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Protein

Olfactory receptor 10H4

Gene

OR10H4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10H4
Alternative name(s):
Olfactory receptor OR19-28
Gene namesi
Name:OR10H4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:15388. OR10H4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
BLAST
Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini48 – 558CytoplasmicSequence Analysis
Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini77 – 10024ExtracellularSequence AnalysisAdd
BLAST
Transmembranei101 – 12121Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei141 – 16121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini162 – 19837ExtracellularSequence AnalysisAdd
BLAST
Transmembranei199 – 21921Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini220 – 23920CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei240 – 26021Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini261 – 27313ExtracellularSequence AnalysisAdd
BLAST
Transmembranei274 – 29421Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini295 – 31622CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31980.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Olfactory receptor 10H4PRO_0000150705Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NGA5.

Expressioni

Gene expression databases

CleanExiHS_OR10H4.
GenevestigatoriQ8NGA5.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000318834.

Structurei

3D structure databases

ProteinModelPortaliQ8NGA5.
SMRiQ8NGA5. Positions 5-163.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG79272.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGA5.
KOiK04257.
OMAiTIWIEHR.
OrthoDBiEOG78PV9F.
PhylomeDBiQ8NGA5.
TreeFamiTF338279.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSQNYSIIS EFNLFGFSAF PQHLLPILFL LYLLMFLFTL LGNLLIMATI
60 70 80 90 100
WIEHRLHTPM YLFLCTLSVS EILFTVAITP RMLADLLSTH HSITFVACAN
110 120 130 140 150
QMFFSFMFGF THSFLLLVMG YDRYVAICHP LRYNVLMSPR DCAHLVACTW
160 170 180 190 200
AGGSVMGMMV TTIVFHLTFC GSNVIHHFFC HVLSLLKLAC ENKTSSVIMG
210 220 230 240 250
VMLVCVTALI GCLFLIILSY VFIVAAILRI PSAEGRHKTF STCVSHLTVV
260 270 280 290 300
VTHYSFASFI YLKPKGLHSM YSDALMATTY TVFTPFLSPI IFSLRNKELK
310
NAINKNFYRK FCPPSS
Length:316
Mass (Da):35,765
Last modified:October 1, 2002 - v1
Checksum:iE4091E85D5F8A877
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti100 – 1001N → K.
Corresponds to variant rs16980994 [ dbSNP | Ensembl ].
VAR_034290
Natural varianti144 – 1441H → R.
Corresponds to variant rs16980822 [ dbSNP | Ensembl ].
VAR_034291
Natural varianti281 – 2811T → A.
Corresponds to variant rs11880184 [ dbSNP | Ensembl ].
VAR_062063

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065921 Genomic DNA. Translation: BAC06136.1.
CH471106 Genomic DNA. Translation: EAW84516.1.
AF399586 Genomic DNA. Translation: AAK95071.1.
BK004270 Genomic DNA. Translation: DAA04668.1.
CCDSiCCDS32941.1.
RefSeqiNP_001004465.1. NM_001004465.1.
UniGeneiHs.553579.

Genome annotation databases

EnsembliENST00000322107; ENSP00000318834; ENSG00000176231.
GeneIDi126541.
KEGGihsa:126541.
UCSCiuc010xov.2. human.

Polymorphism databases

DMDMi38372653.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065921 Genomic DNA. Translation: BAC06136.1.
CH471106 Genomic DNA. Translation: EAW84516.1.
AF399586 Genomic DNA. Translation: AAK95071.1.
BK004270 Genomic DNA. Translation: DAA04668.1.
CCDSiCCDS32941.1.
RefSeqiNP_001004465.1. NM_001004465.1.
UniGeneiHs.553579.

3D structure databases

ProteinModelPortaliQ8NGA5.
SMRiQ8NGA5. Positions 5-163.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000318834.

Protein family/group databases

GPCRDBiSearch...

Polymorphism databases

DMDMi38372653.

Proteomic databases

PRIDEiQ8NGA5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322107; ENSP00000318834; ENSG00000176231.
GeneIDi126541.
KEGGihsa:126541.
UCSCiuc010xov.2. human.

Organism-specific databases

CTDi126541.
GeneCardsiGC19P016059.
HGNCiHGNC:15388. OR10H4.
neXtProtiNX_Q8NGA5.
PharmGKBiPA31980.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG79272.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGA5.
KOiK04257.
OMAiTIWIEHR.
OrthoDBiEOG78PV9F.
PhylomeDBiQ8NGA5.
TreeFamiTF338279.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR10H4.
GenomeRNAii126541.
NextBioi81846.
PROiQ8NGA5.

Gene expression databases

CleanExiHS_OR10H4.
GenevestigatoriQ8NGA5.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-285.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO10H4_HUMAN
AccessioniPrimary (citable) accession number: Q8NGA5
Secondary accession number(s): Q6IFJ2, Q96R57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: January 7, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.