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Protein

Olfactory receptor 4F6

Gene

OR4F6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-32703-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4F6
Alternative name(s):
Olfactory receptor 4F12
Olfactory receptor OR15-15
Gene namesi
Name:OR4F6
Synonyms:OR4F12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:15372. OR4F6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 235CytoplasmicSequence analysisAdd BLAST16
Transmembranei236 – 258Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini259 – 269ExtracellularSequence analysisAdd BLAST11
Transmembranei270 – 289Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini290 – 312CytoplasmicSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184140.
PharmGKBiPA32292.

Polymorphism and mutation databases

BioMutaiOR4F6.
DMDMi38372660.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505481 – 312Olfactory receptor 4F6Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGB9.
PeptideAtlasiQ8NGB9.
PRIDEiQ8NGB9.

Expressioni

Gene expression databases

CleanExiHS_OR4F6.
ExpressionAtlasiQ8NGB9. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000327525.

Structurei

3D structure databases

ProteinModelPortaliQ8NGB9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVRR. Eukaryota.
ENOG4111AZC. LUCA.
GeneTreeiENSGT00760000118815.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGB9.
KOiK04257.
OMAiQFVNYSK.
OrthoDBiEOG091G0CY9.
PhylomeDBiQ8NGB9.
TreeFamiTF336512.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEANHSVVS EFVFLGLSDS RKIQLLLFLF FSVFYVSSLM GNLLIVLTVT
60 70 80 90 100
SDPRLQSPMY FLLANLSIIN LVFCSSTAPK MIYDLFRKHK TISFGGCVVQ
110 120 130 140 150
IFFIHAVGGT EMVLLIAMAF DRYVAICKPL HYLTIMNPQR CILFLVISWI
160 170 180 190 200
IGIIHSVIQL AFVVDLLFCG PNELDSFFCD LPRFIKLACI ETYTLGFMVT
210 220 230 240 250
ANSGFISLAS FLILIISYIF ILVTVQKKSS GGIFKAFSML SAHVIVVVLV
260 270 280 290 300
FGPLIFFYIF PFPTSHLDKF LAIFDAVITP VLNPVIYTFR NKEMMVAMRR
310
RCSQFVNYSK IF
Length:312
Mass (Da):35,355
Last modified:October 1, 2002 - v1
Checksum:iB4FE59A4354F681A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065899 Genomic DNA. Translation: BAC06115.1.
CH471101 Genomic DNA. Translation: EAX02319.1.
BC137002 mRNA. Translation: AAI37003.1.
BC137003 mRNA. Translation: AAI37004.1.
BK004367 Genomic DNA. Translation: DAA04765.1.
CCDSiCCDS32341.1.
RefSeqiNP_001005326.1. NM_001005326.1.
UniGeneiHs.553399.

Genome annotation databases

EnsembliENST00000328882; ENSP00000327525; ENSG00000184140.
GeneIDi390648.
KEGGihsa:390648.
UCSCiuc010utr.3. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065899 Genomic DNA. Translation: BAC06115.1.
CH471101 Genomic DNA. Translation: EAX02319.1.
BC137002 mRNA. Translation: AAI37003.1.
BC137003 mRNA. Translation: AAI37004.1.
BK004367 Genomic DNA. Translation: DAA04765.1.
CCDSiCCDS32341.1.
RefSeqiNP_001005326.1. NM_001005326.1.
UniGeneiHs.553399.

3D structure databases

ProteinModelPortaliQ8NGB9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000327525.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR4F6.
DMDMi38372660.

Proteomic databases

PaxDbiQ8NGB9.
PeptideAtlasiQ8NGB9.
PRIDEiQ8NGB9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328882; ENSP00000327525; ENSG00000184140.
GeneIDi390648.
KEGGihsa:390648.
UCSCiuc010utr.3. human.

Organism-specific databases

CTDi390648.
GeneCardsiOR4F6.
HGNCiHGNC:15372. OR4F6.
neXtProtiNX_Q8NGB9.
OpenTargetsiENSG00000184140.
PharmGKBiPA32292.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVRR. Eukaryota.
ENOG4111AZC. LUCA.
GeneTreeiENSGT00760000118815.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGB9.
KOiK04257.
OMAiQFVNYSK.
OrthoDBiEOG091G0CY9.
PhylomeDBiQ8NGB9.
TreeFamiTF336512.

Enzyme and pathway databases

BioCyciZFISH:G66-32703-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR4F6.
GenomeRNAii390648.
PROiQ8NGB9.

Gene expression databases

CleanExiHS_OR4F6.
ExpressionAtlasiQ8NGB9. baseline.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR4F6_HUMAN
AccessioniPrimary (citable) accession number: Q8NGB9
Secondary accession number(s): B9EH28, Q6IF95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.