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Q8NFZ6

- VN1R2_HUMAN

UniProt

Q8NFZ6 - VN1R2_HUMAN

Protein

Vomeronasal type-1 receptor 2

Gene

VN1R2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    Putative pheromone receptor.

    GO - Molecular functioni

    1. pheromone receptor activity Source: InterPro

    GO - Biological processi

    1. response to pheromone Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Pheromone response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vomeronasal type-1 receptor 2
    Alternative name(s):
    G-protein coupled receptor GPCR25
    Short name:
    hGPCR25
    V1r-like receptor 2
    Gene namesi
    Name:VN1R2
    Synonyms:V1RL2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:19872. VN1R2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134969616.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 395395Vomeronasal type-1 receptor 2PRO_0000070214Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi343 – 3431N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8NFZ6.
    PRIDEiQ8NFZ6.

    Expressioni

    Gene expression databases

    BgeeiQ8NFZ6.
    CleanExiHS_VN1R2.
    GenevestigatoriQ8NFZ6.

    Organism-specific databases

    HPAiHPA044551.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000351244.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NFZ6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini33 – 5119ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini73 – 9321CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini115 – 17056ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini192 – 20817CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini230 – 26738ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini289 – 31628CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini338 – 3469ExtracellularSequence Analysis
    Topological domaini368 – 39528CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3221Helical; Name=0Sequence AnalysisAdd
    BLAST
    Transmembranei52 – 7221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei94 – 11421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei171 – 19121Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei209 – 22921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei268 – 28821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei317 – 33721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei347 – 36721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi50 – 556Poly-Val

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG279967.
    HOGENOMiHOG000231675.
    HOVERGENiHBG073430.
    InParanoidiQ8NFZ6.
    KOiK04614.
    OMAiSPFVLMC.
    OrthoDBiEOG7CG70G.
    PhylomeDBiQ8NFZ6.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR017452. GPCR_Rhodpsn_7TM.
    IPR004072. Vmron_rcpt_1.
    [Graphical view]
    PfamiPF03402. V1R. 1 hit.
    [Graphical view]
    PRINTSiPR01534. VOMERONASL1R.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NFZ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTHTLYPTPF ALYPINISAA WHLGPLPVSC FVSNKYQCSL AFGATTGLRV    50
    LVVVVPQTQL SFLSSLCLVS LFLHSLVSAH GEKPTKPVGL DPTLFQVVVG 100
    ILGNFSLLYY YMFLYFRGYK PRSTDLILRH LTVADSLVIL SKRIPETMAT 150
    FGLKHFDNYF GCKFLLYAHR VGRGVSIGST CLLSVFQVIT INPRNSRWAE 200
    MKVKAPTYIG LSNILCWAFH MLVNAIFPIY TTGKWSNNNI TKKGDLGYCS 250
    APLSDEVTKS VYAALTSFHD VLCLGLMLWA SSSIVLVLYR HKQQVQHICR 300
    NNLYPNSSPG NRAIQSILAL VSTFALCYAL SFITYVYLAL FDNSSWWLVN 350
    TAALIIACFP TISPFVLMCR DPSRSRLCSI CCRRNRRFFH DFRKM 395
    Length:395
    Mass (Da):44,476
    Last modified:March 6, 2007 - v2
    Checksum:i0C32D3A611B2C4BD
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti38 – 381C → R.3 Publications
    Corresponds to variant rs2965249 [ dbSNP | Ensembl ].
    VAR_022798

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF370359 Genomic DNA. Translation: AAM83034.1.
    AY312480 Genomic DNA. Translation: AAP85615.1.
    AY312481 Genomic DNA. Translation: AAP85616.1.
    AY312482 Genomic DNA. Translation: AAP85617.1.
    AB083607 Genomic DNA. Translation: BAB89320.1.
    CH471135 Genomic DNA. Translation: EAW72126.1.
    BC130356 mRNA. Translation: AAI30357.1.
    BC130358 mRNA. Translation: AAI30359.1.
    CCDSiCCDS12862.1.
    RefSeqiNP_776255.2. NM_173856.2.
    UniGeneiHs.553684.

    Genome annotation databases

    EnsembliENST00000341702; ENSP00000351244; ENSG00000196131.
    GeneIDi317701.
    KEGGihsa:317701.
    UCSCiuc002qbi.2. human.

    Polymorphism databases

    DMDMi146337173.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    No one nose - Issue 61 of August 2005

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF370359 Genomic DNA. Translation: AAM83034.1 .
    AY312480 Genomic DNA. Translation: AAP85615.1 .
    AY312481 Genomic DNA. Translation: AAP85616.1 .
    AY312482 Genomic DNA. Translation: AAP85617.1 .
    AB083607 Genomic DNA. Translation: BAB89320.1 .
    CH471135 Genomic DNA. Translation: EAW72126.1 .
    BC130356 mRNA. Translation: AAI30357.1 .
    BC130358 mRNA. Translation: AAI30359.1 .
    CCDSi CCDS12862.1.
    RefSeqi NP_776255.2. NM_173856.2.
    UniGenei Hs.553684.

    3D structure databases

    ProteinModelPortali Q8NFZ6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000351244.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 146337173.

    Proteomic databases

    PaxDbi Q8NFZ6.
    PRIDEi Q8NFZ6.

    Protocols and materials databases

    DNASUi 317701.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000341702 ; ENSP00000351244 ; ENSG00000196131 .
    GeneIDi 317701.
    KEGGi hsa:317701.
    UCSCi uc002qbi.2. human.

    Organism-specific databases

    CTDi 317701.
    GeneCardsi GC19P053760.
    HGNCi HGNC:19872. VN1R2.
    HPAi HPA044551.
    neXtProti NX_Q8NFZ6.
    PharmGKBi PA134969616.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG279967.
    HOGENOMi HOG000231675.
    HOVERGENi HBG073430.
    InParanoidi Q8NFZ6.
    KOi K04614.
    OMAi SPFVLMC.
    OrthoDBi EOG7CG70G.
    PhylomeDBi Q8NFZ6.

    Miscellaneous databases

    GeneWikii VN1R2.
    GenomeRNAii 317701.
    NextBioi 96362.
    PROi Q8NFZ6.

    Gene expression databases

    Bgeei Q8NFZ6.
    CleanExi HS_VN1R2.
    Genevestigatori Q8NFZ6.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR017452. GPCR_Rhodpsn_7TM.
    IPR004072. Vmron_rcpt_1.
    [Graphical view ]
    Pfami PF03402. V1R. 1 hit.
    [Graphical view ]
    PRINTSi PR01534. VOMERONASL1R.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel human vomeronasal receptor-like genes reveal species-specific families."
      Rodriguez I., Mombaerts P.
      Curr. Biol. 12:R409-R411(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-38.
    2. "Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates."
      Zhang J., Webb D.M.
      Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Identification of G protein-coupled receptor genes from the human genome sequence."
      Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
      FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-38.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-38.

    Entry informationi

    Entry nameiVN1R2_HUMAN
    AccessioniPrimary (citable) accession number: Q8NFZ6
    Secondary accession number(s): A1L411, Q8TDU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The chimpanzee, gorilla and orangutan orthologous proteins do not exist, their genes are pseudogenes.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3