Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 7D4

Gene

OR7D4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor. Selectively activated by androstenone and the related odorous steroid androstadienone.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174667-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 7D4
Alternative name(s):
OR19-B
Odorant receptor family subfamily D member 4RT
Olfactory receptor OR19-7
Gene namesi
Name:OR7D4
Synonyms:OR7D4P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:8380. OR7D4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 312CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000174667.
PharmGKBiPA32628.

Polymorphism and mutation databases

BioMutaiOR7D4.
DMDMi71153032.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506491 – 312Olfactory receptor 7D4Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NG98.
PRIDEiQ8NG98.

Expressioni

Tissue specificityi

Nasal olfactory epithelium.1 Publication

Gene expression databases

CleanExiHS_OR7D4.
ExpressionAtlasiQ8NG98. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000310488.

Structurei

3D structure databases

ProteinModelPortaliQ8NG98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVB1. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00760000118801.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NG98.
KOiK04257.
OMAiFFCEPAQ.
OrthoDBiEOG091G0B53.
PhylomeDBiQ8NG98.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NG98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAENLTELS KFLLLGLSDD PELQPVLFGL FLSMYLVTVL GNLLIILAVS
60 70 80 90 100
SDSHLHTPMY FFLSNLSFVD ICFISTTVPK MLVSIQARSK DISYMGCLTQ
110 120 130 140 150
VYFLMMFAGM DTFLLAVMAY DRFVAICHPL HYTVIMNPCL CGLLVLASWF
160 170 180 190 200
IIFWFSLVHI LLMKRLTFST GTEIPHFFCE PAQVLKVACS NTLLNNIVLY
210 220 230 240 250
VATALLGVFP VAGILFSYSQ IVSSLMGMSS TKGKYKAFST CGSHLCVVSL
260 270 280 290 300
FYGTGLGVYL SSAVTHSSQS SSTASVMYAM VTPMLNPFIY SLRNKDVKGA
310
LERLLSRADS CP
Length:312
Mass (Da):34,448
Last modified:October 1, 2002 - v1
Checksum:iFD97DD41B890B085
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06205617L → F.Corresponds to variant rs57568862dbSNPEnsembl.1
Natural variantiVAR_03777852D → G.1 PublicationCorresponds to variant rs144165121dbSNPEnsembl.1
Natural variantiVAR_03777975S → C.1 PublicationCorresponds to variant rs5020281dbSNPEnsembl.1
Natural variantiVAR_03778079P → L Impaired response to androstenone and androstadienone. 1 PublicationCorresponds to variant rs61732668dbSNPEnsembl.1
Natural variantiVAR_03778184S → N High sensitivity to androstenone and androstadienone. 1 PublicationCorresponds to variant rs5020280dbSNPEnsembl.1
Natural variantiVAR_03778288R → W Impaired response to androstenone and androstadienone; when associated with M-133. 1 PublicationCorresponds to variant rs61729907dbSNPEnsembl.1
Natural variantiVAR_037783131H → Q.1 PublicationCorresponds to variant rs5020279dbSNPEnsembl.1
Natural variantiVAR_037784133T → M Impaired response to androstenone and androstadienone; when associated with W-88. 1 PublicationCorresponds to variant rs5020278dbSNPEnsembl.1
Natural variantiVAR_037785136M → I.1 PublicationCorresponds to variant rs5020277dbSNPEnsembl.1
Natural variantiVAR_037786139C → R.1 PublicationCorresponds to variant rs5020276dbSNPEnsembl.1
Natural variantiVAR_037787139C → Y.1 PublicationCorresponds to variant rs5020275dbSNPEnsembl.1
Natural variantiVAR_037788162L → P.1 Publication1
Natural variantiVAR_037789279A → D.1 PublicationCorresponds to variant rs138510982dbSNPEnsembl.1
Natural variantiVAR_037790292L → M.1 PublicationCorresponds to variant rs4564704dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU049291 Genomic DNA. Translation: ABV66282.1.
EU049292 Genomic DNA. Translation: ABV66283.1.
EU049293 Genomic DNA. Translation: ABV66284.1.
EU049294 Genomic DNA. Translation: ABV66285.1.
AB065929 Genomic DNA. Translation: BAC06144.1.
CH471106 Genomic DNA. Translation: EAW84021.1.
BC137147 mRNA. Translation: AAI37148.1.
BC137162 mRNA. Translation: AAI37163.1.
BK004226 Genomic DNA. Translation: DAA04624.1.
CCDSiCCDS32901.1.
RefSeqiNP_001005191.1. NM_001005191.2.
UniGeneiHs.446910.

Genome annotation databases

EnsembliENST00000308682; ENSP00000310488; ENSG00000174667.
GeneIDi125958.
KEGGihsa:125958.
UCSCiuc002mla.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)
Protein Spotlight

The selfish smell - Issue 94 of May 2008

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU049291 Genomic DNA. Translation: ABV66282.1.
EU049292 Genomic DNA. Translation: ABV66283.1.
EU049293 Genomic DNA. Translation: ABV66284.1.
EU049294 Genomic DNA. Translation: ABV66285.1.
AB065929 Genomic DNA. Translation: BAC06144.1.
CH471106 Genomic DNA. Translation: EAW84021.1.
BC137147 mRNA. Translation: AAI37148.1.
BC137162 mRNA. Translation: AAI37163.1.
BK004226 Genomic DNA. Translation: DAA04624.1.
CCDSiCCDS32901.1.
RefSeqiNP_001005191.1. NM_001005191.2.
UniGeneiHs.446910.

3D structure databases

ProteinModelPortaliQ8NG98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000310488.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR7D4.
DMDMi71153032.

Proteomic databases

PaxDbiQ8NG98.
PRIDEiQ8NG98.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308682; ENSP00000310488; ENSG00000174667.
GeneIDi125958.
KEGGihsa:125958.
UCSCiuc002mla.2. human.

Organism-specific databases

CTDi125958.
GeneCardsiOR7D4.
HGNCiHGNC:8380. OR7D4.
MIMi611538. gene.
neXtProtiNX_Q8NG98.
OpenTargetsiENSG00000174667.
PharmGKBiPA32628.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVB1. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00760000118801.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NG98.
KOiK04257.
OMAiFFCEPAQ.
OrthoDBiEOG091G0B53.
PhylomeDBiQ8NG98.
TreeFamiTF337210.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174667-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR7D4.
GenomeRNAii125958.
PROiQ8NG98.
SOURCEiSearch...

Gene expression databases

CleanExiHS_OR7D4.
ExpressionAtlasiQ8NG98. baseline.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR7D4_HUMAN
AccessioniPrimary (citable) accession number: Q8NG98
Secondary accession number(s): A8CAH8
, A8CAH9, A8CAI0, A8CAI1, B9EH79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.