Reviewed, UniProtKB/Swiss-Prot Q8NG98 (OR7D4_HUMAN)

Names and origin

Protein names

Recommended name:
    Olfactory receptor 7D4
Alternative name(s):
    Olfactory receptor OR19-7
    Odorant receptor family subfamily D member 4RT
    OR19-B

Gene names

Name:	OR7D4
Synonyms:	OR7D4P

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Odorant receptor. Selectively activated by androstenone and the related odorous steroid androstadienone.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Nasal olfactory epithelium. Ref.7
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW sensory perception of smell Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Olfactory receptor 7D4		PRO_0000150649
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 46	21	1 Potential
	Topological domain	47 – 54	8	Cytoplasmic Potential
	Transmembrane	55 – 75	21	2 Potential
	Topological domain	76 – 99	24	Extracellular Potential
	Transmembrane	100 – 120	21	3 Potential
	Topological domain	121 – 139	19	Cytoplasmic Potential
	Transmembrane	140 – 160	21	4 Potential
	Topological domain	161 – 197	37	Extracellular Potential
	Transmembrane	198 – 217	20	5 Potential
	Topological domain	218 – 237	20	Cytoplasmic Potential
	Transmembrane	238 – 258	21	6 Potential
	Topological domain	259 – 271	13	Extracellular Potential
	Transmembrane	272 – 292	21	7 Potential
	Topological domain	293 – 312	20	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	97 ↔ 189		By similarity
Natural variations
	Natural variant	52	1	D → G		VAR_037778
	Natural variant	75	1	S → C: dbSNP rs5020281. Ref.1		VAR_037779
	Natural variant	79	1	P → L Impaired response to androstenone and androstadienone. Ref.1		VAR_037780
	Natural variant	84	1	S → N High sensitivity to androstenone and androstadienone. dbSNP rs5020280. Ref.1		VAR_037781
	Natural variant	88	1	R → W Impaired response to androstenone and androstadienone; when associated with M-133. Ref.1		VAR_037782
	Natural variant	131	1	H → Q: dbSNP rs5020279. Ref.1		VAR_037783
	Natural variant	133	1	T → M Impaired response to androstenone and androstadienone; when associated with W-88. dbSNP rs5020278. Ref.1		VAR_037784
	Natural variant	136	1	M → I: dbSNP rs5020277.		VAR_037785
	Natural variant	139	1	C → R: dbSNP rs5020276. Ref.1		VAR_037786
	Natural variant	139	1	C → Y: dbSNP rs5020275. Ref.1		VAR_037787
	Natural variant	162	1	L → P		VAR_037788
	Natural variant	279	1	A → D		VAR_037789
	Natural variant	292	1	L → M: dbSNP rs4564704. Ref.1		VAR_037790

Sequences

	Sequence		Length	Mass (Da)
	Q8NG98-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: FD97DD41B890B085	FASTA	312	34,448
	10 20 30 40 50 60 MEAENLTELS KFLLLGLSDD PELQPVLFGL FLSMYLVTVL GNLLIILAVS SDSHLHTPMY 70 80 90 100 110 120 FFLSNLSFVD ICFISTTVPK MLVSIQARSK DISYMGCLTQ VYFLMMFAGM DTFLLAVMAY 130 140 150 160 170 180 DRFVAICHPL HYTVIMNPCL CGLLVLASWF IIFWFSLVHI LLMKRLTFST GTEIPHFFCE 190 200 210 220 230 240 PAQVLKVACS NTLLNNIVLY VATALLGVFP VAGILFSYSQ IVSSLMGMSS TKGKYKAFST 250 260 270 280 290 300 CGSHLCVVSL FYGTGLGVYL SSAVTHSSQS SSTASVMYAM VTPMLNPFIY SLRNKDVKGA 310 LERLLSRADS CP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genetic variation in a human odorant receptor alters odour perception." Keller A., Zhuang H., Chi Q., Vosshall L.B., Matsunami H. Nature 449:468-472(2007) [PubMed: 17873857] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLY-52; CYS-75; LEU-79; ASN-84; TRP-88; GLN-131; MET-133; I-136; ARG-139; TYR-139; PRO-162; ASP-279 AND MET-292.
[2]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[5]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed: 14983052] [Abstract] Cited for: IDENTIFICATION.
[6]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
[7]	"Characterizing the expression of the human olfactory receptor gene family using a novel DNA microarray." Zhang X., De la Cruz O., Pinto J.M., Nicolae D., Firestein S., Gilad Y. Genome Biol. 8:RESEARCH0086.1-RESEARCH0086.10(2007) [PubMed: 17509148] [Abstract] Cited for: TISSUE SPECIFICITY.

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Protein Spotlight

The selfish smell - Issue 94 of May 2008

Cross-references

Sequence databases
EMBLGenBankDDBJ	EU049291 Genomic DNA. Translation: ABV66282.1. AB065929 Genomic DNA. Translation: BAC06144.1. CH471106 Genomic DNA. Translation: EAW84021.1. BC137147 mRNA. Translation: AAI37148.1. BC137162 mRNA. Translation: AAI37163.1. BK004226 Genomic DNA. Translation: DAA04624.1.
IPI	IPI00303230.
RefSeq	NP_001005191.1.
UniGene	Hs.446910
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8NG98.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	Q8NG98.
Genome annotation databases
Ensembl	ENST00000308682; ENSP00000310488; ENSG00000174667; Homo sapiens. [Genome view]
GeneID	125958.
KEGG	hsa:125958.
UCSC	uc002mla.1. human.
Organism-specific databases
CTD	125958.
GeneCards	GC19M009187.
H-InvDB	HIX0040177.
HGNC	HGNC:8380. OR7D4.
MIM	611538. gene.
PharmGKB	PA32628.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q8NG98.
HOVERGEN	Q8NG98.
OMA	LTSAVTH.
Enzyme and pathway databases
Reactome	REACT_14797. Signaling by GPCR.
Gene expression databases
CleanEx	HS_OR7D4.
Genevestigator	Q8NG98.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR11398. Olfact_rcpt. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	81586.
SOURCE	Search...

Entry information

Entry name

OR7D4_HUMAN

Accession

Primary (citable) accession number: Q8NG98
Secondary accession number(s): A8CAH8, B9EH79

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	October 1, 2002
Last modified:	November 3, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.