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Protein

Olfactory receptor 11G2

Gene

OR11G2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

Caution

It is uncertain whether Met-1 or Met-35 is the initiator.Curated

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 11G2
Alternative name(s):
Olfactory receptor OR14-34
Gene namesi
Name:OR11G2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000196832.3
HGNCiHGNC:15346 OR11G2
neXtProtiNX_Q8NGC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 62ExtracellularSequence analysisAdd BLAST62
Transmembranei63 – 83Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini84 – 92CytoplasmicSequence analysis9
Transmembranei93 – 113Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini114 – 135ExtracellularSequence analysisAdd BLAST22
Transmembranei136 – 156Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini157 – 181CytoplasmicSequence analysisAdd BLAST25
Transmembranei182 – 202Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini203 – 241ExtracellularSequence analysisAdd BLAST39
Transmembranei242 – 264Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini265 – 275CytoplasmicSequence analysisAdd BLAST11
Transmembranei276 – 296Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini297 – 309ExtracellularSequence analysisAdd BLAST13
Transmembranei310 – 330Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini331 – 345CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32012

Polymorphism and mutation databases

BioMutaiOR11G2
DMDMi212276448

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507231 – 345Olfactory receptor 11G2Add BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi135 ↔ 217PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGC1
PRIDEiQ8NGC1

PTM databases

iPTMnetiQ8NGC1
PhosphoSitePlusiQ8NGC1

Expressioni

Gene expression databases

CleanExiHS_OR11G2
ExpressionAtlasiQ8NGC1 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000349930

Structurei

3D structure databases

ProteinModelPortaliQ8NGC1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFEZ Eukaryota
ENOG411183S LUCA
GeneTreeiENSGT00890000139362
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NGC1
KOiK04257
OMAiFLCDPAP
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGC1
TreeFamiTF337213

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 2 hits
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHFLSQNDLN INLIPHLCLH RHSVIAGAFT IHRHMKIFNS PSNSSTFTGF
60 70 80 90 100
ILLGFPCPRE GQILLFVLFT VVYLLTLMGN GSIICAVHWD QRLHAPMYIL
110 120 130 140 150
LANFSFLEIC YVTSTVPSML ANFLSDTKII SFSGCFLQFY FFFSLGSTEC
160 170 180 190 200
FFLAVMAFDR YLAICRPLRY PTIMTRRLCT NLVVNCWVLG FIWFLIPIVN
210 220 230 240 250
ISQMSFCGSR IIDHFLCDPA PLLTLTCKKG PVIELVFSVL SPLPVFMLFL
260 270 280 290 300
FIVGSYALVV RAVLRVPSAA GRRKAFSTCG SHLAVVSLFY GSVLVMYGSP
310 320 330 340
PSKNEAGKQK TVTLFYSVVT PLLNPVIYSL RNKDMRKALK KFWGT
Length:345
Mass (Da):38,871
Last modified:November 4, 2008 - v2
Checksum:iF450CBA808A027A5
GO

Sequence cautioni

The sequence BAC06113 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04723799I → N. Corresponds to variant dbSNP:rs4981822Ensembl.1
Natural variantiVAR_047238116V → I. Corresponds to variant dbSNP:rs4981088Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065897 Genomic DNA Translation: BAC06113.1 Different initiation.
AL356019 Genomic DNA No translation available.
AF399610 Genomic DNA Translation: AAK95095.1
BK004453 Genomic DNA Translation: DAA04851.1
CCDSiCCDS32032.1
RefSeqiNP_001005503.1, NM_001005503.1
UniGeneiHs.554582

Genome annotation databases

EnsembliENST00000357366; ENSP00000349930; ENSG00000196832
GeneIDi390439
KEGGihsa:390439
UCSCiuc010tlb.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO11G2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGC1
Secondary accession number(s): Q6IF09, Q96R33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 4, 2008
Last modified: May 23, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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