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Protein

Olfactory receptor 10H5

Gene

OR10H5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10H5
Alternative name(s):
Olfactory receptor OR19-25
Olfactory receptor OR19-26
Gene namesi
Name:OR10H5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:15389. OR10H5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence Analysis
Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
BLAST
Transmembranei198 – 21821Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini219 – 23820CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
BLAST
Transmembranei273 – 29321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini294 – 31522CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31981.

Polymorphism and mutation databases

BioMutaiOR10H5.
DMDMi38372654.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Olfactory receptor 10H5PRO_0000150706Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGA6.
PRIDEiQ8NGA6.

Expressioni

Gene expression databases

CleanExiHS_OR10H5.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000310704.

Structurei

3D structure databases

ProteinModelPortaliQ8NGA6.
SMRiQ8NGA6. Positions 24-163.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG79272.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGA6.
KOiK04257.
OMAiLACGDIW.
OrthoDBiEOG78PV9F.
PhylomeDBiQ8NGA6.
TreeFamiTF337675.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGLNHTSVS EFILVGFSAF PHLQLMLFLL FLLMYLFTLL GNLLIMATVW
60 70 80 90 100
SERSLHMPMY LFLCALSITE ILYTVAIIPR MLADLLSTQR SIAFLACASQ
110 120 130 140 150
MFFSFSFGFT HSFLLTVMGY DRYVAICHPL RYNVLMSLRG CTCRVGCSWA
160 170 180 190 200
GGLVMGMVVT SAIFHLAFCG HKEIHHFFCH VPPLLKLACG DDVLVVAKGV
210 220 230 240 250
GLVCITALLG CFLLILLSYA FIVAAILKIP SAEGRNKAFS TCASHLTVVV
260 270 280 290 300
VHYGFASVIY LKPKGPQSPE GDTLMGITYT VLTPFLSPII FSLRNKELKV
310
AMKKTCFTKL FPQNC
Length:315
Mass (Da):34,900
Last modified:October 1, 2002 - v1
Checksum:iD43DAFA36E2F8F50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065920 Genomic DNA. Translation: BAC06135.1.
BC136869 mRNA. Translation: AAI36870.1.
AF399583 Genomic DNA. Translation: AAK95068.1.
BK004271 Genomic DNA. Translation: DAA04669.1.
BK004272 Genomic DNA. Translation: DAA04670.1.
CCDSiCCDS32940.1.
RefSeqiNP_001004466.1. NM_001004466.1.
UniGeneiHs.553676.

Genome annotation databases

EnsembliENST00000308940; ENSP00000310704; ENSG00000172519.
GeneIDi284433.
KEGGihsa:284433.
UCSCiuc010xos.2. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065920 Genomic DNA. Translation: BAC06135.1.
BC136869 mRNA. Translation: AAI36870.1.
AF399583 Genomic DNA. Translation: AAK95068.1.
BK004271 Genomic DNA. Translation: DAA04669.1.
BK004272 Genomic DNA. Translation: DAA04670.1.
CCDSiCCDS32940.1.
RefSeqiNP_001004466.1. NM_001004466.1.
UniGeneiHs.553676.

3D structure databases

ProteinModelPortaliQ8NGA6.
SMRiQ8NGA6. Positions 24-163.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000310704.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR10H5.
DMDMi38372654.

Proteomic databases

PaxDbiQ8NGA6.
PRIDEiQ8NGA6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308940; ENSP00000310704; ENSG00000172519.
GeneIDi284433.
KEGGihsa:284433.
UCSCiuc010xos.2. human.

Organism-specific databases

CTDi284433.
GeneCardsiGC19P015904.
H-InvDBHIX0174445.
HGNCiHGNC:15389. OR10H5.
neXtProtiNX_Q8NGA6.
PharmGKBiPA31981.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG79272.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGA6.
KOiK04257.
OMAiLACGDIW.
OrthoDBiEOG78PV9F.
PhylomeDBiQ8NGA6.
TreeFamiTF337675.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii284433.
NextBioi94881.
PROiQ8NGA6.

Gene expression databases

CleanExiHS_OR10H5.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO10H5_HUMAN
AccessioniPrimary (citable) accession number: Q8NGA6
Secondary accession number(s): Q6IFJ0, Q96R60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: July 22, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.