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Protein

Solute carrier family 26 member 10

Gene

SLC26A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Chloride/bicarbonate exchanger.By similarity

Caution

According to PubMed:12759755, it is a transcribed pseudogene. They however do not provide experimental evidences to support this affirmation.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAntiport, Transport
LigandChloride

Protein family/group databases

TCDBi2.A.53.2.13 the sulfate permease (sulp) family

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 26 member 10
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000135502.16
HGNCiHGNC:14470 SLC26A10
neXtProtiNX_Q8NG04

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Transmembranei75 – 91HelicalSequence analysisAdd BLAST17
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Transmembranei352 – 372HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000135502
PharmGKBiPA37887

Polymorphism and mutation databases

BioMutaiSLC26A10
DMDMi74715621

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003442301 – 563Solute carrier family 26 member 10Add BLAST563

Proteomic databases

PaxDbiQ8NG04
PeptideAtlasiQ8NG04
PRIDEiQ8NG04

PTM databases

iPTMnetiQ8NG04
PhosphoSitePlusiQ8NG04

Expressioni

Gene expression databases

BgeeiENSG00000135502
CleanExiHS_SLC26A10
ExpressionAtlasiQ8NG04 baseline and differential
GenevisibleiQ8NG04 HS

Organism-specific databases

HPAiHPA044719

Interactioni

Protein-protein interaction databases

BioGridi1223741 interactor.
STRINGi9606.ENSP00000320217

Structurei

3D structure databases

ProteinModelPortaliQ8NG04
SMRiQ8NG04
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini406 – 541STASPROSITE-ProRule annotationAdd BLAST136

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0236 Eukaryota
COG0659 LUCA
GeneTreeiENSGT00760000119026
HOGENOMiHOG000006546
HOVERGENiHBG105688
InParanoidiQ8NG04
KOiK14707
OrthoDBiEOG091G07RT
PhylomeDBiQ8NG04
TreeFamiTF313784

Family and domain databases

Gene3Di3.30.750.241 hit
InterProiView protein in InterPro
IPR011547 SLC26A/SulP_dom
IPR001902 SLC26A/SulP_fam
IPR030324 SLC26A10
IPR002645 STAS_dom
IPR036513 STAS_dom_sf
PANTHERiPTHR11814 PTHR11814, 1 hit
PTHR11814:SF99 PTHR11814:SF99, 1 hit
PfamiView protein in Pfam
PF01740 STAS, 1 hit
PF00916 Sulfate_transp, 1 hit
SUPFAMiSSF52091 SSF52091, 1 hit
PROSITEiView protein in PROSITE
PS50801 STAS, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NG04-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLDLASLMS APKSLGSAFK SWRLDKAPSP QHTFPSTSIP GMAFALLASV
60 70 80 90 100
PPVFGLYTSF FPVLIYSLLG TGRHLSTGTF AILSLMTGSA VERLVPEPLV
110 120 130 140 150
GNLSGIEKEQ LDAQRVGVAA AVAFGSGALM LGMFVLQLGV LSTFLSEPVV
160 170 180 190 200
KALTSGAALH VLLSQLPSLL GLSLPRQIGC FSLFKTLASL LTALPRSSPA
210 220 230 240 250
ELTISALSLA LLVPVKELNV RFRDRLPTPI PGEVVLVLLA SVLCFTSSVD
260 270 280 290 300
TRYQVQIVGL LPGGFPQPLL PNLAELPRIL ADSLPIALVS FAVSASLASI
310 320 330 340 350
HADKYSYTID SNQEFLAHGA SNLISSLFSC FPNSATLATT NLLVDAGGKT
360 370 380 390 400
QLAGLFSCTV VLSVLLWLGP FFYYLPKAVL ACINISSMRQ VFCQMQELPQ
410 420 430 440 450
LWHISRVDFL LQVPGLCILS YPTPLYFGTR GQFRCNLEWH LGLGEGEKET
460 470 480 490 500
SKPDGPMVAV AEPVRVVVLD FSGVTFADAA GAREVVQVRE RLASRCRDAR
510 520 530 540 550
IRLLLAQCNA LVQGTLTRVG LLDRVTPDQL FVSVQDAAAY ALGSLLRGSS
560
TRSGSQEALG CGK
Length:563
Mass (Da):60,059
Last modified:October 1, 2002 - v1
Checksum:i6C7380C7E4E2CC99
GO
Isoform 2 (identifier: Q8NG04-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     410-454: LLQVPGLCIL...EGEKETSKPD → AVWMVTWVAV...SSSRSRGSAS
     455-563: Missing.

Note: No experimental confirmation available.
Show »
Length:454
Mass (Da):48,303
Checksum:i5C7F06F7939FE083
GO

Sequence cautioni

The sequence BAC85515 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_045599130M → T. Corresponds to variant dbSNP:rs971209Ensembl.1
Natural variantiVAR_045600193A → T1 PublicationCorresponds to variant dbSNP:rs923828Ensembl.1
Natural variantiVAR_045678270L → S in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_045601546L → V. Corresponds to variant dbSNP:rs774895Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034748410 – 454LLQVP…TSKPD → AVWMVTWVAVVTLSVDLGLA VGVVFSMMTVVCRTRSSSRS RGSAS in isoform 2. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_034749455 – 563Missing in isoform 2. 1 PublicationAdd BLAST109

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF331523 mRNA Translation: AAM92901.1
AC025165 Genomic DNA No translation available.
AK122981 mRNA Translation: BAC85515.1 Different initiation.
CCDSiCCDS8949.2 [Q8NG04-1]
RefSeqiNP_597996.2, NM_133489.2 [Q8NG04-1]
UniGeneiHs.727726

Genome annotation databases

EnsembliENST00000320442; ENSP00000320217; ENSG00000135502 [Q8NG04-1]
GeneIDi65012
KEGGihsa:65012
UCSCiuc001spe.4 human [Q8NG04-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiS2610_HUMAN
AccessioniPrimary (citable) accession number: Q8NG04
Secondary accession number(s): A6NMJ2, B6ZDQ3, Q6ZWI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome