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Protein

Olfactory receptor 5T1

Gene

OR5T1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5T1
Alternative name(s):
Olfactory receptor OR11-179
Gene namesi
Name:OR5T1
Synonyms:OR5T1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14821. OR5T1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737ExtracellularSequence analysisAdd
BLAST
Transmembranei38 – 5821Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini59 – 668CytoplasmicSequence analysis
Transmembranei67 – 8721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini88 – 11124ExtracellularSequence analysisAdd
BLAST
Transmembranei112 – 13221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini133 – 15119CytoplasmicSequence analysisAdd
BLAST
Transmembranei152 – 17221Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini173 – 20836ExtracellularSequence analysisAdd
BLAST
Transmembranei209 – 22921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini230 – 24920CytoplasmicSequence analysisAdd
BLAST
Transmembranei250 – 27021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini271 – 28313ExtracellularSequence analysisAdd
BLAST
Transmembranei284 – 30421Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini305 – 32622CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32566.

Polymorphism and mutation databases

BioMutaiOR5T1.
DMDMi71153031.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Olfactory receptor 5T1PRO_0000150613Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence analysis
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NG75.
PRIDEiQ8NG75.

PTM databases

iPTMnetiQ8NG75.
PhosphoSiteiQ8NG75.

Expressioni

Gene expression databases

CleanExiHS_OR5T1.

Organism-specific databases

HPAiHPA050952.

Interactioni

Protein-protein interaction databases

BioGridi133424. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8NG75.
SMRiQ8NG75. Positions 121-152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410III0. Eukaryota.
ENOG4111ADU. LUCA.
GeneTreeiENSGT00760000118942.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NG75.
KOiK04257.
OMAiFLACTFG.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NG75.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NG75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGLPSDMDL YKLQLNNFTE VTMFILISFT EEFDVQVFLF LLFLAIYLFT
60 70 80 90 100
LIGNLGLVVP IIGDFWLHSP MYYFLGVLSF LDVCYSTVVT PKMLVNFLAK
110 120 130 140 150
NKSISFLGCA TQMFLACTFG TTECFLLAAM AYDRYVAIYN PLLYSVSMSP
160 170 180 190 200
RVYVPLITAS YVASILHATI HTVATFSLSF CGSNEIRHVF CNMPPLLAIS
210 220 230 240 250
CSDTHVIQLL FFYFVGSIEI VTILIVLISY GFILLAILKM QSAEGRRKVF
260 270 280 290 300
STCGAHLTGV TIYHGTILFM YVRPSSSYTS DNDMIVSIFY TIVIPMLNPI
310 320
IYSLRNKDVK EAIKRLLVRN WFINKL
Length:326
Mass (Da):36,885
Last modified:October 1, 2002 - v1
Checksum:iFE6C8ED733E18E97
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti60 – 601P → L.
Corresponds to variant rs7126079 [ dbSNP | Ensembl ].
VAR_053210
Natural varianti164 – 1641S → G.
Corresponds to variant rs12360890 [ dbSNP | Ensembl ].
VAR_034233

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065962 Genomic DNA. Translation: BAC06174.1.
CH471076 Genomic DNA. Translation: EAW73706.1.
BC136992 mRNA. Translation: AAI36993.1.
BC136993 mRNA. Translation: AAI36994.1.
BK004336 Genomic DNA. Translation: DAA04734.1.
CCDSiCCDS31525.1.
RefSeqiNP_001004745.1. NM_001004745.1.
UniGeneiHs.553747.

Genome annotation databases

EnsembliENST00000313033; ENSP00000323612; ENSG00000181698.
ENST00000576733; ENSP00000459132; ENSG00000262784.
GeneIDi390155.
KEGGihsa:390155.
UCSCiuc001nio.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065962 Genomic DNA. Translation: BAC06174.1.
CH471076 Genomic DNA. Translation: EAW73706.1.
BC136992 mRNA. Translation: AAI36993.1.
BC136993 mRNA. Translation: AAI36994.1.
BK004336 Genomic DNA. Translation: DAA04734.1.
CCDSiCCDS31525.1.
RefSeqiNP_001004745.1. NM_001004745.1.
UniGeneiHs.553747.

3D structure databases

ProteinModelPortaliQ8NG75.
SMRiQ8NG75. Positions 121-152.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi133424. 1 interaction.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NG75.
PhosphoSiteiQ8NG75.

Polymorphism and mutation databases

BioMutaiOR5T1.
DMDMi71153031.

Proteomic databases

PaxDbiQ8NG75.
PRIDEiQ8NG75.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313033; ENSP00000323612; ENSG00000181698.
ENST00000576733; ENSP00000459132; ENSG00000262784.
GeneIDi390155.
KEGGihsa:390155.
UCSCiuc001nio.1. human.

Organism-specific databases

CTDi390155.
GeneCardsiOR5T1.
HGNCiHGNC:14821. OR5T1.
HPAiHPA050952.
neXtProtiNX_Q8NG75.
PharmGKBiPA32566.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410III0. Eukaryota.
ENOG4111ADU. LUCA.
GeneTreeiENSGT00760000118942.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NG75.
KOiK04257.
OMAiFLACTFG.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NG75.
TreeFamiTF352753.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5T1.
GenomeRNAii390155.
PROiQ8NG75.

Gene expression databases

CleanExiHS_OR5T1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR5T1_HUMAN
AccessioniPrimary (citable) accession number: Q8NG75
Secondary accession number(s): B2RNM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.