Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8NG98

- OR7D4_HUMAN

UniProt

Q8NG98 - OR7D4_HUMAN

Protein

Olfactory receptor 7D4

Gene

OR7D4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Odorant receptor. Selectively activated by androstenone and the related odorous steroid androstadienone.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 7D4
    Alternative name(s):
    OR19-B
    Odorant receptor family subfamily D member 4RT
    Olfactory receptor OR19-7
    Gene namesi
    Name:OR7D4
    Synonyms:OR7D4P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:8380. OR7D4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32628.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Olfactory receptor 7D4PRO_0000150649Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8NG98.

    Expressioni

    Tissue specificityi

    Nasal olfactory epithelium.1 Publication

    Gene expression databases

    CleanExiHS_OR7D4.
    GenevestigatoriQ8NG98.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000310488.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NG98.
    SMRiQ8NG98. Positions 22-151.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini47 – 548CytoplasmicSequence Analysis
    Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 31220CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei198 – 21720Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150292.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ8NG98.
    KOiK04257.
    OMAiFFCEPAQ.
    OrthoDBiEOG7HXCR6.
    PhylomeDBiQ8NG98.
    TreeFamiTF337210.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NG98-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAENLTELS KFLLLGLSDD PELQPVLFGL FLSMYLVTVL GNLLIILAVS    50
    SDSHLHTPMY FFLSNLSFVD ICFISTTVPK MLVSIQARSK DISYMGCLTQ 100
    VYFLMMFAGM DTFLLAVMAY DRFVAICHPL HYTVIMNPCL CGLLVLASWF 150
    IIFWFSLVHI LLMKRLTFST GTEIPHFFCE PAQVLKVACS NTLLNNIVLY 200
    VATALLGVFP VAGILFSYSQ IVSSLMGMSS TKGKYKAFST CGSHLCVVSL 250
    FYGTGLGVYL SSAVTHSSQS SSTASVMYAM VTPMLNPFIY SLRNKDVKGA 300
    LERLLSRADS CP 312
    Length:312
    Mass (Da):34,448
    Last modified:October 1, 2002 - v1
    Checksum:iFD97DD41B890B085
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti17 – 171L → F.
    Corresponds to variant rs57568862 [ dbSNP | Ensembl ].
    VAR_062056
    Natural varianti52 – 521D → G.1 Publication
    VAR_037778
    Natural varianti75 – 751S → C.1 Publication
    Corresponds to variant rs5020281 [ dbSNP | Ensembl ].
    VAR_037779
    Natural varianti79 – 791P → L Impaired response to androstenone and androstadienone. 1 Publication
    Corresponds to variant rs61732668 [ dbSNP | Ensembl ].
    VAR_037780
    Natural varianti84 – 841S → N High sensitivity to androstenone and androstadienone. 1 Publication
    Corresponds to variant rs5020280 [ dbSNP | Ensembl ].
    VAR_037781
    Natural varianti88 – 881R → W Impaired response to androstenone and androstadienone; when associated with M-133. 1 Publication
    Corresponds to variant rs61729907 [ dbSNP | Ensembl ].
    VAR_037782
    Natural varianti131 – 1311H → Q.1 Publication
    Corresponds to variant rs5020279 [ dbSNP | Ensembl ].
    VAR_037783
    Natural varianti133 – 1331T → M Impaired response to androstenone and androstadienone; when associated with W-88. 1 Publication
    Corresponds to variant rs5020278 [ dbSNP | Ensembl ].
    VAR_037784
    Natural varianti136 – 1361M → I.
    Corresponds to variant rs5020277 [ dbSNP | Ensembl ].
    VAR_037785
    Natural varianti139 – 1391C → R.1 Publication
    Corresponds to variant rs5020276 [ dbSNP | Ensembl ].
    VAR_037786
    Natural varianti139 – 1391C → Y.1 Publication
    Corresponds to variant rs5020275 [ dbSNP | Ensembl ].
    VAR_037787
    Natural varianti162 – 1621L → P.1 Publication
    VAR_037788
    Natural varianti279 – 2791A → D.1 Publication
    Corresponds to variant rs138510982 [ dbSNP | Ensembl ].
    VAR_037789
    Natural varianti292 – 2921L → M.1 Publication
    Corresponds to variant rs4564704 [ dbSNP | Ensembl ].
    VAR_037790

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU049291 Genomic DNA. Translation: ABV66282.1.
    EU049292 Genomic DNA. Translation: ABV66283.1.
    EU049293 Genomic DNA. Translation: ABV66284.1.
    EU049294 Genomic DNA. Translation: ABV66285.1.
    AB065929 Genomic DNA. Translation: BAC06144.1.
    CH471106 Genomic DNA. Translation: EAW84021.1.
    BC137147 mRNA. Translation: AAI37148.1.
    BC137162 mRNA. Translation: AAI37163.1.
    BK004226 Genomic DNA. Translation: DAA04624.1.
    CCDSiCCDS32901.1.
    RefSeqiNP_001005191.1. NM_001005191.2.
    UniGeneiHs.446910.

    Genome annotation databases

    EnsembliENST00000308682; ENSP00000310488; ENSG00000174667.
    GeneIDi125958.
    KEGGihsa:125958.
    UCSCiuc002mla.2. human.

    Polymorphism databases

    DMDMi71153032.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)
    Protein Spotlight

    The selfish smell - Issue 94 of May 2008

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU049291 Genomic DNA. Translation: ABV66282.1 .
    EU049292 Genomic DNA. Translation: ABV66283.1 .
    EU049293 Genomic DNA. Translation: ABV66284.1 .
    EU049294 Genomic DNA. Translation: ABV66285.1 .
    AB065929 Genomic DNA. Translation: BAC06144.1 .
    CH471106 Genomic DNA. Translation: EAW84021.1 .
    BC137147 mRNA. Translation: AAI37148.1 .
    BC137162 mRNA. Translation: AAI37163.1 .
    BK004226 Genomic DNA. Translation: DAA04624.1 .
    CCDSi CCDS32901.1.
    RefSeqi NP_001005191.1. NM_001005191.2.
    UniGenei Hs.446910.

    3D structure databases

    ProteinModelPortali Q8NG98.
    SMRi Q8NG98. Positions 22-151.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000310488.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 71153032.

    Proteomic databases

    PRIDEi Q8NG98.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000308682 ; ENSP00000310488 ; ENSG00000174667 .
    GeneIDi 125958.
    KEGGi hsa:125958.
    UCSCi uc002mla.2. human.

    Organism-specific databases

    CTDi 125958.
    GeneCardsi GC19M009324.
    HGNCi HGNC:8380. OR7D4.
    MIMi 611538. gene.
    neXtProti NX_Q8NG98.
    PharmGKBi PA32628.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG150292.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q8NG98.
    KOi K04257.
    OMAi FFCEPAQ.
    OrthoDBi EOG7HXCR6.
    PhylomeDBi Q8NG98.
    TreeFami TF337210.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR7D4.
    GenomeRNAii 125958.
    NextBioi 35463595.
    PROi Q8NG98.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_OR7D4.
    Genevestigatori Q8NG98.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genetic variation in a human odorant receptor alters odour perception."
      Keller A., Zhuang H., Chi Q., Vosshall L.B., Matsunami H.
      Nature 449:468-472(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLY-52; CYS-75; LEU-79; ASN-84; TRP-88; GLN-131; MET-133; I-136; ARG-139; TYR-139; PRO-162; ASP-279 AND MET-292.
    2. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    5. Cited for: IDENTIFICATION.
    6. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
    7. "Characterizing the expression of the human olfactory receptor gene family using a novel DNA microarray."
      Zhang X., De la Cruz O., Pinto J.M., Nicolae D., Firestein S., Gilad Y.
      Genome Biol. 8:R86.1-R86.10(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiOR7D4_HUMAN
    AccessioniPrimary (citable) accession number: Q8NG98
    Secondary accession number(s): A8CAH8
    , A8CAH9, A8CAI0, A8CAI1, B9EH79
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3