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Q8NG95 (OR7G3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 7G3
Alternative name(s):
OST085
Olfactory receptor OR19-9
Gene names
Name:OR7G3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Olfactory receptor 7G3
PRO_0000150652

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4621Helical; Name=1; Potential
Topological domain47 – 548Cytoplasmic Potential
Transmembrane55 – 7521Helical; Name=2; Potential
Topological domain76 – 9924Extracellular Potential
Transmembrane100 – 12021Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 16021Helical; Name=4; Potential
Topological domain161 – 19737Extracellular Potential
Transmembrane198 – 21720Helical; Name=5; Potential
Topological domain218 – 23720Cytoplasmic Potential
Transmembrane238 – 25821Helical; Name=6; Potential
Topological domain259 – 27113Extracellular Potential
Transmembrane272 – 29221Helical; Name=7; Potential
Topological domain293 – 31220Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation931N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Natural variations

Natural variant291M → V.
Corresponds to variant rs10414255 [ dbSNP | Ensembl ].
VAR_024114

Sequences

Sequence LengthMass (Da)Tools
Q8NG95 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: B59CD272B9B1264B

FASTA31234,439
        10         20         30         40         50         60 
MKAGNFSDTP EFFLLGLSGD PELQPILFML FLSMYLATML GNLLIILAVN SDSHLHTPMY 

        70         80         90        100        110        120 
FLLSILSLVD ICFTSTTMPK MLVNIQAQAQ SINYTGCLTQ ICFVLVFVGL ENGILVMMAY 

       130        140        150        160        170        180 
DRFVAICHPL RYNVIMNPKL CGLLLLLSFI VSVLDALLHT LMVLQLTFCI DLEIPHFFCE 

       190        200        210        220        230        240 
LAHILKLACS DVLINNILVY LVTSLLGVVP LSGIIFSYTR IVSSVMKIPS AGGKYKAFSI 

       250        260        270        280        290        300 
CGSHLIVVSL FYGTGFGVYL SSGATHSSRK GAIASVMYTV VTPMLNPLIY SLRNKDMLKA 

       310 
LRKLISRIPS FH 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065932 Genomic DNA. Translation: BAC06147.1.
AF399540 Genomic DNA. Translation: AAK95025.1.
BK004266 Genomic DNA. Translation: DAA04664.1.
CCDSCCDS32899.1.
RefSeqNP_001001958.1. NM_001001958.1.
UniGeneHs.553775.

3D structure databases

ProteinModelPortalQ8NG95.
SMRQ8NG95. Positions 26-305.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid133721. 1 interaction.
STRING9606.ENSP00000302867.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NG95.

Polymorphism databases

DMDM38372647.

Proteomic databases

PaxDbQ8NG95.
PRIDEQ8NG95.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000305444; ENSP00000302867; ENSG00000170920.
GeneID390883.
KEGGhsa:390883.
UCSCuc010xkl.2. human.

Organism-specific databases

CTD390883.
GeneCardsGC19M009241.
HGNCHGNC:8467. OR7G3.
neXtProtNX_Q8NG95.
PharmGKBPA32739.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG305303.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ8NG95.
KOK04257.
OMATFCIDLE.
OrthoDBEOG7HXCR6.
PhylomeDBQ8NG95.
TreeFamTF337210.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR7G3.
GenevestigatorQ8NG95.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR7G3.
NextBio104134.
PROQ8NG95.

Entry information

Entry nameOR7G3_HUMAN
AccessionPrimary (citable) accession number: Q8NG95
Secondary accession number(s): Q6IFJ6, Q96R99
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries