Q8NG04 (S2610_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier family 26 member 10

Gene names

Name:

SLC26A10

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	563 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Chloride/bicarbonate exchanger By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. [View classification] Contains 1 STAS domain.
Caution	According to Ref.4, it is a transcribed pseudogene. They however do not provide experimental evidences to support this affirmation.
Sequence caution	The sequence BAC85515.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Antiport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Chloride
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	sulfate transport Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	antiporter activity Inferred from electronic annotation. Source: UniProtKB-KW sulfate transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NG04-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NG04-2)

The sequence of this isoform differs from the canonical sequence as follows:
     410-454: LLQVPGLCIL...EGEKETSKPD → AVWMVTWVAV...SSSRSRGSAS
     455-563: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 563	563	Solute carrier family 26 member 10		PRO_0000344230
Regions
	Transmembrane	45 – 65	21	Helical; Potential
	Transmembrane	75 – 91	17	Helical; Potential
	Transmembrane	116 – 136	21	Helical; Potential
	Transmembrane	152 – 172	21	Helical; Potential
	Transmembrane	352 – 372	21	Helical; Potential
	Domain	406 – 541	136	STAS
Natural variations
	Alternative sequence	410 – 454	45	LLQVP…TSKPD → AVWMVTWVAVVTLSVDLGLA VGVVFSMMTVVCRTRSSSRS RGSAS in isoform 2.		VSP_034748
	Alternative sequence	455 – 563	109	Missing in isoform 2.		VSP_034749
	Natural variant	130	1	M → T. Corresponds to variant rs971209 [ dbSNP | Ensembl ].		VAR_045599
	Natural variant	193	1	A → T. Ref.3 Corresponds to variant rs923828 [ dbSNP | Ensembl ].		VAR_045600
	Natural variant	270	1	L → S in a colorectal cancer sample; somatic mutation. Ref.5		VAR_045678
	Natural variant	546	1	L → V. Corresponds to variant rs774895 [ dbSNP | Ensembl ].		VAR_045601

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 6C7380C7E4E2CC99	FASTA	563	60,059
	10 20 30 40 50 60 MRLDLASLMS APKSLGSAFK SWRLDKAPSP QHTFPSTSIP GMAFALLASV PPVFGLYTSF 70 80 90 100 110 120 FPVLIYSLLG TGRHLSTGTF AILSLMTGSA VERLVPEPLV GNLSGIEKEQ LDAQRVGVAA 130 140 150 160 170 180 AVAFGSGALM LGMFVLQLGV LSTFLSEPVV KALTSGAALH VLLSQLPSLL GLSLPRQIGC 190 200 210 220 230 240 FSLFKTLASL LTALPRSSPA ELTISALSLA LLVPVKELNV RFRDRLPTPI PGEVVLVLLA 250 260 270 280 290 300 SVLCFTSSVD TRYQVQIVGL LPGGFPQPLL PNLAELPRIL ADSLPIALVS FAVSASLASI 310 320 330 340 350 360 HADKYSYTID SNQEFLAHGA SNLISSLFSC FPNSATLATT NLLVDAGGKT QLAGLFSCTV 370 380 390 400 410 420 VLSVLLWLGP FFYYLPKAVL ACINISSMRQ VFCQMQELPQ LWHISRVDFL LQVPGLCILS 430 440 450 460 470 480 YPTPLYFGTR GQFRCNLEWH LGLGEGEKET SKPDGPMVAV AEPVRVVVLD FSGVTFADAA 490 500 510 520 530 540 GAREVVQVRE RLASRCRDAR IRLLLAQCNA LVQGTLTRVG LLDRVTPDQL FVSVQDAAAY 550 560 ALGSLLRGSS TRSGSQEALG CGK
	Isoform 2 [UniParc]. Checksum: 5C7F06F7939FE083	FASTA	454	48,303
	10 20 30 40 50 60 MRLDLASLMS APKSLGSAFK SWRLDKAPSP QHTFPSTSIP GMAFALLASV PPVFGLYTSF 70 80 90 100 110 120 FPVLIYSLLG TGRHLSTGTF AILSLMTGSA VERLVPEPLV GNLSGIEKEQ LDAQRVGVAA 130 140 150 160 170 180 AVAFGSGALM LGMFVLQLGV LSTFLSEPVV KALTSGAALH VLLSQLPSLL GLSLPRQIGC 190 200 210 220 230 240 FSLFKTLASL LTALPRSSPA ELTISALSLA LLVPVKELNV RFRDRLPTPI PGEVVLVLLA 250 260 270 280 290 300 SVLCFTSSVD TRYQVQIVGL LPGGFPQPLL PNLAELPRIL ADSLPIALVS FAVSASLASI 310 320 330 340 350 360 HADKYSYTID SNQEFLAHGA SNLISSLFSC FPNSATLATT NLLVDAGGKT QLAGLFSCTV 370 380 390 400 410 420 VLSVLLWLGP FFYYLPKAVL ACINISSMRQ VFCQMQELPQ LWHISRVDFA VWMVTWVAVV 430 440 450 TLSVDLGLAV GVVFSMMTVV CRTRSSSRSR GSAS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger." Lohi H., Kujala M., Kerkelae E., Saarialho-Kere U., Kestilae M., Kere J. Genomics 70:102-112(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 44-563 (ISOFORM 2), VARIANT THR-193. Tissue: Cerebellum.
[4]	"The SLC26 gene family of multifunctional anion exchangers." Mount D.B., Romero M.F. Pflugers Arch. 447:710-721(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[5]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-270.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF331523 mRNA. Translation: AAM92901.1. AC025165 Genomic DNA. No translation available. AK122981 mRNA. Translation: BAC85515.1. Different initiation.
IPI	IPI00168873. IPI00884970.
RefSeq	NP_597996.2. NM_133489.2.
UniGene	Hs.727726.
3D structure databases
ProteinModelPortal	Q8NG04.
ModBase	Search...
PTM databases
PhosphoSite	Q8NG04.
Polymorphism databases
DMDM	74715621.
Proteomic databases
PaxDb	Q8NG04.
PRIDE	Q8NG04.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000320442; ENSP00000320217; ENSG00000135502. ENST00000379218; ENSP00000368520; ENSG00000135502.
GeneID	65012.
KEGG	hsa:65012.
UCSC	uc001spe.3. human.
Organism-specific databases
CTD	65012.
GeneCards	GC12P058013.
H-InvDB	HIX0037121. HIX0079408.
HGNC	HGNC:14470. SLC26A10.
HPA	HPA044719.
neXtProt	NX_Q8NG04.
PharmGKB	PA37887.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0659.
HOGENOM	HOG000006546.
HOVERGEN	HBG105688.
KO	K14707.
OrthoDB	EOG45HRWX.
Gene expression databases
ArrayExpress	Q8NG04.
Bgee	Q8NG04.
CleanEx	HS_SLC26A10.
Genevestigator	Q8NG04.
Family and domain databases
Gene3D	3.30.750.24. 1 hit.
InterPro	IPR002645. STAS_dom. IPR011547. Sulph_transpt. [Graphical view]
Pfam	PF01740. STAS. 1 hit. PF00916. Sulfate_transp. 1 hit. [Graphical view]
SUPFAM	SSF52091. STAS. 1 hit.
PROSITE	PS01130. SLC26A. False negative. PS50801. STAS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	65012.
NextBio	67212.

Entry information

Entry name

S2610_HUMAN

Accession

Primary (citable) accession number: Q8NG04
Secondary accession number(s): A6NMJ2, B6ZDQ3, Q6ZWI7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.