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Q8NG98 (OR7D4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 7D4
Alternative name(s):
OR19-B
Odorant receptor family subfamily D member 4RT
Olfactory receptor OR19-7
Gene names
Name:OR7D4
Synonyms:OR7D4P
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor. Selectively activated by androstenone and the related odorous steroid androstadienone.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Nasal olfactory epithelium. Ref.7

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Olfactory receptor 7D4
PRO_0000150649

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4621Helical; Name=1; Potential
Topological domain47 – 548Cytoplasmic Potential
Transmembrane55 – 7521Helical; Name=2; Potential
Topological domain76 – 9924Extracellular Potential
Transmembrane100 – 12021Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 16021Helical; Name=4; Potential
Topological domain161 – 19737Extracellular Potential
Transmembrane198 – 21720Helical; Name=5; Potential
Topological domain218 – 23720Cytoplasmic Potential
Transmembrane238 – 25821Helical; Name=6; Potential
Topological domain259 – 27113Extracellular Potential
Transmembrane272 – 29221Helical; Name=7; Potential
Topological domain293 – 31220Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Natural variations

Natural variant171L → F.
Corresponds to variant rs57568862 [ dbSNP | Ensembl ].
VAR_062056
Natural variant521D → G. Ref.1
VAR_037778
Natural variant751S → C. Ref.1
Corresponds to variant rs5020281 [ dbSNP | Ensembl ].
VAR_037779
Natural variant791P → L Impaired response to androstenone and androstadienone. Ref.1
Corresponds to variant rs61732668 [ dbSNP | Ensembl ].
VAR_037780
Natural variant841S → N High sensitivity to androstenone and androstadienone. Ref.1
Corresponds to variant rs5020280 [ dbSNP | Ensembl ].
VAR_037781
Natural variant881R → W Impaired response to androstenone and androstadienone; when associated with M-133. Ref.1
Corresponds to variant rs61729907 [ dbSNP | Ensembl ].
VAR_037782
Natural variant1311H → Q. Ref.1
Corresponds to variant rs5020279 [ dbSNP | Ensembl ].
VAR_037783
Natural variant1331T → M Impaired response to androstenone and androstadienone; when associated with W-88. Ref.1
Corresponds to variant rs5020278 [ dbSNP | Ensembl ].
VAR_037784
Natural variant1361M → I.
Corresponds to variant rs5020277 [ dbSNP | Ensembl ].
VAR_037785
Natural variant1391C → R. Ref.1
Corresponds to variant rs5020276 [ dbSNP | Ensembl ].
VAR_037786
Natural variant1391C → Y. Ref.1
Corresponds to variant rs5020275 [ dbSNP | Ensembl ].
VAR_037787
Natural variant1621L → P. Ref.1
VAR_037788
Natural variant2791A → D. Ref.1
Corresponds to variant rs138510982 [ dbSNP | Ensembl ].
VAR_037789
Natural variant2921L → M. Ref.1
Corresponds to variant rs4564704 [ dbSNP | Ensembl ].
VAR_037790

Sequences

Sequence LengthMass (Da)Tools
Q8NG98 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: FD97DD41B890B085

FASTA31234,448
        10         20         30         40         50         60 
MEAENLTELS KFLLLGLSDD PELQPVLFGL FLSMYLVTVL GNLLIILAVS SDSHLHTPMY 

        70         80         90        100        110        120 
FFLSNLSFVD ICFISTTVPK MLVSIQARSK DISYMGCLTQ VYFLMMFAGM DTFLLAVMAY 

       130        140        150        160        170        180 
DRFVAICHPL HYTVIMNPCL CGLLVLASWF IIFWFSLVHI LLMKRLTFST GTEIPHFFCE 

       190        200        210        220        230        240 
PAQVLKVACS NTLLNNIVLY VATALLGVFP VAGILFSYSQ IVSSLMGMSS TKGKYKAFST 

       250        260        270        280        290        300 
CGSHLCVVSL FYGTGLGVYL SSAVTHSSQS SSTASVMYAM VTPMLNPFIY SLRNKDVKGA 

       310 
LERLLSRADS CP 

« Hide

References

« Hide 'large scale' references
[1]"Genetic variation in a human odorant receptor alters odour perception."
Keller A., Zhuang H., Chi Q., Vosshall L.B., Matsunami H.
Nature 449:468-472(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLY-52; CYS-75; LEU-79; ASN-84; TRP-88; GLN-131; MET-133; I-136; ARG-139; TYR-139; PRO-162; ASP-279 AND MET-292.
[2]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[5]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[6]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
[7]"Characterizing the expression of the human olfactory receptor gene family using a novel DNA microarray."
Zhang X., De la Cruz O., Pinto J.M., Nicolae D., Firestein S., Gilad Y.
Genome Biol. 8:R86.1-R86.10(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EU049291 Genomic DNA. Translation: ABV66282.1.
EU049293 Genomic DNA. Translation: ABV66284.1.
AB065929 Genomic DNA. Translation: BAC06144.1.
CH471106 Genomic DNA. Translation: EAW84021.1.
BC137147 mRNA. Translation: AAI37148.1.
BC137162 mRNA. Translation: AAI37163.1.
BK004226 Genomic DNA. Translation: DAA04624.1.
RefSeqNP_001005191.1. NM_001005191.2.
UniGeneHs.446910.

3D structure databases

ProteinModelPortalQ8NG98.
SMRQ8NG98. Positions 22-201, 277-307.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000310488.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM71153032.

Proteomic databases

PRIDEQ8NG98.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000308682; ENSP00000310488; ENSG00000174667.
GeneID125958.
KEGGhsa:125958.
UCSCuc002mla.2. human.

Organism-specific databases

CTD125958.
GeneCardsGC19M009324.
HGNCHGNC:8380. OR7D4.
MIM611538. gene.
neXtProtNX_Q8NG98.
PharmGKBPA32628.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG150292.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ8NG98.
KOK04257.
OMAFFCEPAQ.
OrthoDBEOG7HXCR6.
PhylomeDBQ8NG98.
TreeFamTF337210.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR7D4.
GenevestigatorQ8NG98.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR7D4.
GenomeRNAi125958.
NextBio81586.
PROQ8NG98.
SOURCESearch...

Entry information

Entry nameOR7D4_HUMAN
AccessionPrimary (citable) accession number: Q8NG98
Secondary accession number(s): A8CAH8, A8CAI0, B9EH79
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

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Human chromosome 19

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