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Q8NGA8

- O4F17_HUMAN

UniProt

Q8NGA8 - O4F17_HUMAN

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Protein

Olfactory receptor 4F17

Gene

OR4F17

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4F17
Alternative name(s):
Olfactory receptor 4F11
Olfactory receptor 4F18
Olfactory receptor 4F19
Gene namesi
Name:OR4F17
Synonyms:OR4F11P, OR4F18, OR4F19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:15381. OR4F17.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32285.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Olfactory receptor 4F17PRO_0000150550Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi90 ↔ 182PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8NGA8.
PRIDEiQ8NGA8.

PTM databases

PhosphoSiteiQ8NGA8.

Expressioni

Gene expression databases

CleanExiHS_OR4F17.
GenevestigatoriQ8NGA8.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000315047.

Structurei

3D structure databases

ProteinModelPortaliQ8NGA8.
SMRiQ8NGA8. Positions 32-294.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1818ExtracellularSequence AnalysisAdd
BLAST
Topological domaini43 – 508CytoplasmicSequence Analysis
Topological domaini73 – 9321ExtracellularSequence AnalysisAdd
BLAST
Topological domaini114 – 13219CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini152 – 18837ExtracellularSequence AnalysisAdd
BLAST
Topological domaini213 – 22816CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini252 – 26211ExtracellularSequence AnalysisAdd
BLAST
Topological domaini283 – 30523CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 4224Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei51 – 7222Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei94 – 11320Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei133 – 15119Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei189 – 21224Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei229 – 25123Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei263 – 28220Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146672.
GeneTreeiENSGT00760000118815.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGA8.
KOiK04257.
OMAiMRRLRQW.
OrthoDBiEOG7J9VPZ.
PhylomeDBiQ8NGA8.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGA8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVTEFIFLGL SDSQGLQTFL FMLFFVFYGG IVFGNLLIVI TVVSDSHLHS
60 70 80 90 100
PMYFLLANLS LIDLSLSSVT APKMITDFFS QRKVISFKGC LVQIFLLHFF
110 120 130 140 150
GGSEMVILIA MGFDRYIAIC KPLHYTTIMC GNACVGIMAV AWGIGFLHSV
160 170 180 190 200
SQLAFAVHLP FCGPNEVDSF YCDLPRVIKL ACTDTYRLDI MVIANSGVLT
210 220 230 240 250
VCSFVLLIIS YTIILMTIQH RPLDKSSKAL STLTAHITVV LLFFGPCVFI
260 270 280 290 300
YAWPFPIKSL DKFLAVFYSV ITPLLNPIIY TLRNKDMKTA IRQLRKWDAH

SSVKF
Length:305
Mass (Da):34,212
Last modified:October 1, 2002 - v1
Checksum:i2DDFAC5504EDFA6E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065917 Genomic DNA. Translation: BAC06132.1.
BC136848 mRNA. Translation: AAI36849.1.
BC136867 mRNA. Translation: AAI36868.1.
CCDSiCCDS32854.1.
RefSeqiNP_001005240.1. NM_001005240.1.
XP_005259705.1. XM_005259648.1.
UniGeneiHs.572591.

Genome annotation databases

EnsembliENST00000318050; ENSP00000315047; ENSG00000176695.
ENST00000585993; ENSP00000467301; ENSG00000176695.
GeneIDi81099.
KEGGihsa:81099.
UCSCiuc002lob.1. human.

Polymorphism databases

DMDMi38372655.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065917 Genomic DNA. Translation: BAC06132.1 .
BC136848 mRNA. Translation: AAI36849.1 .
BC136867 mRNA. Translation: AAI36868.1 .
CCDSi CCDS32854.1.
RefSeqi NP_001005240.1. NM_001005240.1.
XP_005259705.1. XM_005259648.1.
UniGenei Hs.572591.

3D structure databases

ProteinModelPortali Q8NGA8.
SMRi Q8NGA8. Positions 32-294.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000315047.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGA8.

Polymorphism databases

DMDMi 38372655.

Proteomic databases

PaxDbi Q8NGA8.
PRIDEi Q8NGA8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000318050 ; ENSP00000315047 ; ENSG00000176695 .
ENST00000585993 ; ENSP00000467301 ; ENSG00000176695 .
GeneIDi 81099.
KEGGi hsa:81099.
UCSCi uc002lob.1. human.

Organism-specific databases

CTDi 81099.
GeneCardsi GC19P000107.
HGNCi HGNC:15381. OR4F17.
neXtProti NX_Q8NGA8.
PharmGKBi PA32285.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146672.
GeneTreei ENSGT00760000118815.
HOGENOMi HOG000041362.
HOVERGENi HBG017625.
InParanoidi Q8NGA8.
KOi K04257.
OMAi MRRLRQW.
OrthoDBi EOG7J9VPZ.
PhylomeDBi Q8NGA8.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii 81099.
NextBioi 49037.
PROi Q8NGA8.

Gene expression databases

CleanExi HS_OR4F17.
Genevestigatori Q8NGA8.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiO4F17_HUMAN
AccessioniPrimary (citable) accession number: Q8NGA8
Secondary accession number(s): B2RNE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3