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Q8NG98

- OR7D4_HUMAN

UniProt

Q8NG98 - OR7D4_HUMAN

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Protein

Olfactory receptor 7D4

Gene
OR7D4, OR7D4P
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor. Selectively activated by androstenone and the related odorous steroid androstadienone.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 7D4
Alternative name(s):
OR19-B
Odorant receptor family subfamily D member 4RT
Olfactory receptor OR19-7
Gene namesi
Name:OR7D4
Synonyms:OR7D4P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:8380. OR7D4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Extracellular Reviewed predictionAdd
BLAST
Transmembranei26 – 4621Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini47 – 548Cytoplasmic Reviewed prediction
Transmembranei55 – 7521Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini76 – 9924Extracellular Reviewed predictionAdd
BLAST
Transmembranei100 – 12021Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini121 – 13919Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei140 – 16021Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini161 – 19737Extracellular Reviewed predictionAdd
BLAST
Transmembranei198 – 21720Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini218 – 23720Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei238 – 25821Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini259 – 27113Extracellular Reviewed predictionAdd
BLAST
Transmembranei272 – 29221Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini293 – 31220Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32628.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 7D4PRO_0000150649Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi97 ↔ 189 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NG98.

Expressioni

Tissue specificityi

Nasal olfactory epithelium.1 Publication

Gene expression databases

CleanExiHS_OR7D4.
GenevestigatoriQ8NG98.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000310488.

Structurei

3D structure databases

ProteinModelPortaliQ8NG98.
SMRiQ8NG98. Positions 22-151.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150292.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NG98.
KOiK04257.
OMAiFFCEPAQ.
OrthoDBiEOG7HXCR6.
PhylomeDBiQ8NG98.
TreeFamiTF337210.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NG98-1 [UniParc]FASTAAdd to Basket

« Hide

MEAENLTELS KFLLLGLSDD PELQPVLFGL FLSMYLVTVL GNLLIILAVS    50
SDSHLHTPMY FFLSNLSFVD ICFISTTVPK MLVSIQARSK DISYMGCLTQ 100
VYFLMMFAGM DTFLLAVMAY DRFVAICHPL HYTVIMNPCL CGLLVLASWF 150
IIFWFSLVHI LLMKRLTFST GTEIPHFFCE PAQVLKVACS NTLLNNIVLY 200
VATALLGVFP VAGILFSYSQ IVSSLMGMSS TKGKYKAFST CGSHLCVVSL 250
FYGTGLGVYL SSAVTHSSQS SSTASVMYAM VTPMLNPFIY SLRNKDVKGA 300
LERLLSRADS CP 312
Length:312
Mass (Da):34,448
Last modified:October 1, 2002 - v1
Checksum:iFD97DD41B890B085
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171L → F.
Corresponds to variant rs57568862 [ dbSNP | Ensembl ].
VAR_062056
Natural varianti52 – 521D → G.1 Publication
VAR_037778
Natural varianti75 – 751S → C.1 Publication
Corresponds to variant rs5020281 [ dbSNP | Ensembl ].
VAR_037779
Natural varianti79 – 791P → L Impaired response to androstenone and androstadienone. 1 Publication
Corresponds to variant rs61732668 [ dbSNP | Ensembl ].
VAR_037780
Natural varianti84 – 841S → N High sensitivity to androstenone and androstadienone. 1 Publication
Corresponds to variant rs5020280 [ dbSNP | Ensembl ].
VAR_037781
Natural varianti88 – 881R → W Impaired response to androstenone and androstadienone; when associated with M-133. 1 Publication
Corresponds to variant rs61729907 [ dbSNP | Ensembl ].
VAR_037782
Natural varianti131 – 1311H → Q.1 Publication
Corresponds to variant rs5020279 [ dbSNP | Ensembl ].
VAR_037783
Natural varianti133 – 1331T → M Impaired response to androstenone and androstadienone; when associated with W-88. 1 Publication
Corresponds to variant rs5020278 [ dbSNP | Ensembl ].
VAR_037784
Natural varianti136 – 1361M → I.
Corresponds to variant rs5020277 [ dbSNP | Ensembl ].
VAR_037785
Natural varianti139 – 1391C → R.1 Publication
Corresponds to variant rs5020276 [ dbSNP | Ensembl ].
VAR_037786
Natural varianti139 – 1391C → Y.1 Publication
Corresponds to variant rs5020275 [ dbSNP | Ensembl ].
VAR_037787
Natural varianti162 – 1621L → P.1 Publication
VAR_037788
Natural varianti279 – 2791A → D.1 Publication
Corresponds to variant rs138510982 [ dbSNP | Ensembl ].
VAR_037789
Natural varianti292 – 2921L → M.1 Publication
Corresponds to variant rs4564704 [ dbSNP | Ensembl ].
VAR_037790

