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Q8NG35

- D105A_HUMAN

UniProt

Q8NG35 - D105A_HUMAN

Protein

Beta-defensin 105

Gene

DEFB105A

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Has antibacterial activity.Curated

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Defensin

    Enzyme and pathway databases

    ReactomeiREACT_115846. Defensins.
    REACT_115897. Beta defensins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-defensin 105
    Alternative name(s):
    Beta-defensin 5
    Short name:
    BD-5
    Short name:
    DEFB-5
    Defensin, beta 105
    Gene namesi
    Name:DEFB105A
    Synonyms:BD5, DEFB105, DEFB5
    AND
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:18087. DEFB105A.
    HGNC:29930. DEFB105B.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671991.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Peptidei28 – 7851Beta-defensin 105PRO_0000006975Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi43 ↔ 74By similarity
    Disulfide bondi53 ↔ 67By similarity
    Disulfide bondi57 ↔ 73By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ8NG35.

    Expressioni

    Tissue specificityi

    Specifically expressed in testis.

    Gene expression databases

    BgeeiQ8NG35.
    CleanExiHS_DEFB105A.
    GenevestigatoriQ8NG35.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000334330.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NG35.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-defensin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44763.
    HOGENOMiHOG000112136.
    HOVERGENiHBG051284.
    InParanoidiQ8NG35.
    OMAiRLNFLCC.
    OrthoDBiEOG7P02MN.
    PhylomeDBiQ8NG35.

    Family and domain databases

    InterProiIPR025933. Beta_defensin.
    [Graphical view]
    PfamiPF13841. Defensin_beta_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8NG35-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALIRKTFYF LFAMFFILVQ LPSGCQAGLD FSQPFPSGEF AVCESCKLGR   50
    GKCRKECLEN EKPDGNCRLN FLCCRQRI 78
    Length:78
    Mass (Da):8,923
    Last modified:October 1, 2002 - v1
    Checksum:iA0B07B01A7F41A05
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB089180 mRNA. Translation: BAC10630.1.
    BC128437 mRNA. Translation: AAI28438.1.
    BC128438 mRNA. Translation: AAI28439.1.
    AF540977 mRNA. Translation: AAN33113.1.
    CCDSiCCDS34814.1.
    CCDS34832.1.
    RefSeqiNP_001035793.1. NM_001040703.2.
    NP_689463.1. NM_152250.2.
    UniGeneiHs.381378.

    Genome annotation databases

    EnsembliENST00000334773; ENSP00000334330; ENSG00000186562.
    ENST00000335510; ENSP00000335281; ENSG00000186599.
    GeneIDi245908.
    504180.
    KEGGihsa:245908.
    hsa:504180.
    UCSCiuc011kwp.2. human.

    Polymorphism databases

    DMDMi37077353.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB089180 mRNA. Translation: BAC10630.1 .
    BC128437 mRNA. Translation: AAI28438.1 .
    BC128438 mRNA. Translation: AAI28439.1 .
    AF540977 mRNA. Translation: AAN33113.1 .
    CCDSi CCDS34814.1.
    CCDS34832.1.
    RefSeqi NP_001035793.1. NM_001040703.2.
    NP_689463.1. NM_152250.2.
    UniGenei Hs.381378.

    3D structure databases

    ProteinModelPortali Q8NG35.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000334330.

    Polymorphism databases

    DMDMi 37077353.

    Proteomic databases

    PRIDEi Q8NG35.

    Protocols and materials databases

    DNASUi 245908.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000334773 ; ENSP00000334330 ; ENSG00000186562 .
    ENST00000335510 ; ENSP00000335281 ; ENSG00000186599 .
    GeneIDi 245908.
    504180.
    KEGGi hsa:245908.
    hsa:504180.
    UCSCi uc011kwp.2. human.

    Organism-specific databases

    CTDi 245908.
    504180.
    GeneCardsi GC08M007679.
    GC08P007334.
    HGNCi HGNC:18087. DEFB105A.
    HGNC:29930. DEFB105B.
    neXtProti NX_Q8NG35.
    PharmGKBi PA142671991.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44763.
    HOGENOMi HOG000112136.
    HOVERGENi HBG051284.
    InParanoidi Q8NG35.
    OMAi RLNFLCC.
    OrthoDBi EOG7P02MN.
    PhylomeDBi Q8NG35.

    Enzyme and pathway databases

    Reactomei REACT_115846. Defensins.
    REACT_115897. Beta defensins.

    Miscellaneous databases

    GeneWikii DEFB105A.
    NextBioi 91745.
    PROi Q8NG35.

    Gene expression databases

    Bgeei Q8NG35.
    CleanExi HS_DEFB105A.
    Genevestigatori Q8NG35.

    Family and domain databases

    InterProi IPR025933. Beta_defensin.
    [Graphical view ]
    Pfami PF13841. Defensin_beta_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice."
      Yamaguchi Y., Nagase T., Makita R., Fukuhara S., Tomita T., Tominaga T., Kurihara H., Ouchi Y.
      J. Immunol. 169:2516-2523(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Epididymis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Duplication and selection in the evolution of primate beta-defensin genes."
      Semple C.A.M., Rolfe M., Dorin J.R.
      Genome Biol. 4:R31.1-R31.11(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-77.

    Entry informationi

    Entry nameiD105A_HUMAN
    AccessioniPrimary (citable) accession number: Q8NG35
    Secondary accession number(s): A1A581, Q8IZN8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3