Q8NG11 (TSN14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tetraspanin-14
Short name=Tspan-14

Alternative name(s):
DC-TM4F2
Transmembrane 4 superfamily member 14

Gene names

Name:	TSPAN14
Synonyms:	TM4SF14

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Probable.
Sequence similarities	Belongs to the tetraspanin (TM4SF) family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NG11-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NG11-2)

The sequence of this isoform differs from the canonical sequence as follows:
     28-44: Missing.

Isoform 3 (identifier: Q8NG11-3)

The sequence of this isoform differs from the canonical sequence as follows:
     28-150: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 270	270	Tetraspanin-14		PRO_0000219261
Regions
	Transmembrane	18 – 38	21	Helical; Potential
	Transmembrane	62 – 82	21	Helical; Potential
	Transmembrane	93 – 113	21	Helical; Potential
	Transmembrane	233 – 253	21	Helical; Potential
Amino acid modifications
	Glycosylation	169	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	28 – 150	123	Missing in isoform 3.		VSP_043194
	Alternative sequence	28 – 44	17	Missing in isoform 2.		VSP_011878
Experimental info
	Sequence conflict	143	1	L → V in CAB66573. Ref.2
	Sequence conflict	268	1	H → R in CAB66573. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: C74D64CDC52DF107	FASTA	270	30,691
	10 20 30 40 50 60 MHYYRYSNAK VSCWYKYLLF SYNIIFWLAG VVFLGVGLWA WSEKGVLSDL TKVTRMHGID 70 80 90 100 110 120 PVVLVLMVGV VMFTLGFAGC VGALRENICL LNFFCGTIVL IFFLELAVAV LAFLFQDWVR 130 140 150 160 170 180 DRFREFFESN IKSYRDDIDL QNLIDSLQKA NQCCGAYGPE DWDLNVYFNC SGASYSREKC 190 200 210 220 230 240 GVPFSCCVPD PAQKVVNTQC GYDVRIQLKS KWDESIFTKG CIQALESWLP RNIYIVAGVF 250 260 270 IAISLLQIFG IFLARTLISD IEAVKAGHHF
	Isoform 2 [UniParc]. Checksum: F83140442CFCAC16	FASTA	253	28,877
	10 20 30 40 50 60 MHYYRYSNAK VSCWYKYLLF SYNIIFWGVL SDLTKVTRMH GIDPVVLVLM VGVVMFTLGF 70 80 90 100 110 120 AGCVGALREN ICLLNFFCGT IVLIFFLELA VAVLAFLFQD WVRDRFREFF ESNIKSYRDD 130 140 150 160 170 180 IDLQNLIDSL QKANQCCGAY GPEDWDLNVY FNCSGASYSR EKCGVPFSCC VPDPAQKVVN 190 200 210 220 230 240 TQCGYDVRIQ LKSKWDESIF TKGCIQALES WLPRNIYIVA GVFIAISLLQ IFGIFLARTL 250 ISDIEAVKAG HHF
	Isoform 3 [UniParc]. Checksum: 8F58678C7AF340B5	FASTA	147	16,902
	10 20 30 40 50 60 MHYYRYSNAK VSCWYKYLLF SYNIIFWNQC CGAYGPEDWD LNVYFNCSGA SYSREKCGVP 70 80 90 100 110 120 FSCCVPDPAQ KVVNTQCGYD VRIQLKSKWD ESIFTKGCIQ ALESWLPRNI YIVAGVFIAI 130 140 SLLQIFGIFL ARTLISDIEA VKAGHHF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of novel membrane proteins." Zhang W., Li N., Wan T., Cao X. Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Caudate nucleus.
[4]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Placenta and Skin.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF311903 mRNA. Translation: AAM94899.1. AL136638 mRNA. Translation: CAB66573.1. AK295321 mRNA. Translation: BAG58298.1. AC021028 Genomic DNA. No translation available. CH471142 Genomic DNA. Translation: EAW80384.1. CH471142 Genomic DNA. Translation: EAW80385.1. CH471142 Genomic DNA. Translation: EAW80386.1. CH471142 Genomic DNA. Translation: EAW80388.1. CH471142 Genomic DNA. Translation: EAW80389.1. BC002920 mRNA. Translation: AAH02920.1. BC093016 mRNA. Translation: AAH93016.1.
IPI	IPI00165394. IPI00303059. IPI00641869.
RefSeq	NP_001121781.1. NM_001128309.1. NP_112189.2. NM_030927.2.
UniGene	Hs.718943.
3D structure databases
ProteinModelPortal	Q8NG11.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8NG11. 1 interaction.
STRING	9606.ENSP00000361229.
PTM databases
PhosphoSite	Q8NG11.
Polymorphism databases
DMDM	55976537.
Proteomic databases
PaxDb	Q8NG11.
PRIDE	Q8NG11.
Protocols and materials databases
DNASU	81619.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000372156; ENSP00000361229; ENSG00000108219. ENST00000372158; ENSP00000361231; ENSG00000108219. ENST00000372164; ENSP00000361237; ENSG00000108219. ENST00000429989; ENSP00000396270; ENSG00000108219. ENST00000481124; ENSP00000418195; ENSG00000108219.
GeneID	81619.
KEGG	hsa:81619.
UCSC	uc001kci.4. human. uc001kcj.4. human.
Organism-specific databases
CTD	81619.
GeneCards	GC10P082205.
HGNC	HGNC:23303. TSPAN14.
HPA	HPA014773.
neXtProt	NX_Q8NG11.
PharmGKB	PA128394731.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG312878.
HOGENOM	HOG000230652.
HOVERGEN	HBG108605.
InParanoid	Q8NG11.
OMA	EDWLPRN.
OrthoDB	EOG4FR0S9.
PhylomeDB	Q8NG11.
Gene expression databases
ArrayExpress	Q8NG11.
Bgee	Q8NG11.
CleanEx	HS_TSPAN14.
Genevestigator	Q8NG11.
GermOnline	ENSG00000108219. Homo sapiens.
Family and domain databases
InterPro	IPR000301. Tetraspanin. IPR018499. Tetraspanin/Peripherin. IPR018503. Tetraspanin_CS. IPR008952. Tetraspanin_EC2. [Graphical view]
Pfam	PF00335. Tetraspannin. 1 hit. [Graphical view]
PIRSF	PIRSF002419. Tetraspanin. 1 hit.
PRINTS	PR00259. TMFOUR.
SUPFAM	SSF48652. Tetraspanin. 1 hit.
PROSITE	PS00421. TM4_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TSPAN14. human.
GenomeRNAi	81619.
NextBio	71976.

Entry information

Entry name

TSN14_HUMAN

Accession

Primary (citable) accession number: Q8NG11
Secondary accession number(s): A6NHE1 , B4DHY6, D3DWD7, D3DWD8, Q567U7, Q9BU34, Q9H0U1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
Last sequence update:	October 1, 2002
Last modified:	April 3, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.