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Protein

Solute carrier family 26 member 10

Gene

SLC26A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Chloride/bicarbonate exchanger.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135502-MONOMER.

Protein family/group databases

TCDBi2.A.53.2.13. the sulfate permease (sulp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 26 member 10
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:14470. SLC26A10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Transmembranei75 – 91HelicalSequence analysisAdd BLAST17
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Transmembranei352 – 372HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000135502.
PharmGKBiPA37887.

Polymorphism and mutation databases

BioMutaiSLC26A10.
DMDMi74715621.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003442301 – 563Solute carrier family 26 member 10Add BLAST563

Proteomic databases

PaxDbiQ8NG04.
PRIDEiQ8NG04.

PTM databases

iPTMnetiQ8NG04.
PhosphoSitePlusiQ8NG04.

Expressioni

Gene expression databases

BgeeiENSG00000135502.
CleanExiHS_SLC26A10.
ExpressionAtlasiQ8NG04. baseline and differential.
GenevisibleiQ8NG04. HS.

Organism-specific databases

HPAiHPA044719.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000320217.

Structurei

3D structure databases

ProteinModelPortaliQ8NG04.
SMRiQ8NG04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini406 – 541STASPROSITE-ProRule annotationAdd BLAST136

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000006546.
HOVERGENiHBG105688.
InParanoidiQ8NG04.
KOiK14707.
OrthoDBiEOG091G07RT.
PhylomeDBiQ8NG04.
TreeFamiTF313784.

Family and domain databases

Gene3Di3.30.750.24. 1 hit.
InterProiIPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR030324. SLC26A10.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 1 hit.
PTHR11814:SF99. PTHR11814:SF99. 1 hit.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 1 hit.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NG04-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLDLASLMS APKSLGSAFK SWRLDKAPSP QHTFPSTSIP GMAFALLASV
60 70 80 90 100
PPVFGLYTSF FPVLIYSLLG TGRHLSTGTF AILSLMTGSA VERLVPEPLV
110 120 130 140 150
GNLSGIEKEQ LDAQRVGVAA AVAFGSGALM LGMFVLQLGV LSTFLSEPVV
160 170 180 190 200
KALTSGAALH VLLSQLPSLL GLSLPRQIGC FSLFKTLASL LTALPRSSPA
210 220 230 240 250
ELTISALSLA LLVPVKELNV RFRDRLPTPI PGEVVLVLLA SVLCFTSSVD
260 270 280 290 300
TRYQVQIVGL LPGGFPQPLL PNLAELPRIL ADSLPIALVS FAVSASLASI
310 320 330 340 350
HADKYSYTID SNQEFLAHGA SNLISSLFSC FPNSATLATT NLLVDAGGKT
360 370 380 390 400
QLAGLFSCTV VLSVLLWLGP FFYYLPKAVL ACINISSMRQ VFCQMQELPQ
410 420 430 440 450
LWHISRVDFL LQVPGLCILS YPTPLYFGTR GQFRCNLEWH LGLGEGEKET
460 470 480 490 500
SKPDGPMVAV AEPVRVVVLD FSGVTFADAA GAREVVQVRE RLASRCRDAR
510 520 530 540 550
IRLLLAQCNA LVQGTLTRVG LLDRVTPDQL FVSVQDAAAY ALGSLLRGSS
560
TRSGSQEALG CGK
Length:563
Mass (Da):60,059
Last modified:October 1, 2002 - v1
Checksum:i6C7380C7E4E2CC99
GO
Isoform 2 (identifier: Q8NG04-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     410-454: LLQVPGLCIL...EGEKETSKPD → AVWMVTWVAV...SSSRSRGSAS
     455-563: Missing.

Note: No experimental confirmation available.
Show »
Length:454
Mass (Da):48,303
Checksum:i5C7F06F7939FE083
GO

Sequence cautioni

The sequence BAC85515 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_045599130M → T.Corresponds to variant rs971209dbSNPEnsembl.1
Natural variantiVAR_045600193A → T.1 PublicationCorresponds to variant rs923828dbSNPEnsembl.1
Natural variantiVAR_045678270L → S in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_045601546L → V.Corresponds to variant rs774895dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034748410 – 454LLQVP…TSKPD → AVWMVTWVAVVTLSVDLGLA VGVVFSMMTVVCRTRSSSRS RGSAS in isoform 2. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_034749455 – 563Missing in isoform 2. 1 PublicationAdd BLAST109

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF331523 mRNA. Translation: AAM92901.1.
AC025165 Genomic DNA. No translation available.
AK122981 mRNA. Translation: BAC85515.1. Different initiation.
CCDSiCCDS8949.2. [Q8NG04-1]
RefSeqiNP_597996.2. NM_133489.2. [Q8NG04-1]
UniGeneiHs.727726.

Genome annotation databases

EnsembliENST00000320442; ENSP00000320217; ENSG00000135502. [Q8NG04-1]
GeneIDi65012.
KEGGihsa:65012.
UCSCiuc001spe.4. human. [Q8NG04-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF331523 mRNA. Translation: AAM92901.1.
AC025165 Genomic DNA. No translation available.
AK122981 mRNA. Translation: BAC85515.1. Different initiation.
CCDSiCCDS8949.2. [Q8NG04-1]
RefSeqiNP_597996.2. NM_133489.2. [Q8NG04-1]
UniGeneiHs.727726.

3D structure databases

ProteinModelPortaliQ8NG04.
SMRiQ8NG04.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000320217.

Protein family/group databases

TCDBi2.A.53.2.13. the sulfate permease (sulp) family.

PTM databases

iPTMnetiQ8NG04.
PhosphoSitePlusiQ8NG04.

Polymorphism and mutation databases

BioMutaiSLC26A10.
DMDMi74715621.

Proteomic databases

PaxDbiQ8NG04.
PRIDEiQ8NG04.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320442; ENSP00000320217; ENSG00000135502. [Q8NG04-1]
GeneIDi65012.
KEGGihsa:65012.
UCSCiuc001spe.4. human. [Q8NG04-1]

Organism-specific databases

CTDi65012.
GeneCardsiSLC26A10.
H-InvDBHIX0037121.
HIX0079408.
HGNCiHGNC:14470. SLC26A10.
HPAiHPA044719.
neXtProtiNX_Q8NG04.
OpenTargetsiENSG00000135502.
PharmGKBiPA37887.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000006546.
HOVERGENiHBG105688.
InParanoidiQ8NG04.
KOiK14707.
OrthoDBiEOG091G07RT.
PhylomeDBiQ8NG04.
TreeFamiTF313784.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135502-MONOMER.

Miscellaneous databases

GenomeRNAii65012.
PROiQ8NG04.

Gene expression databases

BgeeiENSG00000135502.
CleanExiHS_SLC26A10.
ExpressionAtlasiQ8NG04. baseline and differential.
GenevisibleiQ8NG04. HS.

Family and domain databases

Gene3Di3.30.750.24. 1 hit.
InterProiIPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR030324. SLC26A10.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 1 hit.
PTHR11814:SF99. PTHR11814:SF99. 1 hit.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 1 hit.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS2610_HUMAN
AccessioniPrimary (citable) accession number: Q8NG04
Secondary accession number(s): A6NMJ2, B6ZDQ3, Q6ZWI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

According to PubMed:12759755, it is a transcribed pseudogene. They however do not provide experimental evidences to support this affirmation.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.