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Protein

Tubulin--tyrosine ligase

Gene

TTL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.By similarity

Catalytic activityi

ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate.By similarity

Cofactori

Protein has several cofactor binding sites:
  • Mg2+By similarity
  • K+By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding, Potassium

Enzyme and pathway databases

BRENDAi6.3.2.25. 2681.
SIGNORiQ8NG68.

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin--tyrosine ligase (EC:6.3.2.25By similarity)
Short name:
TTL
Gene namesi
Name:TTL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:21586. TTL.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134934330.

Chemistry

ChEMBLiCHEMBL5549.

Polymorphism and mutation databases

BioMutaiTTL.
DMDMi47117358.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Tubulin--tyrosine ligasePRO_0000212434Add
BLAST

Proteomic databases

EPDiQ8NG68.
MaxQBiQ8NG68.
PaxDbiQ8NG68.
PeptideAtlasiQ8NG68.
PRIDEiQ8NG68.

PTM databases

iPTMnetiQ8NG68.
PhosphoSiteiQ8NG68.

Expressioni

Gene expression databases

BgeeiQ8NG68.
CleanExiHS_TTL.
GenevisibleiQ8NG68. HS.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi127297. 6 interactions.
STRINGi9606.ENSP00000233336.

Chemistry

BindingDBiQ8NG68.

Structurei

3D structure databases

ProteinModelPortaliQ8NG68.
SMRiQ8NG68. Positions 1-360.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 370368TTLPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the tubulin--tyrosine ligase family.Curated
Contains 1 TTL domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2157. Eukaryota.
ENOG410XQDM. LUCA.
GeneTreeiENSGT00760000118951.
HOGENOMiHOG000231734.
HOVERGENiHBG016579.
InParanoidiQ8NG68.
KOiK06047.
OMAiQNYGRYE.
OrthoDBiEOG72ZCDZ.
PhylomeDBiQ8NG68.
TreeFamiTF350555.

Family and domain databases

InterProiIPR004344. TTL/TTLL_fam.
[Graphical view]
PfamiPF03133. TTL. 1 hit.
[Graphical view]
PROSITEiPS51221. TTL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NG68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYTFVVRDEN SSVYAEVSRL LLATGHWKRL RRDNPRFNLM LGERNRLPFG
60 70 80 90 100
RLGHEPGLVQ LVNYYRGADK LCRKASLVKL IKTSPELAES CTWFPESYVI
110 120 130 140 150
YPTNLKTPVA PAQNGIQPPI SNSRTDEREF FLASYNRKKE DGEGNVWIAK
160 170 180 190 200
SSAGAKGEGI LISSEASELL DFIDNQGQVH VIQKYLEHPL LLEPGHRKFD
210 220 230 240 250
IRSWVLVDHQ YNIYLYREGV LRTASEPYHV DNFQDKTCHL TNHCIQKEYS
260 270 280 290 300
KNYGKYEEGN EMFFKEFNQY LTSALNITLE SSILLQIKHI IRNCLLSVEP
310 320 330 340 350
AISTKHLPYQ SFQLFGFDFM VDEELKVWLI EVNGAPACAQ KLYAELCQGI
360 370
VDIAISSVFP PPDVEQPQTQ PAAFIKL
Length:377
Mass (Da):43,212
Last modified:March 1, 2004 - v2
Checksum:i7A13E2C28E1AD6EA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti245 – 2451I → V in CAD98091 (PubMed:17974005).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB071393 mRNA. Translation: BAC06832.2.
AC012442 Genomic DNA. Translation: AAX81998.1.
CH471217 Genomic DNA. Translation: EAW73589.1.
BC036819 mRNA. Translation: AAH36819.1.
BX538316 mRNA. Translation: CAD98091.1.
CCDSiCCDS2096.1.
RefSeqiNP_714923.1. NM_153712.4.
UniGeneiHs.358997.

Genome annotation databases

EnsembliENST00000233336; ENSP00000233336; ENSG00000114999.
GeneIDi150465.
KEGGihsa:150465.
UCSCiuc002thu.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB071393 mRNA. Translation: BAC06832.2.
AC012442 Genomic DNA. Translation: AAX81998.1.
CH471217 Genomic DNA. Translation: EAW73589.1.
BC036819 mRNA. Translation: AAH36819.1.
BX538316 mRNA. Translation: CAD98091.1.
CCDSiCCDS2096.1.
RefSeqiNP_714923.1. NM_153712.4.
UniGeneiHs.358997.

3D structure databases

ProteinModelPortaliQ8NG68.
SMRiQ8NG68. Positions 1-360.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127297. 6 interactions.
STRINGi9606.ENSP00000233336.

Chemistry

BindingDBiQ8NG68.
ChEMBLiCHEMBL5549.

PTM databases

iPTMnetiQ8NG68.
PhosphoSiteiQ8NG68.

Polymorphism and mutation databases

BioMutaiTTL.
DMDMi47117358.

Proteomic databases

EPDiQ8NG68.
MaxQBiQ8NG68.
PaxDbiQ8NG68.
PeptideAtlasiQ8NG68.
PRIDEiQ8NG68.

Protocols and materials databases

DNASUi150465.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233336; ENSP00000233336; ENSG00000114999.
GeneIDi150465.
KEGGihsa:150465.
UCSCiuc002thu.4. human.

Organism-specific databases

CTDi150465.
GeneCardsiTTL.
HGNCiHGNC:21586. TTL.
MIMi608291. gene.
neXtProtiNX_Q8NG68.
PharmGKBiPA134934330.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2157. Eukaryota.
ENOG410XQDM. LUCA.
GeneTreeiENSGT00760000118951.
HOGENOMiHOG000231734.
HOVERGENiHBG016579.
InParanoidiQ8NG68.
KOiK06047.
OMAiQNYGRYE.
OrthoDBiEOG72ZCDZ.
PhylomeDBiQ8NG68.
TreeFamiTF350555.

Enzyme and pathway databases

BRENDAi6.3.2.25. 2681.
SIGNORiQ8NG68.

Miscellaneous databases

ChiTaRSiTTL. human.
GenomeRNAii150465.
PROiQ8NG68.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NG68.
CleanExiHS_TTL.
GenevisibleiQ8NG68. HS.

Family and domain databases

InterProiIPR004344. TTL/TTLL_fam.
[Graphical view]
PfamiPF03133. TTL. 1 hit.
[Graphical view]
PROSITEiPS51221. TTL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Homo sapiens tubulin tyrosine ligase mRNA, complete cds."
    Miyazaki K., Okamoto Y., Kato C., Sakamoto M., Ohira M., Morohashi A., Nakagawara A.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 205-377.
    Tissue: Uterus.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTTL_HUMAN
AccessioniPrimary (citable) accession number: Q8NG68
Secondary accession number(s): Q585T3, Q7Z302, Q8N426
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2004
Last modified: June 8, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.