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Q8NGA5 (O10H4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 10H4
Alternative name(s):
Olfactory receptor OR19-28
Gene names
Name:OR10H4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316Olfactory receptor 10H4
PRO_0000150705

Regions

Topological domain1 – 2626Extracellular Potential
Transmembrane27 – 4721Helical; Name=1; Potential
Topological domain48 – 558Cytoplasmic Potential
Transmembrane56 – 7621Helical; Name=2; Potential
Topological domain77 – 10024Extracellular Potential
Transmembrane101 – 12121Helical; Name=3; Potential
Topological domain122 – 14019Cytoplasmic Potential
Transmembrane141 – 16121Helical; Name=4; Potential
Topological domain162 – 19837Extracellular Potential
Transmembrane199 – 21921Helical; Name=5; Potential
Topological domain220 – 23920Cytoplasmic Potential
Transmembrane240 – 26021Helical; Name=6; Potential
Topological domain261 – 27313Extracellular Potential
Transmembrane274 – 29421Helical; Name=7; Potential
Topological domain295 – 31622Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond98 ↔ 190 By similarity

Natural variations

Natural variant1001N → K.
Corresponds to variant rs16980994 [ dbSNP | Ensembl ].
VAR_034290
Natural variant1441H → R.
Corresponds to variant rs16980822 [ dbSNP | Ensembl ].
VAR_034291
Natural variant2811T → A.
Corresponds to variant rs11880184 [ dbSNP | Ensembl ].
VAR_062063

Sequences

Sequence LengthMass (Da)Tools
Q8NGA5 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: E4091E85D5F8A877

FASTA31635,765
        10         20         30         40         50         60 
MPSQNYSIIS EFNLFGFSAF PQHLLPILFL LYLLMFLFTL LGNLLIMATI WIEHRLHTPM 

        70         80         90        100        110        120 
YLFLCTLSVS EILFTVAITP RMLADLLSTH HSITFVACAN QMFFSFMFGF THSFLLLVMG 

       130        140        150        160        170        180 
YDRYVAICHP LRYNVLMSPR DCAHLVACTW AGGSVMGMMV TTIVFHLTFC GSNVIHHFFC 

       190        200        210        220        230        240 
HVLSLLKLAC ENKTSSVIMG VMLVCVTALI GCLFLIILSY VFIVAAILRI PSAEGRHKTF 

       250        260        270        280        290        300 
STCVSHLTVV VTHYSFASFI YLKPKGLHSM YSDALMATTY TVFTPFLSPI IFSLRNKELK 

       310 
NAINKNFYRK FCPPSS 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-285.
[4]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065921 Genomic DNA. Translation: BAC06136.1.
CH471106 Genomic DNA. Translation: EAW84516.1.
AF399586 Genomic DNA. Translation: AAK95071.1.
BK004270 Genomic DNA. Translation: DAA04668.1.
CCDSCCDS32941.1.
RefSeqNP_001004465.1. NM_001004465.1.
UniGeneHs.553579.

3D structure databases

ProteinModelPortalQ8NGA5.
SMRQ8NGA5. Positions 5-163.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000318834.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM38372653.

Proteomic databases

PRIDEQ8NGA5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000322107; ENSP00000318834; ENSG00000176231.
GeneID126541.
KEGGhsa:126541.
UCSCuc010xov.2. human.

Organism-specific databases

CTD126541.
GeneCardsGC19P016059.
HGNCHGNC:15388. OR10H4.
neXtProtNX_Q8NGA5.
PharmGKBPA31980.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG79272.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NGA5.
KOK04257.
OMATIWIEHR.
OrthoDBEOG78PV9F.
PhylomeDBQ8NGA5.
TreeFamTF338279.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR10H4.
GenevestigatorQ8NGA5.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR10H4.
GenomeRNAi126541.
NextBio81846.
PROQ8NGA5.

Entry information

Entry nameO10H4_HUMAN
AccessionPrimary (citable) accession number: Q8NGA5
Secondary accession number(s): Q6IFJ2, Q96R57
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries