ID   O10H5_HUMAN             Reviewed;         315 AA.
AC   Q8NGA6; Q6IFJ0; Q96R60;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   24-JAN-2024, entry version 162.
DE   RecName: Full=Olfactory receptor 10H5;
DE   AltName: Full=Olfactory receptor OR19-25;
DE   AltName: Full=Olfactory receptor OR19-26;
GN   Name=OR10H5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [5]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10H5";
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DR   EMBL; AB065920; BAC06135.1; -; Genomic_DNA.
DR   EMBL; BC136869; AAI36870.1; -; mRNA.
DR   EMBL; AF399583; AAK95068.1; -; Genomic_DNA.
DR   EMBL; BK004271; DAA04669.1; -; Genomic_DNA.
DR   EMBL; BK004272; DAA04670.1; -; Genomic_DNA.
DR   CCDS; CCDS32940.1; -.
DR   RefSeq; NP_001004466.1; NM_001004466.1.
DR   AlphaFoldDB; Q8NGA6; -.
DR   SMR; Q8NGA6; -.
DR   STRING; 9606.ENSP00000493242; -.
DR   GlyCosmos; Q8NGA6; 1 site, No reported glycans.
DR   GlyGen; Q8NGA6; 1 site.
DR   iPTMnet; Q8NGA6; -.
DR   PhosphoSitePlus; Q8NGA6; -.
DR   BioMuta; OR10H5; -.
DR   DMDM; 38372654; -.
DR   MassIVE; Q8NGA6; -.
DR   PaxDb; 9606-ENSP00000310704; -.
DR   PeptideAtlas; Q8NGA6; -.
DR   Antibodypedia; 57128; 79 antibodies from 19 providers.
DR   DNASU; 284433; -.
DR   Ensembl; ENST00000308940.8; ENSP00000310704.8; ENSG00000172519.10.
DR   Ensembl; ENST00000642092.2; ENSP00000493242.1; ENSG00000172519.10.
DR   GeneID; 284433; -.
DR   KEGG; hsa:284433; -.
DR   MANE-Select; ENST00000642092.2; ENSP00000493242.1; NM_001004466.2; NP_001004466.1.
DR   UCSC; uc010xos.3; human.
DR   AGR; HGNC:15389; -.
DR   CTD; 284433; -.
DR   GeneCards; OR10H5; -.
DR   HGNC; HGNC:15389; OR10H5.
DR   HPA; ENSG00000172519; Not detected.
DR   neXtProt; NX_Q8NGA6; -.
DR   PharmGKB; PA31981; -.
DR   VEuPathDB; HostDB:ENSG00000172519; -.
DR   eggNOG; ENOG502SJHK; Eukaryota.
DR   GeneTree; ENSGT01100000263561; -.
DR   HOGENOM; CLU_012526_1_0_1; -.
DR   InParanoid; Q8NGA6; -.
DR   OMA; HTIPFAA; -.
DR   OrthoDB; 4514128at2759; -.
DR   PhylomeDB; Q8NGA6; -.
DR   TreeFam; TF337675; -.
DR   PathwayCommons; Q8NGA6; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 284433; 11 hits in 721 CRISPR screens.
DR   ChiTaRS; OR10H5; human.
DR   GenomeRNAi; 284433; -.
DR   Pharos; Q8NGA6; Tdark.
DR   PRO; PR:Q8NGA6; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q8NGA6; Protein.
DR   Bgee; ENSG00000172519; Expressed in islet of Langerhans.
DR   ExpressionAtlas; Q8NGA6; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   CDD; cd15225; 7tmA_OR10A-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF712; OLFACTORY RECEPTOR 10H1-RELATED; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; Q8NGA6; HS.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..315
FT                   /note="Olfactory receptor 10H5"
FT                   /id="PRO_0000150706"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..54
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        76..99
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        161..197
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..218
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        219..238
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..272
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        294..315
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   315 AA;  34900 MW;  D43DAFA36E2F8F50 CRC64;
     MQGLNHTSVS EFILVGFSAF PHLQLMLFLL FLLMYLFTLL GNLLIMATVW SERSLHMPMY
     LFLCALSITE ILYTVAIIPR MLADLLSTQR SIAFLACASQ MFFSFSFGFT HSFLLTVMGY
     DRYVAICHPL RYNVLMSLRG CTCRVGCSWA GGLVMGMVVT SAIFHLAFCG HKEIHHFFCH
     VPPLLKLACG DDVLVVAKGV GLVCITALLG CFLLILLSYA FIVAAILKIP SAEGRNKAFS
     TCASHLTVVV VHYGFASVIY LKPKGPQSPE GDTLMGITYT VLTPFLSPII FSLRNKELKV
     AMKKTCFTKL FPQNC
//