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Protein

Olfactory receptor 2T33

Gene

OR2T33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2T33
Alternative name(s):
Olfactory receptor OR1-56
Gene namesi
Name:OR2T33
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:31255. OR2T33.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence analysisAdd
BLAST
Transmembranei24 – 4724Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini48 – 558CytoplasmicSequence analysis
Transmembranei56 – 7722Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini78 – 9821ExtracellularSequence analysisAdd
BLAST
Transmembranei99 – 11820Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini119 – 13719CytoplasmicSequence analysisAdd
BLAST
Transmembranei138 – 15619Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini157 – 19337ExtracellularSequence analysisAdd
BLAST
Transmembranei194 – 21724Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini218 – 23417CytoplasmicSequence analysisAdd
BLAST
Transmembranei235 – 25723Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini258 – 27013ExtracellularSequence analysisAdd
BLAST
Transmembranei271 – 29020Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini291 – 32030CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134889138.

Polymorphism and mutation databases

BioMutaiOR2T33.
DMDMi71153024.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Olfactory receptor 2T33PRO_0000150507Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence analysis
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NG76.
PRIDEiQ8NG76.

Expressioni

Gene expression databases

BgeeiQ8NG76.
CleanExiHS_OR2T33.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000324687.

Structurei

3D structure databases

ProteinModelPortaliQ8NG76.
SMRiQ8NG76. Positions 24-301.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEQD. Eukaryota.
ENOG4111EHF. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NG76.
KOiK04257.
OMAiRTHEIDH.
OrthoDBiEOG7966H7.
PhylomeDBiQ8NG76.
TreeFamiTF337295.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NG76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMRNTTPDF ILLGLFNHTR AHQVLFMMVL SIVLTSLFGN SLMILLIHWD
60 70 80 90 100
HRLHTPMYFL LSQLSLMDMM LVSTTVPKMA ADYLTGSKAI SRAGCGVQIF
110 120 130 140 150
FLPTLGGGEC FLLAAMAYDR YAAVCHPLRY PTLMSWQLCL RMTMSCWLLG
160 170 180 190 200
AADGLLQAVV TLSFPYCGAH EIDHFFCETP VLVRLACADT SVFENAMYIC
210 220 230 240 250
CVLMLLVPFS LILSSYGLIL AAVLHMRSTE ARKKAFATCS SHVAVVGLFY
260 270 280 290 300
GAAIFTYMRP KSHRSTNHDK VVSAFYTMFT PLLNPLIYSV KNSEVKGALK
310 320
RWLGTCVNIK HQQNEAHRSR
Length:320
Mass (Da):35,876
Last modified:October 1, 2002 - v1
Checksum:iFB63E5CC900E99DC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti169 – 1691A → V.
Corresponds to variant rs10888338 [ dbSNP | Ensembl ].
VAR_053159

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065961 Genomic DNA. Translation: BAC06173.1.
AL450303 Genomic DNA. Translation: CAH71664.1.
CH471148 Genomic DNA. Translation: EAW77220.1.
BC136994 mRNA. Translation: AAI36995.1.
BC136995 mRNA. Translation: AAI36996.1.
BK004484 Genomic DNA. Translation: DAA04882.1.
CCDSiCCDS31109.1.
RefSeqiNP_001004695.1. NM_001004695.1.
UniGeneiHs.553783.

Genome annotation databases

EnsembliENST00000318021; ENSP00000324687; ENSG00000177212.
GeneIDi391195.
KEGGihsa:391195.
UCSCiuc010pzi.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065961 Genomic DNA. Translation: BAC06173.1.
AL450303 Genomic DNA. Translation: CAH71664.1.
CH471148 Genomic DNA. Translation: EAW77220.1.
BC136994 mRNA. Translation: AAI36995.1.
BC136995 mRNA. Translation: AAI36996.1.
BK004484 Genomic DNA. Translation: DAA04882.1.
CCDSiCCDS31109.1.
RefSeqiNP_001004695.1. NM_001004695.1.
UniGeneiHs.553783.

3D structure databases

ProteinModelPortaliQ8NG76.
SMRiQ8NG76. Positions 24-301.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000324687.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR2T33.
DMDMi71153024.

Proteomic databases

PaxDbiQ8NG76.
PRIDEiQ8NG76.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318021; ENSP00000324687; ENSG00000177212.
GeneIDi391195.
KEGGihsa:391195.
UCSCiuc010pzi.2. human.

Organism-specific databases

CTDi391195.
GeneCardsiOR2T33.
HGNCiHGNC:31255. OR2T33.
neXtProtiNX_Q8NG76.
PharmGKBiPA134889138.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEQD. Eukaryota.
ENOG4111EHF. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NG76.
KOiK04257.
OMAiRTHEIDH.
OrthoDBiEOG7966H7.
PhylomeDBiQ8NG76.
TreeFamiTF337295.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2T33.
GenomeRNAii391195.
NextBioi104457.
PROiQ8NG76.

Gene expression databases

BgeeiQ8NG76.
CleanExiHS_OR2T33.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO2T33_HUMAN
AccessioniPrimary (citable) accession number: Q8NG76
Secondary accession number(s): B2RNN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2002
Last modified: November 11, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.