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Q8NGA8

- O4F17_HUMAN

UniProt

Q8NGA8 - O4F17_HUMAN

Protein

Olfactory receptor 4F17

Gene

OR4F17

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 4F17
    Alternative name(s):
    Olfactory receptor 4F11
    Olfactory receptor 4F18
    Olfactory receptor 4F19
    Gene namesi
    Name:OR4F17
    Synonyms:OR4F11P, OR4F18, OR4F19
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:15381. OR4F17.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32285.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 305305Olfactory receptor 4F17PRO_0000150550Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi90 ↔ 182PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ8NGA8.
    PRIDEiQ8NGA8.

    PTM databases

    PhosphoSiteiQ8NGA8.

    Expressioni

    Gene expression databases

    CleanExiHS_OR4F17.
    GenevestigatoriQ8NGA8.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000315047.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGA8.
    SMRiQ8NGA8. Positions 32-298.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1818ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini43 – 508CytoplasmicSequence Analysis
    Topological domaini73 – 9321ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini114 – 13219CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini152 – 18837ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini213 – 22816CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini252 – 26211ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini283 – 30523CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei19 – 4224Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei51 – 7222Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei94 – 11320Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei133 – 15119Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei189 – 21224Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei229 – 25123Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei263 – 28220Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146672.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiQ8NGA8.
    KOiK04257.
    OMAiMRRLRQW.
    OrthoDBiEOG7J9VPZ.
    PhylomeDBiQ8NGA8.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGA8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVTEFIFLGL SDSQGLQTFL FMLFFVFYGG IVFGNLLIVI TVVSDSHLHS    50
    PMYFLLANLS LIDLSLSSVT APKMITDFFS QRKVISFKGC LVQIFLLHFF 100
    GGSEMVILIA MGFDRYIAIC KPLHYTTIMC GNACVGIMAV AWGIGFLHSV 150
    SQLAFAVHLP FCGPNEVDSF YCDLPRVIKL ACTDTYRLDI MVIANSGVLT 200
    VCSFVLLIIS YTIILMTIQH RPLDKSSKAL STLTAHITVV LLFFGPCVFI 250
    YAWPFPIKSL DKFLAVFYSV ITPLLNPIIY TLRNKDMKTA IRQLRKWDAH 300
    SSVKF 305
    Length:305
    Mass (Da):34,212
    Last modified:October 1, 2002 - v1
    Checksum:i2DDFAC5504EDFA6E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065917 Genomic DNA. Translation: BAC06132.1.
    BC136848 mRNA. Translation: AAI36849.1.
    BC136867 mRNA. Translation: AAI36868.1.
    CCDSiCCDS32854.1.
    RefSeqiNP_001005240.1. NM_001005240.1.
    XP_005259705.1. XM_005259648.1.
    UniGeneiHs.572591.

    Genome annotation databases

    EnsembliENST00000318050; ENSP00000315047; ENSG00000176695.
    ENST00000585993; ENSP00000467301; ENSG00000176695.
    GeneIDi81099.
    KEGGihsa:81099.
    UCSCiuc002lob.1. human.

    Polymorphism databases

    DMDMi38372655.

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065917 Genomic DNA. Translation: BAC06132.1 .
    BC136848 mRNA. Translation: AAI36849.1 .
    BC136867 mRNA. Translation: AAI36868.1 .
    CCDSi CCDS32854.1.
    RefSeqi NP_001005240.1. NM_001005240.1.
    XP_005259705.1. XM_005259648.1.
    UniGenei Hs.572591.

    3D structure databases

    ProteinModelPortali Q8NGA8.
    SMRi Q8NGA8. Positions 32-298.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000315047.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NGA8.

    Polymorphism databases

    DMDMi 38372655.

    Proteomic databases

    PaxDbi Q8NGA8.
    PRIDEi Q8NGA8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000318050 ; ENSP00000315047 ; ENSG00000176695 .
    ENST00000585993 ; ENSP00000467301 ; ENSG00000176695 .
    GeneIDi 81099.
    KEGGi hsa:81099.
    UCSCi uc002lob.1. human.

    Organism-specific databases

    CTDi 81099.
    GeneCardsi GC19P000107.
    HGNCi HGNC:15381. OR4F17.
    neXtProti NX_Q8NGA8.
    PharmGKBi PA32285.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146672.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi Q8NGA8.
    KOi K04257.
    OMAi MRRLRQW.
    OrthoDBi EOG7J9VPZ.
    PhylomeDBi Q8NGA8.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GenomeRNAii 81099.
    NextBioi 49037.
    PROi Q8NGA8.

    Gene expression databases

    CleanExi HS_OR4F17.
    Genevestigatori Q8NGA8.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiO4F17_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGA8
    Secondary accession number(s): B2RNE8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3