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Protein

Olfactory receptor 11H1

Gene

OR11H1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

Caution

It is uncertain whether Met-1 or Met-12 is the initiator.Curated

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 11H1
Alternative name(s):
Olfactory receptor OR22-1
Gene namesi
Name:OR11H1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000130538.4
HGNCiHGNC:15404 OR11H1
neXtProtiNX_Q8NG94

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44ExtracellularSequence analysisAdd BLAST44
Transmembranei45 – 65Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini66 – 72CytoplasmicSequence analysis7
Transmembranei73 – 93Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini94 – 112ExtracellularSequence analysisAdd BLAST19
Transmembranei113 – 133Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini134 – 158CytoplasmicSequence analysisAdd BLAST25
Transmembranei159 – 179Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini180 – 216ExtracellularSequence analysisAdd BLAST37
Transmembranei217 – 237Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini238 – 259CytoplasmicSequence analysisAdd BLAST22
Transmembranei260 – 280Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini281 – 287ExtracellularSequence analysis7
Transmembranei288 – 308Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini309 – 326CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000130538
PharmGKBiPA32013

Polymorphism and mutation databases

BioMutaiOR11H1
DMDMi212276498

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507241 – 326Olfactory receptor 11H1Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi13N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi112 ↔ 194PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NG94
PRIDEiQ8NG94

Expressioni

Gene expression databases

BgeeiENSG00000130538
CleanExiHS_OR11H1

Organism-specific databases

HPAiHPA047370

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000252835

Structurei

3D structure databases

ProteinModelPortaliQ8NG94
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFEZ Eukaryota
ENOG411183S LUCA
GeneTreeiENSGT00890000139362
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NG94
KOiK04257
OMAiNISFACF
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NG94
TreeFamiTF337213

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NG94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCPLTLQVTG LMNVSEPNSS FAFVNEFILQ GFSCEWTIQI FLFSLFTTTY
60 70 80 90 100
ALTITGNGAI AFVLWCDRRL HTPMYMFLGN FSFLEIWYVS STVPKMLVNF
110 120 130 140 150
LSEKKNISFA GCFLQFYFFF SLGTSECLLL TVMAFDQYLA ICRPLLYPNI
160 170 180 190 200
MTGHLYAKLV ILCWVCGFLW FLIPIVLISQ MPFCGPNIID HVVCDPGPRF
210 220 230 240 250
ALDCVSAPRI QLFCYTLSSL VIFGNFLFII GSYTLVLKAM LGMPSSTGRH
260 270 280 290 300
KAFSTCGSHL AVVSLCYSSL MVMYVSPGLG HSTGMQKIET LFYAMVTPLF
310 320
NPLIYSLQNK EIKAALRKVL GSSNII
Length:326
Mass (Da):36,578
Last modified:November 4, 2008 - v3
Checksum:iE17598E1006885F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065933 Genomic DNA Translation: BAC06148.1
AP000534 Genomic DNA No translation available.
AF399611 Genomic DNA Translation: AAK95096.1
BK004492 Genomic DNA Translation: DAA04890.1
CCDSiCCDS74807.1
RefSeqiNP_001005239.1, NM_001005239.1
UniGeneiHs.554706

Genome annotation databases

EnsembliENST00000252835; ENSP00000252835; ENSG00000130538
GeneIDi81061
KEGGihsa:81061
UCSCiuc011agd.3 human

Similar proteinsi

Entry informationi

Entry nameiO11H1_HUMAN
AccessioniPrimary (citable) accession number: Q8NG94
Secondary accession number(s): Q6IEX0, Q96R32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 4, 2008
Last modified: February 28, 2018
This is version 125 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health