Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 7G1

Gene

OR7G1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000161807-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 7G1
Alternative name(s):
Olfactory receptor 19-15
Short name:
OR19-15
Olfactory receptor OR19-8
Gene namesi
Name:OR7G1
Synonyms:OR7G1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:8465. OR7G1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 50Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini51 – 57CytoplasmicSequence analysis7
Transmembranei58 – 78Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini79 – 97ExtracellularSequence analysisAdd BLAST19
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 133CytoplasmicSequence analysisAdd BLAST15
Transmembranei134 – 154Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini155 – 196ExtracellularSequence analysisAdd BLAST42
Transmembranei197 – 217Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini218 – 244CytoplasmicSequence analysisAdd BLAST27
Transmembranei245 – 265Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini266 – 269ExtracellularSequence analysis4
Transmembranei270 – 290Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini291 – 311CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000161807.
PharmGKBiPA32737.

Polymorphism and mutation databases

BioMutaiOR7G1.
DMDMi218511731.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506501 – 311Olfactory receptor 7G1Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Glycosylationi89N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGA0.
PeptideAtlasiQ8NGA0.
PRIDEiQ8NGA0.

Expressioni

Gene expression databases

CleanExiHS_OR7G1.
ExpressionAtlasiQ8NGA0. baseline.

Organism-specific databases

HPAiCAB004962.
CAB004963.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000444134.

Structurei

3D structure databases

ProteinModelPortaliQ8NGA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVB1. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00840000129792.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGA0.
KOiK04257.
OMAiESCFLAV.
OrthoDBiEOG091G0B53.
PhylomeDBiQ8NGA0.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPRNQTAVS EFLLMKVTED PELKLIPFSL FLSMYLVTIL GNLLILLAVI
60 70 80 90 100
SDSHLHTPMY FLLFNLSFTD ICLTTTTVPK ILVNIQAQNQ SITYTGCLTQ
110 120 130 140 150
ICLVLVFAGL ESCFLAVMAY DRYVAICHPL RYTVLMNVHF WGLLILLSMF
160 170 180 190 200
MSTMDALVQS LMVLQLSFCK NVEIPLFFCE VVQVIKLACS DTLINNILIY
210 220 230 240 250
FASSVFGAIP LSGIIFSYSQ IVTSVLRMPS ARGKYKAFST CGCHLSVFSL
260 270 280 290 300
FYGTAFGVYI SSAVAESSRI TAVASVMYTV VPQMMNPFIY SLRNKEMKKA
310
LRKLIGRLFP F
Length:311
Mass (Da):34,803
Last modified:December 16, 2008 - v2
Checksum:iC408FFF590A95340
GO

Sequence cautioni

The sequence BAC06141 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04807483V → A.Corresponds to variant rs6511874dbSNPEnsembl.1
Natural variantiVAR_034255141W → C.Corresponds to variant rs2217657dbSNPEnsembl.1
Natural variantiVAR_048075156A → V.Corresponds to variant rs7246980dbSNPEnsembl.1
Natural variantiVAR_048076167S → F.Corresponds to variant rs7246969dbSNPEnsembl.1
Natural variantiVAR_034256252Y → C.Corresponds to variant rs2195951dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065926 Genomic DNA. Translation: BAC06141.1. Sequence problems.
AC011464 Genomic DNA. No translation available.
AF399538 Genomic DNA. Translation: AAK95023.1.
BK004267 Genomic DNA. Translation: DAA04665.1.
CCDSiCCDS32898.2.
RefSeqiNP_001005192.2. NM_001005192.2.
UniGeneiHs.553576.

Genome annotation databases

EnsembliENST00000541538; ENSP00000444134; ENSG00000161807.
GeneIDi125962.
KEGGihsa:125962.
UCSCiuc021uoi.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065926 Genomic DNA. Translation: BAC06141.1. Sequence problems.
AC011464 Genomic DNA. No translation available.
AF399538 Genomic DNA. Translation: AAK95023.1.
BK004267 Genomic DNA. Translation: DAA04665.1.
CCDSiCCDS32898.2.
RefSeqiNP_001005192.2. NM_001005192.2.
UniGeneiHs.553576.

3D structure databases

ProteinModelPortaliQ8NGA0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000444134.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR7G1.
DMDMi218511731.

Proteomic databases

PaxDbiQ8NGA0.
PeptideAtlasiQ8NGA0.
PRIDEiQ8NGA0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000541538; ENSP00000444134; ENSG00000161807.
GeneIDi125962.
KEGGihsa:125962.
UCSCiuc021uoi.1. human.

Organism-specific databases

CTDi125962.
GeneCardsiOR7G1.
HGNCiHGNC:8465. OR7G1.
HPAiCAB004962.
CAB004963.
neXtProtiNX_Q8NGA0.
OpenTargetsiENSG00000161807.
PharmGKBiPA32737.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVB1. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00840000129792.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGA0.
KOiK04257.
OMAiESCFLAV.
OrthoDBiEOG091G0B53.
PhylomeDBiQ8NGA0.
TreeFamiTF337210.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000161807-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR7G1.
GenomeRNAii125962.
PROiQ8NGA0.

Gene expression databases

CleanExiHS_OR7G1.
ExpressionAtlasiQ8NGA0. baseline.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR7G1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGA0
Secondary accession number(s): Q6IFJ5, Q96RA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 16, 2008
Last modified: November 30, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.