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Q8NG66

- NEK11_HUMAN

UniProt

Q8NG66 - NEK11_HUMAN

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Protein

Serine/threonine-protein kinase Nek11

Gene

NEK11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.3 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.2 Publications

Cofactori

Manganese or magnesium.2 Publications

Enzyme regulationi

Autorepressed by intramolecular binding of the C-terminus which dissociates following phosphorylation by NEK2 isoform 1 in G1/S-arrested cells. NEK2 isoform 2 is largely not present in the nucleolus, and does not appear to phosphorylate NEK11. Activated in response to DNA damage. Inhibited by zinc.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611ATP1 PublicationPROSITE-ProRule annotation
Active sitei158 – 1581Proton acceptorBy similarityPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi35 – 439ATPBy similarityPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW
  3. protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  1. G2 DNA damage checkpoint Source: UniProtKB
  2. intracellular signal transduction Source: UniProtKB
  3. intra-S DNA damage checkpoint Source: UniProtKB
  4. protein phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ8NG66.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase Nek11 (EC:2.7.11.1)
Alternative name(s):
Never in mitosis A-related kinase 11
Short name:
NimA-related protein kinase 11
Gene namesi
Name:NEK11Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:18593. NEK11.

Subcellular locationi

Nucleus. Nucleusnucleolus
Note: Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase. Accumulates in the nucleolus in G1/S-arrested cells.

GO - Cellular componenti

  1. nucleolus Source: UniProtKB
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi61 – 611K → R: Loss of kinase activity. 1 Publication

Organism-specific databases

PharmGKBiPA38595.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 645645Serine/threonine-protein kinase Nek11PRO_0000086438Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei273 – 2731Phosphoserine; by CHEK12 Publications

Post-translational modificationi

Phosphorylated by NEK2. Phosphorylation at Ser-273 is important for its activation.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8NG66.
PRIDEiQ8NG66.

PTM databases

PhosphoSiteiQ8NG66.

Expressioni

Tissue specificityi

Poorly expressed in cerebellum, trachea, lung, appendix, and uterus.1 Publication

Developmental stagei

Predominantly expressed at S/G2/M phase.1 Publication

Gene expression databases

BgeeiQ8NG66.
CleanExiHS_NEK11.
ExpressionAtlasiQ8NG66. baseline and differential.
GenevestigatoriQ8NG66.

Organism-specific databases

HPAiHPA016908.

Interactioni

Subunit structurei

Interacts with isoform 1 of NEK2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NEK2P519555EBI-633195,EBI-633182
NEK2P51955-12EBI-633195,EBI-687792

Protein-protein interaction databases

BioGridi122947. 3 interactions.
IntActiQ8NG66. 3 interactions.
STRINGi9606.ENSP00000372857.

Structurei

3D structure databases

ProteinModelPortaliQ8NG66.
SMRiQ8NG66. Positions 26-359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 287259Protein kinasePROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili346 – 38540By similaritySequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118997.
HOGENOMiHOG000293260.
HOVERGENiHBG082016.
InParanoidiQ8NG66.
KOiK08857.
OMAiISHTANM.
OrthoDBiEOG7WMCJ7.
PhylomeDBiQ8NG66.
TreeFamiTF106472.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q8NG66-1) [UniParc]FASTAAdd to Basket

Also known as: Long1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLKFQEAAKC VSGSTAISTY PKTLIARRYV LQQKLGSGSF GTVYLVSDKK
60 70 80 90 100
AKRGEELKVL KEISVGELNP NETVQANLEA QLLSKLDHPA IVKFHASFVE
110 120 130 140 150
QDNFCIITEY CEGRDLDDKI QEYKQAGKIF PENQIIEWFI QLLLGVDYMH
160 170 180 190 200
ERRILHRDLK SKNVFLKNNL LKIGDFGVSR LLMGSCDLAT TLTGTPHYMS
210 220 230 240 250
PEALKHQGYD TKSDIWSLAC ILYEMCCMNH AFAGSNFLSI VLKIVEGDTP
260 270 280 290 300
SLPERYPKEL NAIMESMLNK NPSLRPSAIE ILKIPYLDEQ LQNLMCRYSE
310 320 330 340 350
MTLEDKNLDC QKEAAHIINA MQKRIHLQTL RALSEVQKMT PRERMRLRKL
360 370 380 390 400
QAADEKARKL KKIVEEKYEE NSKRMQELRS RNFQQLSVDV LHEKTHLKGM
410 420 430 440 450
EEKEEQPEGR LSCSPQDEDE ERWQGREEES DEPTLENLPE SQPIPSMDLH
460 470 480 490 500
ELESIVEDAT SDLGYHEIPE DPLVAEEYYA DAFDSYCEES DEEEEEIALE
510 520 530 540 550
RPEKEIRNEG SQPAYRTNQQ DSDIEALARC LENVLGCTSL DTKTITTMAE
560 570 580 590 600
DMSPGPPIFN SVMARTKMKR MRESAMQKLG TEVFEEVYNY LKRARHQNAS
610 620 630 640
EAEIRECLEK VVPQASDCFE VDQLLYFEEQ LLITMGKEPT LQNHL
Length:645
Mass (Da):74,192
Last modified:November 30, 2010 - v2
Checksum:i7D11AE1D89711DEC
GO
Isoform 21 Publication (identifier: Q8NG66-2) [UniParc]FASTAAdd to Basket

Also known as: Short1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     467-470: EIPE → ATHS
     471-645: Missing.

Show »
Length:470
Mass (Da):54,007
Checksum:iF52B82ED2B096FFB
GO
Isoform 3Curated (identifier: Q8NG66-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     467-482: EIPEDPLVAEEYYADA → GDCNLISLDEYWKNEK
     483-645: Missing.

Note: No experimental confirmation available.Curated

Show »
Length:482
Mass (Da):55,519
Checksum:iFA6D89E50C0223A5
GO
Isoform 4 (identifier: Q8NG66-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     542-599: TKTITTMAED...YLKRARHQNA → QPCRSWGQKY...TSSCTLKSSC
     600-645: Missing.

Note: No experimental confirmation available.

Show »
Length:599
Mass (Da):68,880
Checksum:iD9080C265940829F
GO

Sequence cautioni

The sequence BAB15672.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti108 – 1081T → M in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
VAR_040935
Natural varianti123 – 1231Y → C.1 Publication
Corresponds to variant rs55806123 [ dbSNP | Ensembl ].
VAR_040936
Natural varianti213 – 2131S → L.1 Publication
Corresponds to variant rs55920129 [ dbSNP | Ensembl ].
VAR_040937
Natural varianti263 – 2631I → V.1 Publication
Corresponds to variant rs35567155 [ dbSNP | Ensembl ].
VAR_040938
Natural varianti451 – 4511E → K.1 Publication
Corresponds to variant rs35409692 [ dbSNP | Ensembl ].
VAR_040939
Natural varianti488 – 4881E → V.4 Publications
Corresponds to variant rs3738000 [ dbSNP | Ensembl ].
VAR_040940
Natural varianti492 – 4921E → K in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
VAR_040941
Natural varianti548 – 5481M → T.1 Publication
Corresponds to variant rs55813244 [ dbSNP | Ensembl ].
VAR_040942
Natural varianti562 – 5621V → A.1 Publication
Corresponds to variant rs16836266 [ dbSNP | Ensembl ].
VAR_033907
Natural varianti606 – 6061E → K.1 Publication
Corresponds to variant rs55944737 [ dbSNP | Ensembl ].
VAR_040943
Natural varianti617 – 6171D → N in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
VAR_040944

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei467 – 48216EIPED…YYADA → GDCNLISLDEYWKNEK in isoform 3. 1 PublicationVSP_051820Add
BLAST
Alternative sequencei467 – 4704EIPE → ATHS in isoform 2. 1 PublicationVSP_051821
Alternative sequencei471 – 645175Missing in isoform 2. 1 PublicationVSP_051822Add
BLAST
Alternative sequencei483 – 645163Missing in isoform 3. 1 PublicationVSP_051823Add
BLAST
Alternative sequencei542 – 59958TKTIT…RHQNA → QPCRSWGQKYLKRSIITSRE QGIRMLAKQRSASVWKKWCL KPATVLKWTSSCTLKSSC in isoform 4. 1 PublicationVSP_040080Add
BLAST
Alternative sequencei600 – 64546Missing in isoform 4. 1 PublicationVSP_040081Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB071996 mRNA. Translation: BAC06350.1.
AB071997 mRNA. Translation: BAC06351.1.
AL833472 mRNA. Translation: CAI46114.1.
AC055733 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79213.1.
BC028587 mRNA. Translation: AAH28587.1.
AK027148 mRNA. Translation: BAB15672.1. Different initiation.
CCDSiCCDS3069.1. [Q8NG66-1]
CCDS46915.1. [Q8NG66-2]
CCDS54639.1. [Q8NG66-4]
RefSeqiNP_001139475.1. NM_001146003.1. [Q8NG66-4]
NP_079076.3. NM_024800.4. [Q8NG66-1]
NP_665917.1. NM_145910.3. [Q8NG66-2]
XP_005247840.1. XM_005247783.1. [Q8NG66-1]
XP_006713813.1. XM_006713750.1. [Q8NG66-3]
UniGeneiHs.657336.

Genome annotation databases

EnsembliENST00000356918; ENSP00000349389; ENSG00000114670. [Q8NG66-2]
ENST00000383366; ENSP00000372857; ENSG00000114670. [Q8NG66-1]
ENST00000507910; ENSP00000426662; ENSG00000114670. [Q8NG66-3]
ENST00000508196; ENSP00000421851; ENSG00000114670. [Q8NG66-1]
ENST00000510688; ENSP00000423458; ENSG00000114670. [Q8NG66-4]
ENST00000511262; ENSP00000425114; ENSG00000114670. [Q8NG66-2]
GeneIDi79858.
KEGGihsa:79858.
UCSCiuc003enx.3. human. [Q8NG66-2]
uc003eny.3. human. [Q8NG66-1]
uc003eoa.3. human. [Q8NG66-4]
uc011blm.2. human. [Q8NG66-3]

Polymorphism databases

DMDMi313104142.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB071996 mRNA. Translation: BAC06350.1 .
AB071997 mRNA. Translation: BAC06351.1 .
AL833472 mRNA. Translation: CAI46114.1 .
AC055733 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79213.1 .
BC028587 mRNA. Translation: AAH28587.1 .
AK027148 mRNA. Translation: BAB15672.1 . Different initiation.
CCDSi CCDS3069.1. [Q8NG66-1 ]
CCDS46915.1. [Q8NG66-2 ]
CCDS54639.1. [Q8NG66-4 ]
RefSeqi NP_001139475.1. NM_001146003.1. [Q8NG66-4 ]
NP_079076.3. NM_024800.4. [Q8NG66-1 ]
NP_665917.1. NM_145910.3. [Q8NG66-2 ]
XP_005247840.1. XM_005247783.1. [Q8NG66-1 ]
XP_006713813.1. XM_006713750.1. [Q8NG66-3 ]
UniGenei Hs.657336.

3D structure databases

ProteinModelPortali Q8NG66.
SMRi Q8NG66. Positions 26-359.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122947. 3 interactions.
IntActi Q8NG66. 3 interactions.
STRINGi 9606.ENSP00000372857.

Chemistry

BindingDBi Q8NG66.
ChEMBLi CHEMBL5638.
DrugBanki DB08912. Dabrafenib.
GuidetoPHARMACOLOGYi 2116.

PTM databases

PhosphoSitei Q8NG66.

Polymorphism databases

DMDMi 313104142.

Proteomic databases

PaxDbi Q8NG66.
PRIDEi Q8NG66.

Protocols and materials databases

DNASUi 79858.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000356918 ; ENSP00000349389 ; ENSG00000114670 . [Q8NG66-2 ]
ENST00000383366 ; ENSP00000372857 ; ENSG00000114670 . [Q8NG66-1 ]
ENST00000507910 ; ENSP00000426662 ; ENSG00000114670 . [Q8NG66-3 ]
ENST00000508196 ; ENSP00000421851 ; ENSG00000114670 . [Q8NG66-1 ]
ENST00000510688 ; ENSP00000423458 ; ENSG00000114670 . [Q8NG66-4 ]
ENST00000511262 ; ENSP00000425114 ; ENSG00000114670 . [Q8NG66-2 ]
GeneIDi 79858.
KEGGi hsa:79858.
UCSCi uc003enx.3. human. [Q8NG66-2 ]
uc003eny.3. human. [Q8NG66-1 ]
uc003eoa.3. human. [Q8NG66-4 ]
uc011blm.2. human. [Q8NG66-3 ]

Organism-specific databases

CTDi 79858.
GeneCardsi GC03P130745.
HGNCi HGNC:18593. NEK11.
HPAi HPA016908.
MIMi 609779. gene.
neXtProti NX_Q8NG66.
PharmGKBi PA38595.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118997.
HOGENOMi HOG000293260.
HOVERGENi HBG082016.
InParanoidi Q8NG66.
KOi K08857.
OMAi ISHTANM.
OrthoDBi EOG7WMCJ7.
PhylomeDBi Q8NG66.
TreeFami TF106472.

Enzyme and pathway databases

SignaLinki Q8NG66.

Miscellaneous databases

GenomeRNAii 79858.
NextBioi 69585.
PROi Q8NG66.
SOURCEi Search...

Gene expression databases

Bgeei Q8NG66.
CleanExi HS_NEK11.
ExpressionAtlasi Q8NG66. baseline and differential.
Genevestigatori Q8NG66.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nek11, a new member of the NIMA family of kinases, involved in DNA replication and genotoxic stress responses."
    Noguchi K., Fukazawa H., Murakami Y., Uehara Y.
    J. Biol. Chem. 277:39655-39665(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, ENZYME REGULATION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-61, VARIANT VAL-488.
    Tissue: Cervix carcinoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT VAL-488.
    Tissue: Cervix.
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: TestisImported.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 162-645 (ISOFORM 1), VARIANT VAL-488.
    Tissue: LungImported.
  7. "Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells."
    Noguchi K., Fukazawa H., Murakami Y., Uehara Y.
    J. Biol. Chem. 279:32716-32727(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, ENZYME REGULATION, INTERACTION WITH NEK2.
  8. "NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint."
    Melixetian M., Klein D.K., Soerensen C.S., Helin K.
    Nat. Cell Biol. 11:1247-1253(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION AT SER-273.
  9. "NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling."
    Soerensen C.S., Melixetian M., Klein D.K., Helin K.
    Cell Cycle 9:450-455(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION AT SER-273.
  10. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] MET-108; CYS-123; LEU-213; VAL-263; LYS-451; VAL-488; LYS-492; THR-548; ALA-562; LYS-606 AND ASN-617.

Entry informationi

Entry nameiNEK11_HUMAN
AccessioniPrimary (citable) accession number: Q8NG66
Secondary accession number(s): A6NHD7
, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: November 30, 2010
Last modified: October 29, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3