Q8NG98 (OR7D4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 7D4

Alternative name(s):
OR19-B
Odorant receptor family subfamily D member 4RT
Olfactory receptor OR19-7

Gene names

Name:	OR7D4
Synonyms:	OR7D4P

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor. Selectively activated by androstenone and the related odorous steroid androstadienone.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Nasal olfactory epithelium. Ref.7
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Olfactory receptor 7D4		PRO_0000150649
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 46	21	Helical; Name=1; Potential
	Topological domain	47 – 54	8	Cytoplasmic Potential
	Transmembrane	55 – 75	21	Helical; Name=2; Potential
	Topological domain	76 – 99	24	Extracellular Potential
	Transmembrane	100 – 120	21	Helical; Name=3; Potential
	Topological domain	121 – 139	19	Cytoplasmic Potential
	Transmembrane	140 – 160	21	Helical; Name=4; Potential
	Topological domain	161 – 197	37	Extracellular Potential
	Transmembrane	198 – 217	20	Helical; Name=5; Potential
	Topological domain	218 – 237	20	Cytoplasmic Potential
	Transmembrane	238 – 258	21	Helical; Name=6; Potential
	Topological domain	259 – 271	13	Extracellular Potential
	Transmembrane	272 – 292	21	Helical; Name=7; Potential
	Topological domain	293 – 312	20	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	97 ↔ 189		By similarity
Natural variations
	Natural variant	17	1	L → F. Corresponds to variant rs57568862 [ dbSNP | Ensembl ].		VAR_062056
	Natural variant	52	1	D → G. Ref.1		VAR_037778
	Natural variant	75	1	S → C. Ref.1 Corresponds to variant rs5020281 [ dbSNP | Ensembl ].		VAR_037779
	Natural variant	79	1	P → L Impaired response to androstenone and androstadienone. Ref.1		VAR_037780
	Natural variant	84	1	S → N High sensitivity to androstenone and androstadienone. Ref.1 Corresponds to variant rs5020280 [ dbSNP | Ensembl ].		VAR_037781
	Natural variant	88	1	R → W Impaired response to androstenone and androstadienone; when associated with M-133. Ref.1		VAR_037782
	Natural variant	131	1	H → Q. Ref.1 Corresponds to variant rs5020279 [ dbSNP | Ensembl ].		VAR_037783
	Natural variant	133	1	T → M Impaired response to androstenone and androstadienone; when associated with W-88. Ref.1 Corresponds to variant rs5020278 [ dbSNP | Ensembl ].		VAR_037784
	Natural variant	136	1	M → I. Corresponds to variant rs5020277 [ dbSNP | Ensembl ].		VAR_037785
	Natural variant	139	1	C → R. Ref.1 Corresponds to variant rs5020276 [ dbSNP | Ensembl ].		VAR_037786
	Natural variant	139	1	C → Y. Ref.1 Corresponds to variant rs5020275 [ dbSNP | Ensembl ].		VAR_037787
	Natural variant	162	1	L → P. Ref.1		VAR_037788
	Natural variant	279	1	A → D. Ref.1		VAR_037789
	Natural variant	292	1	L → M. Ref.1 Corresponds to variant rs4564704 [ dbSNP | Ensembl ].		VAR_037790

Sequences

	Sequence		Length	Mass (Da)
	Q8NG98 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: FD97DD41B890B085	FASTA	312	34,448
	10 20 30 40 50 60 MEAENLTELS KFLLLGLSDD PELQPVLFGL FLSMYLVTVL GNLLIILAVS SDSHLHTPMY 70 80 90 100 110 120 FFLSNLSFVD ICFISTTVPK MLVSIQARSK DISYMGCLTQ VYFLMMFAGM DTFLLAVMAY 130 140 150 160 170 180 DRFVAICHPL HYTVIMNPCL CGLLVLASWF IIFWFSLVHI LLMKRLTFST GTEIPHFFCE 190 200 210 220 230 240 PAQVLKVACS NTLLNNIVLY VATALLGVFP VAGILFSYSQ IVSSLMGMSS TKGKYKAFST 250 260 270 280 290 300 CGSHLCVVSL FYGTGLGVYL SSAVTHSSQS SSTASVMYAM VTPMLNPFIY SLRNKDVKGA 310 LERLLSRADS CP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genetic variation in a human odorant receptor alters odour perception." Keller A., Zhuang H., Chi Q., Vosshall L.B., Matsunami H. Nature 449:468-472(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLY-52; CYS-75; LEU-79; ASN-84; TRP-88; GLN-131; MET-133; I-136; ARG-139; TYR-139; PRO-162; ASP-279 AND MET-292.
[2]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[5]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[6]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
[7]	"Characterizing the expression of the human olfactory receptor gene family using a novel DNA microarray." Zhang X., De la Cruz O., Pinto J.M., Nicolae D., Firestein S., Gilad Y. Genome Biol. 8:R86.1-R86.10(2007) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Protein Spotlight

The selfish smell - Issue 94 of May 2008

Cross-references

Sequence databases
EMBL GenBank DDBJ	EU049291 Genomic DNA. Translation: ABV66282.1. EU049293 Genomic DNA. Translation: ABV66284.1. AB065929 Genomic DNA. Translation: BAC06144.1. CH471106 Genomic DNA. Translation: EAW84021.1. BC137147 mRNA. Translation: AAI37148.1. BC137162 mRNA. Translation: AAI37163.1. BK004226 Genomic DNA. Translation: DAA04624.1.
IPI	IPI00303230.
RefSeq	NP_001005191.1. NM_001005191.2.
UniGene	Hs.446910.
3D structure databases
ProteinModelPortal	Q8NG98.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000310488.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	71153032.
Proteomic databases
PRIDE	Q8NG98.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000308682; ENSP00000310488; ENSG00000174667.
GeneID	125958.
KEGG	hsa:125958.
UCSC	uc002mla.2. human.
Organism-specific databases
CTD	125958.
GeneCards	GC19M009324.
HGNC	HGNC:8380. OR7D4.
MIM	611538. gene.
neXtProt	NX_Q8NG98.
PharmGKB	PA32628.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG150292.
HOGENOM	HOG000041365.
HOVERGEN	HBG017625.
InParanoid	Q8NG98.
KO	K04257.
OMA	FFCEPAQ.
OrthoDB	EOG4W0XDJ.
PhylomeDB	Q8NG98.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR7D4.
Genevestigator	Q8NG98.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	125958.
NextBio	81586.
SOURCE	Search...

Entry information

Entry name

OR7D4_HUMAN

Accession

Primary (citable) accession number: Q8NG98
Secondary accession number(s): A8CAH8, A8CAI0, B9EH79

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.