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Q8NGC1

- O11G2_HUMAN

UniProt

Q8NGC1 - O11G2_HUMAN

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Protein
Olfactory receptor 11G2
Gene
OR11G2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 11G2
Alternative name(s):
Olfactory receptor OR14-34
Gene namesi
Name:OR11G2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:15346. OR11G2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6262Extracellular Reviewed prediction
Add
BLAST
Transmembranei63 – 8321Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini84 – 929Cytoplasmic Reviewed prediction
Transmembranei93 – 11321Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini114 – 13522Extracellular Reviewed prediction
Add
BLAST
Transmembranei136 – 15621Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini157 – 18125Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei182 – 20221Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini203 – 24139Extracellular Reviewed prediction
Add
BLAST
Transmembranei242 – 26423Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini265 – 27511Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei276 – 29621Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini297 – 30913Extracellular Reviewed prediction
Add
BLAST
Transmembranei310 – 33021Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini331 – 34515Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32012.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Olfactory receptor 11G2
PRO_0000150723Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi43 – 431N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi135 ↔ 217 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGC1.
PRIDEiQ8NGC1.

Expressioni

Gene expression databases

CleanExiHS_OR11G2.
GenevestigatoriQ8NGC1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000349930.

Structurei

3D structure databases

ProteinModelPortaliQ8NGC1.
SMRiQ8NGC1. Positions 67-342.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG72414.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGC1.
KOiK04257.
OMAiSEHEAGT.
OrthoDBiEOG7N0C51.
PhylomeDBiQ8NGC1.
TreeFamiTF337213.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 2 hits.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGC1-1 [UniParc]FASTAAdd to Basket

« Hide

MHFLSQNDLN INLIPHLCLH RHSVIAGAFT IHRHMKIFNS PSNSSTFTGF    50
ILLGFPCPRE GQILLFVLFT VVYLLTLMGN GSIICAVHWD QRLHAPMYIL 100
LANFSFLEIC YVTSTVPSML ANFLSDTKII SFSGCFLQFY FFFSLGSTEC 150
FFLAVMAFDR YLAICRPLRY PTIMTRRLCT NLVVNCWVLG FIWFLIPIVN 200
ISQMSFCGSR IIDHFLCDPA PLLTLTCKKG PVIELVFSVL SPLPVFMLFL 250
FIVGSYALVV RAVLRVPSAA GRRKAFSTCG SHLAVVSLFY GSVLVMYGSP 300
PSKNEAGKQK TVTLFYSVVT PLLNPVIYSL RNKDMRKALK KFWGT 345
Length:345
Mass (Da):38,871
Last modified:November 4, 2008 - v2
Checksum:iF450CBA808A027A5
GO

Sequence cautioni

The sequence BAC06113.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti99 – 991I → N.
Corresponds to variant rs4981822 [ dbSNP | Ensembl ].
VAR_047237
Natural varianti116 – 1161V → I.
Corresponds to variant rs4981088 [ dbSNP | Ensembl ].
VAR_047238

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065897 Genomic DNA. Translation: BAC06113.1. Different initiation.
AL356019 Genomic DNA. No translation available.
AF399610 Genomic DNA. Translation: AAK95095.1.
BK004453 Genomic DNA. Translation: DAA04851.1.
CCDSiCCDS32032.1.
RefSeqiNP_001005503.1. NM_001005503.1.
UniGeneiHs.554582.

Genome annotation databases

EnsembliENST00000357366; ENSP00000349930; ENSG00000196832.
GeneIDi390439.
KEGGihsa:390439.
UCSCiuc010tlb.2. human.

Polymorphism databases

DMDMi212276448.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065897 Genomic DNA. Translation: BAC06113.1 . Different initiation.
AL356019 Genomic DNA. No translation available.
AF399610 Genomic DNA. Translation: AAK95095.1 .
BK004453 Genomic DNA. Translation: DAA04851.1 .
CCDSi CCDS32032.1.
RefSeqi NP_001005503.1. NM_001005503.1.
UniGenei Hs.554582.

3D structure databases

ProteinModelPortali Q8NGC1.
SMRi Q8NGC1. Positions 67-342.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000349930.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 212276448.

Proteomic databases

PaxDbi Q8NGC1.
PRIDEi Q8NGC1.

Protocols and materials databases

DNASUi 390439.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000357366 ; ENSP00000349930 ; ENSG00000196832 .
GeneIDi 390439.
KEGGi hsa:390439.
UCSCi uc010tlb.2. human.

Organism-specific databases

CTDi 390439.
GeneCardsi GC14P020666.
H-InvDB HIX0172396.
HGNCi HGNC:15346. OR11G2.
neXtProti NX_Q8NGC1.
PharmGKBi PA32012.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG72414.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q8NGC1.
KOi K04257.
OMAi SEHEAGT.
OrthoDBi EOG7N0C51.
PhylomeDBi Q8NGC1.
TreeFami TF337213.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR11G2.
GenomeRNAii 390439.
NextBioi 103810.
PROi Q8NGC1.

Gene expression databases

CleanExi HS_OR11G2.
Genevestigatori Q8NGC1.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 2 hits.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 106-322.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO11G2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGC1
Secondary accession number(s): Q6IF09, Q96R33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 4, 2008
Last modified: September 3, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-35 is the initiator.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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