Q8NG42 (Q8NG42_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Delta 6/2 progesterone receptor EMBL BAC11013.1

Submitted name:
Progesterone receptor Ensembl ENSP00000432352
Submitted name:
Progesterone receptor, isoform CRA_a EMBL EAW66997.1

Gene names

Name:	PR EMBL BAC11013.1
Synonyms:	PGR Ensembl ENSP00000432352 EMBL EAW66997.1
ORF Names:	hCG_39657 EMBL EAW66997.1

Organism

Homo sapiens (Human) [Reference proteome] EMBL BAC11013.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	803 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the nuclear hormone receptor family. RuleBase RU000377 Contains 1 nuclear receptor DNA-binding domain. SAAS SAAS000536

Ontologies

Keywords
Biological process	Transcription Transcription regulation SAAS SAAS000536
Cellular component	Nucleus SAAS SAAS000536
Domain	Zinc-finger SAAS SAAS000536
Ligand	DNA-binding SAAS SAAS000536 Metal-binding Zinc
Molecular function	Receptor EMBL BAC11013.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from direct assay. Source: HPA
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro steroid binding Inferred from electronic annotation. Source: InterPro steroid hormone receptor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8NG42 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 07BA27B3AB7703F5	FASTA	803	83,662
	10 20 30 40 50 60 MTELKAKGPR APHVAGGPPS PEVGSPLLCR PAAGPFPGSQ TSDTLPEVSA IPISLDGLLF 70 80 90 100 110 120 PRPCQGQDPS DEKTQDQQSL SDVEGAYSRA EATRGAGGSS SSPPEKDSGL LDSVLDTLLA 130 140 150 160 170 180 PSGPGQSQPS PPACEVTSSW CLFGPELPED PPAAPATQRV LSPLMSRSGC KVGDSSGTAA 190 200 210 220 230 240 AHKVLPRGLS PARQLLLPAS ESPHWSGAPV KPSPQAAAVE VEEEDGSESE ESAGPLLKGK 250 260 270 280 290 300 PRALGGAAAG GGAAAVPPGA AAGGVALVPK EDSRFSAPRV ALVEQDAPMA PGRSPLATTV 310 320 330 340 350 360 MDFIHVPILP LNHALLAART RQLLEDESYD GGAGAASAFA PPRSSPCASS TPVAVGDFPD 370 380 390 400 410 420 CAYPPDAEPK DDAYPLYSDF QPPALKIKEE EEGAEASARS PRSYLVAGAN PAAFPDFPLG 430 440 450 460 470 480 PPPPLPPRAT PSRPGEAAVT AAPASASVSS ASSSGSTLEC ILYKAEGAPP QQGPFAPPPC 490 500 510 520 530 540 KAPGASGCLL PRDGLPSTSA SAAAAGAAPA LYPALGLNGL PQLGYQAAVL KEGLPQVYPP 550 560 570 580 590 600 YLNYLRPDSE ASQSPQYSFE SLPQKICLIC GDEASGCHYG VLTCGSCKVF FKRAMEGQHN 610 620 630 640 650 660 YLCAGRNDCI VDKIRRKNCP ACRLRKCCQA GMVLGGRKFK KFNKVRVVRA LDAVALPQPV 670 680 690 700 710 720 GVPNESQALS QRFTFSPGQD IQLIPPLINL LMSIEPDVIY AGHDNTKPDT SSSLLTSLNQ 730 740 750 760 770 780 LGERQLLSVV KWSKSLPGFR NLHIDDQITL IQYSWMSLMV FGLGWRSYKH VSGQMLYFAP 790 800 DLILNESHRS LSSFKLAKKS SSV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel alternatively spliced variant with a deletion of 52 BP in exon 6 of the progesterone receptor gene is observed frequently in breast cancer tissues." Hisatomi H., Kohno N., Wakita K., Nagao K., Hirata H., Hikiji K., Harada S. Int. J. Cancer 105:182-185(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Breast cancer EMBL BAC11013.1.
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP001533 Genomic DNA. No translation available. AB085845 mRNA. Translation: BAC11013.1. CH471065 Genomic DNA. Translation: EAW66997.1.
IPI	IPI00982228.
UniGene	Hs.32405. Hs.742403.
3D structure databases
HSSP	HSSP built from PDB template 1A28 based on UniProtKB P06401.
SMR	Q8NG42. Positions 563-794.
ModBase	Search...
Proteomic databases
PRIDE	Q8NG42.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000534780; ENSP00000432352; ENSG00000082175.
Organism-specific databases
HGNC	HGNC:8910. PGR.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG007583.
Gene expression databases
ArrayExpress	Q8NG42.
Family and domain databases
Gene3D	1.10.565.10. 2 hits. 3.30.50.10. 1 hit.
InterPro	IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR000536. Nucl_hrmn_rcpt_lig-bd_core. IPR000128. Progest_rcpt. IPR001723. Str_hrmn_rcpt. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Pfam	PF00104. Hormone_recep. 1 hit. PF02161. Prog_receptor. 1 hit. PF00105. zf-C4. 1 hit. [Graphical view]
PRINTS	PR00544. PROGESTRONER. PR00398. STRDHORMONER. PR00047. STROIDFINGER.
SMART	SM00399. ZnF_C4. 1 hit. [Graphical view]
SUPFAM	SSF48508. Str_ncl_receptor. 1 hit.
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8NG42_HUMAN

Accession

Primary (citable) accession number: Q8NG42

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.