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Protein

Neuropeptide B

Gene

NPB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide B
Alternative name(s):
Preproprotein L7
Short name:
hPPL7
Cleaved into the following 2 chains:
Neuropeptide B-23
Short name:
NPB23
Short name:
hL7
Neuropeptide B-29
Short name:
NPB29
Short name:
hL7C
Gene namesi
Name:NPB
Synonyms:PPL7, PPNPB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:30099. NPB.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671255.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Peptidei25 – 5329Neuropeptide B-29PRO_0000019836Add
BLAST
Peptidei25 – 4824Neuropeptide B-23PRO_0000019837Add
BLAST
Propeptidei56 – 12570Sequence analysisPRO_0000019838Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ8NG41.
PRIDEiQ8NG41.

PTM databases

PhosphoSiteiQ8NG41.

Expressioni

Tissue specificityi

Widely expressed in the central nervous system. High levels are found in substantia nigra, hypothalamus, hyppocampus, spinal cord, placenta and fetal brain; lower levels are found in testis, uterus and ovary. Also detected at high levels in colorectal adenocarcinoma.

Gene expression databases

BgeeiQ8NG41.
CleanExiHS_NPB.
ExpressionAtlasiQ8NG41. baseline and differential.
GenevisibleiQ8NG41. HS.

Organism-specific databases

HPAiHPA057419.

Interactioni

Protein-protein interaction databases

BioGridi129184. 27 interactions.
STRINGi9606.ENSP00000332766.

Structurei

3D structure databases

ProteinModelPortaliQ8NG41.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the neuropeptide B/W family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J07G. Eukaryota.
ENOG41120QH. LUCA.
GeneTreeiENSGT00390000013683.
HOGENOMiHOG000231239.
HOVERGENiHBG039578.
InParanoidiQ8NG41.
KOiK05267.
PhylomeDBiQ8NG41.
TreeFamiTF333179.

Family and domain databases

InterProiIPR013298. Neuropept_B_pre.
IPR013297. Neuropept_BW_pre.
[Graphical view]
PfamiPF15180. NPBW. 1 hit.
[Graphical view]
PRINTSiPR01888. NROPEPTIDEBW.
PR01889. PPNRPEPTIDEB.
ProDomiPD685249. PD685249. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NG41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARSATLAAA ALALCLLLAP PGLAWYKPAA GHSSYSVGRA AGLLSGLRRS
60 70 80 90 100
PYARRSQPYR GAEPPGGAGA SPELQLHPRL RSLAVCVQDV APNLQRCERL
110 120
PDGRGTYQCK ANVFLSLRAA DCLAA
Length:125
Mass (Da):13,097
Last modified:October 1, 2002 - v1
Checksum:i98CBFAB33B42AC90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085942 mRNA. Translation: BAC07175.1.
AF525737 mRNA. Translation: AAP80794.1.
AF525738 Transcribed RNA. Translation: AAP80795.1.
AL360181 Genomic DNA. No translation available.
BC126128 mRNA. Translation: AAI26129.1.
BC126485 mRNA. Translation: AAI26486.1.
BC146875 mRNA. Translation: AAI46876.1.
BC146890 mRNA. Translation: AAI46891.1.
CCDSiCCDS11790.1.
RefSeqiNP_683694.1. NM_148896.4.
UniGeneiHs.569843.
Hs.708916.

Genome annotation databases

EnsembliENST00000333383; ENSP00000332766; ENSG00000183979.
GeneIDi256933.
KEGGihsa:256933.
UCSCiuc002kcd.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085942 mRNA. Translation: BAC07175.1.
AF525737 mRNA. Translation: AAP80794.1.
AF525738 Transcribed RNA. Translation: AAP80795.1.
AL360181 Genomic DNA. No translation available.
BC126128 mRNA. Translation: AAI26129.1.
BC126485 mRNA. Translation: AAI26486.1.
BC146875 mRNA. Translation: AAI46876.1.
BC146890 mRNA. Translation: AAI46891.1.
CCDSiCCDS11790.1.
RefSeqiNP_683694.1. NM_148896.4.
UniGeneiHs.569843.
Hs.708916.

3D structure databases

ProteinModelPortaliQ8NG41.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129184. 27 interactions.
STRINGi9606.ENSP00000332766.

PTM databases

PhosphoSiteiQ8NG41.

Proteomic databases

PaxDbiQ8NG41.
PRIDEiQ8NG41.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333383; ENSP00000332766; ENSG00000183979.
GeneIDi256933.
KEGGihsa:256933.
UCSCiuc002kcd.4. human.

Organism-specific databases

CTDi256933.
GeneCardsiNPB.
HGNCiHGNC:30099. NPB.
HPAiHPA057419.
MIMi607996. gene.
neXtProtiNX_Q8NG41.
PharmGKBiPA142671255.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J07G. Eukaryota.
ENOG41120QH. LUCA.
GeneTreeiENSGT00390000013683.
HOGENOMiHOG000231239.
HOVERGENiHBG039578.
InParanoidiQ8NG41.
KOiK05267.
PhylomeDBiQ8NG41.
TreeFamiTF333179.

Enzyme and pathway databases

ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.

Miscellaneous databases

GenomeRNAii256933.
NextBioi92877.
PROiQ8NG41.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NG41.
CleanExiHS_NPB.
ExpressionAtlasiQ8NG41. baseline and differential.
GenevisibleiQ8NG41. HS.

Family and domain databases

InterProiIPR013298. Neuropept_B_pre.
IPR013297. Neuropept_BW_pre.
[Graphical view]
PfamiPF15180. NPBW. 1 hit.
[Graphical view]
PRINTSiPR01888. NROPEPTIDEBW.
PR01889. PPNRPEPTIDEB.
ProDomiPD685249. PD685249. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7."
    Fujii R., Yoshida H., Fukusumi S., Habata Y., Hosoya M., Kawamata Y., Yano T., Hinuma S., Kitada C., Asami T., Mori M., Fujisawa Y., Fujino M.
    J. Biol. Chem. 277:34010-34016(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 25-48, SYNTHESIS OF NPB23.
  2. "Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8."
    Brezillon S., Lannoy V., Franssen J.-D., Le Poul E., Dupriez V., Lucchetti J., Detheux M., Parmentier M.
    J. Biol. Chem. 278:776-783(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiNPB_HUMAN
AccessioniPrimary (citable) accession number: Q8NG41
Secondary accession number(s): A0AUX9, A6NJD6, B9EJC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: October 1, 2002
Last modified: May 11, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.