Q8NGB6 (OR4M2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 4M2

Alternative name(s):
Olfactory receptor OR15-3

Gene names

Name:

OR4M2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	Olfactory receptor 4M2		PRO_0000150562
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 49	24	Helical; Name=1; Potential
	Topological domain	50 – 57	8	Cytoplasmic Potential
	Transmembrane	58 – 79	22	Helical; Name=2; Potential
	Topological domain	80 – 100	21	Extracellular Potential
	Transmembrane	101 – 120	20	Helical; Name=3; Potential
	Topological domain	121 – 139	19	Cytoplasmic Potential
	Transmembrane	140 – 158	19	Helical; Name=4; Potential
	Topological domain	159 – 195	37	Extracellular Potential
	Transmembrane	196 – 219	24	Helical; Name=5; Potential
	Topological domain	220 – 237	18	Cytoplasmic Potential
	Transmembrane	238 – 260	23	Helical; Name=6; Potential
	Topological domain	261 – 271	11	Extracellular Potential
	Transmembrane	272 – 291	20	Helical; Name=7; Potential
	Topological domain	292 – 313	22	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	97 ↔ 189		By similarity
Natural variations
	Natural variant	96	1	G → E. Ref.3 Corresponds to variant rs1835183 [ dbSNP | Ensembl ].		VAR_047831
	Natural variant	121	1	D → N. Corresponds to variant rs11857531 [ dbSNP | Ensembl ].		VAR_047832
	Natural variant	225	1	F → L. Ref.1 Ref.3 Corresponds to variant rs491208 [ dbSNP | Ensembl ].		VAR_047833
	Natural variant	239	1	M → V. Corresponds to variant rs12593418 [ dbSNP | Ensembl ].		VAR_047834
	Natural variant	284	1	R → H. Corresponds to variant rs4087943 [ dbSNP | Ensembl ].		VAR_047835

Sequences

	Sequence		Length	Mass (Da)
	Q8NGB6 [UniParc]. Last modified November 2, 2010. Version 2. Checksum: C64ADE94D1F97533	FASTA	313	35,416
	10 20 30 40 50 60 METANYTKVT EFVLTGLSQT PEVQLVLFVI FLSFYLFILP GNILIICTIS LDPHLTSPMY 70 80 90 100 110 120 FLLANLAFLD IWYSSITAPE MLIDFFVERK IISFDGCIAQ LFFLHFAGAS EMFLLTVMAF 130 140 150 160 170 180 DLYTAICRPL HYATIMNQRL CCILVALSWR GGFIHSIIQV ALIVRLPFCG PNELDSYFCD 190 200 210 220 230 240 ITQVVRIACA NTFPEELVMI CSSGLISVVC LIALLMSYAF LLALFKKLSG SGENTNRAMS 250 260 270 280 290 300 TCYSHITIVV LMFGPSIYIY ARPFDSFSLD KVVSVFNTLI FPLRNPIIYT LRNKEVKAAM 310 RKLVTKYILC KEK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-225.
[2]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed: 16572171] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLU-96 AND LEU-225. Tissue: Testis.
[4]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed: 14983052] [Abstract] Cited for: IDENTIFICATION.
[5]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065903 Genomic DNA. Translation: BAC06118.1. AC134980 Genomic DNA. No translation available. BC136985 mRNA. Translation: AAI36986.1. BK004480 Genomic DNA. Translation: DAA04878.1.
IPI	IPI00168969.
RefSeq	NP_001004719.2. NM_001004719.2.
UniGene	Hs.729625.
3D structure databases
ProteinModelPortal	Q8NGB6.
SMR	Q8NGB6. Positions 109-140, 276-305.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8NGB6.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	311033407.
Proteomic databases
PRIDE	Q8NGB6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000332663; ENSP00000329467; ENSG00000182974.
GeneID	390538.
KEGG	hsa:390538.
UCSC	uc001yud.1. human.
Organism-specific databases
CTD	390538.
GeneCards	GC15P022368.
HGNC	HGNC:15373. OR4M2.
neXtProt	NX_Q8NGB6.
PharmGKB	PA32328.
GenAtlas	Search...
Phylogenomic databases
eggNOG	maNOG13336.
GeneTree	ENSGT00580000081417.
HOGENOM	HBG755317.
HOVERGEN	HBG017625.
InParanoid	Q8NGB6.
OMA	TERNAIM.
OrthoDB	EOG4C2HB1.
PhylomeDB	Q8NGB6.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	Q8NGB6.
CleanEx	HS_OR4M2.
Genevestigator	Q8NGB6.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR000725. Olfact_rcpt. [Graphical view]
KO	K04257.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	103858.

Entry information

Entry name

OR4M2_HUMAN

Accession

Primary (citable) accession number: Q8NGB6
Secondary accession number(s): B9EH16, Q6IEY2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	November 2, 2010
Last modified:	December 14, 2011
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.