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Protein

Tetraspanin-14

Gene

TSPAN14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

GO - Biological processi

  • establishment of protein localization to plasma membrane Source: UniProtKB
  • positive regulation of Notch signaling pathway Source: UniProtKB
  • protein maturation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-14
Short name:
Tspan-14
Alternative name(s):
DC-TM4F2
Transmembrane 4 superfamily member 14
Gene namesi
Name:TSPAN14
Synonyms:TM4SF14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23303. TSPAN14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821HelicalSequence analysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence analysisAdd
BLAST
Transmembranei93 – 11321HelicalSequence analysisAdd
BLAST
Transmembranei233 – 25321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394731.

Polymorphism and mutation databases

BioMutaiTSPAN14.
DMDMi55976537.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Tetraspanin-14PRO_0000219261Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8NG11.
MaxQBiQ8NG11.
PaxDbiQ8NG11.
PRIDEiQ8NG11.

PTM databases

iPTMnetiQ8NG11.
PhosphoSiteiQ8NG11.
SwissPalmiQ8NG11.

Expressioni

Gene expression databases

BgeeiQ8NG11.
CleanExiHS_TSPAN14.
ExpressionAtlasiQ8NG11. baseline and differential.
GenevisibleiQ8NG11. HS.

Organism-specific databases

HPAiHPA014773.
HPA057174.

Interactioni

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi123554. 4 interactions.
IntActiQ8NG11. 2 interactions.
MINTiMINT-6941206.
STRINGi9606.ENSP00000361229.

Structurei

3D structure databases

ProteinModelPortaliQ8NG11.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230652.
HOVERGENiHBG108605.
InParanoidiQ8NG11.
KOiK17296.
OMAiEDWLPRN.
OrthoDBiEOG73FQNF.
PhylomeDBiQ8NG11.
TreeFamiTF313002.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NG11-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHYYRYSNAK VSCWYKYLLF SYNIIFWLAG VVFLGVGLWA WSEKGVLSDL
60 70 80 90 100
TKVTRMHGID PVVLVLMVGV VMFTLGFAGC VGALRENICL LNFFCGTIVL
110 120 130 140 150
IFFLELAVAV LAFLFQDWVR DRFREFFESN IKSYRDDIDL QNLIDSLQKA
160 170 180 190 200
NQCCGAYGPE DWDLNVYFNC SGASYSREKC GVPFSCCVPD PAQKVVNTQC
210 220 230 240 250
GYDVRIQLKS KWDESIFTKG CIQALESWLP RNIYIVAGVF IAISLLQIFG
260 270
IFLARTLISD IEAVKAGHHF
Length:270
Mass (Da):30,691
Last modified:October 1, 2002 - v1
Checksum:iC74D64CDC52DF107
GO
Isoform 2 (identifier: Q8NG11-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-44: Missing.

Show »
Length:253
Mass (Da):28,877
Checksum:iF83140442CFCAC16
GO
Isoform 3 (identifier: Q8NG11-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-150: Missing.

Note: No experimental confirmation available.
Show »
Length:147
Mass (Da):16,902
Checksum:i8F58678C7AF340B5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti143 – 1431L → V in CAB66573 (PubMed:11230166).Curated
Sequence conflicti268 – 2681H → R in CAB66573 (PubMed:11230166).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei28 – 150123Missing in isoform 3. 1 PublicationVSP_043194Add
BLAST
Alternative sequencei28 – 4417Missing in isoform 2. 1 PublicationVSP_011878Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311903 mRNA. Translation: AAM94899.1.
AL136638 mRNA. Translation: CAB66573.1.
AK295321 mRNA. Translation: BAG58298.1.
AC021028 Genomic DNA. No translation available.
CH471142 Genomic DNA. Translation: EAW80384.1.
CH471142 Genomic DNA. Translation: EAW80385.1.
CH471142 Genomic DNA. Translation: EAW80386.1.
CH471142 Genomic DNA. Translation: EAW80388.1.
CH471142 Genomic DNA. Translation: EAW80389.1.
BC002920 mRNA. Translation: AAH02920.1.
BC093016 mRNA. Translation: AAH93016.1.
CCDSiCCDS44448.1. [Q8NG11-3]
CCDS7369.1. [Q8NG11-1]
RefSeqiNP_001121781.1. NM_001128309.1. [Q8NG11-3]
NP_112189.2. NM_030927.2. [Q8NG11-1]
XP_006718055.1. XM_006717992.2. [Q8NG11-1]
XP_011538524.1. XM_011540222.1. [Q8NG11-1]
UniGeneiHs.718943.

