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Protein

Olfactory receptor 1M1

Gene

OR1M1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170929-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1M1
Alternative name(s):
Olfactory receptor 19-6
Short name:
OR19-6
Olfactory receptor OR19-5
Gene namesi
Name:OR1M1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:8220. OR1M1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 196ExtracellularSequence analysisAdd BLAST38
Transmembranei197 – 219Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 313CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170929.
PharmGKBiPA32089.

Polymorphism and mutation databases

BioMutaiOR1M1.
DMDMi38372651.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504471 – 313Olfactory receptor 1M1Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8NGA1.
PaxDbiQ8NGA1.
PeptideAtlasiQ8NGA1.
PRIDEiQ8NGA1.

PTM databases

iPTMnetiQ8NGA1.
PhosphoSitePlusiQ8NGA1.

Expressioni

Gene expression databases

CleanExiHS_OR1M1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000401966.

Structurei

3D structure databases

ProteinModelPortaliQ8NGA1.
SMRiQ8NGA1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEFQ. Eukaryota.
ENOG411158C. LUCA.
GeneTreeiENSGT00860000133676.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGA1.
KOiK04257.
OMAiCFISLTH.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGA1.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPRNQTSAS QFILLGLSEK PEQETLLFSL FFCMYLVMVV GNLLIILAIS
60 70 80 90 100
IDSHLHTPMY FFLANLSLVD FCLATNTIPK MLVSLQTGSK AISYPCCLIQ
110 120 130 140 150
MYFFHFFGIV DSVIIAMMAY DRFVAICHPL HYAKIMSLRL CRLLVGALWA
160 170 180 190 200
FSCFISLTHI LLMARLVFCG SHEVPHYFCD LTPILRLSCT DTSVNRIFIL
210 220 230 240 250
IVAGMVIATP FVCILASYAR ILVAIMKVPS AGGRKKAFST CSSHLSVVAL
260 270 280 290 300
FYGTTIGVYL CPSSVLTTVK EKASAVMYTA VTPMLNPFIY SLRNRDLKGA
310
LRKLVNRKIT SSS
Length:313
Mass (Da):34,840
Last modified:October 1, 2002 - v1
Checksum:i2B965387C73074C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065925 Genomic DNA. Translation: BAC06140.1.
BC137551 mRNA. Translation: AAI37552.1.
BC137555 mRNA. Translation: AAI37556.1.
AF399549 Genomic DNA. Translation: AAK95034.1.
BK004269 Genomic DNA. Translation: DAA04667.1.
CCDSiCCDS32896.1.
RefSeqiNP_001004456.1. NM_001004456.1.
UniGeneiHs.553577.

Genome annotation databases

EnsembliENST00000429566; ENSP00000401966; ENSG00000170929.
GeneIDi125963.
KEGGihsa:125963.
UCSCiuc010xkj.3. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065925 Genomic DNA. Translation: BAC06140.1.
BC137551 mRNA. Translation: AAI37552.1.
BC137555 mRNA. Translation: AAI37556.1.
AF399549 Genomic DNA. Translation: AAK95034.1.
BK004269 Genomic DNA. Translation: DAA04667.1.
CCDSiCCDS32896.1.
RefSeqiNP_001004456.1. NM_001004456.1.
UniGeneiHs.553577.

3D structure databases

ProteinModelPortaliQ8NGA1.
SMRiQ8NGA1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000401966.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGA1.
PhosphoSitePlusiQ8NGA1.

Polymorphism and mutation databases

BioMutaiOR1M1.
DMDMi38372651.

Proteomic databases

MaxQBiQ8NGA1.
PaxDbiQ8NGA1.
PeptideAtlasiQ8NGA1.
PRIDEiQ8NGA1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000429566; ENSP00000401966; ENSG00000170929.
GeneIDi125963.
KEGGihsa:125963.
UCSCiuc010xkj.3. human.

Organism-specific databases

CTDi125963.
GeneCardsiOR1M1.
HGNCiHGNC:8220. OR1M1.
neXtProtiNX_Q8NGA1.
OpenTargetsiENSG00000170929.
PharmGKBiPA32089.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEFQ. Eukaryota.
ENOG411158C. LUCA.
GeneTreeiENSGT00860000133676.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGA1.
KOiK04257.
OMAiCFISLTH.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGA1.
TreeFamiTF337210.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170929-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR1M1.
GenomeRNAii125963.
PROiQ8NGA1.

Gene expression databases

CleanExiHS_OR1M1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR1M1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGA1
Secondary accession number(s): B9EHA6, Q6IFJ3, Q96R91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.