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU049291 Genomic DNA. Translation: ABV66282.1.
EU049292 Genomic DNA. Translation: ABV66283.1.
EU049293 Genomic DNA. Translation: ABV66284.1.
EU049294 Genomic DNA. Translation: ABV66285.1.
AB065929 Genomic DNA. Translation: BAC06144.1.
CH471106 Genomic DNA. Translation: EAW84021.1.
BC137147 mRNA. Translation: AAI37148.1.
BC137162 mRNA. Translation: AAI37163.1.
BK004226 Genomic DNA. Translation: DAA04624.1.
CCDSiCCDS32901.1.
RefSeqiNP_001005191.1. NM_001005191.2.
UniGeneiHs.446910.

Genome annotation databases

EnsembliENST00000308682; ENSP00000310488; ENSG00000174667.
GeneIDi125958.
KEGGihsa:125958.
UCSCiuc002mla.2. human.

Polymorphism databases

DMDMi71153032.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)
Protein Spotlight

The selfish smell - Issue 94 of May 2008

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU049291 Genomic DNA. Translation: ABV66282.1 .
EU049292 Genomic DNA. Translation: ABV66283.1 .
EU049293 Genomic DNA. Translation: ABV66284.1 .
EU049294 Genomic DNA. Translation: ABV66285.1 .
AB065929 Genomic DNA. Translation: BAC06144.1 .
CH471106 Genomic DNA. Translation: EAW84021.1 .
BC137147 mRNA. Translation: AAI37148.1 .
BC137162 mRNA. Translation: AAI37163.1 .
BK004226 Genomic DNA. Translation: DAA04624.1 .
CCDSi CCDS32901.1.
RefSeqi NP_001005191.1. NM_001005191.2.
UniGenei Hs.446910.

3D structure databases

ProteinModelPortali Q8NG98.
SMRi Q8NG98. Positions 22-151.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000310488.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 71153032.

Proteomic databases

PRIDEi Q8NG98.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000308682 ; ENSP00000310488 ; ENSG00000174667 .
GeneIDi 125958.
KEGGi hsa:125958.
UCSCi uc002mla.2. human.

Organism-specific databases

CTDi 125958.
GeneCardsi GC19M009324.
HGNCi HGNC:8380. OR7D4.
MIMi 611538. gene.
neXtProti NX_Q8NG98.
PharmGKBi PA32628.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG150292.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q8NG98.
KOi K04257.
OMAi FFCEPAQ.
OrthoDBi EOG7HXCR6.
PhylomeDBi Q8NG98.
TreeFami TF337210.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR7D4.
GenomeRNAii 125958.
NextBioi 35463595.
PROi Q8NG98.
SOURCEi Search...

Gene expression databases

CleanExi HS_OR7D4.
Genevestigatori Q8NG98.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic variation in a human odorant receptor alters odour perception."
    Keller A., Zhuang H., Chi Q., Vosshall L.B., Matsunami H.
    Nature 449:468-472(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLY-52; CYS-75; LEU-79; ASN-84; TRP-88; GLN-131; MET-133; I-136; ARG-139; TYR-139; PRO-162; ASP-279 AND MET-292.
  2. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
  7. "Characterizing the expression of the human olfactory receptor gene family using a novel DNA microarray."
    Zhang X., De la Cruz O., Pinto J.M., Nicolae D., Firestein S., Gilad Y.
    Genome Biol. 8:R86.1-R86.10(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiOR7D4_HUMAN
AccessioniPrimary (citable) accession number: Q8NG98
Secondary accession number(s): A8CAH8
, A8CAH9, A8CAI0, A8CAI1, B9EH79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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