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Protein

Beta-defensin 105

Gene

DEFB105A

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has antibacterial activity.Curated

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957. Beta defensins.
R-HSA-1461973. Defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 105
Alternative name(s):
Beta-defensin 5
Short name:
BD-5
Short name:
DEFB-5
Defensin, beta 105
Gene namesi
Name:DEFB105A
Synonyms:BD5, DEFB105, DEFB5
AND
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000186562.7.
HostDB:ENSG00000186599.7.
HGNCiHGNC:18087. DEFB105A.
HGNC:29930. DEFB105B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi245908.
OpenTargetsiENSG00000186599.
PharmGKBiPA142671991.

Polymorphism and mutation databases

BioMutaiDEFB105A.
DMDMi37077353.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
PeptideiPRO_000000697528 – 78Beta-defensin 105Add BLAST51

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 74By similarity
Disulfide bondi53 ↔ 67By similarity
Disulfide bondi57 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8NG35.
PeptideAtlasiQ8NG35.
PRIDEiQ8NG35.

Expressioni

Tissue specificityi

Specifically expressed in testis.

Gene expression databases

BgeeiENSG00000186562.
CleanExiHS_DEFB105A.
GenevisibleiQ8NG35. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000335281.

Structurei

3D structure databases

ProteinModelPortaliQ8NG35.
SMRiQ8NG35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4YU. Eukaryota.
ENOG411168M. LUCA.
GeneTreeiENSGT00390000002317.
HOGENOMiHOG000112136.
HOVERGENiHBG051284.
InParanoidiQ8NG35.
OMAiRTCIESE.
OrthoDBiEOG091G135R.
PhylomeDBiQ8NG35.

Family and domain databases

InterProiView protein in InterPro
IPR025933. Beta_defensin.
PANTHERiPTHR15001. PTHR15001. 1 hit.
PfamiView protein in Pfam
PF13841. Defensin_beta_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NG35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALIRKTFYF LFAMFFILVQ LPSGCQAGLD FSQPFPSGEF AVCESCKLGR
60 70
GKCRKECLEN EKPDGNCRLN FLCCRQRI
Length:78
Mass (Da):8,923
Last modified:October 1, 2002 - v1
Checksum:iA0B07B01A7F41A05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB089180 mRNA. Translation: BAC10630.1.
BC128437 mRNA. Translation: AAI28438.1.
BC128438 mRNA. Translation: AAI28439.1.
AF540977 mRNA. Translation: AAN33113.1.
CCDSiCCDS34814.1.
CCDS34832.1.
RefSeqiNP_001035793.1. NM_001040703.2.
NP_689463.1. NM_152250.2.
UniGeneiHs.381378.

Genome annotation databases

EnsembliENST00000334773; ENSP00000334330; ENSG00000186562.
ENST00000335510; ENSP00000335281; ENSG00000186599.
ENST00000611610; ENSP00000482176; ENSG00000274729.
GeneIDi245908.
504180.
KEGGihsa:245908.
hsa:504180.
UCSCiuc011kwp.3. human.

Similar proteinsi

Entry informationi

Entry nameiD105A_HUMAN
AccessioniPrimary (citable) accession number: Q8NG35
Secondary accession number(s): A1A581, Q8IZN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families