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Protein

Olfactory receptor 2L5

Gene

OR2L5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2L5
Alternative name(s):
Olfactory receptor 2L11
Olfactory receptor OR1-53
Gene namesi
Name:OR2L5
Synonyms:OR2L11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000197454.1
HGNCiHGNC:15011 OR2L5
neXtProtiNX_Q8NG80

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 48Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 78Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini79 – 99ExtracellularSequence analysisAdd BLAST21
Transmembranei100 – 119Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini120 – 138CytoplasmicSequence analysisAdd BLAST19
Transmembranei139 – 157Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini158 – 194ExtracellularSequence analysisAdd BLAST37
Transmembranei195 – 218Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini219 – 235CytoplasmicSequence analysisAdd BLAST17
Transmembranei236 – 258Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 291Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini292 – 312CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197454

Polymorphism and mutation databases

BioMutaiOR2L5
DMDMi38372496

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504881 – 312Olfactory receptor 2L5Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8NG80
PaxDbiQ8NG80
PeptideAtlasiQ8NG80
PRIDEiQ8NG80
ProteomicsDBi73447

Expressioni

Gene expression databases

BgeeiENSG00000197454
ExpressionAtlasiQ8NG80 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000347428

Structurei

3D structure databases

ProteinModelPortaliQ8NG80
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIYV Eukaryota
ENOG41116WC LUCA
GeneTreeiENSGT00910000144053
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NG80
KOiK04257
OMAiMTFAGAE
OrthoDBiEOG091G0F82
PhylomeDBiQ8NG80
TreeFamiTF337295

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NG80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENYNQTSTD FILLGLFPPS KIGLFLFILF VLIFLMALIG NLSMILLIFL
60 70 80 90 100
DTHLHTPMYF LLSQLSLIDL NYISTIVPKM ASDFLYGNKS ISFIGCGIQS
110 120 130 140 150
FFFMTFAGAE ALLLTSMAYD RYVAICFPLH YPIRMSKRMY VLMITGSWMI
160 170 180 190 200
GSINSCAHTV YAFRIPYCKS RAINHFFCDV PAMLTLACTD TWVYEYTVFL
210 220 230 240 250
SSTIFLVFPF TGIACSYGWV LLAVYRMHSA EGRKKAYSTC STHLTVVTFY
260 270 280 290 300
YAPFAYTYLC PRSLRSLTED KVLAVFYTIL TPMLNPIIYS LRNKEVMGAL
310
TRVIQNIFSV KM
Length:312
Mass (Da):35,648
Last modified:October 1, 2002 - v1
Checksum:iE04FEB775A902863
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065956 Genomic DNA Translation: BAC06169.1
BK004458 Genomic DNA Translation: DAA04856.1
CCDSiCCDS58068.1
RefSeqiNP_001245213.1, NM_001258284.1
UniGeneiHs.742583

Genome annotation databases

EnsembliENST00000355281; ENSP00000347428; ENSG00000197454
GeneIDi81466
KEGGihsa:81466
UCSCiuc031psy.1 human

Similar proteinsi

Entry informationi

Entry nameiOR2L5_HUMAN
AccessioniPrimary (citable) accession number: Q8NG80
Secondary accession number(s): Q6IF04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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