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Protein

Olfactory receptor 4C5

Gene

OR4C5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4C5
Alternative name(s):
Olfactory receptor OR11-99
Gene namesi
Name:OR4C5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14702. OR4C5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4646ExtracellularSequence analysisAdd
BLAST
Transmembranei47 – 7024Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini71 – 788CytoplasmicSequence analysis
Transmembranei79 – 10022Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini101 – 12121ExtracellularSequence analysisAdd
BLAST
Transmembranei122 – 14120Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini142 – 16019CytoplasmicSequence analysisAdd
BLAST
Transmembranei161 – 17919Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini180 – 21637ExtracellularSequence analysisAdd
BLAST
Transmembranei217 – 24024Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini241 – 2488CytoplasmicSequence analysis
Transmembranei249 – 27123Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini272 – 28211ExtracellularSequence analysisAdd
BLAST
Transmembranei283 – 30220Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini303 – 32624CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi74760242.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Olfactory receptor 4C5PRO_0000150530Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence analysis
Disulfide bondi118 ↔ 210PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGB2.
PRIDEiQ8NGB2.

Expressioni

Organism-specific databases

HPAiHPA049516.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000321338.

Structurei

3D structure databases

ProteinModelPortaliQ8NGB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKHV. Eukaryota.
ENOG4111834. LUCA.
GeneTreeiENSGT00840000129693.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGB2.
OMAiFHALIQI.
OrthoDBiEOG754HPT.
PhylomeDBiQ8NGB2.
TreeFamiTF337350.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYVSNCNPCA IHRKINYPNT KLDFEQVNNI TEFILLGLTQ NAEAQKLLFA
60 70 80 90 100
VFTLIYFLTM VDNLIIVVTI TTSPALDSPV YFFLSFFSFI DGCSSSTMAP
110 120 130 140 150
KMIFDLLTEK KTISFSGCMT QLFVEHFFGG VEIILLVVMA YDCYVAICKP
160 170 180 190 200
LYYLITMNRQ VCGLLVAMAW VGGFLHALIQ MLLIVWLPFC GPNVIDHFIC
210 220 230 240 250
DLFPLLKLSC TDTHVFGLFV AANSGLMCML IFSILITSYV LILCSQRKAL
260 270 280 290 300
STCAFHITVV VLFFVPCILV YLRPMITFPI DKAVSVFYTV VTPMLNPLIY
310 320
TLRNTEVKNA MKQLWSQIIW GNNLCD
Length:326
Mass (Da):36,862
Last modified:October 1, 2002 - v1
Checksum:i18669FB8FB019166
GO

Sequence cautioni

The sequence DAA04748.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065910 Genomic DNA. Translation: BAC06125.1.
BK004350 Genomic DNA. Translation: DAA04748.1. Different initiation.

Genome annotation databases

EnsembliENST00000319813; ENSP00000321338; ENSG00000176540.
UCSCiuc058bja.1. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065910 Genomic DNA. Translation: BAC06125.1.
BK004350 Genomic DNA. Translation: DAA04748.1. Different initiation.

3D structure databases

ProteinModelPortaliQ8NGB2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000321338.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

DMDMi74760242.

Proteomic databases

PaxDbiQ8NGB2.
PRIDEiQ8NGB2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319813; ENSP00000321338; ENSG00000176540.
UCSCiuc058bja.1. human.

Organism-specific databases

GeneCardsiOR4C5.
HGNCiHGNC:14702. OR4C5.
HPAiHPA049516.
neXtProtiNX_Q8NGB2.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKHV. Eukaryota.
ENOG4111834. LUCA.
GeneTreeiENSGT00840000129693.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGB2.
OMAiFHALIQI.
OrthoDBiEOG754HPT.
PhylomeDBiQ8NGB2.
TreeFamiTF337350.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

PROiQ8NGB2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR4C5_HUMAN
AccessioniPrimary (citable) accession number: Q8NGB2
Secondary accession number(s): Q6IFB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2002
Last modified: May 11, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.