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Protein

Olfactory receptor 2Z1

Gene

OR2Z1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2Z1
Alternative name(s):
Olfactory receptor 2Z2
Olfactory receptor OR19-4
Gene namesi
Name:OR2Z1
Synonyms:OR2Z2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:15391. OR2Z1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence Analysis
Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
BLAST
Transmembranei196 – 21924Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini220 – 23617CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei237 – 25923Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
BLAST
Transmembranei273 – 29220Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini293 – 31422CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32221.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 2Z1PRO_0000150514Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NG97.
PRIDEiQ8NG97.

Expressioni

Gene expression databases

CleanExiHS_OR2Z1.
GenevestigatoriQ8NG97.

Organism-specific databases

HPAiHPA048760.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000316284.

Structurei

3D structure databases

ProteinModelPortaliQ8NG97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG247706.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NG97.
KOiK04257.
OMAiCIQTSIT.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NG97.
TreeFamiTF337295.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NG97-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGDVNQSVAS DFILVGLFSH SGSRQLLFSL VAVMFVIGLL GNTVLLFLIR
60 70 80 90 100
VDSRLHTPMY FLLSQLSLFD IGCPMVTIPK MASDFLRGEG ATSYGGGAAQ
110 120 130 140 150
IFFLTLMGVA EGVLLVLMSY DRYVAVCQPL QYPVLMRRQV CLLMMGSSWV
160 170 180 190 200
VGVLNASIQT SITLHFPYCA SRIVDHFFCE VPALLKLSCA DTCAYEMALS
210 220 230 240 250
TSGVLILMLP LSLIATSYGH VLQAVLSMRS EEARHKAVTT CSSHITVVGL
260 270 280 290 300
FYGAAVFMYM VPCAYHSPQQ DNVVSLFYSL VTPTLNPLIY SLRNPEVWMA
310
LVKVLSRAGL RQMC
Length:314
Mass (Da):34,444
Last modified:October 1, 2002 - v1
Checksum:i537E389A5EDA471F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti138 – 1381R → C.
Corresponds to variant rs58741481 [ dbSNP | Ensembl ].
VAR_062031

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065930 Genomic DNA. Translation: BAC06145.1.
CH471139 Genomic DNA. Translation: EAW68902.1.
BC137046 mRNA. Translation: AAI37047.1.
BC151149 mRNA. Translation: AAI51150.1.
AF399619 Genomic DNA. Translation: AAK95104.1.
BK004262 Genomic DNA. Translation: DAA04660.1.
CCDSiCCDS32895.1.
RefSeqiNP_001004699.1. NM_001004699.2.
UniGeneiHs.553675.

Genome annotation databases

EnsembliENST00000324060; ENSP00000316284; ENSG00000181733.
GeneIDi284383.
KEGGihsa:284383.
UCSCiuc010xkg.2. human.

Polymorphism databases

DMDMi38372648.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065930 Genomic DNA. Translation: BAC06145.1.
CH471139 Genomic DNA. Translation: EAW68902.1.
BC137046 mRNA. Translation: AAI37047.1.
BC151149 mRNA. Translation: AAI51150.1.
AF399619 Genomic DNA. Translation: AAK95104.1.
BK004262 Genomic DNA. Translation: DAA04660.1.
CCDSiCCDS32895.1.
RefSeqiNP_001004699.1. NM_001004699.2.
UniGeneiHs.553675.

3D structure databases

ProteinModelPortaliQ8NG97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000316284.

Protein family/group databases

GPCRDBiSearch...

Polymorphism databases

DMDMi38372648.

Proteomic databases

PaxDbiQ8NG97.
PRIDEiQ8NG97.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324060; ENSP00000316284; ENSG00000181733.
GeneIDi284383.
KEGGihsa:284383.
UCSCiuc010xkg.2. human.

Organism-specific databases

CTDi284383.
GeneCardsiGC19P008841.
H-InvDBHIX0174447.
HGNCiHGNC:15391. OR2Z1.
HPAiHPA048760.
neXtProtiNX_Q8NG97.
PharmGKBiPA32221.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG247706.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NG97.
KOiK04257.
OMAiCIQTSIT.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NG97.
TreeFamiTF337295.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2Z1.
GenomeRNAii284383.
NextBioi94813.
PROiQ8NG97.

Gene expression databases

CleanExiHS_OR2Z1.
GenevestigatoriQ8NG97.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR2Z1_HUMAN
AccessioniPrimary (citable) accession number: Q8NG97
Secondary accession number(s): B9EH50, Q6IFK0, Q96R25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: January 7, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.