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Protein

Elongin-A3

Gene

ELOA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).1 Publication

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-112382. Formation of RNA Pol II elongation complex.
R-HSA-112387. Elongation arrest and recovery.
R-HSA-167152. Formation of HIV elongation complex in the absence of HIV Tat.
R-HSA-167200. Formation of HIV-1 elongation complex containing HIV-1 Tat.
R-HSA-167238. Pausing and recovery of Tat-mediated HIV elongation.
R-HSA-167243. Tat-mediated HIV elongation arrest and recovery.
R-HSA-167246. Tat-mediated elongation of the HIV-1 transcript.
R-HSA-167287. HIV elongation arrest and recovery.
R-HSA-167290. Pausing and recovery of HIV elongation.
R-HSA-674695. RNA Polymerase II Pre-transcription Events.
R-HSA-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-HSA-75955. RNA Polymerase II Transcription Elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongin-A3
Short name:
EloA3
Alternative name(s):
RNA polymerase II transcription factor SIII subunit A3
Transcription elongation factor B polypeptide 3C
Gene namesi
Name:ELOA3Imported
Synonyms:TCEB3C, TCEB3L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:24617. ELOA3.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi162699.
OpenTargetsiENSG00000183791.
PharmGKBiPA134940475.

Polymorphism and mutation databases

BioMutaiTCEB3C.
DMDMi296434491.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000869641 – 546Elongin-A3Add BLAST546

Proteomic databases

PaxDbiQ8NG57.
PeptideAtlasiQ8NG57.
PRIDEiQ8NG57.

PTM databases

iPTMnetiQ8NG57.
PhosphoSitePlusiQ8NG57.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000183791.
CleanExiHS_TCEB3C.
GenevisibleiQ8NG57. HS.

Organism-specific databases

HPAiHPA048971.
HPA049178.
HPA050086.

Interactioni

Subunit structurei

Heterotrimer of an A (ELOA, ELOA2 or ELOA3), ELOB and ELOC subunit.1 Publication

Protein-protein interaction databases

BioGridi127829. 3 interactors.
STRINGi9606.ENSP00000328232.

Structurei

3D structure databases

ProteinModelPortaliQ8NG57.
SMRiQ8NG57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 80TFIIS N-terminalPROSITE-ProRule annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni308 – 467Activation domainBy similarityAdd BLAST160
Regioni336 – 345BC-boxBy similarity10
Regioni336 – 345Interaction with elongin BCBy similarity10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi119 – 193Pro-richAdd BLAST75

Domaini

The BC-box, which mediates binding to the elongin BC complex, has the consensus sequence [APST]-L-x3-C-x3-[AILV].By similarity

Phylogenomic databases

eggNOGiKOG2821. Eukaryota.
ENOG4110PG3. LUCA.
GeneTreeiENSGT00390000002428.
HOGENOMiHOG000059565.
HOVERGENiHBG051467.
InParanoidiQ8NG57.
KOiK15076.
OMAiCEENERK.
OrthoDBiEOG091G0D2G.
PhylomeDBiQ8NG57.
TreeFamiTF317259.

Family and domain databases

InterProiView protein in InterPro
IPR010684. RNA_pol_II_trans_fac_SIII_A.
IPR003617. TFIIS/CRSP70_N_sub.
IPR017923. TFIIS_N.
PfamiView protein in Pfam
PF06881. Elongin_A. 1 hit.
PF08711. Med26. 1 hit.
SMARTiView protein in SMART
SM00509. TFS2N. 1 hit.
SUPFAMiSSF47676. SSF47676. 1 hit.
PROSITEiView protein in PROSITE
PS51319. TFIIS_N. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NG57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGSTTLRA VGKLQVRLAT KTEPKKLEKY LQKLSALPMT ADILAETGIR
60 70 80 90 100
KTVKRLRKHQ HVGDFARDLA ARWKKLVLVD RNTGPDPQDP EESASRQRFG
110 120 130 140 150
EALQEREKAW GFPENATAPR SPSHSPEHRR TARRTPPGQQ RPHPRSPSRE
160 170 180 190 200
PRAERKRPRM APADSGPHRD PPTRTAPLPM PEGPEPAVPG EQPGRGHAHA
210 220 230 240 250
AQGGPLLGQG CQGQPQGEAV GSHSKGHKSS RGASAQKSPP VQESQSERLQ
260 270 280 290 300
AAGADSAGPK TVPSHVFSEL WDPSEAWMQA NYDLLSAFEA MTSQANPEAL
310 320 330 340 350
SAPALQEEAA FPGRRVNAKM PVYSGSRPAC QLQVPTLRQQ CLRVPRNNPD
360 370 380 390 400
ALGDVEGVPY SVLEPVLEGW TPDQLYRTEK DNAALARETD ELWRIHCLQD
410 420 430 440 450
FKEEKPQEHE SWRELYLRLR DAREQRLRVV TTKIRSAREN KPSGRQTKMI
460 470 480 490 500
CFNSVAKTPY DASRRQEKSA GAADPGNGEM EPAPKPAGSS QAPSGLGDGD
510 520 530 540
GGSVSGGGSS NRHAAPADKT RKQAAKKVAP LMAKAIRDYK GRFSRR
Length:546
Mass (Da):59,744
Last modified:May 18, 2010 - v2
Checksum:iF981E3DD548B2555
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti301S → C in BAC01113 (PubMed:11994304).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059654375L → P. Corresponds to variant dbSNP:rs2261291Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076840 mRNA. Translation: BAC01113.1.
AC012254 Genomic DNA. No translation available.
CCDSiCCDS11931.1.
RefSeqiNP_663628.2. NM_145653.3.
XP_005276693.1. XM_005276636.3.
XP_011507118.1. XM_011508816.2.
UniGeneiHs.515381.
Hs.729823.

Genome annotation databases

EnsembliENST00000330682; ENSP00000328232; ENSG00000183791.
GeneIDi101930165.
105369241.
162699.
KEGGihsa:101930165.
hsa:105369241.
hsa:162699.
UCSCiuc010xdb.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiELOA3_HUMAN
AccessioniPrimary (citable) accession number: Q8NG57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: May 18, 2010
Last modified: August 30, 2017
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations