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Protein

RNA polymerase II transcription factor SIII subunit A3

Gene

TCEB3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor SIII subunit A3
Alternative name(s):
Elongin-A3
Short name:
EloA3
Transcription elongation factor B polypeptide 3C
Gene namesi
Name:TCEB3C
Synonyms:TCEB3L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:24617. TCEB3C.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134940475.

Polymorphism and mutation databases

BioMutaiTCEB3C.
DMDMi296434491.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 546546RNA polymerase II transcription factor SIII subunit A3PRO_0000086964Add
BLAST

Proteomic databases

PaxDbiQ8NG57.
PeptideAtlasiQ8NG57.
PRIDEiQ8NG57.

PTM databases

iPTMnetiQ8NG57.
PhosphoSiteiQ8NG57.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

CleanExiHS_TCEB3C.
GenevisibleiQ8NG57. HS.

Organism-specific databases

HPAiHPA048971.
HPA049178.
HPA050086.

Interactioni

Subunit structurei

Heterotrimer of an A (A1, A2 or A3), B and C subunit.1 Publication

Protein-protein interaction databases

BioGridi127829. 3 interactions.
STRINGi9606.ENSP00000328232.

Structurei

3D structure databases

ProteinModelPortaliQ8NG57.
SMRiQ8NG57. Positions 365-431.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 8076TFIIS N-terminalPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni308 – 467160Activation domainBy similarityAdd
BLAST
Regioni336 – 34510Interaction with elongin BCBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi119 – 19375Pro-richAdd
BLAST

Domaini

The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].

Sequence similaritiesi

Contains 1 TFIIS N-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2821. Eukaryota.
ENOG4110PG3. LUCA.
GeneTreeiENSGT00390000002428.
HOGENOMiHOG000059565.
HOVERGENiHBG051467.
InParanoidiQ8NG57.
KOiK15076.
OMAiRATRENK.
OrthoDBiEOG091G0D2G.
PhylomeDBiQ8NG57.
TreeFamiTF317259.

Family and domain databases

Gene3Di1.20.930.10. 1 hit.
InterProiIPR010684. RNA_pol_II_trans_fac_SIII_A.
IPR003617. TFIIS/CRSP70_N_sub.
IPR017923. TFIIS_N.
[Graphical view]
PfamiPF06881. Elongin_A. 1 hit.
PF08711. Med26. 1 hit.
[Graphical view]
SMARTiSM00509. TFS2N. 1 hit.
[Graphical view]
SUPFAMiSSF47676. SSF47676. 1 hit.
PROSITEiPS51319. TFIIS_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NG57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGSTTLRA VGKLQVRLAT KTEPKKLEKY LQKLSALPMT ADILAETGIR
60 70 80 90 100
KTVKRLRKHQ HVGDFARDLA ARWKKLVLVD RNTGPDPQDP EESASRQRFG
110 120 130 140 150
EALQEREKAW GFPENATAPR SPSHSPEHRR TARRTPPGQQ RPHPRSPSRE
160 170 180 190 200
PRAERKRPRM APADSGPHRD PPTRTAPLPM PEGPEPAVPG EQPGRGHAHA
210 220 230 240 250
AQGGPLLGQG CQGQPQGEAV GSHSKGHKSS RGASAQKSPP VQESQSERLQ
260 270 280 290 300
AAGADSAGPK TVPSHVFSEL WDPSEAWMQA NYDLLSAFEA MTSQANPEAL
310 320 330 340 350
SAPALQEEAA FPGRRVNAKM PVYSGSRPAC QLQVPTLRQQ CLRVPRNNPD
360 370 380 390 400
ALGDVEGVPY SVLEPVLEGW TPDQLYRTEK DNAALARETD ELWRIHCLQD
410 420 430 440 450
FKEEKPQEHE SWRELYLRLR DAREQRLRVV TTKIRSAREN KPSGRQTKMI
460 470 480 490 500
CFNSVAKTPY DASRRQEKSA GAADPGNGEM EPAPKPAGSS QAPSGLGDGD
510 520 530 540
GGSVSGGGSS NRHAAPADKT RKQAAKKVAP LMAKAIRDYK GRFSRR
Length:546
Mass (Da):59,744
Last modified:May 18, 2010 - v2
Checksum:iF981E3DD548B2555
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti301 – 3011S → C in BAC01113 (PubMed:11994304).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti375 – 3751L → P.
Corresponds to variant rs2261291 [ dbSNP | Ensembl ].
VAR_059654

