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Protein

Olfactory receptor 5AU1

Gene

OR5AU1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169327-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5AU1
Alternative name(s):
Olfactory receptor OR14-38
Gene namesi
Name:OR5AU1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:15362. OR5AU1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 79ExtracellularSequence analysisAdd BLAST79
Transmembranei80 – 100Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini101 – 116CytoplasmicSequence analysisAdd BLAST16
Transmembranei117 – 139Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini140 – 150ExtracellularSequence analysisAdd BLAST11
Transmembranei151 – 171Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini172 – 194CytoplasmicSequence analysisAdd BLAST23
Transmembranei195 – 215Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini216 – 247ExtracellularSequence analysisAdd BLAST32
Transmembranei248 – 268Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini269 – 290CytoplasmicSequence analysisAdd BLAST22
Transmembranei291 – 311Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini312 – 322ExtracellularSequence analysisAdd BLAST11
Transmembranei323 – 343Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini344 – 362CytoplasmicSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169327.
PharmGKBiPA32474.

Polymorphism and mutation databases

BioMutaiOR5AU1.
DMDMi212276450.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505821 – 362Olfactory receptor 5AU1Add BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi56N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi148 ↔ 230PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGC0.
PRIDEiQ8NGC0.

PTM databases

iPTMnetiQ8NGC0.
PhosphoSitePlusiQ8NGC0.

Expressioni

Gene expression databases

CleanExiHS_OR5AU1.
ExpressionAtlasiQ8NGC0. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000302057.

Structurei

3D structure databases

ProteinModelPortaliQ8NGC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9KZ. Eukaryota.
ENOG41113B2. LUCA.
GeneTreeiENSGT00760000118941.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGC0.
KOiK04257.
OMAiIHTSCIF.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGC0.
TreeFamiTF352750.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEFHLQSQM PSIRLIFRRL SLGRIKPSQS PRCSTSFMVV PSFSIAEHWR
60 70 80 90 100
RMKGANLSQG MEFELLGLTT DPQLQRLLFV VFLGMYTATL LGNLVMFLLI
110 120 130 140 150
HVSATLHTPM YSLLKSLSFL DFCYSSTVVP QTLVNFLAKR KVISYFGCMT
160 170 180 190 200
QMFFYAGFAT SECYLIAAMA YDRYAAICNP LLYSTIMSPE VCASLIVGSY
210 220 230 240 250
SAGFLNSLIH TGCIFSLKFC GAHVVTHFFC DGPPILSLSC VDTSLCEILL
260 270 280 290 300
FIFAGFNLLS CTLTILISYF LILNTILKMS SAQGRFKAFS TCASHLTAIC
310 320 330 340 350
LFFGTTLFMY LRPRSSYSLT QDRTVAVIYT VVIPVLNPLM YSLRNKDVKK
360
ALIKVWGRKT ME
Length:362
Mass (Da):40,658
Last modified:November 4, 2008 - v2
Checksum:i3E6E7BF1DA20864E
GO

Sequence cautioni

The sequence BAC06114 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04723480V → M.Corresponds to variant rs17102042dbSNPEnsembl.1
Natural variantiVAR_047235117L → F.1 PublicationCorresponds to variant rs4982419dbSNPEnsembl.1
Natural variantiVAR_062039194S → L.Corresponds to variant rs59120409dbSNPEnsembl.1
Natural variantiVAR_062040274N → K.Corresponds to variant rs57985939dbSNPEnsembl.1
Natural variantiVAR_047236299I → V.1 PublicationCorresponds to variant rs7145814dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065898 Genomic DNA. Translation: BAC06114.1. Different initiation.
AL157687 Genomic DNA. No translation available.
BC137304 mRNA. Translation: AAI37305.1.
BC137305 mRNA. Translation: AAI37306.1.
AF399635 Genomic DNA. Translation: AAK95120.1.
BK004520 Genomic DNA. Translation: DAA04918.1.
CCDSiCCDS32042.1.
RefSeqiNP_001004731.1. NM_001004731.1.
UniGeneiHs.553768.

Genome annotation databases

EnsembliENST00000304418; ENSP00000302057; ENSG00000169327.
GeneIDi390445.
KEGGihsa:390445.
UCSCiuc010tlp.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065898 Genomic DNA. Translation: BAC06114.1. Different initiation.
AL157687 Genomic DNA. No translation available.
BC137304 mRNA. Translation: AAI37305.1.
BC137305 mRNA. Translation: AAI37306.1.
AF399635 Genomic DNA. Translation: AAK95120.1.
BK004520 Genomic DNA. Translation: DAA04918.1.
CCDSiCCDS32042.1.
RefSeqiNP_001004731.1. NM_001004731.1.
UniGeneiHs.553768.

3D structure databases

ProteinModelPortaliQ8NGC0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000302057.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGC0.
PhosphoSitePlusiQ8NGC0.

Polymorphism and mutation databases

BioMutaiOR5AU1.
DMDMi212276450.

Proteomic databases

PaxDbiQ8NGC0.
PRIDEiQ8NGC0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304418; ENSP00000302057; ENSG00000169327.
GeneIDi390445.
KEGGihsa:390445.
UCSCiuc010tlp.3. human.

Organism-specific databases

CTDi390445.
GeneCardsiOR5AU1.
HGNCiHGNC:15362. OR5AU1.
neXtProtiNX_Q8NGC0.
OpenTargetsiENSG00000169327.
PharmGKBiPA32474.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9KZ. Eukaryota.
ENOG41113B2. LUCA.
GeneTreeiENSGT00760000118941.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGC0.
KOiK04257.
OMAiIHTSCIF.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGC0.
TreeFamiTF352750.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169327-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5AU1.
GenomeRNAii390445.
PROiQ8NGC0.

Gene expression databases

CleanExiHS_OR5AU1.
ExpressionAtlasiQ8NGC0. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO5AU1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGC0
Secondary accession number(s): B2RP78, Q6IEU2, Q96R10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 4, 2008
Last modified: November 30, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.