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Q8NGA8 (O4F17_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 4F17
Alternative name(s):
Olfactory receptor 4F11
Olfactory receptor 4F18
Olfactory receptor 4F19
Gene names
Name:OR4F17
Synonyms:OR4F11P, OR4F18, OR4F19
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305Olfactory receptor 4F17
PRO_0000150550

Regions

Topological domain1 – 1818Extracellular Potential
Transmembrane19 – 4224Helical; Name=1; Potential
Topological domain43 – 508Cytoplasmic Potential
Transmembrane51 – 7222Helical; Name=2; Potential
Topological domain73 – 9321Extracellular Potential
Transmembrane94 – 11320Helical; Name=3; Potential
Topological domain114 – 13219Cytoplasmic Potential
Transmembrane133 – 15119Helical; Name=4; Potential
Topological domain152 – 18837Extracellular Potential
Transmembrane189 – 21224Helical; Name=5; Potential
Topological domain213 – 22816Cytoplasmic Potential
Transmembrane229 – 25123Helical; Name=6; Potential
Topological domain252 – 26211Extracellular Potential
Transmembrane263 – 28220Helical; Name=7; Potential
Topological domain283 – 30523Cytoplasmic Potential

Amino acid modifications

Disulfide bond90 ↔ 182 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8NGA8 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 2DDFAC5504EDFA6E

FASTA30534,212
        10         20         30         40         50         60 
MVTEFIFLGL SDSQGLQTFL FMLFFVFYGG IVFGNLLIVI TVVSDSHLHS PMYFLLANLS 

        70         80         90        100        110        120 
LIDLSLSSVT APKMITDFFS QRKVISFKGC LVQIFLLHFF GGSEMVILIA MGFDRYIAIC 

       130        140        150        160        170        180 
KPLHYTTIMC GNACVGIMAV AWGIGFLHSV SQLAFAVHLP FCGPNEVDSF YCDLPRVIKL 

       190        200        210        220        230        240 
ACTDTYRLDI MVIANSGVLT VCSFVLLIIS YTIILMTIQH RPLDKSSKAL STLTAHITVV 

       250        260        270        280        290        300 
LLFFGPCVFI YAWPFPIKSL DKFLAVFYSV ITPLLNPIIY TLRNKDMKTA IRQLRKWDAH 


SSVKF 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065917 Genomic DNA. Translation: BAC06132.1.
BC136848 mRNA. Translation: AAI36849.1.
BC136867 mRNA. Translation: AAI36868.1.
CCDSCCDS32854.1.
RefSeqNP_001005240.1. NM_001005240.1.
XP_005259705.1. XM_005259648.1.
UniGeneHs.572591.

3D structure databases

ProteinModelPortalQ8NGA8.
SMRQ8NGA8. Positions 32-298.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000315047.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NGA8.

Polymorphism databases

DMDM38372655.

Proteomic databases

PaxDbQ8NGA8.
PRIDEQ8NGA8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000318050; ENSP00000315047; ENSG00000176695.
ENST00000585993; ENSP00000467301; ENSG00000176695.
GeneID81099.
KEGGhsa:81099.
UCSCuc002lob.1. human.

Organism-specific databases

CTD81099.
GeneCardsGC19P000107.
HGNCHGNC:15381. OR4F17.
neXtProtNX_Q8NGA8.
PharmGKBPA32285.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG146672.
HOGENOMHOG000041362.
HOVERGENHBG017625.
InParanoidQ8NGA8.
KOK04257.
OMAMRRLRQW.
OrthoDBEOG7J9VPZ.
PhylomeDBQ8NGA8.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR4F17.
GenevestigatorQ8NGA8.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi81099.
NextBio49037.
PROQ8NGA8.

Entry information

Entry nameO4F17_HUMAN
AccessionPrimary (citable) accession number: Q8NGA8
Secondary accession number(s): B2RNE8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries