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Q8NG97 (OR2Z1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 2Z1
Alternative name(s):
Olfactory receptor 2Z2
Olfactory receptor OR19-4
Gene names
Name:OR2Z1
Synonyms:OR2Z2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Olfactory receptor 2Z1
PRO_0000150514

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4924Helical; Name=1; Potential
Topological domain50 – 578Cytoplasmic Potential
Transmembrane58 – 7922Helical; Name=2; Potential
Topological domain80 – 10021Extracellular Potential
Transmembrane101 – 12020Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 15819Helical; Name=4; Potential
Topological domain159 – 19537Extracellular Potential
Transmembrane196 – 21924Helical; Name=5; Potential
Topological domain220 – 23617Cytoplasmic Potential
Transmembrane237 – 25923Helical; Name=6; Potential
Topological domain260 – 27213Extracellular Potential
Transmembrane273 – 29220Helical; Name=7; Potential
Topological domain293 – 31422Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential

Natural variations

Natural variant1381R → C.
Corresponds to variant rs58741481 [ dbSNP | Ensembl ].
VAR_062031

Sequences

Sequence LengthMass (Da)Tools
Q8NG97 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 537E389A5EDA471F

FASTA31434,444
        10         20         30         40         50         60 
MGDVNQSVAS DFILVGLFSH SGSRQLLFSL VAVMFVIGLL GNTVLLFLIR VDSRLHTPMY 

        70         80         90        100        110        120 
FLLSQLSLFD IGCPMVTIPK MASDFLRGEG ATSYGGGAAQ IFFLTLMGVA EGVLLVLMSY 

       130        140        150        160        170        180 
DRYVAVCQPL QYPVLMRRQV CLLMMGSSWV VGVLNASIQT SITLHFPYCA SRIVDHFFCE 

       190        200        210        220        230        240 
VPALLKLSCA DTCAYEMALS TSGVLILMLP LSLIATSYGH VLQAVLSMRS EEARHKAVTT 

       250        260        270        280        290        300 
CSSHITVVGL FYGAAVFMYM VPCAYHSPQQ DNVVSLFYSL VTPTLNPLIY SLRNPEVWMA 

       310 
LVKVLSRAGL RQMC 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284.
[5]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[6]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065930 Genomic DNA. Translation: BAC06145.1.
CH471139 Genomic DNA. Translation: EAW68902.1.
BC137046 mRNA. Translation: AAI37047.1.
BC151149 mRNA. Translation: AAI51150.1.
AF399619 Genomic DNA. Translation: AAK95104.1.
BK004262 Genomic DNA. Translation: DAA04660.1.
CCDSCCDS32895.1.
RefSeqNP_001004699.1. NM_001004699.2.
UniGeneHs.553675.

3D structure databases

ProteinModelPortalQ8NG97.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000316284.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM38372648.

Proteomic databases

PaxDbQ8NG97.
PRIDEQ8NG97.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000324060; ENSP00000316284; ENSG00000181733.
ENST00000574760; ENSP00000461542; ENSG00000263211.
GeneID284383.
KEGGhsa:284383.
UCSCuc010xkg.2. human.

Organism-specific databases

CTD284383.
GeneCardsGC19P008841.
H-InvDBHIX0174447.
HGNCHGNC:15391. OR2Z1.
HPAHPA048760.
neXtProtNX_Q8NG97.
PharmGKBPA32221.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG247706.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ8NG97.
KOK04257.
OMAMASHFLQ.
OrthoDBEOG71K63J.
PhylomeDBQ8NG97.
TreeFamTF337295.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR2Z1.
GenevestigatorQ8NG97.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR2Z1.
GenomeRNAi284383.
NextBio94813.
PROQ8NG97.

Entry information

Entry nameOR2Z1_HUMAN
AccessionPrimary (citable) accession number: Q8NG97
Secondary accession number(s): B9EH50, Q6IFK0, Q96R25
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries