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Protein

Olfactory receptor 11G2

Gene

OR11G2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 11G2
Alternative name(s):
Olfactory receptor OR14-34
Gene namesi
Name:OR11G2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:15346. OR11G2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 62ExtracellularSequence analysisAdd BLAST62
Transmembranei63 – 83Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini84 – 92CytoplasmicSequence analysis9
Transmembranei93 – 113Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini114 – 135ExtracellularSequence analysisAdd BLAST22
Transmembranei136 – 156Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini157 – 181CytoplasmicSequence analysisAdd BLAST25
Transmembranei182 – 202Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini203 – 241ExtracellularSequence analysisAdd BLAST39
Transmembranei242 – 264Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini265 – 275CytoplasmicSequence analysisAdd BLAST11
Transmembranei276 – 296Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini297 – 309ExtracellularSequence analysisAdd BLAST13
Transmembranei310 – 330Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini331 – 345CytoplasmicSequence analysisAdd BLAST15

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196832.
PharmGKBiPA32012.

Polymorphism and mutation databases

BioMutaiOR11G2.
DMDMi212276448.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507231 – 345Olfactory receptor 11G2Add BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi135 ↔ 217PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGC1.
PRIDEiQ8NGC1.

PTM databases

iPTMnetiQ8NGC1.
PhosphoSitePlusiQ8NGC1.

Expressioni

Gene expression databases

CleanExiHS_OR11G2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000349930.

Structurei

3D structure databases

ProteinModelPortaliQ8NGC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFEZ. Eukaryota.
ENOG411183S. LUCA.
GeneTreeiENSGT00840000129709.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGC1.
KOiK04257.
OMAiPVFMLFL.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGC1.
TreeFamiTF337213.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 2 hits.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHFLSQNDLN INLIPHLCLH RHSVIAGAFT IHRHMKIFNS PSNSSTFTGF
60 70 80 90 100
ILLGFPCPRE GQILLFVLFT VVYLLTLMGN GSIICAVHWD QRLHAPMYIL
110 120 130 140 150
LANFSFLEIC YVTSTVPSML ANFLSDTKII SFSGCFLQFY FFFSLGSTEC
160 170 180 190 200
FFLAVMAFDR YLAICRPLRY PTIMTRRLCT NLVVNCWVLG FIWFLIPIVN
210 220 230 240 250
ISQMSFCGSR IIDHFLCDPA PLLTLTCKKG PVIELVFSVL SPLPVFMLFL
260 270 280 290 300
FIVGSYALVV RAVLRVPSAA GRRKAFSTCG SHLAVVSLFY GSVLVMYGSP
310 320 330 340
PSKNEAGKQK TVTLFYSVVT PLLNPVIYSL RNKDMRKALK KFWGT
Length:345
Mass (Da):38,871
Last modified:November 4, 2008 - v2
Checksum:iF450CBA808A027A5
GO

Sequence cautioni

The sequence BAC06113 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04723799I → N.Corresponds to variant rs4981822dbSNPEnsembl.1
Natural variantiVAR_047238116V → I.Corresponds to variant rs4981088dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065897 Genomic DNA. Translation: BAC06113.1. Different initiation.
AL356019 Genomic DNA. No translation available.
AF399610 Genomic DNA. Translation: AAK95095.1.
BK004453 Genomic DNA. Translation: DAA04851.1.
CCDSiCCDS32032.1.
RefSeqiNP_001005503.1. NM_001005503.1.
UniGeneiHs.554582.

Genome annotation databases

EnsembliENST00000357366; ENSP00000349930; ENSG00000196832.
GeneIDi390439.
KEGGihsa:390439.
UCSCiuc010tlb.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065897 Genomic DNA. Translation: BAC06113.1. Different initiation.
AL356019 Genomic DNA. No translation available.
AF399610 Genomic DNA. Translation: AAK95095.1.
BK004453 Genomic DNA. Translation: DAA04851.1.
CCDSiCCDS32032.1.
RefSeqiNP_001005503.1. NM_001005503.1.
UniGeneiHs.554582.

3D structure databases

ProteinModelPortaliQ8NGC1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000349930.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGC1.
PhosphoSitePlusiQ8NGC1.

Polymorphism and mutation databases

BioMutaiOR11G2.
DMDMi212276448.

Proteomic databases

PaxDbiQ8NGC1.
PRIDEiQ8NGC1.

Protocols and materials databases

DNASUi390439.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357366; ENSP00000349930; ENSG00000196832.
GeneIDi390439.
KEGGihsa:390439.
UCSCiuc010tlb.3. human.

Organism-specific databases

CTDi390439.
GeneCardsiOR11G2.
H-InvDBHIX0172396.
HGNCiHGNC:15346. OR11G2.
neXtProtiNX_Q8NGC1.
OpenTargetsiENSG00000196832.
PharmGKBiPA32012.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFEZ. Eukaryota.
ENOG411183S. LUCA.
GeneTreeiENSGT00840000129709.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGC1.
KOiK04257.
OMAiPVFMLFL.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGC1.
TreeFamiTF337213.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR11G2.
GenomeRNAii390439.
PROiQ8NGC1.

Gene expression databases

CleanExiHS_OR11G2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 2 hits.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO11G2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGC1
Secondary accession number(s): Q6IF09, Q96R33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 4, 2008
Last modified: November 2, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-35 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.