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Protein

E3 ubiquitin-protein ligase TRIM58

Gene

TRIM58

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization.1 Publication

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 61RING-typePROSITE-ProRule annotationAdd BLAST46
Zinc fingeri91 – 132B box-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM58 (EC:2.3.2.27)
Alternative name(s):
Protein BIA2
RING-type E3 ubiquitin transferase TRIM58Curated
Tripartite motif-containing protein 58
Gene namesi
Name:TRIM58
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162722.8.
HGNCiHGNC:24150. TRIM58.

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162722.
PharmGKBiPA134942549.

Polymorphism and mutation databases

BioMutaiTRIM58.
DMDMi124053416.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002723011 – 486E3 ubiquitin-protein ligase TRIM58Add BLAST486

Proteomic databases

EPDiQ8NG06.
MaxQBiQ8NG06.
PaxDbiQ8NG06.
PeptideAtlasiQ8NG06.
PRIDEiQ8NG06.

PTM databases

iPTMnetiQ8NG06.
PhosphoSitePlusiQ8NG06.

Expressioni

Tissue specificityi

Expressed in erythroblasts.1 Publication

Gene expression databases

BgeeiENSG00000162722.
CleanExiHS_TRIM58.
GenevisibleiQ8NG06. HS.

Organism-specific databases

HPAiHPA023637.

Interactioni

Protein-protein interaction databases

BioGridi117401. 7 interactors.
STRINGi9606.ENSP00000355437.

Structurei

3D structure databases

ProteinModelPortaliQ8NG06.
SMRiQ8NG06.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini273 – 463B30.2/SPRYPROSITE-ProRule annotationAdd BLAST191

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili193 – 242Sequence analysisAdd BLAST50

Domaini

The RING finger is required for ubiquitin ligase activity.1 Publication

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 61RING-typePROSITE-ProRule annotationAdd BLAST46
Zinc fingeri91 – 132B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG410Z2ZE. LUCA.
GeneTreeiENSGT00760000118893.
HOGENOMiHOG000234133.
HOVERGENiHBG001357.
InParanoidiQ8NG06.
KOiK12027.
OMAiQEANVGK.
OrthoDBiEOG091G05W2.
PhylomeDBiQ8NG06.
TreeFamiTF338674.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001870. B30.2/SPRY.
IPR003879. Butyrophylin_SPRY.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
PfamiView protein in Pfam
PF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiView protein in SMART
SM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NG06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWAPPGERL REDARCPVCL DFLQEPVSVD CGHSFCLRCI SEFCEKSDGA
60 70 80 90 100
QGGVYACPQC RGPFRPSGFR PNRQLAGLVE SVRRLGLGAG PGARRCARHG
110 120 130 140 150
EDLSRFCEED EAALCWVCDA GPEHRTHRTA PLQEAAGSYQ VKLQMALELM
160 170 180 190 200
RKELEDALTQ EANVGKKTVI WKEKVEMQRQ RFRLEFEKHR GFLAQEEQRQ
210 220 230 240 250
LRRLEAEERA TLQRLRESKS RLVQQSKALK ELADELQERC QRPALGLLEG
260 270 280 290 300
VRGVLSRSKA VTRLEAENIP MELKTACCIP GRRELLRKFQ VDVKLDPATA
310 320 330 340 350
HPSLLLTADL RSVQDGEPWR DVPNNPERFD TWPCILGLQS FSSGRHYWEV
360 370 380 390 400
LVGEGAEWGL GVCQDTLPRK GETTPSPENG VWALWLLKGN EYMVLASPSV
410 420 430 440 450
PLLQLESPRC IGIFLDYEAG EISFYNVTDG SYIYTFNQLF SGLLRPYFFI
460 470 480
CDATPLILPP TTIAGSGNWA SRDHLDPASD VRDDHL
Length:486
Mass (Da):54,766
Last modified:January 23, 2007 - v2
Checksum:i3A536C529A850063
GO

Sequence cautioni

The sequence AAM63958 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti292D → G in AAM63958 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0300363W → S1 PublicationCorresponds to variant dbSNP:rs11204523Ensembl.1
Natural variantiVAR_030037322V → I. Corresponds to variant dbSNP:rs1339847Ensembl.1
Natural variantiVAR_030038374T → M1 PublicationCorresponds to variant dbSNP:rs3811444Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327057 mRNA. Translation: AAM63958.1. Different initiation.
BC074748 mRNA. Translation: AAH74748.1.
CCDSiCCDS1636.1.
RefSeqiNP_056246.3. NM_015431.3.
UniGeneiHs.269151.

Genome annotation databases

EnsembliENST00000366481; ENSP00000355437; ENSG00000162722.
GeneIDi25893.
KEGGihsa:25893.
UCSCiuc001ido.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTRI58_HUMAN
AccessioniPrimary (citable) accession number: Q8NG06
Secondary accession number(s): Q6B0H9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. SIMILARITY comments
    Index of protein domains and families