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Q8NG95

- OR7G3_HUMAN

UniProt

Q8NG95 - OR7G3_HUMAN

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Protein

Olfactory receptor 7G3

Gene

OR7G3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 7G3
Alternative name(s):
OST085
Olfactory receptor OR19-9
Gene namesi
Name:OR7G3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:8467. OR7G3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence Analysis
Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
BLAST
Transmembranei198 – 21720Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini293 – 31220CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32739.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 7G3PRO_0000150652Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Glycosylationi93 – 931N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NG95.
PRIDEiQ8NG95.

PTM databases

PhosphoSiteiQ8NG95.

Expressioni

Gene expression databases

CleanExiHS_OR7G3.
GenevestigatoriQ8NG95.

Interactioni

Protein-protein interaction databases

BioGridi133721. 1 interaction.
STRINGi9606.ENSP00000302867.

Structurei

3D structure databases

ProteinModelPortaliQ8NG95.
SMRiQ8NG95. Positions 26-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG305303.
GeneTreeiENSGT00760000118801.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NG95.
KOiK04257.
OMAiTFCIDLE.
OrthoDBiEOG7HXCR6.
PhylomeDBiQ8NG95.
TreeFamiTF337210.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NG95-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKAGNFSDTP EFFLLGLSGD PELQPILFML FLSMYLATML GNLLIILAVN
60 70 80 90 100
SDSHLHTPMY FLLSILSLVD ICFTSTTMPK MLVNIQAQAQ SINYTGCLTQ
110 120 130 140 150
ICFVLVFVGL ENGILVMMAY DRFVAICHPL RYNVIMNPKL CGLLLLLSFI
160 170 180 190 200
VSVLDALLHT LMVLQLTFCI DLEIPHFFCE LAHILKLACS DVLINNILVY
210 220 230 240 250
LVTSLLGVVP LSGIIFSYTR IVSSVMKIPS AGGKYKAFSI CGSHLIVVSL
260 270 280 290 300
FYGTGFGVYL SSGATHSSRK GAIASVMYTV VTPMLNPLIY SLRNKDMLKA
310
LRKLISRIPS FH
Length:312
Mass (Da):34,439
Last modified:October 1, 2002 - v1
Checksum:iB59CD272B9B1264B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291M → V.
Corresponds to variant rs10414255 [ dbSNP | Ensembl ].
VAR_024114

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065932 Genomic DNA. Translation: BAC06147.1.
AF399540 Genomic DNA. Translation: AAK95025.1.
BK004266 Genomic DNA. Translation: DAA04664.1.
CCDSiCCDS32899.1.
RefSeqiNP_001001958.1. NM_001001958.1.
UniGeneiHs.553775.

Genome annotation databases

EnsembliENST00000305444; ENSP00000302867; ENSG00000170920.
GeneIDi390883.
KEGGihsa:390883.
UCSCiuc010xkl.2. human.

Polymorphism databases

DMDMi38372647.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065932 Genomic DNA. Translation: BAC06147.1 .
AF399540 Genomic DNA. Translation: AAK95025.1 .
BK004266 Genomic DNA. Translation: DAA04664.1 .
CCDSi CCDS32899.1.
RefSeqi NP_001001958.1. NM_001001958.1.
UniGenei Hs.553775.

3D structure databases

ProteinModelPortali Q8NG95.
SMRi Q8NG95. Positions 26-305.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 133721. 1 interaction.
STRINGi 9606.ENSP00000302867.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NG95.

Polymorphism databases

DMDMi 38372647.

Proteomic databases

PaxDbi Q8NG95.
PRIDEi Q8NG95.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000305444 ; ENSP00000302867 ; ENSG00000170920 .
GeneIDi 390883.
KEGGi hsa:390883.
UCSCi uc010xkl.2. human.

Organism-specific databases

CTDi 390883.
GeneCardsi GC19M009241.
HGNCi HGNC:8467. OR7G3.
neXtProti NX_Q8NG95.
PharmGKBi PA32739.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG305303.
GeneTreei ENSGT00760000118801.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q8NG95.
KOi K04257.
OMAi TFCIDLE.
OrthoDBi EOG7HXCR6.
PhylomeDBi Q8NG95.
TreeFami TF337210.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR7G3.
GenomeRNAii 390883.
NextBioi 104134.
PROi Q8NG95.

Gene expression databases

CleanExi HS_OR7G3.
Genevestigatori Q8NG95.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR7G3_HUMAN
AccessioniPrimary (citable) accession number: Q8NG95
Secondary accession number(s): Q6IFJ6, Q96R99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3