Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 2T12

Gene

OR2T12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2T12
Alternative name(s):
Olfactory receptor OR1-57
Gene namesi
Name:OR2T12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000177201.1.
HGNCiHGNC:19592. OR2T12.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 47Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 77Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini78 – 98ExtracellularSequence analysisAdd BLAST21
Transmembranei99 – 118Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 156Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini157 – 193ExtracellularSequence analysisAdd BLAST37
Transmembranei194 – 217Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini218 – 234CytoplasmicSequence analysisAdd BLAST17
Transmembranei235 – 257Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini258 – 270ExtracellularSequence analysisAdd BLAST13
Transmembranei271 – 290Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini291 – 320CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134941840.

Polymorphism and mutation databases

BioMutaiOR2T12.
DMDMi71153027.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505041 – 320Olfactory receptor 2T12Add BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi17N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NG77.
PeptideAtlasiQ8NG77.
PRIDEiQ8NG77.

Expressioni

Gene expression databases

BgeeiENSG00000177201.
CleanExiHS_OR2T12.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000324583.

Structurei

3D structure databases

ProteinModelPortaliQ8NG77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEQD. Eukaryota.
ENOG4111EHF. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NG77.
KOiK04257.
OMAiQMTLGSW.
OrthoDBiEOG091G0DUZ.
PhylomeDBiQ8NG77.
TreeFamiTF337295.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NG77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMRNTTPDF ILLGLFNHTR AHQVLFMMLL ATVLTSLFSN ALMILLIHWD
60 70 80 90 100
HRLHRPMYFL LSQLSLMDMM LVSTTVPKMA ADYLTGNKAI SRAGCGVQIF
110 120 130 140 150
FLPTLGGGEC FLLAAMAYDR YAAVCHPLRY PTLMSWQLCL RMTMSSWLLG
160 170 180 190 200
AADGLLQAVA TLSFPYCGAH EIDHFFCEAP VLVRLACADT SVFENAMYIC
210 220 230 240 250
CVLMLLVPFS LILSSYGLIL AAVLLMRSTE ARKKAFATCS SHVAVVGLFY
260 270 280 290 300
GAGIFTYMRP KSHRSTNHDK VVSAFYTMFT PLLNPLIYSV RNSEVKEALK
310 320
RWLGTCVNLK HQQNEAHRSR
Length:320
Mass (Da):35,946
Last modified:October 1, 2002 - v1
Checksum:iDD6281B07E95F2EE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06000341A → S. Corresponds to variant dbSNP:rs12135684Ensembl.1
Natural variantiVAR_06000469M → V. Corresponds to variant dbSNP:rs6678138Ensembl.1
Natural variantiVAR_060005104T → S. Corresponds to variant dbSNP:rs12137982Ensembl.1
Natural variantiVAR_053157296K → N. Corresponds to variant dbSNP:rs11204625Ensembl.1
Natural variantiVAR_060006301R → L. Corresponds to variant dbSNP:rs6667171Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065960 Genomic DNA. Translation: BAC06172.1.
AL450303 Genomic DNA. No translation available.
BK004485 Genomic DNA. Translation: DAA04883.1.
CCDSiCCDS31110.1.
RefSeqiNP_001004692.1. NM_001004692.1.
UniGeneiHs.553582.

Genome annotation databases

EnsembliENST00000317996; ENSP00000324583; ENSG00000177201.
GeneIDi127064.
KEGGihsa:127064.
UCSCiuc010pzj.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO2T12_HUMAN
AccessioniPrimary (citable) accession number: Q8NG77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families