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Protein

Tetraspanin-14

Gene

TSPAN14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26668317, PubMed:23035126, PubMed:26686862). Negatively regulates ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity).By similarity3 Publications

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

GO - Biological processi

  • establishment of protein localization to plasma membrane Source: UniProtKB
  • positive regulation of Notch signaling pathway Source: UniProtKB
  • protein maturation Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-14
Short name:
Tspan-14
Alternative name(s):
DC-TM4F2
Transmembrane 4 superfamily member 14
Gene namesi
Name:TSPAN14
Synonyms:TM4SF14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23303. TSPAN14.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicCuratedAdd BLAST17
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Topological domaini39 – 61ExtracellularCuratedAdd BLAST23
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 92CytoplasmicCurated10
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Topological domaini114 – 232ExtracellularCuratedAdd BLAST119
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Topological domaini254 – 270CytoplasmicCuratedAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi81619.
OpenTargetsiENSG00000108219.
PharmGKBiPA128394731.

Polymorphism and mutation databases

BioMutaiTSPAN14.
DMDMi55976537.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192611 – 270Tetraspanin-14Add BLAST270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi169N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8NG11.
MaxQBiQ8NG11.
PaxDbiQ8NG11.
PeptideAtlasiQ8NG11.
PRIDEiQ8NG11.

PTM databases

iPTMnetiQ8NG11.
PhosphoSitePlusiQ8NG11.
SwissPalmiQ8NG11.

Expressioni

Gene expression databases

BgeeiENSG00000108219.
CleanExiHS_TSPAN14.
ExpressionAtlasiQ8NG11. baseline and differential.
GenevisibleiQ8NG11. HS.

Organism-specific databases

HPAiHPA014773.
HPA057174.

Interactioni

Subunit structurei

Interacts with ADAM10; the interaction promotes ADAM10 maturation and cell surface expression.3 Publications

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi123554. 4 interactors.
IntActiQ8NG11. 2 interactors.
MINTiMINT-6941206.
STRINGi9606.ENSP00000361229.

Structurei

3D structure databases

ProteinModelPortaliQ8NG11.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni114 – 232Necessary and sufficient for interaction with ADAM101 PublicationAdd BLAST119

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230652.
HOVERGENiHBG108605.
InParanoidiQ8NG11.
KOiK17296.
OMAiEDWLPRN.
OrthoDBiEOG091G0CHZ.
PhylomeDBiQ8NG11.
TreeFamiTF313002.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NG11-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHYYRYSNAK VSCWYKYLLF SYNIIFWLAG VVFLGVGLWA WSEKGVLSDL
60 70 80 90 100
TKVTRMHGID PVVLVLMVGV VMFTLGFAGC VGALRENICL LNFFCGTIVL
110 120 130 140 150
IFFLELAVAV LAFLFQDWVR DRFREFFESN IKSYRDDIDL QNLIDSLQKA
160 170 180 190 200
NQCCGAYGPE DWDLNVYFNC SGASYSREKC GVPFSCCVPD PAQKVVNTQC
210 220 230 240 250
GYDVRIQLKS KWDESIFTKG CIQALESWLP RNIYIVAGVF IAISLLQIFG
260 270
IFLARTLISD IEAVKAGHHF
Length:270
Mass (Da):30,691
Last modified:October 1, 2002 - v1
Checksum:iC74D64CDC52DF107
GO
Isoform 2 (identifier: Q8NG11-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-44: Missing.

Show »
Length:253
Mass (Da):28,877
Checksum:iF83140442CFCAC16
GO
Isoform 3 (identifier: Q8NG11-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-150: Missing.

Note: No experimental confirmation available.
Show »
Length:147
Mass (Da):16,902
Checksum:i8F58678C7AF340B5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti143L → V in CAB66573 (PubMed:11230166).Curated1
Sequence conflicti268H → R in CAB66573 (PubMed:11230166).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04319428 – 150Missing in isoform 3. 1 PublicationAdd BLAST123
Alternative sequenceiVSP_01187828 – 44Missing in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311903 mRNA. Translation: AAM94899.1.
AL136638 mRNA. Translation: CAB66573.1.
AK295321 mRNA. Translation: BAG58298.1.
AC021028 Genomic DNA. No translation available.
CH471142 Genomic DNA. Translation: EAW80384.1.
CH471142 Genomic DNA. Translation: EAW80385.1.
CH471142 Genomic DNA. Translation: EAW80386.1.
CH471142 Genomic DNA. Translation: EAW80388.1.
CH471142 Genomic DNA. Translation: EAW80389.1.
BC002920 mRNA. Translation: AAH02920.1.
BC093016 mRNA. Translation: AAH93016.1.
CCDSiCCDS44448.1. [Q8NG11-3]
CCDS7369.1. [Q8NG11-1]
RefSeqiNP_001121781.1. NM_001128309.1. [Q8NG11-3]
NP_112189.2. NM_030927.2. [Q8NG11-1]
XP_006718055.1. XM_006717992.3. [Q8NG11-1]
XP_011538524.1. XM_011540222.2. [Q8NG11-1]
XP_016872196.1. XM_017016707.1. [Q8NG11-1]
XP_016872197.1. XM_017016708.1. [Q8NG11-1]
XP_016872198.1. XM_017016709.1. [Q8NG11-1]
XP_016872199.1. XM_017016710.1. [Q8NG11-1]
XP_016872200.1. XM_017016711.1. [Q8NG11-1]
UniGeneiHs.718943.

Genome annotation databases

EnsembliENST00000372156; ENSP00000361229; ENSG00000108219. [Q8NG11-1]
ENST00000372158; ENSP00000361231; ENSG00000108219. [Q8NG11-1]
ENST00000372164; ENSP00000361237; ENSG00000108219. [Q8NG11-2]
ENST00000429989; ENSP00000396270; ENSG00000108219. [Q8NG11-1]
ENST00000481124; ENSP00000418195; ENSG00000108219. [Q8NG11-3]
ENST00000616406; ENSP00000480263; ENSG00000108219. [Q8NG11-2]
GeneIDi81619.
KEGGihsa:81619.
UCSCiuc001kci.5. human. [Q8NG11-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311903 mRNA. Translation: AAM94899.1.
AL136638 mRNA. Translation: CAB66573.1.
AK295321 mRNA. Translation: BAG58298.1.
AC021028 Genomic DNA. No translation available.
CH471142 Genomic DNA. Translation: EAW80384.1.
CH471142 Genomic DNA. Translation: EAW80385.1.
CH471142 Genomic DNA. Translation: EAW80386.1.
CH471142 Genomic DNA. Translation: EAW80388.1.
CH471142 Genomic DNA. Translation: EAW80389.1.
BC002920 mRNA. Translation: AAH02920.1.
BC093016 mRNA. Translation: AAH93016.1.
CCDSiCCDS44448.1. [Q8NG11-3]
CCDS7369.1. [Q8NG11-1]
RefSeqiNP_001121781.1. NM_001128309.1. [Q8NG11-3]
NP_112189.2. NM_030927.2. [Q8NG11-1]
XP_006718055.1. XM_006717992.3. [Q8NG11-1]
XP_011538524.1. XM_011540222.2. [Q8NG11-1]
XP_016872196.1. XM_017016707.1. [Q8NG11-1]
XP_016872197.1. XM_017016708.1. [Q8NG11-1]
XP_016872198.1. XM_017016709.1. [Q8NG11-1]
XP_016872199.1. XM_017016710.1. [Q8NG11-1]
XP_016872200.1. XM_017016711.1. [Q8NG11-1]
UniGeneiHs.718943.

3D structure databases

ProteinModelPortaliQ8NG11.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123554. 4 interactors.
IntActiQ8NG11. 2 interactors.
MINTiMINT-6941206.
STRINGi9606.ENSP00000361229.

PTM databases

iPTMnetiQ8NG11.
PhosphoSitePlusiQ8NG11.
SwissPalmiQ8NG11.

Polymorphism and mutation databases

BioMutaiTSPAN14.
DMDMi55976537.

Proteomic databases

EPDiQ8NG11.
MaxQBiQ8NG11.
PaxDbiQ8NG11.
PeptideAtlasiQ8NG11.
PRIDEiQ8NG11.

Protocols and materials databases

DNASUi81619.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372156; ENSP00000361229; ENSG00000108219. [Q8NG11-1]
ENST00000372158; ENSP00000361231; ENSG00000108219. [Q8NG11-1]
ENST00000372164; ENSP00000361237; ENSG00000108219. [Q8NG11-2]
ENST00000429989; ENSP00000396270; ENSG00000108219. [Q8NG11-1]
ENST00000481124; ENSP00000418195; ENSG00000108219. [Q8NG11-3]
ENST00000616406; ENSP00000480263; ENSG00000108219. [Q8NG11-2]
GeneIDi81619.
KEGGihsa:81619.
UCSCiuc001kci.5. human. [Q8NG11-1]

Organism-specific databases

CTDi81619.
DisGeNETi81619.
GeneCardsiTSPAN14.
HGNCiHGNC:23303. TSPAN14.
HPAiHPA014773.
HPA057174.
neXtProtiNX_Q8NG11.
OpenTargetsiENSG00000108219.
PharmGKBiPA128394731.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230652.
HOVERGENiHBG108605.
InParanoidiQ8NG11.
KOiK17296.
OMAiEDWLPRN.
OrthoDBiEOG091G0CHZ.
PhylomeDBiQ8NG11.
TreeFamiTF313002.

Enzyme and pathway databases

ReactomeiR-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiTSPAN14. human.
GenomeRNAii81619.
PROiQ8NG11.

Gene expression databases

BgeeiENSG00000108219.
CleanExiHS_TSPAN14.
ExpressionAtlasiQ8NG11. baseline and differential.
GenevisibleiQ8NG11. HS.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSN14_HUMAN
AccessioniPrimary (citable) accession number: Q8NG11
Secondary accession number(s): A6NHE1
, B4DHY6, D3DWD7, D3DWD8, Q567U7, Q9BU34, Q9H0U1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.