Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8NG04 (S2610_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 26 member 10
Gene names
Name:SLC26A10
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length563 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Chloride/bicarbonate exchanger By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. [View classification]

Contains 1 STAS domain.

Caution

According to Ref.4, it is a transcribed pseudogene. They however do not provide experimental evidences to support this affirmation.

Sequence caution

The sequence BAC85515.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processAntiport
Transport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   LigandChloride
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionantiporter activity

Inferred from electronic annotation. Source: UniProtKB-KW

sulfate transmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8NG04-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8NG04-2)

The sequence of this isoform differs from the canonical sequence as follows:
     410-454: LLQVPGLCIL...EGEKETSKPD → AVWMVTWVAV...SSSRSRGSAS
     455-563: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 563563Solute carrier family 26 member 10
PRO_0000344230

Regions

Transmembrane45 – 6521Helical; Potential
Transmembrane75 – 9117Helical; Potential
Transmembrane116 – 13621Helical; Potential
Transmembrane152 – 17221Helical; Potential
Transmembrane352 – 37221Helical; Potential
Domain406 – 541136STAS

Natural variations

Alternative sequence410 – 45445LLQVP…TSKPD → AVWMVTWVAVVTLSVDLGLA VGVVFSMMTVVCRTRSSSRS RGSAS in isoform 2.
VSP_034748
Alternative sequence455 – 563109Missing in isoform 2.
VSP_034749
Natural variant1301M → T.
Corresponds to variant rs971209 [ dbSNP | Ensembl ].
VAR_045599
Natural variant1931A → T. Ref.3
Corresponds to variant rs923828 [ dbSNP | Ensembl ].
VAR_045600
Natural variant2701L → S in a colorectal cancer sample; somatic mutation. Ref.5
VAR_045678
Natural variant5461L → V.
Corresponds to variant rs774895 [ dbSNP | Ensembl ].
VAR_045601

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 6C7380C7E4E2CC99

FASTA56360,059
        10         20         30         40         50         60 
MRLDLASLMS APKSLGSAFK SWRLDKAPSP QHTFPSTSIP GMAFALLASV PPVFGLYTSF 

        70         80         90        100        110        120 
FPVLIYSLLG TGRHLSTGTF AILSLMTGSA VERLVPEPLV GNLSGIEKEQ LDAQRVGVAA 

       130        140        150        160        170        180 
AVAFGSGALM LGMFVLQLGV LSTFLSEPVV KALTSGAALH VLLSQLPSLL GLSLPRQIGC 

       190        200        210        220        230        240 
FSLFKTLASL LTALPRSSPA ELTISALSLA LLVPVKELNV RFRDRLPTPI PGEVVLVLLA 

       250        260        270        280        290        300 
SVLCFTSSVD TRYQVQIVGL LPGGFPQPLL PNLAELPRIL ADSLPIALVS FAVSASLASI 

       310        320        330        340        350        360 
HADKYSYTID SNQEFLAHGA SNLISSLFSC FPNSATLATT NLLVDAGGKT QLAGLFSCTV 

       370        380        390        400        410        420 
VLSVLLWLGP FFYYLPKAVL ACINISSMRQ VFCQMQELPQ LWHISRVDFL LQVPGLCILS 

       430        440        450        460        470        480 
YPTPLYFGTR GQFRCNLEWH LGLGEGEKET SKPDGPMVAV AEPVRVVVLD FSGVTFADAA 

       490        500        510        520        530        540 
GAREVVQVRE RLASRCRDAR IRLLLAQCNA LVQGTLTRVG LLDRVTPDQL FVSVQDAAAY 

       550        560 
ALGSLLRGSS TRSGSQEALG CGK 

« Hide

Isoform 2 [UniParc].

Checksum: 5C7F06F7939FE083
Show »

FASTA45448,303

References

« Hide 'large scale' references
[1]"Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger."
Lohi H., Kujala M., Kerkelae E., Saarialho-Kere U., Kestilae M., Kere J.
Genomics 70:102-112(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 44-563 (ISOFORM 2), VARIANT THR-193.
Tissue: Cerebellum.
[4]"The SLC26 gene family of multifunctional anion exchangers."
Mount D.B., Romero M.F.
Pflugers Arch. 447:710-721(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-270.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF331523 mRNA. Translation: AAM92901.1.
AC025165 Genomic DNA. No translation available.
AK122981 mRNA. Translation: BAC85515.1. Different initiation.
CCDSCCDS8949.2. [Q8NG04-1]
RefSeqNP_597996.2. NM_133489.2. [Q8NG04-1]
UniGeneHs.727726.

3D structure databases

ProteinModelPortalQ8NG04.
SMRQ8NG04. Positions 446-544.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

TCDB2.A.53.2.13. the sulfate permease (sulp) family.

PTM databases

PhosphoSiteQ8NG04.

Polymorphism databases

DMDM74715621.

Proteomic databases

PaxDbQ8NG04.
PRIDEQ8NG04.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000320442; ENSP00000320217; ENSG00000135502. [Q8NG04-1]
ENST00000379218; ENSP00000368520; ENSG00000135502. [Q8NG04-2]
GeneID65012.
KEGGhsa:65012.
UCSCuc001spe.3. human. [Q8NG04-1]

Organism-specific databases

CTD65012.
GeneCardsGC12P058013.
H-InvDBHIX0037121.
HIX0079408.
HGNCHGNC:14470. SLC26A10.
HPAHPA044719.
neXtProtNX_Q8NG04.
PharmGKBPA37887.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0659.
HOGENOMHOG000006546.
HOVERGENHBG105688.
KOK14707.
OMAQCNALVQ.
OrthoDBEOG76T9QT.
PhylomeDBQ8NG04.
TreeFamTF313784.

Gene expression databases

ArrayExpressQ8NG04.
BgeeQ8NG04.
CleanExHS_SLC26A10.
GenevestigatorQ8NG04.

Family and domain databases

Gene3D3.30.750.24. 1 hit.
InterProIPR002645. STAS_dom.
IPR011547. Sulph_transpt.
[Graphical view]
PfamPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMSSF52091. SSF52091. 1 hit.
PROSITEPS50801. STAS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi65012.
NextBio67212.
PROQ8NG04.

Entry information

Entry nameS2610_HUMAN
AccessionPrimary (citable) accession number: Q8NG04
Secondary accession number(s): A6NMJ2, B6ZDQ3, Q6ZWI7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM