70 80 90 100
FTPSLHTPMY FFLSNLSFID ICHSSVTVPK MLEGLLLERK TISFDNCITQ
110 120 130 140 150
LFFLHLFACA EIFLLIIVAY DRYVAICTPL HYPNVMNMRV CIQLVFALWL
160 170 180 190 200
GGTVHSLGQT FLTIRLPYCG PNIIDSYFCD VPLVIKLACT DTYLTGILIV
210 220 230 240 250
TNSGTISLSC FLAVVTSYMV ILVSLRKHSA EGRQKALSTC SAHFMVVALF
260 270 280 290 300
FGPCIFIYTR PDTSFSIDKV VSVFYTVVTP LLNPFIYTLR NEEVKSAMKQ
310
LRQRQVFFTK SYT
Length:313
Mass (Da):35,466
Last modified:October 1, 2002 - v1
Checksum:i59A922BBA6978452
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti118 – 1181V → M.
Corresponds to variant rs2874103 [ dbSNP | Ensembl ].
VAR_034198
Natural varianti234 – 2341Q → R.
Corresponds to variant rs970382 [ dbSNP | Ensembl ].
VAR_034199

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065895 Genomic DNA. Translation: BAC06111.1.
AF399581 Genomic DNA. Translation: AAK95066.1.
BK004526 Genomic DNA. Translation: DAA04924.1.
CCDSiCCDS41916.1.
UniGeneiHs.547982.

Genome annotation databases

EnsembliENST00000408935; ENSP00000386195; ENSG00000221977.
UCSCiuc010tmd.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065895 Genomic DNA. Translation: BAC06111.1.
AF399581 Genomic DNA. Translation: AAK95066.1.
BK004526 Genomic DNA. Translation: DAA04924.1.
CCDSiCCDS41916.1.
UniGeneiHs.547982.

3D structure databases

ProteinModelPortaliQ8NGC2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000386195.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGC2.
PhosphoSiteiQ8NGC2.

Polymorphism and mutation databases

BioMutaiOR4E2.
DMDMi38372663.

Proteomic databases

PaxDbiQ8NGC2.
PRIDEiQ8NGC2.

Protocols and materials databases

DNASUi26686.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000408935; ENSP00000386195; ENSG00000221977.
UCSCiuc010tmd.2. human.

Organism-specific databases

GeneCardsiOR4E2.
H-InvDBHIX0172373.
HGNCiHGNC:8297. OR4E2.
neXtProtiNX_Q8NGC2.
PharmGKBiPA32278.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVIK. Eukaryota.
ENOG410YB9C. LUCA.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGC2.
OrthoDBiEOG091G0CY9.
PhylomeDBiQ8NGC2.
TreeFamiTF337251.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

PROiQ8NGC2.

Gene expression databases

CleanExiHS_OR4E2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR4E2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGC2
Secondary accession number(s): Q6IET6, Q96R62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.