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Q8NGA0

- OR7G1_HUMAN

UniProt

Q8NGA0 - OR7G1_HUMAN

Protein

Olfactory receptor 7G1

Gene

OR7G1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 7G1
    Alternative name(s):
    Olfactory receptor 19-15
    Short name:
    OR19-15
    Olfactory receptor OR19-8
    Gene namesi
    Name:OR7G1
    Synonyms:OR7G1P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:8465. OR7G1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32737.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Olfactory receptor 7G1PRO_0000150650Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGA0.
    PRIDEiQ8NGA0.

    Expressioni

    Gene expression databases

    CleanExiHS_OR7G1.
    GenevestigatoriQ8NGA0.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000293614.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGA0.
    SMRiQ8NGA0. Positions 32-136.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2929ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini51 – 577CytoplasmicSequence Analysis
    Topological domaini79 – 9719ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini119 – 13315CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini155 – 19642ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 24427CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini266 – 2694ExtracellularSequence Analysis
    Topological domaini291 – 31121CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei30 – 5021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei98 – 11821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei134 – 15421Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei245 – 26521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei270 – 29021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150292.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NGA0.
    KOiK04257.
    OrthoDBiEOG7HXCR6.
    PhylomeDBiQ8NGA0.
    TreeFamiTF337210.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGA0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGPRNQTAVS EFLLMKVTED PELKLIPFSL FLSMYLVTIL GNLLILLAVI    50
    SDSHLHTPMY FLLFNLSFTD ICLTTTTVPK ILVNIQAQNQ SITYTGCLTQ 100
    ICLVLVFAGL ESCFLAVMAY DRYVAICHPL RYTVLMNVHF WGLLILLSMF 150
    MSTMDALVQS LMVLQLSFCK NVEIPLFFCE VVQVIKLACS DTLINNILIY 200
    FASSVFGAIP LSGIIFSYSQ IVTSVLRMPS ARGKYKAFST CGCHLSVFSL 250
    FYGTAFGVYI SSAVAESSRI TAVASVMYTV VPQMMNPFIY SLRNKEMKKA 300
    LRKLIGRLFP F 311
    Length:311
    Mass (Da):34,803
    Last modified:December 16, 2008 - v2
    Checksum:iC408FFF590A95340
    GO

    Sequence cautioni

    The sequence BAC06141.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti83 – 831V → A.
    Corresponds to variant rs6511874 [ dbSNP | Ensembl ].
    VAR_048074
    Natural varianti141 – 1411W → C.
    Corresponds to variant rs2217657 [ dbSNP | Ensembl ].
    VAR_034255
    Natural varianti156 – 1561A → V.
    Corresponds to variant rs7246980 [ dbSNP | Ensembl ].
    VAR_048075
    Natural varianti167 – 1671S → F.
    Corresponds to variant rs7246969 [ dbSNP | Ensembl ].
    VAR_048076
    Natural varianti252 – 2521Y → C.
    Corresponds to variant rs2195951 [ dbSNP | Ensembl ].
    VAR_034256

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065926 Genomic DNA. Translation: BAC06141.1. Sequence problems.
    AC011464 Genomic DNA. No translation available.
    AF399538 Genomic DNA. Translation: AAK95023.1.
    BK004267 Genomic DNA. Translation: DAA04665.1.
    CCDSiCCDS32898.2.
    RefSeqiNP_001005192.2. NM_001005192.2.
    UniGeneiHs.553576.

    Genome annotation databases

    EnsembliENST00000541538; ENSP00000444134; ENSG00000161807.
    GeneIDi125962.
    KEGGihsa:125962.
    UCSCiuc021uoi.1. human.

    Polymorphism databases

    DMDMi218511731.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065926 Genomic DNA. Translation: BAC06141.1 . Sequence problems.
    AC011464 Genomic DNA. No translation available.
    AF399538 Genomic DNA. Translation: AAK95023.1 .
    BK004267 Genomic DNA. Translation: DAA04665.1 .
    CCDSi CCDS32898.2.
    RefSeqi NP_001005192.2. NM_001005192.2.
    UniGenei Hs.553576.

    3D structure databases

    ProteinModelPortali Q8NGA0.
    SMRi Q8NGA0. Positions 32-136.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000293614.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 218511731.

    Proteomic databases

    PaxDbi Q8NGA0.
    PRIDEi Q8NGA0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000541538 ; ENSP00000444134 ; ENSG00000161807 .
    GeneIDi 125962.
    KEGGi hsa:125962.
    UCSCi uc021uoi.1. human.

    Organism-specific databases

    CTDi 125962.
    GeneCardsi GC19M009225.
    HGNCi HGNC:8465. OR7G1.
    neXtProti NX_Q8NGA0.
    PharmGKBi PA32737.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG150292.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NGA0.
    KOi K04257.
    OrthoDBi EOG7HXCR6.
    PhylomeDBi Q8NGA0.
    TreeFami TF337210.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR7G1.
    GenomeRNAii 125962.
    NextBioi 81590.
    PROi Q8NGA0.

    Gene expression databases

    CleanExi HS_OR7G1.
    Genevestigatori Q8NGA0.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR7G1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGA0
    Secondary accession number(s): Q6IFJ5, Q96RA1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3