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Protein

Olfactory receptor 2L5

Gene

OR2L5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-33907-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2L5
Alternative name(s):
Olfactory receptor 2L11
Olfactory receptor OR1-53
Gene namesi
Name:OR2L5
Synonyms:OR2L11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15011. OR2L5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 48Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 78Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini79 – 99ExtracellularSequence analysisAdd BLAST21
Transmembranei100 – 119Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini120 – 138CytoplasmicSequence analysisAdd BLAST19
Transmembranei139 – 157Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini158 – 194ExtracellularSequence analysisAdd BLAST37
Transmembranei195 – 218Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini219 – 235CytoplasmicSequence analysisAdd BLAST17
Transmembranei236 – 258Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 291Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini292 – 312CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197454.

Polymorphism and mutation databases

BioMutaiOR2L5.
DMDMi38372496.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504881 – 312Olfactory receptor 2L5Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NG80.
PRIDEiQ8NG80.

Expressioni

Gene expression databases

ExpressionAtlasiQ8NG80. baseline and differential.

Organism-specific databases

HPAiCAB004280.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000347428.

Structurei

3D structure databases

ProteinModelPortaliQ8NG80.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIYV. Eukaryota.
ENOG41116WC. LUCA.
GeneTreeiENSGT00760000119248.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NG80.
KOiK04257.
OMAiMTFAGAE.
OrthoDBiEOG091G0F82.
PhylomeDBiQ8NG80.
TreeFamiTF337295.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NG80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENYNQTSTD FILLGLFPPS KIGLFLFILF VLIFLMALIG NLSMILLIFL
60 70 80 90 100
DTHLHTPMYF LLSQLSLIDL NYISTIVPKM ASDFLYGNKS ISFIGCGIQS
110 120 130 140 150
FFFMTFAGAE ALLLTSMAYD RYVAICFPLH YPIRMSKRMY VLMITGSWMI
160 170 180 190 200
GSINSCAHTV YAFRIPYCKS RAINHFFCDV PAMLTLACTD TWVYEYTVFL
210 220 230 240 250
SSTIFLVFPF TGIACSYGWV LLAVYRMHSA EGRKKAYSTC STHLTVVTFY
260 270 280 290 300
YAPFAYTYLC PRSLRSLTED KVLAVFYTIL TPMLNPIIYS LRNKEVMGAL
310
TRVIQNIFSV KM
Length:312
Mass (Da):35,648
Last modified:October 1, 2002 - v1
Checksum:iE04FEB775A902863
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065956 Genomic DNA. Translation: BAC06169.1.
BK004458 Genomic DNA. Translation: DAA04856.1.
CCDSiCCDS58068.1.
RefSeqiNP_001245213.1. NM_001258284.1.
UniGeneiHs.742583.

Genome annotation databases

EnsembliENST00000355281; ENSP00000347428; ENSG00000197454.
GeneIDi81466.
KEGGihsa:81466.
UCSCiuc031psy.1. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065956 Genomic DNA. Translation: BAC06169.1.
BK004458 Genomic DNA. Translation: DAA04856.1.
CCDSiCCDS58068.1.
RefSeqiNP_001245213.1. NM_001258284.1.
UniGeneiHs.742583.

3D structure databases

ProteinModelPortaliQ8NG80.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000347428.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR2L5.
DMDMi38372496.

Proteomic databases

PaxDbiQ8NG80.
PRIDEiQ8NG80.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355281; ENSP00000347428; ENSG00000197454.
GeneIDi81466.
KEGGihsa:81466.
UCSCiuc031psy.1. human.

Organism-specific databases

CTDi81466.
GeneCardsiOR2L5.
H-InvDBHIX0028957.
HIX0029663.
HGNCiHGNC:15011. OR2L5.
HPAiCAB004280.
neXtProtiNX_Q8NG80.
OpenTargetsiENSG00000197454.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIYV. Eukaryota.
ENOG41116WC. LUCA.
GeneTreeiENSGT00760000119248.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NG80.
KOiK04257.
OMAiMTFAGAE.
OrthoDBiEOG091G0F82.
PhylomeDBiQ8NG80.
TreeFamiTF337295.

Enzyme and pathway databases

BioCyciZFISH:G66-33907-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii81466.
PROiQ8NG80.

Gene expression databases

ExpressionAtlasiQ8NG80. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR2L5_HUMAN
AccessioniPrimary (citable) accession number: Q8NG80
Secondary accession number(s): Q6IF04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.