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Q8NGA5

- O10H4_HUMAN

UniProt

Q8NGA5 - O10H4_HUMAN

Protein

Olfactory receptor 10H4

Gene

OR10H4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 10H4
    Alternative name(s):
    Olfactory receptor OR19-28
    Gene namesi
    Name:OR10H4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:15388. OR10H4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31980.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316Olfactory receptor 10H4PRO_0000150705Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8NGA5.

    Expressioni

    Gene expression databases

    CleanExiHS_OR10H4.
    GenevestigatoriQ8NGA5.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000318834.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGA5.
    SMRiQ8NGA5. Positions 5-163.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini48 – 558CytoplasmicSequence Analysis
    Topological domaini77 – 10024ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini162 – 19837ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 23920CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini261 – 27313ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini295 – 31622CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12121Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei141 – 16121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei199 – 21921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei240 – 26021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei274 – 29421Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG79272.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NGA5.
    KOiK04257.
    OMAiTIWIEHR.
    OrthoDBiEOG78PV9F.
    PhylomeDBiQ8NGA5.
    TreeFamiTF338279.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGA5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSQNYSIIS EFNLFGFSAF PQHLLPILFL LYLLMFLFTL LGNLLIMATI    50
    WIEHRLHTPM YLFLCTLSVS EILFTVAITP RMLADLLSTH HSITFVACAN 100
    QMFFSFMFGF THSFLLLVMG YDRYVAICHP LRYNVLMSPR DCAHLVACTW 150
    AGGSVMGMMV TTIVFHLTFC GSNVIHHFFC HVLSLLKLAC ENKTSSVIMG 200
    VMLVCVTALI GCLFLIILSY VFIVAAILRI PSAEGRHKTF STCVSHLTVV 250
    VTHYSFASFI YLKPKGLHSM YSDALMATTY TVFTPFLSPI IFSLRNKELK 300
    NAINKNFYRK FCPPSS 316
    Length:316
    Mass (Da):35,765
    Last modified:October 1, 2002 - v1
    Checksum:iE4091E85D5F8A877
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti100 – 1001N → K.
    Corresponds to variant rs16980994 [ dbSNP | Ensembl ].
    VAR_034290
    Natural varianti144 – 1441H → R.
    Corresponds to variant rs16980822 [ dbSNP | Ensembl ].
    VAR_034291
    Natural varianti281 – 2811T → A.
    Corresponds to variant rs11880184 [ dbSNP | Ensembl ].
    VAR_062063

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065921 Genomic DNA. Translation: BAC06136.1.
    CH471106 Genomic DNA. Translation: EAW84516.1.
    AF399586 Genomic DNA. Translation: AAK95071.1.
    BK004270 Genomic DNA. Translation: DAA04668.1.
    CCDSiCCDS32941.1.
    RefSeqiNP_001004465.1. NM_001004465.1.
    UniGeneiHs.553579.

    Genome annotation databases

    EnsembliENST00000322107; ENSP00000318834; ENSG00000176231.
    GeneIDi126541.
    KEGGihsa:126541.
    UCSCiuc010xov.2. human.

    Polymorphism databases

    DMDMi38372653.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065921 Genomic DNA. Translation: BAC06136.1 .
    CH471106 Genomic DNA. Translation: EAW84516.1 .
    AF399586 Genomic DNA. Translation: AAK95071.1 .
    BK004270 Genomic DNA. Translation: DAA04668.1 .
    CCDSi CCDS32941.1.
    RefSeqi NP_001004465.1. NM_001004465.1.
    UniGenei Hs.553579.

    3D structure databases

    ProteinModelPortali Q8NGA5.
    SMRi Q8NGA5. Positions 5-163.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000318834.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38372653.

    Proteomic databases

    PRIDEi Q8NGA5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000322107 ; ENSP00000318834 ; ENSG00000176231 .
    GeneIDi 126541.
    KEGGi hsa:126541.
    UCSCi uc010xov.2. human.

    Organism-specific databases

    CTDi 126541.
    GeneCardsi GC19P016059.
    HGNCi HGNC:15388. OR10H4.
    neXtProti NX_Q8NGA5.
    PharmGKBi PA31980.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG79272.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NGA5.
    KOi K04257.
    OMAi TIWIEHR.
    OrthoDBi EOG78PV9F.
    PhylomeDBi Q8NGA5.
    TreeFami TF338279.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR10H4.
    GenomeRNAii 126541.
    NextBioi 81846.
    PROi Q8NGA5.

    Gene expression databases

    CleanExi HS_OR10H4.
    Genevestigatori Q8NGA5.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-285.
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO10H4_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGA5
    Secondary accession number(s): Q6IFJ2, Q96R57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3