ID   CADM4_HUMAN             Reviewed;         388 AA.
AC   Q8NFZ8; B2R7L5; Q9Y4A4;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-NOV-2009, entry version 57.
DE   RecName: Full=Cell adhesion molecule 4;
DE   AltName: Full=Immunoglobulin superfamily member 4C;
DE   AltName: Full=Nectin-like protein 4;
DE   AltName: Full=TSLC1-like protein 2;
DE   Flags: Precursor;
GN   Name=CADM4; Synonyms=IGSF4C, NECL4, TSLL2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   MEDLINE=21427520; PubMed=11536053; DOI=10.1038/sj.onc.1204696;
RA   Fukuhara H., Kuramochi M., Nobukuni T., Fukami T., Saino M.,
RA   Maruyama T., Nomura S., Sekiya T., Murakami Y.;
RT   "Isolation of the TSLL1 and TSLL2 genes, members of the tumor
RT   suppressor TSLC1 gene family encoding transmembrane proteins.";
RL   Oncogene 20:5401-5407(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Amygdala;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [4]
RP   FUNCTION, SUBUNIT, AND TISSUE SPECIFICITY.
RX   PubMed=16261159; DOI=10.1038/sj.onc.1209192;
RA   Williams Y.N., Masuda M., Sakurai-Yageta M., Maruyama T., Shibuya M.,
RA   Murakami Y.;
RT   "Cell adhesion and prostate tumor-suppressor activity of TSLL2/IGSF4C,
RT   an immunoglobulin superfamily molecule homologous to TSLC1/IGSF4.";
RL   Oncogene 25:1446-1453(2006).
CC   -!- FUNCTION: Involved in the cell-cell adhesion. Has calcium- and
CC       magnesium-independent cell-cell adhesion activity. May have tumor-
CC       suppressor activity.
CC   -!- SUBUNIT: Monomer and homodimer.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein (Potential).
CC   -!- TISSUE SPECIFICITY: Expressed in brain, prostate, brain, kidney
CC       and some other organs.
CC   -!- PTM: N-glycosylated (By similarity).
CC   -!- SIMILARITY: Belongs to the nectin family.
CC   -!- SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like)
CC       domains.
CC   -!- SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like)
CC       domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC32740.1; Type=Erroneous gene model prediction;
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DR   EMBL; AF363368; AAM60750.1; -; mRNA.
DR   EMBL; AK313028; BAG35862.1; -; mRNA.
DR   EMBL; AC005525; AAC32740.1; ALT_SEQ; Genomic_DNA.
DR   IPI; IPI00176427; -.
DR   RefSeq; NP_660339.1; -.
DR   UniGene; Hs.370984; -.
DR   STRING; Q8NFZ8; -.
DR   PhosphoSite; Q8NFZ8; -.
DR   PeptideAtlas; Q8NFZ8; -.
DR   PRIDE; Q8NFZ8; -.
DR   Ensembl; ENST00000222374; ENSP00000222374; ENSG00000105767; Homo sapiens.
DR   GeneID; 199731; -.
DR   KEGG; hsa:199731; -.
DR   UCSC; uc002oxc.1; human.
DR   CTD; 199731; -.
DR   GeneCards; GC19M048821; -.
DR   HGNC; HGNC:30825; CADM4.
DR   HPA; HPA012612; -.
DR   MIM; 609744; gene.
DR   HOGENOM; Q8NFZ8; -.
DR   HOVERGEN; Q8NFZ8; -.
DR   OMA; MGRARRF; -.
DR   NextBio; 89714; -.
DR   ArrayExpress; Q8NFZ8; -.
DR   Bgee; Q8NFZ8; -.
DR   CleanEx; HS_CADM4; -.
DR   Genevestigator; Q8NFZ8; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005515; F:protein binding; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   InterPro; IPR013162; CD80_C2-set.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR003585; Neurexin-like.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 2.
DR   Pfam; PF08205; C2-set_2; 1.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00294; 4.1m; 1.
DR   SMART; SM00409; IG; 2.
DR   SMART; SM00408; IGc2; 1.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   1: Evidence at protein level;
KW   Cell adhesion; Complete proteome; Disulfide bond; Glycoprotein;
KW   Immunoglobulin domain; Membrane; Phosphoprotein; Polymorphism; Repeat;
KW   Signal; Transmembrane; Tumor suppressor.
FT   SIGNAL        1     20       Potential.
FT   CHAIN        21    388       Cell adhesion molecule 4.
FT                                /FTId=PRO_0000291980.
FT   TOPO_DOM     21    324       Extracellular (Potential).
FT   TRANSMEM    325    345       Potential.
FT   TOPO_DOM    346    388       Cytoplasmic (Potential).
FT   DOMAIN       21    119       Ig-like V-type.
FT   DOMAIN      124    219       Ig-like C2-type 1.
FT   DOMAIN      224    307       Ig-like C2-type 2.
FT   MOD_RES     361    361       Phosphoserine (By similarity).
FT   CARBOHYD     31     31       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     67     67       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    286    286       N-linked (GlcNAc...) (Potential).
FT   DISULFID     44    104       By similarity.
FT   DISULFID    145    199       By similarity.
FT   DISULFID    245    291       By similarity.
FT   VARIANT     225    225       T -> A (in dbSNP:rs34246023).
FT                                /FTId=VAR_032906.
SQ   SEQUENCE   388 AA;  42785 MW;  B22301C9E21A9339 CRC64;
     MGRARRFQWP LLLLWAAAAG PGAGQEVQTE NVTVAEGGVA EITCRLHQYD GSIVVIQNPA
     RQTLFFNGTR ALKDERFQLE EFSPRRVRIR LSDARLEDEG GYFCQLYTED THHQIATLTV
     LVAPENPVVE VREQAVEGGE VELSCLVPRS RPAATLRWYR DRKELKGVSS SQENGKVWSV
     ASTVRFRVDR KDDGGIIICE AQNQALPSGH SKQTQYVLDV QYSPTARIHA SQAVVREGDT
     LVLTCAVTGN PRPNQIRWNR GNESLPERAE AVGETLTLPG LVSADNGTYT CEASNKHGHA
     RALYVLVVYD PGAVVEAQTS VPYAIVGGIL ALLVFLIICV LVGMVWCSVR QKGSYLTHEA
     SGLDEQGEAR EAFLNGSDGH KRKEEFFI
//