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Q8NG35

- D105A_HUMAN

UniProt

Q8NG35 - D105A_HUMAN

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Protein

Beta-defensin 105

Gene

DEFB105A

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Has antibacterial activity.Curated

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 105
Alternative name(s):
Beta-defensin 5
Short name:
BD-5
Short name:
DEFB-5
Defensin, beta 105
Gene namesi
Name:DEFB105A
Synonyms:BD5, DEFB105, DEFB5
AND
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:18087. DEFB105A.
HGNC:29930. DEFB105B.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671991.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Peptidei28 – 7851Beta-defensin 105PRO_0000006975Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 74By similarity
Disulfide bondi53 ↔ 67By similarity
Disulfide bondi57 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ8NG35.

Expressioni

Tissue specificityi

Specifically expressed in testis.

Gene expression databases

BgeeiQ8NG35.
CleanExiHS_DEFB105A.
GenevestigatoriQ8NG35.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000334330.

Structurei

3D structure databases

ProteinModelPortaliQ8NG35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44763.
GeneTreeiENSGT00390000002317.
HOGENOMiHOG000112136.
HOVERGENiHBG051284.
InParanoidiQ8NG35.
OMAiRLNFLCC.
OrthoDBiEOG7P02MN.
PhylomeDBiQ8NG35.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NG35-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALIRKTFYF LFAMFFILVQ LPSGCQAGLD FSQPFPSGEF AVCESCKLGR
60 70
GKCRKECLEN EKPDGNCRLN FLCCRQRI
Length:78
Mass (Da):8,923
Last modified:October 1, 2002 - v1
Checksum:iA0B07B01A7F41A05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB089180 mRNA. Translation: BAC10630.1.
BC128437 mRNA. Translation: AAI28438.1.
BC128438 mRNA. Translation: AAI28439.1.
AF540977 mRNA. Translation: AAN33113.1.
CCDSiCCDS34814.1.
CCDS34832.1.
RefSeqiNP_001035793.1. NM_001040703.2.
NP_689463.1. NM_152250.2.
UniGeneiHs.381378.

Genome annotation databases

EnsembliENST00000334773; ENSP00000334330; ENSG00000186562.
ENST00000335510; ENSP00000335281; ENSG00000186599.
ENST00000611610; ENSP00000482176; ENSG00000274729.
GeneIDi245908.
504180.
KEGGihsa:245908.
hsa:504180.
UCSCiuc011kwp.2. human.

Polymorphism databases

DMDMi37077353.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB089180 mRNA. Translation: BAC10630.1 .
BC128437 mRNA. Translation: AAI28438.1 .
BC128438 mRNA. Translation: AAI28439.1 .
AF540977 mRNA. Translation: AAN33113.1 .
CCDSi CCDS34814.1.
CCDS34832.1.
RefSeqi NP_001035793.1. NM_001040703.2.
NP_689463.1. NM_152250.2.
UniGenei Hs.381378.

3D structure databases

ProteinModelPortali Q8NG35.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000334330.

Polymorphism databases

DMDMi 37077353.

Proteomic databases

PRIDEi Q8NG35.

Protocols and materials databases

DNASUi 245908.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000334773 ; ENSP00000334330 ; ENSG00000186562 .
ENST00000335510 ; ENSP00000335281 ; ENSG00000186599 .
ENST00000611610 ; ENSP00000482176 ; ENSG00000274729 .
GeneIDi 245908.
504180.
KEGGi hsa:245908.
hsa:504180.
UCSCi uc011kwp.2. human.

Organism-specific databases

CTDi 245908.
504180.
GeneCardsi GC08M007679.
GC08P007334.
HGNCi HGNC:18087. DEFB105A.
HGNC:29930. DEFB105B.
neXtProti NX_Q8NG35.
PharmGKBi PA142671991.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44763.
GeneTreei ENSGT00390000002317.
HOGENOMi HOG000112136.
HOVERGENi HBG051284.
InParanoidi Q8NG35.
OMAi RLNFLCC.
OrthoDBi EOG7P02MN.
PhylomeDBi Q8NG35.

Enzyme and pathway databases

Reactomei REACT_115846. Defensins.
REACT_115897. Beta defensins.

Miscellaneous databases

GeneWikii DEFB105A.
NextBioi 91745.
PROi Q8NG35.

Gene expression databases

Bgeei Q8NG35.
CleanExi HS_DEFB105A.
Genevestigatori Q8NG35.

Family and domain databases

InterProi IPR025933. Beta_defensin.
[Graphical view ]
Pfami PF13841. Defensin_beta_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice."
    Yamaguchi Y., Nagase T., Makita R., Fukuhara S., Tomita T., Tominaga T., Kurihara H., Ouchi Y.
    J. Immunol. 169:2516-2523(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Epididymis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Duplication and selection in the evolution of primate beta-defensin genes."
    Semple C.A.M., Rolfe M., Dorin J.R.
    Genome Biol. 4:R31.1-R31.11(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-77.

Entry informationi

Entry nameiD105A_HUMAN
AccessioniPrimary (citable) accession number: Q8NG35
Secondary accession number(s): A1A581, Q8IZN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3