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Q8NG97

- OR2Z1_HUMAN

UniProt

Q8NG97 - OR2Z1_HUMAN

Protein

Olfactory receptor 2Z1

Gene

OR2Z1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 2Z1
    Alternative name(s):
    Olfactory receptor 2Z2
    Olfactory receptor OR19-4
    Gene namesi
    Name:OR2Z1
    Synonyms:OR2Z2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:15391. OR2Z1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32221.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Olfactory receptor 2Z1PRO_0000150514Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8NG97.
    PRIDEiQ8NG97.

    Expressioni

    Gene expression databases

    CleanExiHS_OR2Z1.
    GenevestigatoriQ8NG97.

    Organism-specific databases

    HPAiHPA048760.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000316284.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NG97.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 578CytoplasmicSequence Analysis
    Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 23617CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 31422CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei196 – 21924Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei237 – 25923Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei273 – 29220Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG247706.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ8NG97.
    KOiK04257.
    OMAiMASHFLQ.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8NG97.
    TreeFamiTF337295.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NG97-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDVNQSVAS DFILVGLFSH SGSRQLLFSL VAVMFVIGLL GNTVLLFLIR    50
    VDSRLHTPMY FLLSQLSLFD IGCPMVTIPK MASDFLRGEG ATSYGGGAAQ 100
    IFFLTLMGVA EGVLLVLMSY DRYVAVCQPL QYPVLMRRQV CLLMMGSSWV 150
    VGVLNASIQT SITLHFPYCA SRIVDHFFCE VPALLKLSCA DTCAYEMALS 200
    TSGVLILMLP LSLIATSYGH VLQAVLSMRS EEARHKAVTT CSSHITVVGL 250
    FYGAAVFMYM VPCAYHSPQQ DNVVSLFYSL VTPTLNPLIY SLRNPEVWMA 300
    LVKVLSRAGL RQMC 314
    Length:314
    Mass (Da):34,444
    Last modified:October 1, 2002 - v1
    Checksum:i537E389A5EDA471F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti138 – 1381R → C.
    Corresponds to variant rs58741481 [ dbSNP | Ensembl ].
    VAR_062031

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065930 Genomic DNA. Translation: BAC06145.1.
    CH471139 Genomic DNA. Translation: EAW68902.1.
    BC137046 mRNA. Translation: AAI37047.1.
    BC151149 mRNA. Translation: AAI51150.1.
    AF399619 Genomic DNA. Translation: AAK95104.1.
    BK004262 Genomic DNA. Translation: DAA04660.1.
    CCDSiCCDS32895.1.
    RefSeqiNP_001004699.1. NM_001004699.2.
    UniGeneiHs.553675.

    Genome annotation databases

    EnsembliENST00000324060; ENSP00000316284; ENSG00000181733.
    GeneIDi284383.
    KEGGihsa:284383.
    UCSCiuc010xkg.2. human.

    Polymorphism databases

    DMDMi38372648.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065930 Genomic DNA. Translation: BAC06145.1 .
    CH471139 Genomic DNA. Translation: EAW68902.1 .
    BC137046 mRNA. Translation: AAI37047.1 .
    BC151149 mRNA. Translation: AAI51150.1 .
    AF399619 Genomic DNA. Translation: AAK95104.1 .
    BK004262 Genomic DNA. Translation: DAA04660.1 .
    CCDSi CCDS32895.1.
    RefSeqi NP_001004699.1. NM_001004699.2.
    UniGenei Hs.553675.

    3D structure databases

    ProteinModelPortali Q8NG97.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000316284.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38372648.

    Proteomic databases

    PaxDbi Q8NG97.
    PRIDEi Q8NG97.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000324060 ; ENSP00000316284 ; ENSG00000181733 .
    GeneIDi 284383.
    KEGGi hsa:284383.
    UCSCi uc010xkg.2. human.

    Organism-specific databases

    CTDi 284383.
    GeneCardsi GC19P008841.
    H-InvDB HIX0174447.
    HGNCi HGNC:15391. OR2Z1.
    HPAi HPA048760.
    neXtProti NX_Q8NG97.
    PharmGKBi PA32221.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG247706.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q8NG97.
    KOi K04257.
    OMAi MASHFLQ.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8NG97.
    TreeFami TF337295.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR2Z1.
    GenomeRNAii 284383.
    NextBioi 94813.
    PROi Q8NG97.

    Gene expression databases

    CleanExi HS_OR2Z1.
    Genevestigatori Q8NG97.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284.
    5. Cited for: IDENTIFICATION.
    6. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR2Z1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NG97
    Secondary accession number(s): B9EH50, Q6IFK0, Q96R25
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3