Q8NG35 (D105A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-defensin 105

Alternative name(s):
Beta-defensin 5
Short name=BD-5
Short name=DEFB-5
Defensin, beta 105

Gene names

Name:	DEFB105A
Synonyms:	BD5, DEFB105, DEFB5
AND
Name:	DEFB105B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	78 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has antibacterial activity Potential.
Subcellular location	Secreted.
Tissue specificity	Specifically expressed in testis.
Sequence similarities	Belongs to the beta-defensin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Antibiotic Antimicrobial Defensin
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Peptide	28 – 78	51	Beta-defensin 105		PRO_0000006975
Amino acid modifications
	Disulfide bond	43 ↔ 74		By similarity
	Disulfide bond	53 ↔ 67		By similarity
	Disulfide bond	57 ↔ 73		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8NG35 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: A0B07B01A7F41A05	FASTA	78	8,923
	10 20 30 40 50 60 MALIRKTFYF LFAMFFILVQ LPSGCQAGLD FSQPFPSGEF AVCESCKLGR GKCRKECLEN 70 EKPDGNCRLN FLCCRQRI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice." Yamaguchi Y., Nagase T., Makita R., Fukuhara S., Tomita T., Tominaga T., Kurihara H., Ouchi Y. J. Immunol. 169:2516-2523(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Epididymis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Duplication and selection in the evolution of primate beta-defensin genes." Semple C.A.M., Rolfe M., Dorin J.R. Genome Biol. 4:R31.1-R31.11(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-77.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB089180 mRNA. Translation: BAC10630.1. BC128437 mRNA. Translation: AAI28438.1. BC128438 mRNA. Translation: AAI28439.1. AF540977 mRNA. Translation: AAN33113.1.
IPI	IPI00168897.
RefSeq	NP_001035793.1. NM_001040703.1. NP_689463.1. NM_152250.1.
UniGene	Hs.381378.
3D structure databases
ProteinModelPortal	Q8NG35.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000334330.
Proteomic databases
PRIDE	Q8NG35.
Protocols and materials databases
DNASU	245908.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000334773; ENSP00000334330; ENSG00000186562. ENST00000335510; ENSP00000335281; ENSG00000186599.
GeneID	245908. 504180.
KEGG	hsa:245908. hsa:504180.
UCSC	uc011kwp.2. human.
Organism-specific databases
CTD	245908. 504180.
GeneCards	GC08M007679. GC08P007334.
HGNC	HGNC:18087. DEFB105A. HGNC:29930. DEFB105B.
neXtProt	NX_Q8NG35.
PharmGKB	PA142671991.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG44763.
HOGENOM	HOG000112136.
HOVERGEN	HBG051284.
InParanoid	Q8NG35.
OMA	AVCESCK.
OrthoDB	EOG4H72D6.
PhylomeDB	Q8NG35.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
Bgee	Q8NG35.
CleanEx	HS_DEFB105A.
Genevestigator	Q8NG35.
GermOnline	ENSG00000186562. Homo sapiens. ENSG00000186599. Homo sapiens.
Family and domain databases
InterPro	IPR025933. Beta_defensin. [Graphical view]
Pfam	PF13841. Defensin_beta_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	91745.

Entry information

Entry name

D105A_HUMAN

Accession

Primary (citable) accession number: Q8NG35
Secondary accession number(s): A1A581, Q8IZN8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2003
Last sequence update:	October 1, 2002
Last modified:	April 3, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.