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076840 mRNA. Translation: BAC01113.1.
AC012254 Genomic DNA. No translation available.
CCDSiCCDS11931.1.
RefSeqiNP_663628.2. NM_145653.3.
XP_005276693.1. XM_005276636.3.
XP_011507118.1. XM_011508816.2.
UniGeneiHs.515381.
Hs.729823.

Genome annotation databases

EnsembliENST00000330682; ENSP00000328232; ENSG00000183791.
GeneIDi101930165.
105369241.
162699.
KEGGihsa:101930165.
hsa:101930171.
hsa:105369241.
hsa:162699.
UCSCiuc010xdb.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076840 mRNA. Translation: BAC01113.1.
AC012254 Genomic DNA. No translation available.
CCDSiCCDS11931.1.
RefSeqiNP_663628.2. NM_145653.3.
XP_005276693.1. XM_005276636.3.
XP_011507118.1. XM_011508816.2.
UniGeneiHs.515381.
Hs.729823.

3D structure databases

ProteinModelPortaliQ8NG57.
SMRiQ8NG57. Positions 365-431.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127829. 3 interactions.
STRINGi9606.ENSP00000328232.

PTM databases

iPTMnetiQ8NG57.
PhosphoSiteiQ8NG57.

Polymorphism and mutation databases

BioMutaiTCEB3C.
DMDMi296434491.

Proteomic databases

PaxDbiQ8NG57.
PeptideAtlasiQ8NG57.
PRIDEiQ8NG57.

Protocols and materials databases

DNASUi162699.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330682; ENSP00000328232; ENSG00000183791.
GeneIDi101930165.
105369241.
162699.
KEGGihsa:101930165.
hsa:101930171.
hsa:105369241.
hsa:162699.
UCSCiuc010xdb.2. human.

Organism-specific databases

CTDi162699.
GeneCardsiTCEB3C.
H-InvDBHIX0059794.
HGNCiHGNC:24617. TCEB3C.
HPAiHPA048971.
HPA049178.
HPA050086.
neXtProtiNX_Q8NG57.
PharmGKBiPA134940475.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2821. Eukaryota.
ENOG4110PG3. LUCA.
GeneTreeiENSGT00390000002428.
HOGENOMiHOG000059565.
HOVERGENiHBG051467.
InParanoidiQ8NG57.
KOiK15076.
OMAiRATRENK.
OrthoDBiEOG091G0D2G.
PhylomeDBiQ8NG57.
TreeFamiTF317259.

Miscellaneous databases

PROiQ8NG57.

Gene expression databases

CleanExiHS_TCEB3C.
GenevisibleiQ8NG57. HS.

Family and domain databases

Gene3Di1.20.930.10. 1 hit.
InterProiIPR010684. RNA_pol_II_trans_fac_SIII_A.
IPR003617. TFIIS/CRSP70_N_sub.
IPR017923. TFIIS_N.
[Graphical view]
PfamiPF06881. Elongin_A. 1 hit.
PF08711. Med26. 1 hit.
[Graphical view]
SMARTiSM00509. TFS2N. 1 hit.
[Graphical view]
SUPFAMiSSF47676. SSF47676. 1 hit.
PROSITEiPS51319. TFIIS_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiELOA3_HUMAN
AccessioniPrimary (citable) accession number: Q8NG57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.