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Protein

Olfactory receptor 8G5

Gene

OR8G5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-31470-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 8G5
Alternative name(s):
Olfactory receptor 8G6
Olfactory receptor OR11-298
Gene namesi
Name:OR8G5
Synonyms:OR8G5P, OR8G6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:19622. OR8G5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 60ExtracellularSequence analysisAdd BLAST60
Transmembranei61 – 81Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini82 – 89CytoplasmicSequence analysis8
Transmembranei90 – 110Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini111 – 134ExtracellularSequence analysisAdd BLAST24
Transmembranei135 – 155Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini156 – 174CytoplasmicSequence analysisAdd BLAST19
Transmembranei175 – 195Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini196 – 232ExtracellularSequence analysisAdd BLAST37
Transmembranei233 – 252Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini253 – 272CytoplasmicSequence analysisAdd BLAST20
Transmembranei273 – 293Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini294 – 306ExtracellularSequence analysisAdd BLAST13
Transmembranei307 – 327Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini328 – 346CytoplasmicSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000255298.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506641 – 346Olfactory receptor 8G5Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi16N-linked (GlcNAc...)Sequence analysis1
Glycosylationi40N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi132 ↔ 214PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8NG78.
PeptideAtlasiQ8NG78.
PRIDEiQ8NG78.

PTM databases

iPTMnetiQ8NG78.
PhosphoSitePlusiQ8NG78.

Expressioni

Gene expression databases

BgeeiENSG00000255298.
ExpressionAtlasiQ8NG78. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ8NG78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118817.
HOVERGENiHBG017625.
InParanoidiQ8NG78.
KOiK04257.
OMAiQKENNNT.
OrthoDBiEOG091G0AZH.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NG78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIYKQGITF LQKENNNTIH LNTMFFLSPA ETHQRMAAEN HSFVTKFILV
60 70 80 90 100
GLTEKSELQL PLFLVFLGIY VVTVLGNLGM ITLIGLSSHL HTPMYCFLSS
110 120 130 140 150
LSFIDFCHST VITPKMLVNF VTEKNIISYP ECMTQLYFFL VFAIAECHML
160 170 180 190 200
AAMAYDGYVA ICSPLLYSII ISNKACFSLI LVVYVIGLIC ASAHIGCMFR
210 220 230 240 250
VQFCKFDVIN HYFCDLISIL KLSCSSTYIN ELLILIFSGI NILVPSLTIL
260 270 280 290 300
SSYIFIIASI LRIRYTEGRS KAFSTCSSHI SAVSVFFGSA AFMYLQPSSV
310 320 330 340
SSMDQGKVSS VFYTIVVPML NPLIYSLRNK DVHVALKKTL GKRTFL
Length:346
Mass (Da):38,798
Last modified:April 16, 2014 - v2
Checksum:i4CE6344D67DB9C0D
GO

Sequence cautioni

The sequence BAC06171 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065958 Genomic DNA. Translation: BAC06171.1. Different initiation.
AP002965 Genomic DNA. No translation available.
BC136820 mRNA. Translation: AAI36821.1.
BK004516 Genomic DNA. Translation: DAA04914.1.
CCDSiCCDS66256.1.
RefSeqiNP_001005198.1. NM_001005198.1.
XP_011540964.1. XM_011542662.2.
XP_011540965.1. XM_011542663.2.
XP_011540966.1. XM_011542664.2.
XP_011540967.1. XM_011542665.2.
XP_011540968.1. XM_011542666.2.
XP_011540969.1. XM_011542667.2.
UniGeneiHs.722725.

Genome annotation databases

EnsembliENST00000524943; ENSP00000477014; ENSG00000255298.
GeneIDi219865.
KEGGihsa:219865.
UCSCiuc031yio.1. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065958 Genomic DNA. Translation: BAC06171.1. Different initiation.
AP002965 Genomic DNA. No translation available.
BC136820 mRNA. Translation: AAI36821.1.
BK004516 Genomic DNA. Translation: DAA04914.1.
CCDSiCCDS66256.1.
RefSeqiNP_001005198.1. NM_001005198.1.
XP_011540964.1. XM_011542662.2.
XP_011540965.1. XM_011542663.2.
XP_011540966.1. XM_011542664.2.
XP_011540967.1. XM_011542665.2.
XP_011540968.1. XM_011542666.2.
XP_011540969.1. XM_011542667.2.
UniGeneiHs.722725.

3D structure databases

ProteinModelPortaliQ8NG78.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NG78.
PhosphoSitePlusiQ8NG78.

Proteomic databases

EPDiQ8NG78.
PeptideAtlasiQ8NG78.
PRIDEiQ8NG78.

Protocols and materials databases

DNASUi219865.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000524943; ENSP00000477014; ENSG00000255298.
GeneIDi219865.
KEGGihsa:219865.
UCSCiuc031yio.1. human.

Organism-specific databases

CTDi219865.
GeneCardsiOR8G5.
HGNCiHGNC:19622. OR8G5.
neXtProtiNX_Q8NG78.
OpenTargetsiENSG00000255298.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118817.
HOVERGENiHBG017625.
InParanoidiQ8NG78.
KOiK04257.
OMAiQKENNNT.
OrthoDBiEOG091G0AZH.

Enzyme and pathway databases

BioCyciZFISH:G66-31470-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR8G5.
GenomeRNAii219865.
PROiQ8NG78.

Gene expression databases

BgeeiENSG00000255298.
ExpressionAtlasiQ8NG78. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR8G5_HUMAN
AccessioniPrimary (citable) accession number: Q8NG78
Secondary accession number(s): B2RND3, Q6IEU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: April 16, 2014
Last modified: November 30, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.