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Q8NG35 (D105A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-defensin 105
Alternative name(s):
Beta-defensin 5
Short name=BD-5
Short name=DEFB-5
Defensin, beta 105
Gene names
Name:DEFB105A
Synonyms:BD5, DEFB105, DEFB5
AND
Name:DEFB105B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length78 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has antibacterial activity Potential.

Subcellular location

Secreted.

Tissue specificity

Specifically expressed in testis.

Sequence similarities

Belongs to the beta-defensin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionAntibiotic
Antimicrobial
Defensin
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdefense response to bacterium

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Peptide28 – 7851Beta-defensin 105
PRO_0000006975

Amino acid modifications

Disulfide bond43 ↔ 74 By similarity
Disulfide bond53 ↔ 67 By similarity
Disulfide bond57 ↔ 73 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8NG35 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: A0B07B01A7F41A05

FASTA788,923
        10         20         30         40         50         60 
MALIRKTFYF LFAMFFILVQ LPSGCQAGLD FSQPFPSGEF AVCESCKLGR GKCRKECLEN 

        70 
EKPDGNCRLN FLCCRQRI 

« Hide

References

« Hide 'large scale' references
[1]"Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice."
Yamaguchi Y., Nagase T., Makita R., Fukuhara S., Tomita T., Tominaga T., Kurihara H., Ouchi Y.
J. Immunol. 169:2516-2523(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Epididymis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Duplication and selection in the evolution of primate beta-defensin genes."
Semple C.A.M., Rolfe M., Dorin J.R.
Genome Biol. 4:R31.1-R31.11(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-77.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB089180 mRNA. Translation: BAC10630.1.
BC128437 mRNA. Translation: AAI28438.1.
BC128438 mRNA. Translation: AAI28439.1.
AF540977 mRNA. Translation: AAN33113.1.
CCDSCCDS34814.1.
CCDS34832.1.
RefSeqNP_001035793.1. NM_001040703.2.
NP_689463.1. NM_152250.2.
UniGeneHs.381378.

3D structure databases

ProteinModelPortalQ8NG35.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000334330.

Polymorphism databases

DMDM37077353.

Proteomic databases

PRIDEQ8NG35.

Protocols and materials databases

DNASU245908.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000334773; ENSP00000334330; ENSG00000186562.
ENST00000335510; ENSP00000335281; ENSG00000186599.
GeneID245908.
504180.
KEGGhsa:245908.
hsa:504180.
UCSCuc011kwp.2. human.

Organism-specific databases

CTD245908.
504180.
GeneCardsGC08M007679.
GC08P007334.
HGNCHGNC:18087. DEFB105A.
HGNC:29930. DEFB105B.
neXtProtNX_Q8NG35.
PharmGKBPA142671991.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44763.
HOGENOMHOG000112136.
HOVERGENHBG051284.
InParanoidQ8NG35.
OMARLNFLCC.
OrthoDBEOG7P02MN.
PhylomeDBQ8NG35.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

BgeeQ8NG35.
CleanExHS_DEFB105A.
GenevestigatorQ8NG35.

Family and domain databases

InterProIPR025933. Beta_defensin.
[Graphical view]
PfamPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiDEFB105A.
NextBio91745.
PROQ8NG35.

Entry information

Entry nameD105A_HUMAN
AccessionPrimary (citable) accession number: Q8NG35
Secondary accession number(s): A1A581, Q8IZN8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM