Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8NFZ8 (CADM4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell adhesion molecule 4
Alternative name(s):
Immunoglobulin superfamily member 4C
Short name=IgSF4C
Nectin-like protein 4
Short name=NECL-4
TSLC1-like protein 2
Gene names
Name:CADM4
Synonyms:IGSF4C, NECL4, TSLL2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity. Ref.4

Subunit structure

Monomer and homodimer. Ref.4

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Tissue specificity

Expressed in brain, prostate, brain, kidney and some other organs. Ref.1 Ref.4

Post-translational modification

N-glycosylated By similarity.

Sequence similarities

Belongs to the nectin family.

Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Sequence caution

The sequence AAC32740.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DiseaseTumor suppressor
   DomainImmunoglobulin domain
Repeat
Signal
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 388368Cell adhesion molecule 4
PRO_0000291980

Regions

Topological domain21 – 324304Extracellular Potential
Transmembrane325 – 34521Helical; Potential
Topological domain346 – 38843Cytoplasmic Potential
Domain21 – 11999Ig-like V-type
Domain124 – 21996Ig-like C2-type 1
Domain224 – 30784Ig-like C2-type 2

Amino acid modifications

Glycosylation311N-linked (GlcNAc...) Potential
Glycosylation671N-linked (GlcNAc...) Potential
Glycosylation2861N-linked (GlcNAc...) Potential
Disulfide bond44 ↔ 104 By similarity
Disulfide bond145 ↔ 199 By similarity
Disulfide bond245 ↔ 291 By similarity

Natural variations

Natural variant2251T → A.
Corresponds to variant rs34246023 [ dbSNP | Ensembl ].
VAR_032906

Sequences

Sequence LengthMass (Da)Tools
Q8NFZ8 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: B22301C9E21A9339

FASTA38842,785
        10         20         30         40         50         60 
MGRARRFQWP LLLLWAAAAG PGAGQEVQTE NVTVAEGGVA EITCRLHQYD GSIVVIQNPA 

        70         80         90        100        110        120 
RQTLFFNGTR ALKDERFQLE EFSPRRVRIR LSDARLEDEG GYFCQLYTED THHQIATLTV 

       130        140        150        160        170        180 
LVAPENPVVE VREQAVEGGE VELSCLVPRS RPAATLRWYR DRKELKGVSS SQENGKVWSV 

       190        200        210        220        230        240 
ASTVRFRVDR KDDGGIIICE AQNQALPSGH SKQTQYVLDV QYSPTARIHA SQAVVREGDT 

       250        260        270        280        290        300 
LVLTCAVTGN PRPNQIRWNR GNESLPERAE AVGETLTLPG LVSADNGTYT CEASNKHGHA 

       310        320        330        340        350        360 
RALYVLVVYD PGAVVEAQTS VPYAIVGGIL ALLVFLIICV LVGMVWCSVR QKGSYLTHEA 

       370        380 
SGLDEQGEAR EAFLNGSDGH KRKEEFFI 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins."
Fukuhara H., Kuramochi M., Nobukuni T., Fukami T., Saino M., Maruyama T., Nomura S., Sekiya T., Murakami Y.
Oncogene 20:5401-5407(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Amygdala.
[3]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Cell adhesion and prostate tumor-suppressor activity of TSLL2/IGSF4C, an immunoglobulin superfamily molecule homologous to TSLC1/IGSF4."
Williams Y.N., Masuda M., Sakurai-Yageta M., Maruyama T., Shibuya M., Murakami Y.
Oncogene 25:1446-1453(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBUNIT, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF363368 mRNA. Translation: AAM60750.1.
AK313028 mRNA. Translation: BAG35862.1.
AC005525 Genomic DNA. Translation: AAC32740.1. Sequence problems.
RefSeqNP_660339.1. NM_145296.1.
UniGeneHs.370984.

3D structure databases

ProteinModelPortalQ8NFZ8.
SMRQ8NFZ8. Positions 25-310.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128268. 3 interactions.
IntActQ8NFZ8. 2 interactions.
STRING9606.ENSP00000222374.

PTM databases

PhosphoSiteQ8NFZ8.

Polymorphism databases

DMDM74762572.

Proteomic databases

PaxDbQ8NFZ8.
PeptideAtlasQ8NFZ8.
PRIDEQ8NFZ8.

Protocols and materials databases

DNASU199731.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000222374; ENSP00000222374; ENSG00000105767.
GeneID199731.
KEGGhsa:199731.
UCSCuc002oxc.1. human.

Organism-specific databases

CTD199731.
GeneCardsGC19M044126.
HGNCHGNC:30825. CADM4.
HPAHPA012612.
MIM609744. gene.
neXtProtNX_Q8NFZ8.
PharmGKBPA162380931.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40137.
HOGENOMHOG000036057.
HOVERGENHBG057086.
InParanoidQ8NFZ8.
KOK06783.
OMAIICEAQN.
OrthoDBEOG7PVWPD.
PhylomeDBQ8NFZ8.
TreeFamTF338300.

Gene expression databases

BgeeQ8NFZ8.
CleanExHS_CADM4.
GenevestigatorQ8NFZ8.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
InterProIPR028807. Cadm.
IPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR003585. Neurexin-like.
[Graphical view]
PANTHERPTHR23277:SF15. PTHR23277:SF15. 1 hit.
PfamPF08205. C2-set_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00294. 4.1m. 1 hit.
SM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCADM4. human.
GenomeRNAi199731.
NextBio89714.
PROQ8NFZ8.
SOURCESearch...

Entry information

Entry nameCADM4_HUMAN
AccessionPrimary (citable) accession number: Q8NFZ8
Secondary accession number(s): B2R7L5, Q9Y4A4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 1, 2002
Last modified: March 19, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM