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Protein

Olfactory receptor 2L3

Gene

OR2L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2L3
Gene namesi
Name:OR2L3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15009. OR2L3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424ExtracellularSequence analysisAdd
BLAST
Transmembranei25 – 4824Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini49 – 568CytoplasmicSequence analysis
Transmembranei57 – 7822Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini79 – 9921ExtracellularSequence analysisAdd
BLAST
Transmembranei100 – 11920Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini120 – 13819CytoplasmicSequence analysisAdd
BLAST
Transmembranei139 – 15719Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini158 – 19437ExtracellularSequence analysisAdd
BLAST
Transmembranei195 – 21824Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini219 – 23517CytoplasmicSequence analysisAdd
BLAST
Transmembranei236 – 25823Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence analysisAdd
BLAST
Transmembranei272 – 29120Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini292 – 31221CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32184.

Polymorphism and mutation databases

BioMutaiOR2L3.
DMDMi74762575.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 2L3PRO_0000150487Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Glycosylationi88 – 881N-linked (GlcNAc...)Sequence analysis
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NG85.
PRIDEiQ8NG85.

PTM databases

iPTMnetiQ8NG85.
PhosphoSiteiQ8NG85.

Expressioni

Gene expression databases

CleanExiHS_OR2L3.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000353044.

Structurei

3D structure databases

ProteinModelPortaliQ8NG85.
SMRiQ8NG85. Positions 20-311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIYV. Eukaryota.
ENOG41116WC. LUCA.
GeneTreeiENSGT00760000119248.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NG85.
KOiK04257.
OMAiACAHIVY.
OrthoDBiEOG7M0NRV.
PhylomeDBiQ8NG85.
TreeFamiTF337295.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NG85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENYNQTSTD FILLGFFPPS RIGLFLFILI VFIFLMALIG NLSMILLIFL
60 70 80 90 100
DTHLHTPMYF LLSQLSLIDL NYISTIVPKM ASDFLSGNKS ISFTGCGIQS
110 120 130 140 150
FFFSALGGAE ALLLASMAYD RYIAICFPLH YPIRMSKRMC VLMITGSWII
160 170 180 190 200
GSINACAHTV YVLHIPYCQS RAINHFFCDV PAMVTLACMD TWVYEGTVFL
210 220 230 240 250
STTIFLVFPF IAISCSYGRV LLAVYHMKSA EGRKKAYLTC STHLTVVTFY
260 270 280 290 300
YAPFVYTYLR PRSLRSPTED KVLAVFYTTL TPMLNPIIYS LRNKEVMGAL
310
TRVSQRICSG KM
Length:312
Mass (Da):35,282
Last modified:October 1, 2002 - v1
Checksum:iF1E30E85789A738E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391I → T.
Corresponds to variant rs6666048 [ dbSNP | Ensembl ].
VAR_062021
Natural varianti78 – 781P → L.
Corresponds to variant rs6658227 [ dbSNP | Ensembl ].
VAR_062022
Natural varianti104 – 1041S → L.
Corresponds to variant rs6658256 [ dbSNP | Ensembl ].
VAR_053146
Natural varianti139 – 1391M → V.
Corresponds to variant rs55937620 [ dbSNP | Ensembl ].
VAR_062023

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065950 Genomic DNA. Translation: BAC06163.1.
CH471148 Genomic DNA. Translation: EAW77215.1.
BC137039 mRNA. Translation: AAI37040.1.
BC137040 mRNA. Translation: AAI37041.1.
CCDSiCCDS31104.1.
RefSeqiNP_001004687.1. NM_001004687.1.
UniGeneiHs.690412.

Genome annotation databases

EnsembliENST00000359959; ENSP00000353044; ENSG00000198128.
GeneIDi391192.
KEGGihsa:391192.
UCSCiuc001idx.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065950 Genomic DNA. Translation: BAC06163.1.
CH471148 Genomic DNA. Translation: EAW77215.1.
BC137039 mRNA. Translation: AAI37040.1.
BC137040 mRNA. Translation: AAI37041.1.
CCDSiCCDS31104.1.
RefSeqiNP_001004687.1. NM_001004687.1.
UniGeneiHs.690412.

3D structure databases

ProteinModelPortaliQ8NG85.
SMRiQ8NG85. Positions 20-311.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000353044.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NG85.
PhosphoSiteiQ8NG85.

Polymorphism and mutation databases

BioMutaiOR2L3.
DMDMi74762575.

Proteomic databases

PaxDbiQ8NG85.
PRIDEiQ8NG85.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359959; ENSP00000353044; ENSG00000198128.
GeneIDi391192.
KEGGihsa:391192.
UCSCiuc001idx.1. human.

Organism-specific databases

CTDi391192.
GeneCardsiOR2L3.
HGNCiHGNC:15009. OR2L3.
neXtProtiNX_Q8NG85.
PharmGKBiPA32184.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIYV. Eukaryota.
ENOG41116WC. LUCA.
GeneTreeiENSGT00760000119248.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NG85.
KOiK04257.
OMAiACAHIVY.
OrthoDBiEOG7M0NRV.
PhylomeDBiQ8NG85.
TreeFamiTF337295.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii391192.
PROiQ8NG85.

Gene expression databases

CleanExiHS_OR2L3.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiOR2L3_HUMAN
AccessioniPrimary (citable) accession number: Q8NG85
Secondary accession number(s): B9EH44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.