Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 11H1

Gene

OR11H1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 11H1
Alternative name(s):
Olfactory receptor OR22-1
Gene namesi
Name:OR11H1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:15404. OR11H1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444ExtracellularSequence AnalysisAdd
BLAST
Transmembranei45 – 6521Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini66 – 727CytoplasmicSequence Analysis
Transmembranei73 – 9321Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini94 – 11219ExtracellularSequence AnalysisAdd
BLAST
Transmembranei113 – 13321Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini134 – 15825CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei159 – 17921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini180 – 21637ExtracellularSequence AnalysisAdd
BLAST
Transmembranei217 – 23721Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini238 – 25922CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei260 – 28021Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini281 – 2877ExtracellularSequence Analysis
Transmembranei288 – 30821Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini309 – 32618CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32013.

Polymorphism and mutation databases

BioMutaiOR11H1.
DMDMi212276498.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Olfactory receptor 11H1PRO_0000150724Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi112 ↔ 194PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NG94.
PRIDEiQ8NG94.

Expressioni

Gene expression databases

CleanExiHS_OR11H1.

Organism-specific databases

HPAiHPA047370.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000252835.

Structurei

3D structure databases

ProteinModelPortaliQ8NG94.
SMRiQ8NG94. Positions 52-322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG74069.
GeneTreeiENSGT00760000119087.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NG94.
KOiK04257.
OrthoDBiEOG7N0C51.
PhylomeDBiQ8NG94.
TreeFamiTF337213.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NG94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCPLTLQVTG LMNVSEPNSS FAFVNEFILQ GFSCEWTIQI FLFSLFTTTY
60 70 80 90 100
ALTITGNGAI AFVLWCDRRL HTPMYMFLGN FSFLEIWYVS STVPKMLVNF
110 120 130 140 150
LSEKKNISFA GCFLQFYFFF SLGTSECLLL TVMAFDQYLA ICRPLLYPNI
160 170 180 190 200
MTGHLYAKLV ILCWVCGFLW FLIPIVLISQ MPFCGPNIID HVVCDPGPRF
210 220 230 240 250
ALDCVSAPRI QLFCYTLSSL VIFGNFLFII GSYTLVLKAM LGMPSSTGRH
260 270 280 290 300
KAFSTCGSHL AVVSLCYSSL MVMYVSPGLG HSTGMQKIET LFYAMVTPLF
310 320
NPLIYSLQNK EIKAALRKVL GSSNII
Length:326
Mass (Da):36,578
Last modified:November 4, 2008 - v3
Checksum:iE17598E1006885F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065933 Genomic DNA. Translation: BAC06148.1.
AP000534 Genomic DNA. No translation available.
AF399611 Genomic DNA. Translation: AAK95096.1.
BK004492 Genomic DNA. Translation: DAA04890.1.
CCDSiCCDS74807.1.
RefSeqiNP_001005239.1. NM_001005239.1.
UniGeneiHs.554706.

Genome annotation databases

EnsembliENST00000252835; ENSP00000252835; ENSG00000130538.
GeneIDi81061.
KEGGihsa:81061.
UCSCiuc011agd.2. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065933 Genomic DNA. Translation: BAC06148.1.
AP000534 Genomic DNA. No translation available.
AF399611 Genomic DNA. Translation: AAK95096.1.
BK004492 Genomic DNA. Translation: DAA04890.1.
CCDSiCCDS74807.1.
RefSeqiNP_001005239.1. NM_001005239.1.
UniGeneiHs.554706.

3D structure databases

ProteinModelPortaliQ8NG94.
SMRiQ8NG94. Positions 52-322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000252835.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR11H1.
DMDMi212276498.

Proteomic databases

PaxDbiQ8NG94.
PRIDEiQ8NG94.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252835; ENSP00000252835; ENSG00000130538.
GeneIDi81061.
KEGGihsa:81061.
UCSCiuc011agd.2. human.

Organism-specific databases

CTDi81061.
GeneCardsiGC22M016448.
H-InvDBHIX0038033.
HIX0096246.
HGNCiHGNC:15404. OR11H1.
HPAiHPA047370.
neXtProtiNX_Q8NG94.
PharmGKBiPA32013.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG74069.
GeneTreeiENSGT00760000119087.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NG94.
KOiK04257.
OrthoDBiEOG7N0C51.
PhylomeDBiQ8NG94.
TreeFamiTF337213.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR11H1.
GenomeRNAii81061.
NextBioi71390.
PROiQ8NG94.

Gene expression databases

CleanExiHS_OR11H1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 83-299.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO11H1_HUMAN
AccessioniPrimary (citable) accession number: Q8NG94
Secondary accession number(s): Q6IEX0, Q96R32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 4, 2008
Last modified: June 24, 2015
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-12 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.