Genome annotation databases

EnsembliENST00000372156; ENSP00000361229; ENSG00000108219. [Q8NG11-1]
ENST00000372158; ENSP00000361231; ENSG00000108219. [Q8NG11-1]
ENST00000372164; ENSP00000361237; ENSG00000108219. [Q8NG11-2]
ENST00000429989; ENSP00000396270; ENSG00000108219. [Q8NG11-1]
ENST00000481124; ENSP00000418195; ENSG00000108219. [Q8NG11-3]
ENST00000616406; ENSP00000480263; ENSG00000108219. [Q8NG11-2]
GeneIDi81619.
KEGGihsa:81619.
UCSCiuc001kci.5. human. [Q8NG11-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311903 mRNA. Translation: AAM94899.1.
AL136638 mRNA. Translation: CAB66573.1.
AK295321 mRNA. Translation: BAG58298.1.
AC021028 Genomic DNA. No translation available.
CH471142 Genomic DNA. Translation: EAW80384.1.
CH471142 Genomic DNA. Translation: EAW80385.1.
CH471142 Genomic DNA. Translation: EAW80386.1.
CH471142 Genomic DNA. Translation: EAW80388.1.
CH471142 Genomic DNA. Translation: EAW80389.1.
BC002920 mRNA. Translation: AAH02920.1.
BC093016 mRNA. Translation: AAH93016.1.
CCDSiCCDS44448.1. [Q8NG11-3]
CCDS7369.1. [Q8NG11-1]
RefSeqiNP_001121781.1. NM_001128309.1. [Q8NG11-3]
NP_112189.2. NM_030927.2. [Q8NG11-1]
XP_006718055.1. XM_006717992.2. [Q8NG11-1]
XP_011538524.1. XM_011540222.1. [Q8NG11-1]
UniGeneiHs.718943.

3D structure databases

ProteinModelPortaliQ8NG11.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123554. 4 interactions.
IntActiQ8NG11. 2 interactions.
MINTiMINT-6941206.
STRINGi9606.ENSP00000361229.

PTM databases

iPTMnetiQ8NG11.
PhosphoSiteiQ8NG11.
SwissPalmiQ8NG11.

Polymorphism and mutation databases

BioMutaiTSPAN14.
DMDMi55976537.

Proteomic databases

EPDiQ8NG11.
MaxQBiQ8NG11.
PaxDbiQ8NG11.
PRIDEiQ8NG11.

Protocols and materials databases

DNASUi81619.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372156; ENSP00000361229; ENSG00000108219. [Q8NG11-1]
ENST00000372158; ENSP00000361231; ENSG00000108219. [Q8NG11-1]
ENST00000372164; ENSP00000361237; ENSG00000108219. [Q8NG11-2]
ENST00000429989; ENSP00000396270; ENSG00000108219. [Q8NG11-1]
ENST00000481124; ENSP00000418195; ENSG00000108219. [Q8NG11-3]
ENST00000616406; ENSP00000480263; ENSG00000108219. [Q8NG11-2]
GeneIDi81619.
KEGGihsa:81619.
UCSCiuc001kci.5. human. [Q8NG11-1]

Organism-specific databases

CTDi81619.
GeneCardsiTSPAN14.
HGNCiHGNC:23303. TSPAN14.
HPAiHPA014773.
HPA057174.
neXtProtiNX_Q8NG11.
PharmGKBiPA128394731.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230652.
HOVERGENiHBG108605.
InParanoidiQ8NG11.
KOiK17296.
OMAiEDWLPRN.
OrthoDBiEOG73FQNF.
PhylomeDBiQ8NG11.
TreeFamiTF313002.

Miscellaneous databases

ChiTaRSiTSPAN14. human.
GenomeRNAii81619.
PROiQ8NG11.

Gene expression databases

BgeeiQ8NG11.
CleanExiHS_TSPAN14.
ExpressionAtlasiQ8NG11. baseline and differential.
GenevisibleiQ8NG11. HS.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel membrane proteins."
    Zhang W., Li N., Wan T., Cao X.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Caudate nucleus.
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta and Skin.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTSN14_HUMAN
AccessioniPrimary (citable) accession number: Q8NG11
Secondary accession number(s): A6NHE1
, B4DHY6, D3DWD7, D3DWD8, Q567U7, Q9BU34, Q9H0U1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.