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Q8NGA0 (OR7G1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 7G1
Alternative name(s):
Olfactory receptor 19-15
Short name=OR19-15
Olfactory receptor OR19-8
Gene names
Name:OR7G1
Synonyms:OR7G1P
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence BAC06141.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Olfactory receptor 7G1
PRO_0000150650

Regions

Topological domain1 – 2929Extracellular Potential
Transmembrane30 – 5021Helical; Name=1; Potential
Topological domain51 – 577Cytoplasmic Potential
Transmembrane58 – 7821Helical; Name=2; Potential
Topological domain79 – 9719Extracellular Potential
Transmembrane98 – 11821Helical; Name=3; Potential
Topological domain119 – 13315Cytoplasmic Potential
Transmembrane134 – 15421Helical; Name=4; Potential
Topological domain155 – 19642Extracellular Potential
Transmembrane197 – 21721Helical; Name=5; Potential
Topological domain218 – 24427Cytoplasmic Potential
Transmembrane245 – 26521Helical; Name=6; Potential
Topological domain266 – 2694Extracellular Potential
Transmembrane270 – 29021Helical; Name=7; Potential
Topological domain291 – 31121Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation891N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 179 By similarity

Natural variations

Natural variant831V → A.
Corresponds to variant rs6511874 [ dbSNP | Ensembl ].
VAR_048074
Natural variant1411W → C.
Corresponds to variant rs2217657 [ dbSNP | Ensembl ].
VAR_034255
Natural variant1561A → V.
Corresponds to variant rs7246980 [ dbSNP | Ensembl ].
VAR_048075
Natural variant1671S → F.
Corresponds to variant rs7246969 [ dbSNP | Ensembl ].
VAR_048076
Natural variant2521Y → C.
Corresponds to variant rs2195951 [ dbSNP | Ensembl ].
VAR_034256

Sequences

Sequence LengthMass (Da)Tools
Q8NGA0 [UniParc].

Last modified December 16, 2008. Version 2.
Checksum: C408FFF590A95340

FASTA31134,803
        10         20         30         40         50         60 
MGPRNQTAVS EFLLMKVTED PELKLIPFSL FLSMYLVTIL GNLLILLAVI SDSHLHTPMY 

        70         80         90        100        110        120 
FLLFNLSFTD ICLTTTTVPK ILVNIQAQNQ SITYTGCLTQ ICLVLVFAGL ESCFLAVMAY 

       130        140        150        160        170        180 
DRYVAICHPL RYTVLMNVHF WGLLILLSMF MSTMDALVQS LMVLQLSFCK NVEIPLFFCE 

       190        200        210        220        230        240 
VVQVIKLACS DTLINNILIY FASSVFGAIP LSGIIFSYSQ IVTSVLRMPS ARGKYKAFST 

       250        260        270        280        290        300 
CGCHLSVFSL FYGTAFGVYI SSAVAESSRI TAVASVMYTV VPQMMNPFIY SLRNKEMKKA 

       310 
LRKLIGRLFP F 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
[4]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065926 Genomic DNA. Translation: BAC06141.1. Sequence problems.
AC011464 Genomic DNA. No translation available.
AF399538 Genomic DNA. Translation: AAK95023.1.
BK004267 Genomic DNA. Translation: DAA04665.1.
CCDSCCDS32898.2.
RefSeqNP_001005192.2. NM_001005192.2.
UniGeneHs.553576.

3D structure databases

ProteinModelPortalQ8NGA0.
SMRQ8NGA0. Positions 32-136.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000293614.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM218511731.

Proteomic databases

PaxDbQ8NGA0.
PRIDEQ8NGA0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000293614; ENSP00000293614; ENSG00000161807.
ENST00000541538; ENSP00000444134; ENSG00000161807.
GeneID125962.
KEGGhsa:125962.
UCSCuc021uoi.1. human.

Organism-specific databases

CTD125962.
GeneCardsGC19M009225.
HGNCHGNC:8465. OR7G1.
neXtProtNX_Q8NGA0.
PharmGKBPA32737.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG150292.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NGA0.
KOK04257.
OrthoDBEOG7HXCR6.
PhylomeDBQ8NGA0.
TreeFamTF337210.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR7G1.
GenevestigatorQ8NGA0.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR7G1.
GenomeRNAi125962.
NextBio81590.
PROQ8NGA0.

Entry information

Entry nameOR7G1_HUMAN
AccessionPrimary (citable) accession number: Q8NGA0
Secondary accession number(s): Q6IFJ5, Q96RA1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 16, 2008
Last modified: July 9, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries