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Q8NFZ8

- CADM4_HUMAN

UniProt

Q8NFZ8 - CADM4_HUMAN

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Protein

Cell adhesion molecule 4

Gene
CADM4, IGSF4C, NECL4, TSLL2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity.1 Publication

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Cell adhesion molecule 4
Alternative name(s):
Immunoglobulin superfamily member 4C
Short name:
IgSF4C
Nectin-like protein 4
Short name:
NECL-4
TSLC1-like protein 2
Gene namesi
Name:CADM4
Synonyms:IGSF4C, NECL4, TSLL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:30825. CADM4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 324304Extracellular Reviewed predictionAdd
BLAST
Transmembranei325 – 34521Helical; Reviewed predictionAdd
BLAST
Topological domaini346 – 38843Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

PharmGKBiPA162380931.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 388368Cell adhesion molecule 4PRO_0000291980Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi31 – 311N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi44 ↔ 104 By similarity
Glycosylationi67 – 671N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi145 ↔ 199 By similarity
Disulfide bondi245 ↔ 291 By similarity
Glycosylationi286 – 2861N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8NFZ8.
PaxDbiQ8NFZ8.
PeptideAtlasiQ8NFZ8.
PRIDEiQ8NFZ8.

PTM databases

PhosphoSiteiQ8NFZ8.

Expressioni

Tissue specificityi

Expressed in brain, prostate, brain, kidney and some other organs.2 Publications

Gene expression databases

BgeeiQ8NFZ8.
CleanExiHS_CADM4.
GenevestigatoriQ8NFZ8.

Organism-specific databases

HPAiHPA012612.

Interactioni

Subunit structurei

Monomer and homodimer.1 Publication

Protein-protein interaction databases

BioGridi128268. 3 interactions.
IntActiQ8NFZ8. 2 interactions.
STRINGi9606.ENSP00000222374.

Structurei

3D structure databases

ProteinModelPortaliQ8NFZ8.
SMRiQ8NFZ8. Positions 21-315.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 11999Ig-like V-typeAdd
BLAST
Domaini124 – 21996Ig-like C2-type 1Add
BLAST
Domaini224 – 30784Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Belongs to the nectin family.

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40137.
HOGENOMiHOG000036057.
HOVERGENiHBG057086.
InParanoidiQ8NFZ8.
KOiK06783.
OMAiIICEAQN.
OrthoDBiEOG7PVWPD.
PhylomeDBiQ8NFZ8.
TreeFamiTF338300.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR028807. Cadm4.
IPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR003585. Neurexin-like.
[Graphical view]
PANTHERiPTHR23277:SF50. PTHR23277:SF50. 1 hit.
PfamiPF08205. C2-set_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NFZ8-1 [UniParc]FASTAAdd to Basket

« Hide

MGRARRFQWP LLLLWAAAAG PGAGQEVQTE NVTVAEGGVA EITCRLHQYD    50
GSIVVIQNPA RQTLFFNGTR ALKDERFQLE EFSPRRVRIR LSDARLEDEG 100
GYFCQLYTED THHQIATLTV LVAPENPVVE VREQAVEGGE VELSCLVPRS 150
RPAATLRWYR DRKELKGVSS SQENGKVWSV ASTVRFRVDR KDDGGIIICE 200
AQNQALPSGH SKQTQYVLDV QYSPTARIHA SQAVVREGDT LVLTCAVTGN 250
PRPNQIRWNR GNESLPERAE AVGETLTLPG LVSADNGTYT CEASNKHGHA 300
RALYVLVVYD PGAVVEAQTS VPYAIVGGIL ALLVFLIICV LVGMVWCSVR 350
QKGSYLTHEA SGLDEQGEAR EAFLNGSDGH KRKEEFFI 388
Length:388
Mass (Da):42,785
Last modified:October 1, 2002 - v1
Checksum:iB22301C9E21A9339
GO

Sequence cautioni

The sequence AAC32740.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti225 – 2251T → A.
Corresponds to variant rs34246023 [ dbSNP | Ensembl ].
VAR_032906

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF363368 mRNA. Translation: AAM60750.1.
AK313028 mRNA. Translation: BAG35862.1.
AC005525 Genomic DNA. Translation: AAC32740.1. Sequence problems.
CCDSiCCDS12627.1.
RefSeqiNP_660339.1. NM_145296.1.
UniGeneiHs.370984.

Genome annotation databases

EnsembliENST00000222374; ENSP00000222374; ENSG00000105767.
GeneIDi199731.
KEGGihsa:199731.
UCSCiuc002oxc.1. human.

Polymorphism databases

DMDMi74762572.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF363368 mRNA. Translation: AAM60750.1 .
AK313028 mRNA. Translation: BAG35862.1 .
AC005525 Genomic DNA. Translation: AAC32740.1 . Sequence problems.
CCDSi CCDS12627.1.
RefSeqi NP_660339.1. NM_145296.1.
UniGenei Hs.370984.

3D structure databases

ProteinModelPortali Q8NFZ8.
SMRi Q8NFZ8. Positions 21-315.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128268. 3 interactions.
IntActi Q8NFZ8. 2 interactions.
STRINGi 9606.ENSP00000222374.

PTM databases

PhosphoSitei Q8NFZ8.

Polymorphism databases

DMDMi 74762572.

Proteomic databases

MaxQBi Q8NFZ8.
PaxDbi Q8NFZ8.
PeptideAtlasi Q8NFZ8.
PRIDEi Q8NFZ8.

Protocols and materials databases

DNASUi 199731.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000222374 ; ENSP00000222374 ; ENSG00000105767 .
GeneIDi 199731.
KEGGi hsa:199731.
UCSCi uc002oxc.1. human.

Organism-specific databases

CTDi 199731.
GeneCardsi GC19M044126.
HGNCi HGNC:30825. CADM4.
HPAi HPA012612.
MIMi 609744. gene.
neXtProti NX_Q8NFZ8.
PharmGKBi PA162380931.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40137.
HOGENOMi HOG000036057.
HOVERGENi HBG057086.
InParanoidi Q8NFZ8.
KOi K06783.
OMAi IICEAQN.
OrthoDBi EOG7PVWPD.
PhylomeDBi Q8NFZ8.
TreeFami TF338300.

Miscellaneous databases

ChiTaRSi CADM4. human.
GenomeRNAii 199731.
NextBioi 89714.
PROi Q8NFZ8.
SOURCEi Search...

Gene expression databases

Bgeei Q8NFZ8.
CleanExi HS_CADM4.
Genevestigatori Q8NFZ8.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
InterProi IPR028807. Cadm4.
IPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR003585. Neurexin-like.
[Graphical view ]
PANTHERi PTHR23277:SF50. PTHR23277:SF50. 1 hit.
Pfami PF08205. C2-set_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00294. 4.1m. 1 hit.
SM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins."
    Fukuhara H., Kuramochi M., Nobukuni T., Fukami T., Saino M., Maruyama T., Nomura S., Sekiya T., Murakami Y.
    Oncogene 20:5401-5407(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Cell adhesion and prostate tumor-suppressor activity of TSLL2/IGSF4C, an immunoglobulin superfamily molecule homologous to TSLC1/IGSF4."
    Williams Y.N., Masuda M., Sakurai-Yageta M., Maruyama T., Shibuya M., Murakami Y.
    Oncogene 25:1446-1453(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCADM4_HUMAN
AccessioniPrimary (citable) accession number: Q8NFZ8
Secondary accession number(s): B2R7L5, Q9Y4A4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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