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Protein

Olfactory receptor 2L5

Gene

OR2L5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2L5
Alternative name(s):
Olfactory receptor 2L11
Olfactory receptor OR1-53
Gene namesi
Name:OR2L5
Synonyms:OR2L11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15011. OR2L5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424ExtracellularSequence analysisAdd
BLAST
Transmembranei25 – 4824Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini49 – 568CytoplasmicSequence analysis
Transmembranei57 – 7822Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini79 – 9921ExtracellularSequence analysisAdd
BLAST
Transmembranei100 – 11920Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini120 – 13819CytoplasmicSequence analysisAdd
BLAST
Transmembranei139 – 15719Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini158 – 19437ExtracellularSequence analysisAdd
BLAST
Transmembranei195 – 21824Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini219 – 23517CytoplasmicSequence analysisAdd
BLAST
Transmembranei236 – 25823Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence analysisAdd
BLAST
Transmembranei272 – 29120Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini292 – 31221CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiOR2L5.
DMDMi38372496.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 2L5PRO_0000150488Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NG80.
PRIDEiQ8NG80.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000347428.

Structurei

3D structure databases

ProteinModelPortaliQ8NG80.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIYV. Eukaryota.
ENOG41116WC. LUCA.
GeneTreeiENSGT00760000119248.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NG80.
KOiK04257.
OMAiMTFAGAE.
OrthoDBiEOG7M0NRV.
PhylomeDBiQ8NG80.
TreeFamiTF337295.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NG80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENYNQTSTD FILLGLFPPS KIGLFLFILF VLIFLMALIG NLSMILLIFL
60 70 80 90 100
DTHLHTPMYF LLSQLSLIDL NYISTIVPKM ASDFLYGNKS ISFIGCGIQS
110 120 130 140 150
FFFMTFAGAE ALLLTSMAYD RYVAICFPLH YPIRMSKRMY VLMITGSWMI
160 170 180 190 200
GSINSCAHTV YAFRIPYCKS RAINHFFCDV PAMLTLACTD TWVYEYTVFL
210 220 230 240 250
SSTIFLVFPF TGIACSYGWV LLAVYRMHSA EGRKKAYSTC STHLTVVTFY
260 270 280 290 300
YAPFAYTYLC PRSLRSLTED KVLAVFYTIL TPMLNPIIYS LRNKEVMGAL
310
TRVIQNIFSV KM
Length:312
Mass (Da):35,648
Last modified:October 1, 2002 - v1
Checksum:iE04FEB775A902863
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065956 Genomic DNA. Translation: BAC06169.1.
BK004458 Genomic DNA. Translation: DAA04856.1.
CCDSiCCDS58068.1.
RefSeqiNP_001245213.1. NM_001258284.1.
UniGeneiHs.742583.

Genome annotation databases

EnsembliENST00000355281; ENSP00000347428; ENSG00000197454.
GeneIDi81466.
KEGGihsa:81466.
UCSCiuc031psy.1. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065956 Genomic DNA. Translation: BAC06169.1.
BK004458 Genomic DNA. Translation: DAA04856.1.
CCDSiCCDS58068.1.
RefSeqiNP_001245213.1. NM_001258284.1.
UniGeneiHs.742583.

3D structure databases

ProteinModelPortaliQ8NG80.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000347428.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR2L5.
DMDMi38372496.

Proteomic databases

PaxDbiQ8NG80.
PRIDEiQ8NG80.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355281; ENSP00000347428; ENSG00000197454.
GeneIDi81466.
KEGGihsa:81466.
UCSCiuc031psy.1. human.

Organism-specific databases

CTDi81466.
GeneCardsiOR2L5.
H-InvDBHIX0028957.
HIX0029663.
HGNCiHGNC:15011. OR2L5.
neXtProtiNX_Q8NG80.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIYV. Eukaryota.
ENOG41116WC. LUCA.
GeneTreeiENSGT00760000119248.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NG80.
KOiK04257.
OMAiMTFAGAE.
OrthoDBiEOG7M0NRV.
PhylomeDBiQ8NG80.
TreeFamiTF337295.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii81466.
PROiQ8NG80.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR2L5_HUMAN
AccessioniPrimary (citable) accession number: Q8NG80
Secondary accession number(s): Q6IF04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.