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Protein

Solute carrier family 26 member 10

Gene

SLC26A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Chloride/bicarbonate exchanger.By similarity

GO - Molecular functioni

  1. antiporter activity Source: UniProtKB-KW
  2. secondary active sulfate transmembrane transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Antiport, Transport

Keywords - Ligandi

Chloride

Protein family/group databases

TCDBi2.A.53.2.13. the sulfate permease (sulp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 26 member 10
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:14470. SLC26A10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei45 – 6521HelicalSequence AnalysisAdd
BLAST
Transmembranei75 – 9117HelicalSequence AnalysisAdd
BLAST
Transmembranei116 – 13621HelicalSequence AnalysisAdd
BLAST
Transmembranei152 – 17221HelicalSequence AnalysisAdd
BLAST
Transmembranei352 – 37221HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37887.

Polymorphism and mutation databases

BioMutaiSLC26A10.
DMDMi74715621.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 563563Solute carrier family 26 member 10PRO_0000344230Add
BLAST

Proteomic databases

PaxDbiQ8NG04.
PRIDEiQ8NG04.

PTM databases

PhosphoSiteiQ8NG04.

Expressioni

Gene expression databases

BgeeiQ8NG04.
CleanExiHS_SLC26A10.
ExpressionAtlasiQ8NG04. baseline.
GenevestigatoriQ8NG04.

Organism-specific databases

HPAiHPA044719.

Structurei

3D structure databases

ProteinModelPortaliQ8NG04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini406 – 541136STASPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0659.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000006546.
HOVERGENiHBG105688.
InParanoidiQ8NG04.
KOiK14707.
OrthoDBiEOG76T9QT.
PhylomeDBiQ8NG04.
TreeFamiTF313784.

Family and domain databases

Gene3Di3.30.750.24. 1 hit.
InterProiIPR030324. SLC26A10.
IPR002645. STAS_dom.
IPR001902. Sul_anion_transpt.
IPR030402. Sulfate_tra_GLY.
IPR011547. Sulph_transpt.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 1 hit.
PTHR11814:SF57. PTHR11814:SF57. 1 hit.
PfamiPF01740. STAS. 1 hit.
PF13792. Sulfate_tra_GLY. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 1 hit.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NG04-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLDLASLMS APKSLGSAFK SWRLDKAPSP QHTFPSTSIP GMAFALLASV
60 70 80 90 100
PPVFGLYTSF FPVLIYSLLG TGRHLSTGTF AILSLMTGSA VERLVPEPLV
110 120 130 140 150
GNLSGIEKEQ LDAQRVGVAA AVAFGSGALM LGMFVLQLGV LSTFLSEPVV
160 170 180 190 200
KALTSGAALH VLLSQLPSLL GLSLPRQIGC FSLFKTLASL LTALPRSSPA
210 220 230 240 250
ELTISALSLA LLVPVKELNV RFRDRLPTPI PGEVVLVLLA SVLCFTSSVD
260 270 280 290 300
TRYQVQIVGL LPGGFPQPLL PNLAELPRIL ADSLPIALVS FAVSASLASI
310 320 330 340 350
HADKYSYTID SNQEFLAHGA SNLISSLFSC FPNSATLATT NLLVDAGGKT
360 370 380 390 400
QLAGLFSCTV VLSVLLWLGP FFYYLPKAVL ACINISSMRQ VFCQMQELPQ
410 420 430 440 450
LWHISRVDFL LQVPGLCILS YPTPLYFGTR GQFRCNLEWH LGLGEGEKET
460 470 480 490 500
SKPDGPMVAV AEPVRVVVLD FSGVTFADAA GAREVVQVRE RLASRCRDAR
510 520 530 540 550
IRLLLAQCNA LVQGTLTRVG LLDRVTPDQL FVSVQDAAAY ALGSLLRGSS
560
TRSGSQEALG CGK
Length:563
Mass (Da):60,059
Last modified:October 1, 2002 - v1
Checksum:i6C7380C7E4E2CC99
GO
Isoform 2 (identifier: Q8NG04-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     410-454: LLQVPGLCIL...EGEKETSKPD → AVWMVTWVAV...SSSRSRGSAS
     455-563: Missing.

Note: No experimental confirmation available.

Show »
Length:454
Mass (Da):48,303
Checksum:i5C7F06F7939FE083
GO

Sequence cautioni

The sequence BAC85515.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti130 – 1301M → T.
Corresponds to variant rs971209 [ dbSNP | Ensembl ].
VAR_045599
Natural varianti193 – 1931A → T.1 Publication
Corresponds to variant rs923828 [ dbSNP | Ensembl ].
VAR_045600
Natural varianti270 – 2701L → S in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_045678
Natural varianti546 – 5461L → V.
Corresponds to variant rs774895 [ dbSNP | Ensembl ].
VAR_045601

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei410 – 45445LLQVP…TSKPD → AVWMVTWVAVVTLSVDLGLA VGVVFSMMTVVCRTRSSSRS RGSAS in isoform 2. 1 PublicationVSP_034748Add
BLAST
Alternative sequencei455 – 563109Missing in isoform 2. 1 PublicationVSP_034749Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF331523 mRNA. Translation: AAM92901.1.
AC025165 Genomic DNA. No translation available.
AK122981 mRNA. Translation: BAC85515.1. Different initiation.
CCDSiCCDS8949.2. [Q8NG04-1]
RefSeqiNP_597996.2. NM_133489.2. [Q8NG04-1]
UniGeneiHs.727726.

Genome annotation databases

EnsembliENST00000320442; ENSP00000320217; ENSG00000135502. [Q8NG04-1]
GeneIDi65012.
KEGGihsa:65012.
UCSCiuc001spe.3. human. [Q8NG04-1]

Polymorphism and mutation databases

BioMutaiSLC26A10.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF331523 mRNA. Translation: AAM92901.1.
AC025165 Genomic DNA. No translation available.
AK122981 mRNA. Translation: BAC85515.1. Different initiation.
CCDSiCCDS8949.2. [Q8NG04-1]
RefSeqiNP_597996.2. NM_133489.2. [Q8NG04-1]
UniGeneiHs.727726.

3D structure databases

ProteinModelPortaliQ8NG04.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi2.A.53.2.13. the sulfate permease (sulp) family.

PTM databases

PhosphoSiteiQ8NG04.

Polymorphism and mutation databases

BioMutaiSLC26A10.
DMDMi74715621.

Proteomic databases

PaxDbiQ8NG04.
PRIDEiQ8NG04.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320442; ENSP00000320217; ENSG00000135502. [Q8NG04-1]
GeneIDi65012.
KEGGihsa:65012.
UCSCiuc001spe.3. human. [Q8NG04-1]

Organism-specific databases

CTDi65012.
GeneCardsiGC12P058013.
H-InvDBHIX0037121.
HIX0079408.
HGNCiHGNC:14470. SLC26A10.
HPAiHPA044719.
neXtProtiNX_Q8NG04.
PharmGKBiPA37887.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0659.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000006546.
HOVERGENiHBG105688.
InParanoidiQ8NG04.
KOiK14707.
OrthoDBiEOG76T9QT.
PhylomeDBiQ8NG04.
TreeFamiTF313784.

Miscellaneous databases

GenomeRNAii65012.
NextBioi67212.
PROiQ8NG04.

Gene expression databases

BgeeiQ8NG04.
CleanExiHS_SLC26A10.
ExpressionAtlasiQ8NG04. baseline.
GenevestigatoriQ8NG04.

Family and domain databases

Gene3Di3.30.750.24. 1 hit.
InterProiIPR030324. SLC26A10.
IPR002645. STAS_dom.
IPR001902. Sul_anion_transpt.
IPR030402. Sulfate_tra_GLY.
IPR011547. Sulph_transpt.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 1 hit.
PTHR11814:SF57. PTHR11814:SF57. 1 hit.
PfamiPF01740. STAS. 1 hit.
PF13792. Sulfate_tra_GLY. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 1 hit.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger."
    Lohi H., Kujala M., Kerkelae E., Saarialho-Kere U., Kestilae M., Kere J.
    Genomics 70:102-112(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 44-563 (ISOFORM 2), VARIANT THR-193.
    Tissue: Cerebellum.
  4. "The SLC26 gene family of multifunctional anion exchangers."
    Mount D.B., Romero M.F.
    Pflugers Arch. 447:710-721(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-270.

Entry informationi

Entry nameiS2610_HUMAN
AccessioniPrimary (citable) accession number: Q8NG04
Secondary accession number(s): A6NMJ2, B6ZDQ3, Q6ZWI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: October 1, 2002
Last modified: April 29, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

According to PubMed:12759755, it is a transcribed pseudogene. They however do not provide experimental evidences to support this affirmation.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.