Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8NGC1

- O11G2_HUMAN

UniProt

Q8NGC1 - O11G2_HUMAN

Protein

Olfactory receptor 11G2

Gene

OR11G2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (04 Nov 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 11G2
    Alternative name(s):
    Olfactory receptor OR14-34
    Gene namesi
    Name:OR11G2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:15346. OR11G2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32012.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 345345Olfactory receptor 11G2PRO_0000150723Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi135 ↔ 217PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGC1.
    PRIDEiQ8NGC1.

    Expressioni

    Gene expression databases

    CleanExiHS_OR11G2.
    GenevestigatoriQ8NGC1.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000349930.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGC1.
    SMRiQ8NGC1. Positions 67-342.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6262ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini84 – 929CytoplasmicSequence Analysis
    Topological domaini114 – 13522ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini157 – 18125CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini203 – 24139ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini265 – 27511CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini297 – 30913ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini331 – 34515CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei63 – 8321Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei93 – 11321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei136 – 15621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei182 – 20221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei242 – 26423Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei276 – 29621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei310 – 33021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG72414.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ8NGC1.
    KOiK04257.
    OMAiSEHEAGT.
    OrthoDBiEOG7N0C51.
    PhylomeDBiQ8NGC1.
    TreeFamiTF337213.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 2 hits.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGC1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHFLSQNDLN INLIPHLCLH RHSVIAGAFT IHRHMKIFNS PSNSSTFTGF    50
    ILLGFPCPRE GQILLFVLFT VVYLLTLMGN GSIICAVHWD QRLHAPMYIL 100
    LANFSFLEIC YVTSTVPSML ANFLSDTKII SFSGCFLQFY FFFSLGSTEC 150
    FFLAVMAFDR YLAICRPLRY PTIMTRRLCT NLVVNCWVLG FIWFLIPIVN 200
    ISQMSFCGSR IIDHFLCDPA PLLTLTCKKG PVIELVFSVL SPLPVFMLFL 250
    FIVGSYALVV RAVLRVPSAA GRRKAFSTCG SHLAVVSLFY GSVLVMYGSP 300
    PSKNEAGKQK TVTLFYSVVT PLLNPVIYSL RNKDMRKALK KFWGT 345
    Length:345
    Mass (Da):38,871
    Last modified:November 4, 2008 - v2
    Checksum:iF450CBA808A027A5
    GO

    Sequence cautioni

    The sequence BAC06113.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti99 – 991I → N.
    Corresponds to variant rs4981822 [ dbSNP | Ensembl ].
    VAR_047237
    Natural varianti116 – 1161V → I.
    Corresponds to variant rs4981088 [ dbSNP | Ensembl ].
    VAR_047238

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065897 Genomic DNA. Translation: BAC06113.1. Different initiation.
    AL356019 Genomic DNA. No translation available.
    AF399610 Genomic DNA. Translation: AAK95095.1.
    BK004453 Genomic DNA. Translation: DAA04851.1.
    CCDSiCCDS32032.1.
    RefSeqiNP_001005503.1. NM_001005503.1.
    UniGeneiHs.554582.

    Genome annotation databases

    EnsembliENST00000357366; ENSP00000349930; ENSG00000196832.
    GeneIDi390439.
    KEGGihsa:390439.
    UCSCiuc010tlb.2. human.

    Polymorphism databases

    DMDMi212276448.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065897 Genomic DNA. Translation: BAC06113.1 . Different initiation.
    AL356019 Genomic DNA. No translation available.
    AF399610 Genomic DNA. Translation: AAK95095.1 .
    BK004453 Genomic DNA. Translation: DAA04851.1 .
    CCDSi CCDS32032.1.
    RefSeqi NP_001005503.1. NM_001005503.1.
    UniGenei Hs.554582.

    3D structure databases

    ProteinModelPortali Q8NGC1.
    SMRi Q8NGC1. Positions 67-342.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000349930.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 212276448.

    Proteomic databases

    PaxDbi Q8NGC1.
    PRIDEi Q8NGC1.

    Protocols and materials databases

    DNASUi 390439.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000357366 ; ENSP00000349930 ; ENSG00000196832 .
    GeneIDi 390439.
    KEGGi hsa:390439.
    UCSCi uc010tlb.2. human.

    Organism-specific databases

    CTDi 390439.
    GeneCardsi GC14P020666.
    H-InvDB HIX0172396.
    HGNCi HGNC:15346. OR11G2.
    neXtProti NX_Q8NGC1.
    PharmGKBi PA32012.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG72414.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q8NGC1.
    KOi K04257.
    OMAi SEHEAGT.
    OrthoDBi EOG7N0C51.
    PhylomeDBi Q8NGC1.
    TreeFami TF337213.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR11G2.
    GenomeRNAii 390439.
    NextBioi 103810.
    PROi Q8NGC1.

    Gene expression databases

    CleanExi HS_OR11G2.
    Genevestigatori Q8NGC1.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 2 hits.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 106-322.
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO11G2_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGC1
    Secondary accession number(s): Q6IF09, Q96R33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: November 4, 2008
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-35 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3