ID   OR7G3_HUMAN             Reviewed;         312 AA.
AC   Q8NG95; Q6IFJ6; Q96R99;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   27-MAR-2024, entry version 161.
DE   RecName: Full=Olfactory receptor 7G3;
DE   AltName: Full=OST085;
DE   AltName: Full=Olfactory receptor OR19-9;
GN   Name=OR7G3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [4]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR7G3";
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DR   EMBL; AB065932; BAC06147.1; -; Genomic_DNA.
DR   EMBL; AF399540; AAK95025.1; -; Genomic_DNA.
DR   EMBL; BK004266; DAA04664.1; -; Genomic_DNA.
DR   CCDS; CCDS32899.1; -.
DR   RefSeq; NP_001001958.1; NM_001001958.1.
DR   AlphaFoldDB; Q8NG95; -.
DR   SMR; Q8NG95; -.
DR   BioGRID; 133721; 1.
DR   STRING; 9606.ENSP00000302867; -.
DR   GlyCosmos; Q8NG95; 2 sites, No reported glycans.
DR   GlyGen; Q8NG95; 2 sites.
DR   iPTMnet; Q8NG95; -.
DR   PhosphoSitePlus; Q8NG95; -.
DR   BioMuta; OR7G3; -.
DR   DMDM; 38372647; -.
DR   MassIVE; Q8NG95; -.
DR   PaxDb; 9606-ENSP00000302867; -.
DR   PeptideAtlas; Q8NG95; -.
DR   Antibodypedia; 77402; 4 antibodies from 4 providers.
DR   DNASU; 390883; -.
DR   Ensembl; ENST00000305444.2; ENSP00000302867.2; ENSG00000170920.2.
DR   GeneID; 390883; -.
DR   KEGG; hsa:390883; -.
DR   MANE-Select; ENST00000305444.2; ENSP00000302867.2; NM_001001958.1; NP_001001958.1.
DR   UCSC; uc010xkl.2; human.
DR   AGR; HGNC:8467; -.
DR   CTD; 390883; -.
DR   GeneCards; OR7G3; -.
DR   HGNC; HGNC:8467; OR7G3.
DR   HPA; ENSG00000170920; Not detected.
DR   neXtProt; NX_Q8NG95; -.
DR   OpenTargets; ENSG00000170920; -.
DR   PharmGKB; PA32739; -.
DR   VEuPathDB; HostDB:ENSG00000170920; -.
DR   eggNOG; ENOG502T9M5; Eukaryota.
DR   GeneTree; ENSGT00940000163146; -.
DR   HOGENOM; CLU_012526_1_0_1; -.
DR   InParanoid; Q8NG95; -.
DR   OMA; SINYTGC; -.
DR   OrthoDB; 5401587at2759; -.
DR   PhylomeDB; Q8NG95; -.
DR   TreeFam; TF337210; -.
DR   PathwayCommons; Q8NG95; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 390883; 28 hits in 740 CRISPR screens.
DR   GeneWiki; OR7G3; -.
DR   GenomeRNAi; 390883; -.
DR   Pharos; Q8NG95; Tdark.
DR   PRO; PR:Q8NG95; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q8NG95; Protein.
DR   Bgee; ENSG00000170920; Expressed in fallopian tube.
DR   ExpressionAtlas; Q8NG95; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   CDD; cd15234; 7tmA_OR7-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR48001; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR48001:SF123; OLFACTORY RECEPTOR 7G3; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..312
FT                   /note="Olfactory receptor 7G3"
FT                   /id="PRO_0000150652"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..54
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        76..99
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        161..197
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..217
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..237
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..271
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..312
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        93
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         29
FT                   /note="M -> V (in dbSNP:rs10414255)"
FT                   /id="VAR_024114"
SQ   SEQUENCE   312 AA;  34439 MW;  B59CD272B9B1264B CRC64;
     MKAGNFSDTP EFFLLGLSGD PELQPILFML FLSMYLATML GNLLIILAVN SDSHLHTPMY
     FLLSILSLVD ICFTSTTMPK MLVNIQAQAQ SINYTGCLTQ ICFVLVFVGL ENGILVMMAY
     DRFVAICHPL RYNVIMNPKL CGLLLLLSFI VSVLDALLHT LMVLQLTFCI DLEIPHFFCE
     LAHILKLACS DVLINNILVY LVTSLLGVVP LSGIIFSYTR IVSSVMKIPS AGGKYKAFSI
     CGSHLIVVSL FYGTGFGVYL SSGATHSSRK GAIASVMYTV VTPMLNPLIY SLRNKDMLKA
     LRKLISRIPS FH
//