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Q8NG94

- O11H1_HUMAN

UniProt

Q8NG94 - O11H1_HUMAN

Protein

Olfactory receptor 11H1

Gene

OR11H1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 3 (04 Nov 2008)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 11H1
    Alternative name(s):
    Olfactory receptor OR22-1
    Gene namesi
    Name:OR11H1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:15404. OR11H1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32013.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326Olfactory receptor 11H1PRO_0000150724Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi112 ↔ 194PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NG94.
    PRIDEiQ8NG94.

    Expressioni

    Gene expression databases

    CleanExiHS_OR11H1.
    GenevestigatoriQ8NG94.

    Organism-specific databases

    HPAiHPA047370.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000252835.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NG94.
    SMRiQ8NG94. Positions 52-322.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4444ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini66 – 727CytoplasmicSequence Analysis
    Topological domaini94 – 11219ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini134 – 15825CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini180 – 21637ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini238 – 25922CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini281 – 2877ExtracellularSequence Analysis
    Topological domaini309 – 32618CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei45 – 6521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei73 – 9321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei113 – 13321Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei217 – 23721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei260 – 28021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei288 – 30821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG74069.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ8NG94.
    KOiK04257.
    OMAiSERLETH.
    OrthoDBiEOG7N0C51.
    PhylomeDBiQ8NG94.
    TreeFamiTF337213.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NG94-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCPLTLQVTG LMNVSEPNSS FAFVNEFILQ GFSCEWTIQI FLFSLFTTTY    50
    ALTITGNGAI AFVLWCDRRL HTPMYMFLGN FSFLEIWYVS STVPKMLVNF 100
    LSEKKNISFA GCFLQFYFFF SLGTSECLLL TVMAFDQYLA ICRPLLYPNI 150
    MTGHLYAKLV ILCWVCGFLW FLIPIVLISQ MPFCGPNIID HVVCDPGPRF 200
    ALDCVSAPRI QLFCYTLSSL VIFGNFLFII GSYTLVLKAM LGMPSSTGRH 250
    KAFSTCGSHL AVVSLCYSSL MVMYVSPGLG HSTGMQKIET LFYAMVTPLF 300
    NPLIYSLQNK EIKAALRKVL GSSNII 326
    Length:326
    Mass (Da):36,578
    Last modified:November 4, 2008 - v3
    Checksum:iE17598E1006885F6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065933 Genomic DNA. Translation: BAC06148.1.
    AP000534 Genomic DNA. No translation available.
    AF399611 Genomic DNA. Translation: AAK95096.1.
    BK004492 Genomic DNA. Translation: DAA04890.1.
    CCDSiCCDS33594.1.
    RefSeqiNP_001005239.1. NM_001005239.1.
    UniGeneiHs.554706.

    Genome annotation databases

    EnsembliENST00000252835; ENSP00000252835; ENSG00000130538.
    GeneIDi81061.
    KEGGihsa:81061.
    UCSCiuc011agd.2. human.

    Polymorphism databases

    DMDMi212276498.

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065933 Genomic DNA. Translation: BAC06148.1 .
    AP000534 Genomic DNA. No translation available.
    AF399611 Genomic DNA. Translation: AAK95096.1 .
    BK004492 Genomic DNA. Translation: DAA04890.1 .
    CCDSi CCDS33594.1.
    RefSeqi NP_001005239.1. NM_001005239.1.
    UniGenei Hs.554706.

    3D structure databases

    ProteinModelPortali Q8NG94.
    SMRi Q8NG94. Positions 52-322.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000252835.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 212276498.

    Proteomic databases

    PaxDbi Q8NG94.
    PRIDEi Q8NG94.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000252835 ; ENSP00000252835 ; ENSG00000130538 .
    GeneIDi 81061.
    KEGGi hsa:81061.
    UCSCi uc011agd.2. human.

    Organism-specific databases

    CTDi 81061.
    GeneCardsi GC22M016448.
    H-InvDB HIX0038033.
    HIX0096246.
    HGNCi HGNC:15404. OR11H1.
    HPAi HPA047370.
    neXtProti NX_Q8NG94.
    PharmGKBi PA32013.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG74069.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q8NG94.
    KOi K04257.
    OMAi SERLETH.
    OrthoDBi EOG7N0C51.
    PhylomeDBi Q8NG94.
    TreeFami TF337213.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR11H1.
    GenomeRNAii 81061.
    NextBioi 71390.
    PROi Q8NG94.

    Gene expression databases

    CleanExi HS_OR11H1.
    Genevestigatori Q8NG94.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 83-299.
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO11H1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NG94
    Secondary accession number(s): Q6IEX0, Q96R32
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: November 4, 2008
    Last modified: October 1, 2014
    This is version 103 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-12 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3