Q8NGC1 (O11G2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 11G2

Alternative name(s):
Olfactory receptor OR14-34

Gene names

Name:

OR11G2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Caution	It is uncertain whether Met-1 or Met-35 is the initiator.
Sequence caution	The sequence BAC06113.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 345	345	Olfactory receptor 11G2		PRO_0000150723
Regions
	Topological domain	1 – 62	62	Extracellular Potential
	Transmembrane	63 – 83	21	Helical; Name=1; Potential
	Topological domain	84 – 92	9	Cytoplasmic Potential
	Transmembrane	93 – 113	21	Helical; Name=2; Potential
	Topological domain	114 – 135	22	Extracellular Potential
	Transmembrane	136 – 156	21	Helical; Name=3; Potential
	Topological domain	157 – 181	25	Cytoplasmic Potential
	Transmembrane	182 – 202	21	Helical; Name=4; Potential
	Topological domain	203 – 241	39	Extracellular Potential
	Transmembrane	242 – 264	23	Helical; Name=5; Potential
	Topological domain	265 – 275	11	Cytoplasmic Potential
	Transmembrane	276 – 296	21	Helical; Name=6; Potential
	Topological domain	297 – 309	13	Extracellular Potential
	Transmembrane	310 – 330	21	Helical; Name=7; Potential
	Topological domain	331 – 345	15	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	43	1	N-linked (GlcNAc...) Potential
	Disulfide bond	135 ↔ 217		By similarity
Natural variations
	Natural variant	99	1	I → N. Corresponds to variant rs4981822 [ dbSNP | Ensembl ].		VAR_047237
	Natural variant	116	1	V → I. Corresponds to variant rs4981088 [ dbSNP | Ensembl ].		VAR_047238

Sequences

	Sequence		Length	Mass (Da)
	Q8NGC1 [UniParc]. Last modified November 4, 2008. Version 2. Checksum: F450CBA808A027A5	FASTA	345	38,871
	10 20 30 40 50 60 MHFLSQNDLN INLIPHLCLH RHSVIAGAFT IHRHMKIFNS PSNSSTFTGF ILLGFPCPRE 70 80 90 100 110 120 GQILLFVLFT VVYLLTLMGN GSIICAVHWD QRLHAPMYIL LANFSFLEIC YVTSTVPSML 130 140 150 160 170 180 ANFLSDTKII SFSGCFLQFY FFFSLGSTEC FFLAVMAFDR YLAICRPLRY PTIMTRRLCT 190 200 210 220 230 240 NLVVNCWVLG FIWFLIPIVN ISQMSFCGSR IIDHFLCDPA PLLTLTCKKG PVIELVFSVL 250 260 270 280 290 300 SPLPVFMLFL FIVGSYALVV RAVLRVPSAA GRRKAFSTCG SHLAVVSLFY GSVLVMYGSP 310 320 330 340 PSKNEAGKQK TVTLFYSVVT PLLNPVIYSL RNKDMRKALK KFWGT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 106-322.
[4]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[5]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065897 Genomic DNA. Translation: BAC06113.1. Different initiation. AL356019 Genomic DNA. No translation available. AF399610 Genomic DNA. Translation: AAK95095.1. BK004453 Genomic DNA. Translation: DAA04851.1.
IPI	IPI00456726.
RefSeq	NP_001005503.1. NM_001005503.1.
UniGene	Hs.554582.
3D structure databases
ProteinModelPortal	Q8NGC1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000349930.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	212276448.
Proteomic databases
PaxDb	Q8NGC1.
PRIDE	Q8NGC1.
Protocols and materials databases
DNASU	390439.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000357366; ENSP00000349930; ENSG00000196832.
GeneID	390439.
KEGG	hsa:390439.
UCSC	uc010tlb.2. human.
Organism-specific databases
CTD	390439.
GeneCards	GC14P020666.
H-InvDB	HIX0172396.
HGNC	HGNC:15346. OR11G2.
neXtProt	NX_Q8NGC1.
PharmGKB	PA32012.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG72414.
HOGENOM	HOG000041365.
HOVERGEN	HBG017625.
InParanoid	Q8NGC1.
KO	K04257.
OMA	FIVGSYA.
OrthoDB	EOG49GKGX.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR11G2.
Genevestigator	Q8NGC1.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 2 hits. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	390439.
NextBio	103810.

Entry information

Entry name

O11G2_HUMAN

Accession

Primary (citable) accession number: Q8NGC1
Secondary accession number(s): Q6IF09, Q96R33

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	November 4, 2008
Last modified:	May 1, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.