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Q8NGC1 (O11G2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 11G2
Alternative name(s):
Olfactory receptor OR14-34
Gene names
Name:OR11G2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length345 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

It is uncertain whether Met-1 or Met-35 is the initiator.

Sequence caution

The sequence BAC06113.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 345345Olfactory receptor 11G2
PRO_0000150723

Regions

Topological domain1 – 6262Extracellular Potential
Transmembrane63 – 8321Helical; Name=1; Potential
Topological domain84 – 929Cytoplasmic Potential
Transmembrane93 – 11321Helical; Name=2; Potential
Topological domain114 – 13522Extracellular Potential
Transmembrane136 – 15621Helical; Name=3; Potential
Topological domain157 – 18125Cytoplasmic Potential
Transmembrane182 – 20221Helical; Name=4; Potential
Topological domain203 – 24139Extracellular Potential
Transmembrane242 – 26423Helical; Name=5; Potential
Topological domain265 – 27511Cytoplasmic Potential
Transmembrane276 – 29621Helical; Name=6; Potential
Topological domain297 – 30913Extracellular Potential
Transmembrane310 – 33021Helical; Name=7; Potential
Topological domain331 – 34515Cytoplasmic Potential

Amino acid modifications

Glycosylation431N-linked (GlcNAc...) Potential
Disulfide bond135 ↔ 217 By similarity

Natural variations

Natural variant991I → N.
Corresponds to variant rs4981822 [ dbSNP | Ensembl ].
VAR_047237
Natural variant1161V → I.
Corresponds to variant rs4981088 [ dbSNP | Ensembl ].
VAR_047238

Sequences

Sequence LengthMass (Da)Tools
Q8NGC1 [UniParc].

Last modified November 4, 2008. Version 2.
Checksum: F450CBA808A027A5

FASTA34538,871
        10         20         30         40         50         60 
MHFLSQNDLN INLIPHLCLH RHSVIAGAFT IHRHMKIFNS PSNSSTFTGF ILLGFPCPRE 

        70         80         90        100        110        120 
GQILLFVLFT VVYLLTLMGN GSIICAVHWD QRLHAPMYIL LANFSFLEIC YVTSTVPSML 

       130        140        150        160        170        180 
ANFLSDTKII SFSGCFLQFY FFFSLGSTEC FFLAVMAFDR YLAICRPLRY PTIMTRRLCT 

       190        200        210        220        230        240 
NLVVNCWVLG FIWFLIPIVN ISQMSFCGSR IIDHFLCDPA PLLTLTCKKG PVIELVFSVL 

       250        260        270        280        290        300 
SPLPVFMLFL FIVGSYALVV RAVLRVPSAA GRRKAFSTCG SHLAVVSLFY GSVLVMYGSP 

       310        320        330        340 
PSKNEAGKQK TVTLFYSVVT PLLNPVIYSL RNKDMRKALK KFWGT 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 106-322.
[4]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065897 Genomic DNA. Translation: BAC06113.1. Different initiation.
AL356019 Genomic DNA. No translation available.
AF399610 Genomic DNA. Translation: AAK95095.1.
BK004453 Genomic DNA. Translation: DAA04851.1.
RefSeqNP_001005503.1. NM_001005503.1.
UniGeneHs.554582.

3D structure databases

ProteinModelPortalQ8NGC1.
SMRQ8NGC1. Positions 67-344.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000349930.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM212276448.

Proteomic databases

PaxDbQ8NGC1.
PRIDEQ8NGC1.

Protocols and materials databases

DNASU390439.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000357366; ENSP00000349930; ENSG00000196832.
GeneID390439.
KEGGhsa:390439.
UCSCuc010tlb.2. human.

Organism-specific databases

CTD390439.
GeneCardsGC14P020666.
H-InvDBHIX0172396.
HGNCHGNC:15346. OR11G2.
neXtProtNX_Q8NGC1.
PharmGKBPA32012.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG72414.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ8NGC1.
KOK04257.
OMASEHEAGT.
OrthoDBEOG7N0C51.
PhylomeDBQ8NGC1.
TreeFamTF337213.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR11G2.
GenevestigatorQ8NGC1.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 2 hits.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR11G2.
GenomeRNAi390439.
NextBio103810.
PROQ8NGC1.

Entry information

Entry nameO11G2_HUMAN
AccessionPrimary (citable) accession number: Q8NGC1
Secondary accession number(s): Q6IF09, Q96R33
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 4, 2008
Last modified: April 16, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries