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Q8NG66

- NEK11_HUMAN

UniProt

Q8NG66 - NEK11_HUMAN

Protein

Serine/threonine-protein kinase Nek11

Gene

NEK11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.3 Publications

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.2 Publications

    Cofactori

    Manganese or magnesium.2 Publications

    Enzyme regulationi

    Autorepressed by intramolecular binding of the C-terminus which dissociates following phosphorylation by NEK2 isoform 1 in G1/S-arrested cells. NEK2 isoform 2 is largely not present in the nucleolus, and does not appear to phosphorylate NEK11. Activated in response to DNA damage. Inhibited by zinc.2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei61 – 611ATP1 PublicationPROSITE-ProRule annotation
    Active sitei158 – 1581Proton acceptorBy similarityPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi35 – 439ATPBy similarityPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: IntAct
    4. protein serine/threonine kinase activity Source: UniProtKB

    GO - Biological processi

    1. G2 DNA damage checkpoint Source: UniProtKB
    2. intracellular signal transduction Source: UniProtKB
    3. intra-S DNA damage checkpoint Source: UniProtKB
    4. protein phosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Cell cycle

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ8NG66.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase Nek11 (EC:2.7.11.1)
    Alternative name(s):
    Never in mitosis A-related kinase 11
    Short name:
    NimA-related protein kinase 11
    Gene namesi
    Name:NEK11Imported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:18593. NEK11.

    Subcellular locationi

    Nucleus. Nucleusnucleolus
    Note: Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase. Accumulates in the nucleolus in G1/S-arrested cells.

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB
    2. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi61 – 611K → R: Loss of kinase activity. 1 Publication

    Organism-specific databases

    PharmGKBiPA38595.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 645645Serine/threonine-protein kinase Nek11PRO_0000086438Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei273 – 2731Phosphoserine; by CHEK12 Publications

    Post-translational modificationi

    Phosphorylated by NEK2. Phosphorylation at Ser-273 is important for its activation.2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ8NG66.
    PRIDEiQ8NG66.

    PTM databases

    PhosphoSiteiQ8NG66.

    Expressioni

    Tissue specificityi

    Poorly expressed in cerebellum, trachea, lung, appendix, and uterus.1 Publication

    Developmental stagei

    Predominantly expressed at S/G2/M phase.1 Publication

    Gene expression databases

    ArrayExpressiQ8NG66.
    BgeeiQ8NG66.
    CleanExiHS_NEK11.
    GenevestigatoriQ8NG66.

    Organism-specific databases

    HPAiHPA016908.

    Interactioni

    Subunit structurei

    Interacts with isoform 1 of NEK2.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NEK2P519555EBI-633195,EBI-633182
    NEK2P51955-12EBI-633195,EBI-687792

    Protein-protein interaction databases

    BioGridi122947. 3 interactions.
    IntActiQ8NG66. 3 interactions.
    STRINGi9606.ENSP00000372857.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NG66.
    SMRiQ8NG66. Positions 26-359.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 287259Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili346 – 38540By similaritySequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000293260.
    HOVERGENiHBG082016.
    InParanoidiQ8NG66.
    KOiK08857.
    OMAiISHTANM.
    OrthoDBiEOG7WMCJ7.
    PhylomeDBiQ8NG66.
    TreeFamiTF106472.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: Q8NG66-1) [UniParc]FASTAAdd to Basket

    Also known as: Long1 Publication

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLKFQEAAKC VSGSTAISTY PKTLIARRYV LQQKLGSGSF GTVYLVSDKK    50
    AKRGEELKVL KEISVGELNP NETVQANLEA QLLSKLDHPA IVKFHASFVE 100
    QDNFCIITEY CEGRDLDDKI QEYKQAGKIF PENQIIEWFI QLLLGVDYMH 150
    ERRILHRDLK SKNVFLKNNL LKIGDFGVSR LLMGSCDLAT TLTGTPHYMS 200
    PEALKHQGYD TKSDIWSLAC ILYEMCCMNH AFAGSNFLSI VLKIVEGDTP 250
    SLPERYPKEL NAIMESMLNK NPSLRPSAIE ILKIPYLDEQ LQNLMCRYSE 300
    MTLEDKNLDC QKEAAHIINA MQKRIHLQTL RALSEVQKMT PRERMRLRKL 350
    QAADEKARKL KKIVEEKYEE NSKRMQELRS RNFQQLSVDV LHEKTHLKGM 400
    EEKEEQPEGR LSCSPQDEDE ERWQGREEES DEPTLENLPE SQPIPSMDLH 450
    ELESIVEDAT SDLGYHEIPE DPLVAEEYYA DAFDSYCEES DEEEEEIALE 500
    RPEKEIRNEG SQPAYRTNQQ DSDIEALARC LENVLGCTSL DTKTITTMAE 550
    DMSPGPPIFN SVMARTKMKR MRESAMQKLG TEVFEEVYNY LKRARHQNAS 600
    EAEIRECLEK VVPQASDCFE VDQLLYFEEQ LLITMGKEPT LQNHL 645
    Length:645
    Mass (Da):74,192
    Last modified:November 30, 2010 - v2
    Checksum:i7D11AE1D89711DEC
    GO
    Isoform 21 Publication (identifier: Q8NG66-2) [UniParc]FASTAAdd to Basket

    Also known as: Short1 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         467-470: EIPE → ATHS
         471-645: Missing.

    Show »
    Length:470
    Mass (Da):54,007
    Checksum:iF52B82ED2B096FFB
    GO
    Isoform 3Curated (identifier: Q8NG66-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         467-482: EIPEDPLVAEEYYADA → GDCNLISLDEYWKNEK
         483-645: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:482
    Mass (Da):55,519
    Checksum:iFA6D89E50C0223A5
    GO
    Isoform 4 (identifier: Q8NG66-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         542-599: TKTITTMAED...YLKRARHQNA → QPCRSWGQKY...TSSCTLKSSC
         600-645: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:599
    Mass (Da):68,880
    Checksum:iD9080C265940829F
    GO

    Sequence cautioni

    The sequence BAB15672.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti108 – 1081T → M in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_040935
    Natural varianti123 – 1231Y → C.1 Publication
    Corresponds to variant rs55806123 [ dbSNP | Ensembl ].
    VAR_040936
    Natural varianti213 – 2131S → L.1 Publication
    Corresponds to variant rs55920129 [ dbSNP | Ensembl ].
    VAR_040937
    Natural varianti263 – 2631I → V.1 Publication
    Corresponds to variant rs35567155 [ dbSNP | Ensembl ].
    VAR_040938
    Natural varianti451 – 4511E → K.1 Publication
    Corresponds to variant rs35409692 [ dbSNP | Ensembl ].
    VAR_040939
    Natural varianti488 – 4881E → V.4 Publications
    Corresponds to variant rs3738000 [ dbSNP | Ensembl ].
    VAR_040940
    Natural varianti492 – 4921E → K in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_040941
    Natural varianti548 – 5481M → T.1 Publication
    Corresponds to variant rs55813244 [ dbSNP | Ensembl ].
    VAR_040942
    Natural varianti562 – 5621V → A.1 Publication
    Corresponds to variant rs16836266 [ dbSNP | Ensembl ].
    VAR_033907
    Natural varianti606 – 6061E → K.1 Publication
    Corresponds to variant rs55944737 [ dbSNP | Ensembl ].
    VAR_040943
    Natural varianti617 – 6171D → N in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_040944

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei467 – 48216EIPED…YYADA → GDCNLISLDEYWKNEK in isoform 3. 1 PublicationVSP_051820Add
    BLAST
    Alternative sequencei467 – 4704EIPE → ATHS in isoform 2. 1 PublicationVSP_051821
    Alternative sequencei471 – 645175Missing in isoform 2. 1 PublicationVSP_051822Add
    BLAST
    Alternative sequencei483 – 645163Missing in isoform 3. 1 PublicationVSP_051823Add
    BLAST
    Alternative sequencei542 – 59958TKTIT…RHQNA → QPCRSWGQKYLKRSIITSRE QGIRMLAKQRSASVWKKWCL KPATVLKWTSSCTLKSSC in isoform 4. 1 PublicationVSP_040080Add
    BLAST
    Alternative sequencei600 – 64546Missing in isoform 4. 1 PublicationVSP_040081Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB071996 mRNA. Translation: BAC06350.1.
    AB071997 mRNA. Translation: BAC06351.1.
    AL833472 mRNA. Translation: CAI46114.1.
    AC055733 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW79213.1.
    BC028587 mRNA. Translation: AAH28587.1.
    AK027148 mRNA. Translation: BAB15672.1. Different initiation.
    CCDSiCCDS3069.1. [Q8NG66-1]
    CCDS46915.1. [Q8NG66-2]
    CCDS54639.1. [Q8NG66-4]
    RefSeqiNP_001139475.1. NM_001146003.1. [Q8NG66-4]
    NP_079076.3. NM_024800.4. [Q8NG66-1]
    NP_665917.1. NM_145910.3. [Q8NG66-2]
    XP_005247840.1. XM_005247783.1. [Q8NG66-1]
    XP_006713813.1. XM_006713750.1. [Q8NG66-3]
    UniGeneiHs.657336.

    Genome annotation databases

    EnsembliENST00000356918; ENSP00000349389; ENSG00000114670. [Q8NG66-3]
    ENST00000383366; ENSP00000372857; ENSG00000114670. [Q8NG66-1]
    ENST00000507910; ENSP00000426662; ENSG00000114670. [Q8NG66-3]
    ENST00000508196; ENSP00000421851; ENSG00000114670. [Q8NG66-1]
    ENST00000510688; ENSP00000423458; ENSG00000114670. [Q8NG66-4]
    ENST00000511262; ENSP00000425114; ENSG00000114670. [Q8NG66-2]
    GeneIDi79858.
    KEGGihsa:79858.
    UCSCiuc003enx.3. human. [Q8NG66-2]
    uc003eny.3. human. [Q8NG66-1]
    uc003eoa.3. human. [Q8NG66-4]
    uc011blm.2. human. [Q8NG66-3]

    Polymorphism databases

    DMDMi313104142.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB071996 mRNA. Translation: BAC06350.1 .
    AB071997 mRNA. Translation: BAC06351.1 .
    AL833472 mRNA. Translation: CAI46114.1 .
    AC055733 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW79213.1 .
    BC028587 mRNA. Translation: AAH28587.1 .
    AK027148 mRNA. Translation: BAB15672.1 . Different initiation.
    CCDSi CCDS3069.1. [Q8NG66-1 ]
    CCDS46915.1. [Q8NG66-2 ]
    CCDS54639.1. [Q8NG66-4 ]
    RefSeqi NP_001139475.1. NM_001146003.1. [Q8NG66-4 ]
    NP_079076.3. NM_024800.4. [Q8NG66-1 ]
    NP_665917.1. NM_145910.3. [Q8NG66-2 ]
    XP_005247840.1. XM_005247783.1. [Q8NG66-1 ]
    XP_006713813.1. XM_006713750.1. [Q8NG66-3 ]
    UniGenei Hs.657336.

    3D structure databases

    ProteinModelPortali Q8NG66.
    SMRi Q8NG66. Positions 26-359.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122947. 3 interactions.
    IntActi Q8NG66. 3 interactions.
    STRINGi 9606.ENSP00000372857.

    Chemistry

    BindingDBi Q8NG66.
    ChEMBLi CHEMBL5638.
    GuidetoPHARMACOLOGYi 2116.

    PTM databases

    PhosphoSitei Q8NG66.

    Polymorphism databases

    DMDMi 313104142.

    Proteomic databases

    PaxDbi Q8NG66.
    PRIDEi Q8NG66.

    Protocols and materials databases

    DNASUi 79858.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000356918 ; ENSP00000349389 ; ENSG00000114670 . [Q8NG66-3 ]
    ENST00000383366 ; ENSP00000372857 ; ENSG00000114670 . [Q8NG66-1 ]
    ENST00000507910 ; ENSP00000426662 ; ENSG00000114670 . [Q8NG66-3 ]
    ENST00000508196 ; ENSP00000421851 ; ENSG00000114670 . [Q8NG66-1 ]
    ENST00000510688 ; ENSP00000423458 ; ENSG00000114670 . [Q8NG66-4 ]
    ENST00000511262 ; ENSP00000425114 ; ENSG00000114670 . [Q8NG66-2 ]
    GeneIDi 79858.
    KEGGi hsa:79858.
    UCSCi uc003enx.3. human. [Q8NG66-2 ]
    uc003eny.3. human. [Q8NG66-1 ]
    uc003eoa.3. human. [Q8NG66-4 ]
    uc011blm.2. human. [Q8NG66-3 ]

    Organism-specific databases

    CTDi 79858.
    GeneCardsi GC03P130745.
    HGNCi HGNC:18593. NEK11.
    HPAi HPA016908.
    MIMi 609779. gene.
    neXtProti NX_Q8NG66.
    PharmGKBi PA38595.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000293260.
    HOVERGENi HBG082016.
    InParanoidi Q8NG66.
    KOi K08857.
    OMAi ISHTANM.
    OrthoDBi EOG7WMCJ7.
    PhylomeDBi Q8NG66.
    TreeFami TF106472.

    Enzyme and pathway databases

    SignaLinki Q8NG66.

    Miscellaneous databases

    GenomeRNAii 79858.
    NextBioi 69585.
    PROi Q8NG66.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8NG66.
    Bgeei Q8NG66.
    CleanExi HS_NEK11.
    Genevestigatori Q8NG66.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nek11, a new member of the NIMA family of kinases, involved in DNA replication and genotoxic stress responses."
      Noguchi K., Fukazawa H., Murakami Y., Uehara Y.
      J. Biol. Chem. 277:39655-39665(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, ENZYME REGULATION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-61, VARIANT VAL-488.
      Tissue: Cervix carcinoma.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT VAL-488.
      Tissue: Cervix.
    3. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: TestisImported.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 162-645 (ISOFORM 1), VARIANT VAL-488.
      Tissue: LungImported.
    7. "Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells."
      Noguchi K., Fukazawa H., Murakami Y., Uehara Y.
      J. Biol. Chem. 279:32716-32727(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, ENZYME REGULATION, INTERACTION WITH NEK2.
    8. "NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint."
      Melixetian M., Klein D.K., Soerensen C.S., Helin K.
      Nat. Cell Biol. 11:1247-1253(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHORYLATION AT SER-273.
    9. "NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling."
      Soerensen C.S., Melixetian M., Klein D.K., Helin K.
      Cell Cycle 9:450-455(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHORYLATION AT SER-273.
    10. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] MET-108; CYS-123; LEU-213; VAL-263; LYS-451; VAL-488; LYS-492; THR-548; ALA-562; LYS-606 AND ASN-617.

    Entry informationi

    Entry nameiNEK11_HUMAN
    AccessioniPrimary (citable) accession number: Q8NG66
    Secondary accession number(s): A6NHD7
    , Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3