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Q8NGA0

- OR7G1_HUMAN

UniProt

Q8NGA0 - OR7G1_HUMAN

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Protein

Olfactory receptor 7G1

Gene

OR7G1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 7G1
Alternative name(s):
Olfactory receptor 19-15
Short name:
OR19-15
Olfactory receptor OR19-8
Gene namesi
Name:OR7G1
Synonyms:OR7G1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:8465. OR7G1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929ExtracellularSequence AnalysisAdd
BLAST
Transmembranei30 – 5021Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini51 – 577CytoplasmicSequence Analysis
Transmembranei58 – 7821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini79 – 9719ExtracellularSequence AnalysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini119 – 13315CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei134 – 15421Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini155 – 19642ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 21721Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini218 – 24427CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei245 – 26521Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini266 – 2694ExtracellularSequence Analysis
Transmembranei270 – 29021Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini291 – 31121CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32737.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Olfactory receptor 7G1PRO_0000150650Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGA0.
PRIDEiQ8NGA0.

Expressioni

Gene expression databases

CleanExiHS_OR7G1.
GenevestigatoriQ8NGA0.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000293614.

Structurei

3D structure databases

ProteinModelPortaliQ8NGA0.
SMRiQ8NGA0. Positions 32-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150292.
GeneTreeiENSGT00760000118801.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGA0.
KOiK04257.
OrthoDBiEOG7HXCR6.
PhylomeDBiQ8NGA0.
TreeFamiTF337210.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGA0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPRNQTAVS EFLLMKVTED PELKLIPFSL FLSMYLVTIL GNLLILLAVI
60 70 80 90 100
SDSHLHTPMY FLLFNLSFTD ICLTTTTVPK ILVNIQAQNQ SITYTGCLTQ
110 120 130 140 150
ICLVLVFAGL ESCFLAVMAY DRYVAICHPL RYTVLMNVHF WGLLILLSMF
160 170 180 190 200
MSTMDALVQS LMVLQLSFCK NVEIPLFFCE VVQVIKLACS DTLINNILIY
210 220 230 240 250
FASSVFGAIP LSGIIFSYSQ IVTSVLRMPS ARGKYKAFST CGCHLSVFSL
260 270 280 290 300
FYGTAFGVYI SSAVAESSRI TAVASVMYTV VPQMMNPFIY SLRNKEMKKA
310
LRKLIGRLFP F
Length:311
Mass (Da):34,803
Last modified:December 16, 2008 - v2
Checksum:iC408FFF590A95340
GO

Sequence cautioni

The sequence BAC06141.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti83 – 831V → A.
Corresponds to variant rs6511874 [ dbSNP | Ensembl ].
VAR_048074
Natural varianti141 – 1411W → C.
Corresponds to variant rs2217657 [ dbSNP | Ensembl ].
VAR_034255
Natural varianti156 – 1561A → V.
Corresponds to variant rs7246980 [ dbSNP | Ensembl ].
VAR_048075
Natural varianti167 – 1671S → F.
Corresponds to variant rs7246969 [ dbSNP | Ensembl ].
VAR_048076
Natural varianti252 – 2521Y → C.
Corresponds to variant rs2195951 [ dbSNP | Ensembl ].
VAR_034256

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065926 Genomic DNA. Translation: BAC06141.1. Sequence problems.
AC011464 Genomic DNA. No translation available.
AF399538 Genomic DNA. Translation: AAK95023.1.
BK004267 Genomic DNA. Translation: DAA04665.1.
CCDSiCCDS32898.2.
RefSeqiNP_001005192.2. NM_001005192.2.
UniGeneiHs.553576.

Genome annotation databases

EnsembliENST00000541538; ENSP00000444134; ENSG00000161807.
GeneIDi125962.
KEGGihsa:125962.
UCSCiuc021uoi.1. human.

Polymorphism databases

DMDMi218511731.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065926 Genomic DNA. Translation: BAC06141.1 . Sequence problems.
AC011464 Genomic DNA. No translation available.
AF399538 Genomic DNA. Translation: AAK95023.1 .
BK004267 Genomic DNA. Translation: DAA04665.1 .
CCDSi CCDS32898.2.
RefSeqi NP_001005192.2. NM_001005192.2.
UniGenei Hs.553576.

3D structure databases

ProteinModelPortali Q8NGA0.
SMRi Q8NGA0. Positions 32-305.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000293614.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 218511731.

Proteomic databases

PaxDbi Q8NGA0.
PRIDEi Q8NGA0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000541538 ; ENSP00000444134 ; ENSG00000161807 .
GeneIDi 125962.
KEGGi hsa:125962.
UCSCi uc021uoi.1. human.

Organism-specific databases

CTDi 125962.
GeneCardsi GC19M009225.
HGNCi HGNC:8465. OR7G1.
neXtProti NX_Q8NGA0.
PharmGKBi PA32737.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG150292.
GeneTreei ENSGT00760000118801.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi Q8NGA0.
KOi K04257.
OrthoDBi EOG7HXCR6.
PhylomeDBi Q8NGA0.
TreeFami TF337210.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR7G1.
GenomeRNAii 125962.
NextBioi 81590.
PROi Q8NGA0.

Gene expression databases

CleanExi HS_OR7G1.
Genevestigatori Q8NGA0.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR7G1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGA0
Secondary accession number(s): Q6IFJ5, Q96RA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 16, 2008
Last modified: October 29, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3