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Protein

Olfactory receptor 7G2

Gene

OR7G2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 7G2
Alternative name(s):
OST260
Olfactory receptor 19-13
Short name:
OR19-13
Olfactory receptor OR19-6
Gene namesi
Name:OR7G2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:8466. OR7G2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence analysis
Transmembranei55 – 7521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence analysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence analysisAdd
BLAST
Transmembranei198 – 21720Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence analysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence analysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini293 – 32432CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiOR7G2.
DMDMi38372649.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Olfactory receptor 7G2PRO_0000150651Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NG99.
PRIDEiQ8NG99.

Expressioni

Gene expression databases

CleanExiHS_OR7G2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000303822.

Structurei

3D structure databases

ProteinModelPortaliQ8NG99.
SMRiQ8NG99. Positions 26-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVB1. Eukaryota.
ENOG410YBQN. LUCA.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NG99.
KOiK04257.
OrthoDBiEOG7HXCR6.
PhylomeDBiQ8NG99.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NG99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEARNQTAIS KFLLLGLIED PELQPVLFSL FLSMYLVTIL GNLLILLAVI
60 70 80 90 100
SDSHLHTPMY FFLSNLSFLD ICLSTTTIPK MLVNIQAQNR SITYSGCLTQ
110 120 130 140 150
ICFVLFFAGL ENCLLAAMAY DRYVAICHPL RYTVIMNPRL CGLLILLSLL
160 170 180 190 200
TSVVNALLLS LMVLRLSFCT DLEIPLFFCE LAQVIQLTCS DTLINNILIY
210 220 230 240 250
FAACIFGGVP LSGIILSYTQ ITSCVLRMPS ASGKHKAVST CGSHLSIVLL
260 270 280 290 300
FYGAGLGVYI SSVVTDSPRK TAVASVMYSV FPQMVNPFIY SLRNKDMKGT
310 320
LRKFIGRIPS LLWCAICFGF RFLE
Length:324
Mass (Da):35,931
Last modified:October 1, 2002 - v1
Checksum:iC08808B72ABE34FC
GO

Sequence cautioni

The sequence DAA04666.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti271 – 2711T → A in AAK95024 (PubMed:12213199).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti281 – 2811F → V.
Corresponds to variant rs4804401 [ dbSNP | Ensembl ].
VAR_024113

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065927 Genomic DNA. Translation: BAC06142.1.
AC011464 Genomic DNA. No translation available.
AF399539 Genomic DNA. Translation: AAK95024.1.
BK004268 Genomic DNA. Translation: DAA04666.1. Different initiation.
RefSeqiNP_001005193.1. NM_001005193.1.
UniGeneiHs.553774.

Genome annotation databases

EnsembliENST00000305456; ENSP00000303822; ENSG00000170923.
GeneIDi390882.
KEGGihsa:390882.
UCSCiuc010xkk.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065927 Genomic DNA. Translation: BAC06142.1.
AC011464 Genomic DNA. No translation available.
AF399539 Genomic DNA. Translation: AAK95024.1.
BK004268 Genomic DNA. Translation: DAA04666.1. Different initiation.
RefSeqiNP_001005193.1. NM_001005193.1.
UniGeneiHs.553774.

3D structure databases

ProteinModelPortaliQ8NG99.
SMRiQ8NG99. Positions 26-305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000303822.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR7G2.
DMDMi38372649.

Proteomic databases

PaxDbiQ8NG99.
PRIDEiQ8NG99.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305456; ENSP00000303822; ENSG00000170923.
GeneIDi390882.
KEGGihsa:390882.
UCSCiuc010xkk.2. human.

Organism-specific databases

CTDi390882.
GeneCardsiOR7G2.
HGNCiHGNC:8466. OR7G2.
neXtProtiNX_Q8NG99.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVB1. Eukaryota.
ENOG410YBQN. LUCA.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NG99.
KOiK04257.
OrthoDBiEOG7HXCR6.
PhylomeDBiQ8NG99.
TreeFamiTF337210.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR7G2.
GenomeRNAii390882.
PROiQ8NG99.

Gene expression databases

CleanExiHS_OR7G2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR7G2_HUMAN
AccessioniPrimary (citable) accession number: Q8NG99
Secondary accession number(s): Q6IFJ4, Q96RA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.