Q8NGA6 (O10H5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 10H5

Alternative name(s):
Olfactory receptor OR19-25
Olfactory receptor OR19-26

Gene names

Name:

OR10H5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 315	315	Olfactory receptor 10H5		PRO_0000150706
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 46	21	Helical; Name=1; Potential
	Topological domain	47 – 54	8	Cytoplasmic Potential
	Transmembrane	55 – 75	21	Helical; Name=2; Potential
	Topological domain	76 – 99	24	Extracellular Potential
	Transmembrane	100 – 120	21	Helical; Name=3; Potential
	Topological domain	121 – 139	19	Cytoplasmic Potential
	Transmembrane	140 – 160	21	Helical; Name=4; Potential
	Topological domain	161 – 197	37	Extracellular Potential
	Transmembrane	198 – 218	21	Helical; Name=5; Potential
	Topological domain	219 – 238	20	Cytoplasmic Potential
	Transmembrane	239 – 259	21	Helical; Name=6; Potential
	Topological domain	260 – 272	13	Extracellular Potential
	Transmembrane	273 – 293	21	Helical; Name=7; Potential
	Topological domain	294 – 315	22	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	97 ↔ 189		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8NGA6 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: D43DAFA36E2F8F50	FASTA	315	34,900
	10 20 30 40 50 60 MQGLNHTSVS EFILVGFSAF PHLQLMLFLL FLLMYLFTLL GNLLIMATVW SERSLHMPMY 70 80 90 100 110 120 LFLCALSITE ILYTVAIIPR MLADLLSTQR SIAFLACASQ MFFSFSFGFT HSFLLTVMGY 130 140 150 160 170 180 DRYVAICHPL RYNVLMSLRG CTCRVGCSWA GGLVMGMVVT SAIFHLAFCG HKEIHHFFCH 190 200 210 220 230 240 VPPLLKLACG DDVLVVAKGV GLVCITALLG CFLLILLSYA FIVAAILKIP SAEGRNKAFS 250 260 270 280 290 300 TCASHLTVVV VHYGFASVIY LKPKGPQSPE GDTLMGITYT VLTPFLSPII FSLRNKELKV 310 AMKKTCFTKL FPQNC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284.
[4]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[5]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065920 Genomic DNA. Translation: BAC06135.1. BC136869 mRNA. Translation: AAI36870.1. AF399583 Genomic DNA. Translation: AAK95068.1. BK004271 Genomic DNA. Translation: DAA04669.1. BK004272 Genomic DNA. Translation: DAA04670.1.
IPI	IPI00377004.
RefSeq	NP_001004466.1. NM_001004466.1.
UniGene	Hs.553676.
3D structure databases
ProteinModelPortal	Q8NGA6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000310704.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	38372654.
Proteomic databases
PaxDb	Q8NGA6.
PRIDE	Q8NGA6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000308940; ENSP00000310704; ENSG00000172519.
GeneID	284433.
KEGG	hsa:284433.
UCSC	uc010xos.2. human.
Organism-specific databases
CTD	284433.
GeneCards	GC19P015904.
H-InvDB	HIX0174445.
HGNC	HGNC:15389. OR10H5.
neXtProt	NX_Q8NGA6.
PharmGKB	PA31981.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG79272.
HOGENOM	HOG000041362.
HOVERGEN	HBG017625.
InParanoid	Q8NGA6.
KO	K04257.
OMA	RSLHMPM.
OrthoDB	EOG42V8H0.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR10H5.
Genevestigator	Q8NGA6.
GermOnline	ENSG00000172519. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	284433.
NextBio	94881.

Entry information

Entry name

O10H5_HUMAN

Accession

Primary (citable) accession number: Q8NGA6
Secondary accession number(s): Q6IFJ0, Q96R60

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.