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Q8NG97

- OR2Z1_HUMAN

UniProt

Q8NG97 - OR2Z1_HUMAN

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Protein

Olfactory receptor 2Z1

Gene
OR2Z1, OR2Z2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2Z1
Alternative name(s):
Olfactory receptor 2Z2
Olfactory receptor OR19-4
Gene namesi
Name:OR2Z1
Synonyms:OR2Z2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:15391. OR2Z1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Extracellular Reviewed predictionAdd
BLAST
Transmembranei26 – 4924Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini50 – 578Cytoplasmic Reviewed prediction
Transmembranei58 – 7922Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini80 – 10021Extracellular Reviewed predictionAdd
BLAST
Transmembranei101 – 12020Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini121 – 13919Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei140 – 15819Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini159 – 19537Extracellular Reviewed predictionAdd
BLAST
Transmembranei196 – 21924Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini220 – 23617Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei237 – 25923Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini260 – 27213Extracellular Reviewed predictionAdd
BLAST
Transmembranei273 – 29220Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini293 – 31422Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32221.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 2Z1PRO_0000150514Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NG97.
PRIDEiQ8NG97.

Expressioni

Gene expression databases

CleanExiHS_OR2Z1.
GenevestigatoriQ8NG97.

Organism-specific databases

HPAiHPA048760.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000316284.

Structurei

3D structure databases

ProteinModelPortaliQ8NG97.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG247706.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NG97.
KOiK04257.
OMAiMASHFLQ.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NG97.
TreeFamiTF337295.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NG97-1 [UniParc]FASTAAdd to Basket

« Hide

MGDVNQSVAS DFILVGLFSH SGSRQLLFSL VAVMFVIGLL GNTVLLFLIR    50
VDSRLHTPMY FLLSQLSLFD IGCPMVTIPK MASDFLRGEG ATSYGGGAAQ 100
IFFLTLMGVA EGVLLVLMSY DRYVAVCQPL QYPVLMRRQV CLLMMGSSWV 150
VGVLNASIQT SITLHFPYCA SRIVDHFFCE VPALLKLSCA DTCAYEMALS 200
TSGVLILMLP LSLIATSYGH VLQAVLSMRS EEARHKAVTT CSSHITVVGL 250
FYGAAVFMYM VPCAYHSPQQ DNVVSLFYSL VTPTLNPLIY SLRNPEVWMA 300
LVKVLSRAGL RQMC 314
Length:314
Mass (Da):34,444
Last modified:October 1, 2002 - v1
Checksum:i537E389A5EDA471F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti138 – 1381R → C.
Corresponds to variant rs58741481 [ dbSNP | Ensembl ].
VAR_062031

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065930 Genomic DNA. Translation: BAC06145.1.
CH471139 Genomic DNA. Translation: EAW68902.1.
BC137046 mRNA. Translation: AAI37047.1.
BC151149 mRNA. Translation: AAI51150.1.
AF399619 Genomic DNA. Translation: AAK95104.1.
BK004262 Genomic DNA. Translation: DAA04660.1.
CCDSiCCDS32895.1.
RefSeqiNP_001004699.1. NM_001004699.2.
UniGeneiHs.553675.

Genome annotation databases

EnsembliENST00000324060; ENSP00000316284; ENSG00000181733.
ENST00000574760; ENSP00000461542; ENSG00000263211.
GeneIDi284383.
KEGGihsa:284383.
UCSCiuc010xkg.2. human.

Polymorphism databases

DMDMi38372648.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065930 Genomic DNA. Translation: BAC06145.1 .
CH471139 Genomic DNA. Translation: EAW68902.1 .
BC137046 mRNA. Translation: AAI37047.1 .
BC151149 mRNA. Translation: AAI51150.1 .
AF399619 Genomic DNA. Translation: AAK95104.1 .
BK004262 Genomic DNA. Translation: DAA04660.1 .
CCDSi CCDS32895.1.
RefSeqi NP_001004699.1. NM_001004699.2.
UniGenei Hs.553675.

3D structure databases

ProteinModelPortali Q8NG97.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000316284.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 38372648.

Proteomic databases

PaxDbi Q8NG97.
PRIDEi Q8NG97.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000324060 ; ENSP00000316284 ; ENSG00000181733 .
ENST00000574760 ; ENSP00000461542 ; ENSG00000263211 .
GeneIDi 284383.
KEGGi hsa:284383.
UCSCi uc010xkg.2. human.

Organism-specific databases

CTDi 284383.
GeneCardsi GC19P008841.
H-InvDB HIX0174447.
HGNCi HGNC:15391. OR2Z1.
HPAi HPA048760.
neXtProti NX_Q8NG97.
PharmGKBi PA32221.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG247706.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q8NG97.
KOi K04257.
OMAi MASHFLQ.
OrthoDBi EOG71K63J.
PhylomeDBi Q8NG97.
TreeFami TF337295.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR2Z1.
GenomeRNAii 284383.
NextBioi 94813.
PROi Q8NG97.

Gene expression databases

CleanExi HS_OR2Z1.
Genevestigatori Q8NG97.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR2Z1_HUMAN
AccessioniPrimary (citable) accession number: Q8NG97
Secondary accession number(s): B9EH50, Q6IFK0, Q96R25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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