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Protein

Neuropeptide B

Gene

NPB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide B
Alternative name(s):
Preproprotein L7
Short name:
hPPL7
Cleaved into the following 2 chains:
Neuropeptide B-23
Short name:
NPB23
Short name:
hL7
Neuropeptide B-29
Short name:
NPB29
Short name:
hL7C
Gene namesi
Name:NPB
Synonyms:PPL7, PPNPB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000183979.7
HGNCiHGNC:30099 NPB
MIMi607996 gene
neXtProtiNX_Q8NG41

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi256933
OpenTargetsiENSG00000183979
PharmGKBiPA142671255

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PeptideiPRO_000001983625 – 53Neuropeptide B-29Add BLAST29
PeptideiPRO_000001983725 – 48Neuropeptide B-23Add BLAST24
PropeptideiPRO_000001983856 – 125Sequence analysisAdd BLAST70

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ8NG41
PeptideAtlasiQ8NG41
PRIDEiQ8NG41
ProteomicsDBi73419

PTM databases

iPTMnetiQ8NG41
PhosphoSitePlusiQ8NG41

Expressioni

Tissue specificityi

Widely expressed in the central nervous system. High levels are found in substantia nigra, hypothalamus, hyppocampus, spinal cord, placenta and fetal brain; lower levels are found in testis, uterus and ovary. Also detected at high levels in colorectal adenocarcinoma.

Gene expression databases

BgeeiENSG00000183979
CleanExiHS_NPB
ExpressionAtlasiQ8NG41 baseline and differential
GenevisibleiQ8NG41 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi129184, 28 interactors
STRINGi9606.ENSP00000332766

Structurei

3D structure databases

ProteinModelPortaliQ8NG41
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the neuropeptide B/W family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J07G Eukaryota
ENOG41120QH LUCA
GeneTreeiENSGT00390000013683
HOGENOMiHOG000231239
HOVERGENiHBG039578
InParanoidiQ8NG41
KOiK05267
PhylomeDBiQ8NG41
TreeFamiTF333179

Family and domain databases

InterProiView protein in InterPro
IPR013298 Neuropept_B_pre
IPR013297 Neuropept_BW_pre
PANTHERiPTHR28553 PTHR28553, 1 hit
PfamiView protein in Pfam
PF15180 NPBW, 1 hit
PRINTSiPR01888 NROPEPTIDEBW
PR01889 PPNRPEPTIDEB
ProDomiView protein in ProDom or Entries sharing at least one domain
PD685249 PD685249, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NG41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARSATLAAA ALALCLLLAP PGLAWYKPAA GHSSYSVGRA AGLLSGLRRS
60 70 80 90 100
PYARRSQPYR GAEPPGGAGA SPELQLHPRL RSLAVCVQDV APNLQRCERL
110 120
PDGRGTYQCK ANVFLSLRAA DCLAA
Length:125
Mass (Da):13,097
Last modified:October 1, 2002 - v1
Checksum:i98CBFAB33B42AC90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085942 mRNA Translation: BAC07175.1
AF525737 mRNA Translation: AAP80794.1
AF525738 Transcribed RNA Translation: AAP80795.1
AL360181 Genomic DNA No translation available.
BC126128 mRNA Translation: AAI26129.1
BC126485 mRNA Translation: AAI26486.1
BC146875 mRNA Translation: AAI46876.1
BC146890 mRNA Translation: AAI46891.1
CCDSiCCDS11790.1
RefSeqiNP_683694.1, NM_148896.4
UniGeneiHs.569843
Hs.708916

Genome annotation databases

EnsembliENST00000333383; ENSP00000332766; ENSG00000183979
GeneIDi256933
KEGGihsa:256933
UCSCiuc002kcd.4 human

Similar proteinsi

Entry informationi

Entry nameiNPB_HUMAN
AccessioniPrimary (citable) accession number: Q8NG41
Secondary accession number(s): A0AUX9, A6NJD6, B9EJC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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