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Q8NG04

- S2610_HUMAN

UniProt

Q8NG04 - S2610_HUMAN

Protein

Solute carrier family 26 member 10

Gene

SLC26A10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Chloride/bicarbonate exchanger.By similarity

    GO - Molecular functioni

    1. antiporter activity Source: UniProtKB-KW
    2. sulfate transmembrane transporter activity Source: InterPro

    Keywords - Biological processi

    Antiport, Transport

    Keywords - Ligandi

    Chloride

    Protein family/group databases

    TCDBi2.A.53.2.13. the sulfate permease (sulp) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 26 member 10
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:14470. SLC26A10.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37887.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 563563Solute carrier family 26 member 10PRO_0000344230Add
    BLAST

    Proteomic databases

    PaxDbiQ8NG04.
    PRIDEiQ8NG04.

    PTM databases

    PhosphoSiteiQ8NG04.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8NG04.
    BgeeiQ8NG04.
    CleanExiHS_SLC26A10.
    GenevestigatoriQ8NG04.

    Organism-specific databases

    HPAiHPA044719.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NG04.
    SMRiQ8NG04. Positions 446-544.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei45 – 6521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei75 – 9117HelicalSequence AnalysisAdd
    BLAST
    Transmembranei116 – 13621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei152 – 17221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei352 – 37221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini406 – 541136STASPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 STAS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0659.
    HOGENOMiHOG000006546.
    HOVERGENiHBG105688.
    KOiK14707.
    OMAiQCNALVQ.
    OrthoDBiEOG76T9QT.
    PhylomeDBiQ8NG04.
    TreeFamiTF313784.

    Family and domain databases

    Gene3Di3.30.750.24. 1 hit.
    InterProiIPR002645. STAS_dom.
    IPR011547. Sulph_transpt.
    [Graphical view]
    PfamiPF01740. STAS. 1 hit.
    PF00916. Sulfate_transp. 1 hit.
    [Graphical view]
    SUPFAMiSSF52091. SSF52091. 1 hit.
    PROSITEiPS50801. STAS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8NG04-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRLDLASLMS APKSLGSAFK SWRLDKAPSP QHTFPSTSIP GMAFALLASV    50
    PPVFGLYTSF FPVLIYSLLG TGRHLSTGTF AILSLMTGSA VERLVPEPLV 100
    GNLSGIEKEQ LDAQRVGVAA AVAFGSGALM LGMFVLQLGV LSTFLSEPVV 150
    KALTSGAALH VLLSQLPSLL GLSLPRQIGC FSLFKTLASL LTALPRSSPA 200
    ELTISALSLA LLVPVKELNV RFRDRLPTPI PGEVVLVLLA SVLCFTSSVD 250
    TRYQVQIVGL LPGGFPQPLL PNLAELPRIL ADSLPIALVS FAVSASLASI 300
    HADKYSYTID SNQEFLAHGA SNLISSLFSC FPNSATLATT NLLVDAGGKT 350
    QLAGLFSCTV VLSVLLWLGP FFYYLPKAVL ACINISSMRQ VFCQMQELPQ 400
    LWHISRVDFL LQVPGLCILS YPTPLYFGTR GQFRCNLEWH LGLGEGEKET 450
    SKPDGPMVAV AEPVRVVVLD FSGVTFADAA GAREVVQVRE RLASRCRDAR 500
    IRLLLAQCNA LVQGTLTRVG LLDRVTPDQL FVSVQDAAAY ALGSLLRGSS 550
    TRSGSQEALG CGK 563
    Length:563
    Mass (Da):60,059
    Last modified:October 1, 2002 - v1
    Checksum:i6C7380C7E4E2CC99
    GO
    Isoform 2 (identifier: Q8NG04-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         410-454: LLQVPGLCIL...EGEKETSKPD → AVWMVTWVAV...SSSRSRGSAS
         455-563: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:454
    Mass (Da):48,303
    Checksum:i5C7F06F7939FE083
    GO

    Sequence cautioni

    The sequence BAC85515.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti130 – 1301M → T.
    Corresponds to variant rs971209 [ dbSNP | Ensembl ].
    VAR_045599
    Natural varianti193 – 1931A → T.1 Publication
    Corresponds to variant rs923828 [ dbSNP | Ensembl ].
    VAR_045600
    Natural varianti270 – 2701L → S in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_045678
    Natural varianti546 – 5461L → V.
    Corresponds to variant rs774895 [ dbSNP | Ensembl ].
    VAR_045601

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei410 – 45445LLQVP…TSKPD → AVWMVTWVAVVTLSVDLGLA VGVVFSMMTVVCRTRSSSRS RGSAS in isoform 2. 1 PublicationVSP_034748Add
    BLAST
    Alternative sequencei455 – 563109Missing in isoform 2. 1 PublicationVSP_034749Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF331523 mRNA. Translation: AAM92901.1.
    AC025165 Genomic DNA. No translation available.
    AK122981 mRNA. Translation: BAC85515.1. Different initiation.
    CCDSiCCDS8949.2. [Q8NG04-1]
    RefSeqiNP_597996.2. NM_133489.2. [Q8NG04-1]
    UniGeneiHs.727726.

    Genome annotation databases

    EnsembliENST00000320442; ENSP00000320217; ENSG00000135502. [Q8NG04-1]
    GeneIDi65012.
    KEGGihsa:65012.
    UCSCiuc001spe.3. human. [Q8NG04-1]

    Polymorphism databases

    DMDMi74715621.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF331523 mRNA. Translation: AAM92901.1 .
    AC025165 Genomic DNA. No translation available.
    AK122981 mRNA. Translation: BAC85515.1 . Different initiation.
    CCDSi CCDS8949.2. [Q8NG04-1 ]
    RefSeqi NP_597996.2. NM_133489.2. [Q8NG04-1 ]
    UniGenei Hs.727726.

    3D structure databases

    ProteinModelPortali Q8NG04.
    SMRi Q8NG04. Positions 446-544.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 2.A.53.2.13. the sulfate permease (sulp) family.

    PTM databases

    PhosphoSitei Q8NG04.

    Polymorphism databases

    DMDMi 74715621.

    Proteomic databases

    PaxDbi Q8NG04.
    PRIDEi Q8NG04.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000320442 ; ENSP00000320217 ; ENSG00000135502 . [Q8NG04-1 ]
    GeneIDi 65012.
    KEGGi hsa:65012.
    UCSCi uc001spe.3. human. [Q8NG04-1 ]

    Organism-specific databases

    CTDi 65012.
    GeneCardsi GC12P058013.
    H-InvDB HIX0037121.
    HIX0079408.
    HGNCi HGNC:14470. SLC26A10.
    HPAi HPA044719.
    neXtProti NX_Q8NG04.
    PharmGKBi PA37887.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0659.
    HOGENOMi HOG000006546.
    HOVERGENi HBG105688.
    KOi K14707.
    OMAi QCNALVQ.
    OrthoDBi EOG76T9QT.
    PhylomeDBi Q8NG04.
    TreeFami TF313784.

    Miscellaneous databases

    GenomeRNAii 65012.
    NextBioi 67212.
    PROi Q8NG04.

    Gene expression databases

    ArrayExpressi Q8NG04.
    Bgeei Q8NG04.
    CleanExi HS_SLC26A10.
    Genevestigatori Q8NG04.

    Family and domain databases

    Gene3Di 3.30.750.24. 1 hit.
    InterProi IPR002645. STAS_dom.
    IPR011547. Sulph_transpt.
    [Graphical view ]
    Pfami PF01740. STAS. 1 hit.
    PF00916. Sulfate_transp. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52091. SSF52091. 1 hit.
    PROSITEi PS50801. STAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger."
      Lohi H., Kujala M., Kerkelae E., Saarialho-Kere U., Kestilae M., Kere J.
      Genomics 70:102-112(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 44-563 (ISOFORM 2), VARIANT THR-193.
      Tissue: Cerebellum.
    4. "The SLC26 gene family of multifunctional anion exchangers."
      Mount D.B., Romero M.F.
      Pflugers Arch. 447:710-721(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    5. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-270.

    Entry informationi

    Entry nameiS2610_HUMAN
    AccessioniPrimary (citable) accession number: Q8NG04
    Secondary accession number(s): A6NMJ2, B6ZDQ3, Q6ZWI7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3