ID   OR7G1_HUMAN             Reviewed;         311 AA.
AC   Q8NGA0; Q6IFJ5; Q96RA1;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   24-JAN-2024, entry version 161.
DE   RecName: Full=Olfactory receptor 7G1;
DE   AltName: Full=Olfactory receptor 19-15;
DE            Short=OR19-15;
DE   AltName: Full=Olfactory receptor OR19-8;
GN   Name=OR7G1; Synonyms=OR7G1P;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [5]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC06141.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR7G1";
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DR   EMBL; AB065926; BAC06141.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AC011464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF399538; AAK95023.1; -; Genomic_DNA.
DR   EMBL; BK004267; DAA04665.1; -; Genomic_DNA.
DR   CCDS; CCDS32898.2; -.
DR   RefSeq; NP_001005192.2; NM_001005192.2.
DR   AlphaFoldDB; Q8NGA0; -.
DR   SMR; Q8NGA0; -.
DR   BioGRID; 125938; 1.
DR   IntAct; Q8NGA0; 1.
DR   MINT; Q8NGA0; -.
DR   STRING; 9606.ENSP00000444134; -.
DR   GlyCosmos; Q8NGA0; 2 sites, No reported glycans.
DR   GlyGen; Q8NGA0; 2 sites.
DR   BioMuta; OR7G1; -.
DR   DMDM; 218511731; -.
DR   MassIVE; Q8NGA0; -.
DR   PaxDb; 9606-ENSP00000444134; -.
DR   PeptideAtlas; Q8NGA0; -.
DR   ProteomicsDB; 73458; -.
DR   Antibodypedia; 56336; 68 antibodies from 13 providers.
DR   DNASU; 125962; -.
DR   Ensembl; ENST00000541538.1; ENSP00000444134.1; ENSG00000161807.3.
DR   GeneID; 125962; -.
DR   KEGG; hsa:125962; -.
DR   MANE-Select; ENST00000541538.1; ENSP00000444134.1; NM_001005192.2; NP_001005192.2.
DR   UCSC; uc021uoi.1; human.
DR   AGR; HGNC:8465; -.
DR   CTD; 125962; -.
DR   GeneCards; OR7G1; -.
DR   HGNC; HGNC:8465; OR7G1.
DR   HPA; ENSG00000161807; Not detected.
DR   neXtProt; NX_Q8NGA0; -.
DR   PharmGKB; PA32737; -.
DR   VEuPathDB; HostDB:ENSG00000161807; -.
DR   eggNOG; ENOG502T9M5; Eukaryota.
DR   GeneTree; ENSGT00940000154619; -.
DR   HOGENOM; CLU_012526_1_3_1; -.
DR   InParanoid; Q8NGA0; -.
DR   OMA; QICFALT; -.
DR   OrthoDB; 5401587at2759; -.
DR   PhylomeDB; Q8NGA0; -.
DR   TreeFam; TF337210; -.
DR   PathwayCommons; Q8NGA0; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   SignaLink; Q8NGA0; -.
DR   BioGRID-ORCS; 125962; 7 hits in 709 CRISPR screens.
DR   GeneWiki; OR7G1; -.
DR   GenomeRNAi; 125962; -.
DR   Pharos; Q8NGA0; Tdark.
DR   PRO; PR:Q8NGA0; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q8NGA0; Protein.
DR   ExpressionAtlas; Q8NGA0; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   CDD; cd15234; 7tmA_OR7-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR48001; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR48001:SF67; OLFACTORY RECEPTOR 7G1; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..311
FT                   /note="Olfactory receptor 7G1"
FT                   /id="PRO_0000150650"
FT   TOPO_DOM        1..29
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        30..50
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        51..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        79..97
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..133
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..154
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        155..196
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..217
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..244
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        245..265
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        266..269
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..290
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        291..311
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        89
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..179
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         83
FT                   /note="V -> A (in dbSNP:rs6511874)"
FT                   /id="VAR_048074"
FT   VARIANT         141
FT                   /note="W -> C (in dbSNP:rs2217657)"
FT                   /id="VAR_034255"
FT   VARIANT         156
FT                   /note="A -> V (in dbSNP:rs7246980)"
FT                   /id="VAR_048075"
FT   VARIANT         167
FT                   /note="S -> F (in dbSNP:rs7246969)"
FT                   /id="VAR_048076"
FT   VARIANT         252
FT                   /note="Y -> C (in dbSNP:rs2195951)"
FT                   /id="VAR_034256"
SQ   SEQUENCE   311 AA;  34803 MW;  C408FFF590A95340 CRC64;
     MGPRNQTAVS EFLLMKVTED PELKLIPFSL FLSMYLVTIL GNLLILLAVI SDSHLHTPMY
     FLLFNLSFTD ICLTTTTVPK ILVNIQAQNQ SITYTGCLTQ ICLVLVFAGL ESCFLAVMAY
     DRYVAICHPL RYTVLMNVHF WGLLILLSMF MSTMDALVQS LMVLQLSFCK NVEIPLFFCE
     VVQVIKLACS DTLINNILIY FASSVFGAIP LSGIIFSYSQ IVTSVLRMPS ARGKYKAFST
     CGCHLSVFSL FYGTAFGVYI SSAVAESSRI TAVASVMYTV VPQMMNPFIY SLRNKEMKKA
     LRKLIGRLFP F
//