Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 7G3

Gene

OR7G3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 7G3
Alternative name(s):
OST085
Olfactory receptor OR19-9
Gene namesi
Name:OR7G3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000170920.2
HGNCiHGNC:8467 OR7G3
neXtProtiNX_Q8NG95

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 312CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170920
PharmGKBiPA32739

Polymorphism and mutation databases

BioMutaiOR7G3
DMDMi38372647

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506521 – 312Olfactory receptor 7G3Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NG95
PRIDEiQ8NG95

PTM databases

iPTMnetiQ8NG95
PhosphoSitePlusiQ8NG95

Expressioni

Gene expression databases

BgeeiENSG00000170920
CleanExiHS_OR7G3
ExpressionAtlasiQ8NG95 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi1337211 interactor.
STRINGi9606.ENSP00000302867

Structurei

3D structure databases

ProteinModelPortaliQ8NG95
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVB1 Eukaryota
ENOG410YBQN LUCA
GeneTreeiENSGT00840000129792
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NG95
KOiK04257
OMAiNVIMNPK
OrthoDBiEOG091G0B53
PhylomeDBiQ8NG95
TreeFamiTF337210

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NG95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAGNFSDTP EFFLLGLSGD PELQPILFML FLSMYLATML GNLLIILAVN
60 70 80 90 100
SDSHLHTPMY FLLSILSLVD ICFTSTTMPK MLVNIQAQAQ SINYTGCLTQ
110 120 130 140 150
ICFVLVFVGL ENGILVMMAY DRFVAICHPL RYNVIMNPKL CGLLLLLSFI
160 170 180 190 200
VSVLDALLHT LMVLQLTFCI DLEIPHFFCE LAHILKLACS DVLINNILVY
210 220 230 240 250
LVTSLLGVVP LSGIIFSYTR IVSSVMKIPS AGGKYKAFSI CGSHLIVVSL
260 270 280 290 300
FYGTGFGVYL SSGATHSSRK GAIASVMYTV VTPMLNPLIY SLRNKDMLKA
310
LRKLISRIPS FH
Length:312
Mass (Da):34,439
Last modified:October 1, 2002 - v1
Checksum:iB59CD272B9B1264B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02411429M → V. Corresponds to variant dbSNP:rs10414255Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065932 Genomic DNA Translation: BAC06147.1
AF399540 Genomic DNA Translation: AAK95025.1
BK004266 Genomic DNA Translation: DAA04664.1
CCDSiCCDS32899.1
RefSeqiNP_001001958.1, NM_001001958.1
UniGeneiHs.553775

Genome annotation databases

EnsembliENST00000305444; ENSP00000302867; ENSG00000170920
GeneIDi390883
KEGGihsa:390883
UCSCiuc010xkl.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR7G3_HUMAN
AccessioniPrimary (citable) accession number: Q8NG95
Secondary accession number(s): Q6IFJ6, Q96R99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: February 28, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome