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Protein

Cell adhesion molecule 4

Gene

CADM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity.1 Publication

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Cell adhesion molecule 4
Alternative name(s):
Immunoglobulin superfamily member 4C
Short name:
IgSF4C
Nectin-like protein 4
Short name:
NECL-4
TSLC1-like protein 2
Gene namesi
Name:CADM4
Synonyms:IGSF4C, NECL4, TSLL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:30825. CADM4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 324304ExtracellularSequence AnalysisAdd
BLAST
Transmembranei325 – 34521HelicalSequence AnalysisAdd
BLAST
Topological domaini346 – 38843CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

PharmGKBiPA162380931.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 388368Cell adhesion molecule 4PRO_0000291980Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi31 – 311N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi44 ↔ 104PROSITE-ProRule annotation
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi145 ↔ 199PROSITE-ProRule annotation
Disulfide bondi245 ↔ 291PROSITE-ProRule annotation
Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8NFZ8.
PaxDbiQ8NFZ8.
PeptideAtlasiQ8NFZ8.
PRIDEiQ8NFZ8.

PTM databases

PhosphoSiteiQ8NFZ8.

Expressioni

Tissue specificityi

Expressed in brain, prostate, brain, kidney and some other organs.2 Publications

Gene expression databases

BgeeiQ8NFZ8.
CleanExiHS_CADM4.
GenevestigatoriQ8NFZ8.

Organism-specific databases

HPAiHPA012612.

Interactioni

Subunit structurei

Monomer and homodimer.1 Publication

Protein-protein interaction databases

BioGridi128268. 5 interactions.
IntActiQ8NFZ8. 2 interactions.
STRINGi9606.ENSP00000222374.

Structurei

3D structure databases

ProteinModelPortaliQ8NFZ8.
SMRiQ8NFZ8. Positions 25-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 11999Ig-like V-typeAdd
BLAST
Domaini124 – 21996Ig-like C2-type 1Add
BLAST
Domaini224 – 30784Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Belongs to the nectin family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40137.
GeneTreeiENSGT00770000120518.
HOGENOMiHOG000036057.
HOVERGENiHBG057086.
InParanoidiQ8NFZ8.
KOiK06783.
OMAiIICEAQN.
OrthoDBiEOG7PVWPD.
PhylomeDBiQ8NFZ8.
TreeFamiTF338300.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR028807. Cadm4.
IPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR003585. Neurexin-like.
[Graphical view]
PANTHERiPTHR23277:SF50. PTHR23277:SF50. 1 hit.
PfamiPF08205. C2-set_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NFZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRARRFQWP LLLLWAAAAG PGAGQEVQTE NVTVAEGGVA EITCRLHQYD
60 70 80 90 100
GSIVVIQNPA RQTLFFNGTR ALKDERFQLE EFSPRRVRIR LSDARLEDEG
110 120 130 140 150
GYFCQLYTED THHQIATLTV LVAPENPVVE VREQAVEGGE VELSCLVPRS
160 170 180 190 200
RPAATLRWYR DRKELKGVSS SQENGKVWSV ASTVRFRVDR KDDGGIIICE
210 220 230 240 250
AQNQALPSGH SKQTQYVLDV QYSPTARIHA SQAVVREGDT LVLTCAVTGN
260 270 280 290 300
PRPNQIRWNR GNESLPERAE AVGETLTLPG LVSADNGTYT CEASNKHGHA
310 320 330 340 350
RALYVLVVYD PGAVVEAQTS VPYAIVGGIL ALLVFLIICV LVGMVWCSVR
360 370 380
QKGSYLTHEA SGLDEQGEAR EAFLNGSDGH KRKEEFFI
Length:388
Mass (Da):42,785
Last modified:October 1, 2002 - v1
Checksum:iB22301C9E21A9339
GO

Sequence cautioni

The sequence AAC32740.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti225 – 2251T → A.
Corresponds to variant rs34246023 [ dbSNP | Ensembl ].
VAR_032906

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF363368 mRNA. Translation: AAM60750.1.
AK313028 mRNA. Translation: BAG35862.1.
AC005525 Genomic DNA. Translation: AAC32740.1. Sequence problems.
CCDSiCCDS12627.1.
RefSeqiNP_660339.1. NM_145296.1.
UniGeneiHs.370984.

Genome annotation databases

EnsembliENST00000222374; ENSP00000222374; ENSG00000105767.
GeneIDi199731.
KEGGihsa:199731.
UCSCiuc002oxc.1. human.

Polymorphism databases

DMDMi74762572.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF363368 mRNA. Translation: AAM60750.1.
AK313028 mRNA. Translation: BAG35862.1.
AC005525 Genomic DNA. Translation: AAC32740.1. Sequence problems.
CCDSiCCDS12627.1.
RefSeqiNP_660339.1. NM_145296.1.
UniGeneiHs.370984.

3D structure databases

ProteinModelPortaliQ8NFZ8.
SMRiQ8NFZ8. Positions 25-308.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128268. 5 interactions.
IntActiQ8NFZ8. 2 interactions.
STRINGi9606.ENSP00000222374.

PTM databases

PhosphoSiteiQ8NFZ8.

Polymorphism databases

DMDMi74762572.

Proteomic databases

MaxQBiQ8NFZ8.
PaxDbiQ8NFZ8.
PeptideAtlasiQ8NFZ8.
PRIDEiQ8NFZ8.

Protocols and materials databases

DNASUi199731.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222374; ENSP00000222374; ENSG00000105767.
GeneIDi199731.
KEGGihsa:199731.
UCSCiuc002oxc.1. human.

Organism-specific databases

CTDi199731.
GeneCardsiGC19M044126.
HGNCiHGNC:30825. CADM4.
HPAiHPA012612.
MIMi609744. gene.
neXtProtiNX_Q8NFZ8.
PharmGKBiPA162380931.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG40137.
GeneTreeiENSGT00770000120518.
HOGENOMiHOG000036057.
HOVERGENiHBG057086.
InParanoidiQ8NFZ8.
KOiK06783.
OMAiIICEAQN.
OrthoDBiEOG7PVWPD.
PhylomeDBiQ8NFZ8.
TreeFamiTF338300.

Miscellaneous databases

ChiTaRSiCADM4. human.
GenomeRNAii199731.
NextBioi89714.
PROiQ8NFZ8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NFZ8.
CleanExiHS_CADM4.
GenevestigatoriQ8NFZ8.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR028807. Cadm4.
IPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR003585. Neurexin-like.
[Graphical view]
PANTHERiPTHR23277:SF50. PTHR23277:SF50. 1 hit.
PfamiPF08205. C2-set_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins."
    Fukuhara H., Kuramochi M., Nobukuni T., Fukami T., Saino M., Maruyama T., Nomura S., Sekiya T., Murakami Y.
    Oncogene 20:5401-5407(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Cell adhesion and prostate tumor-suppressor activity of TSLL2/IGSF4C, an immunoglobulin superfamily molecule homologous to TSLC1/IGSF4."
    Williams Y.N., Masuda M., Sakurai-Yageta M., Maruyama T., Shibuya M., Murakami Y.
    Oncogene 25:1446-1453(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCADM4_HUMAN
AccessioniPrimary (citable) accession number: Q8NFZ8
Secondary accession number(s): B2R7L5, Q9Y4A4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 1, 2002
Last modified: March 4, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.