Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 4M2

Gene

OR4M2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4M2
Alternative name(s):
Olfactory receptor OR15-3
Gene namesi
Name:OR4M2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:15373. OR4M2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence analysis
Transmembranei58 – 7922Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence analysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini159 – 19537ExtracellularSequence analysisAdd
BLAST
Transmembranei196 – 21924Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini220 – 23718CytoplasmicSequence analysisAdd
BLAST
Transmembranei238 – 26023Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini261 – 27111ExtracellularSequence analysisAdd
BLAST
Transmembranei272 – 29120Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini292 – 31322CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32328.

Polymorphism and mutation databases

BioMutaiOR4M2.
DMDMi311033407.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Olfactory receptor 4M2PRO_0000150562Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGB6.
PRIDEiQ8NGB6.

Expressioni

Gene expression databases

BgeeiQ8NGB6.
CleanExiHS_OR4M2.

Organism-specific databases

HPAiHPA058889.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000329467.

Structurei

3D structure databases

ProteinModelPortaliQ8NGB6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119104.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGB6.
KOiK04257.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGB6.
TreeFamiTF338273.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METANYTKVT EFVLTGLSQT PEVQLVLFVI FLSFYLFILP GNILIICTIS
60 70 80 90 100
LDPHLTSPMY FLLANLAFLD IWYSSITAPE MLIDFFVERK IISFDGCIAQ
110 120 130 140 150
LFFLHFAGAS EMFLLTVMAF DLYTAICRPL HYATIMNQRL CCILVALSWR
160 170 180 190 200
GGFIHSIIQV ALIVRLPFCG PNELDSYFCD ITQVVRIACA NTFPEELVMI
210 220 230 240 250
CSSGLISVVC LIALLMSYAF LLALFKKLSG SGENTNRAMS TCYSHITIVV
260 270 280 290 300
LMFGPSIYIY ARPFDSFSLD KVVSVFNTLI FPLRNPIIYT LRNKEVKAAM
310
RKLVTKYILC KEK
Length:313
Mass (Da):35,416
Last modified:November 2, 2010 - v2
Checksum:iC64ADE94D1F97533
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti96 – 961G → E.1 Publication
Corresponds to variant rs1835183 [ dbSNP | Ensembl ].
VAR_047831
Natural varianti121 – 1211D → N.
Corresponds to variant rs11857531 [ dbSNP | Ensembl ].
VAR_047832
Natural varianti225 – 2251F → L.2 Publications
Corresponds to variant rs491208 [ dbSNP | Ensembl ].
VAR_047833
Natural varianti239 – 2391M → V.
Corresponds to variant rs12593418 [ dbSNP | Ensembl ].
VAR_047834
Natural varianti284 – 2841R → H.
Corresponds to variant rs4087943 [ dbSNP | Ensembl ].
VAR_047835

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065903 Genomic DNA. Translation: BAC06118.1.
AC134980 Genomic DNA. No translation available.
BC136985 mRNA. Translation: AAI36986.1.
BK004480 Genomic DNA. Translation: DAA04878.1.
CCDSiCCDS32172.1.
RefSeqiNP_001004719.2. NM_001004719.2.
UniGeneiHs.729625.

Genome annotation databases

EnsembliENST00000614722; ENSP00000483239; ENSG00000274102.
GeneIDi390538.
KEGGihsa:390538.
UCSCiuc010tzu.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065903 Genomic DNA. Translation: BAC06118.1.
AC134980 Genomic DNA. No translation available.
BC136985 mRNA. Translation: AAI36986.1.
BK004480 Genomic DNA. Translation: DAA04878.1.
CCDSiCCDS32172.1.
RefSeqiNP_001004719.2. NM_001004719.2.
UniGeneiHs.729625.

3D structure databases

ProteinModelPortaliQ8NGB6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000329467.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR4M2.
DMDMi311033407.

Proteomic databases

PaxDbiQ8NGB6.
PRIDEiQ8NGB6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000614722; ENSP00000483239; ENSG00000274102.
GeneIDi390538.
KEGGihsa:390538.
UCSCiuc010tzu.3. human.

Organism-specific databases

CTDi390538.
GeneCardsiOR4M2.
HGNCiHGNC:15373. OR4M2.
HPAiHPA058889.
neXtProtiNX_Q8NGB6.
PharmGKBiPA32328.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119104.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGB6.
KOiK04257.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGB6.
TreeFamiTF338273.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR4M2.
GenomeRNAii390538.
NextBioi103858.
PROiQ8NGB6.

Gene expression databases

BgeeiQ8NGB6.
CleanExiHS_OR4M2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-225.
  2. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLU-96 AND LEU-225.
    Tissue: Testis.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR4M2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGB6
Secondary accession number(s): B9EH16, Q6IEY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 2, 2010
Last modified: March 16, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.