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Q8NFZ6 (VN1R2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vomeronasal type-1 receptor 2
Alternative name(s):
G-protein coupled receptor GPCR25
Short name=hGPCR25
V1r-like receptor 2
Gene names
Name:VN1R2
Synonyms:V1RL2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length395 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative pheromone receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Miscellaneous

The chimpanzee, gorilla and orangutan orthologous proteins do not exist, their genes are pseudogenes.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Biological processPheromone response
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to pheromone

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionpheromone receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 395395Vomeronasal type-1 receptor 2
PRO_0000070214

Regions

Transmembrane12 – 3221Helical; Name=0; Potential
Topological domain33 – 5119Extracellular Potential
Transmembrane52 – 7221Helical; Name=1; Potential
Topological domain73 – 9321Cytoplasmic Potential
Transmembrane94 – 11421Helical; Name=2; Potential
Topological domain115 – 17056Extracellular Potential
Transmembrane171 – 19121Helical; Name=3; Potential
Topological domain192 – 20817Cytoplasmic Potential
Transmembrane209 – 22921Helical; Name=4; Potential
Topological domain230 – 26738Extracellular Potential
Transmembrane268 – 28821Helical; Name=5; Potential
Topological domain289 – 31628Cytoplasmic Potential
Transmembrane317 – 33721Helical; Name=6; Potential
Topological domain338 – 3469Extracellular Potential
Transmembrane347 – 36721Helical; Name=7; Potential
Topological domain368 – 39528Cytoplasmic Potential
Compositional bias50 – 556Poly-Val

Amino acid modifications

Glycosylation2391N-linked (GlcNAc...) Potential
Glycosylation3431N-linked (GlcNAc...) Potential

Natural variations

Natural variant381C → R. Ref.1 Ref.4 Ref.5
Corresponds to variant rs2965249 [ dbSNP | Ensembl ].
VAR_022798

Sequences

Sequence LengthMass (Da)Tools
Q8NFZ6 [UniParc].

Last modified March 6, 2007. Version 2.
Checksum: 0C32D3A611B2C4BD

FASTA39544,476
        10         20         30         40         50         60 
MTHTLYPTPF ALYPINISAA WHLGPLPVSC FVSNKYQCSL AFGATTGLRV LVVVVPQTQL 

        70         80         90        100        110        120 
SFLSSLCLVS LFLHSLVSAH GEKPTKPVGL DPTLFQVVVG ILGNFSLLYY YMFLYFRGYK 

       130        140        150        160        170        180 
PRSTDLILRH LTVADSLVIL SKRIPETMAT FGLKHFDNYF GCKFLLYAHR VGRGVSIGST 

       190        200        210        220        230        240 
CLLSVFQVIT INPRNSRWAE MKVKAPTYIG LSNILCWAFH MLVNAIFPIY TTGKWSNNNI 

       250        260        270        280        290        300 
TKKGDLGYCS APLSDEVTKS VYAALTSFHD VLCLGLMLWA SSSIVLVLYR HKQQVQHICR 

       310        320        330        340        350        360 
NNLYPNSSPG NRAIQSILAL VSTFALCYAL SFITYVYLAL FDNSSWWLVN TAALIIACFP 

       370        380        390 
TISPFVLMCR DPSRSRLCSI CCRRNRRFFH DFRKM 

« Hide

References

« Hide 'large scale' references
[1]"Novel human vomeronasal receptor-like genes reveal species-specific families."
Rodriguez I., Mombaerts P.
Curr. Biol. 12:R409-R411(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-38.
[2]"Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates."
Zhang J., Webb D.M.
Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Identification of G protein-coupled receptor genes from the human genome sequence."
Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-38.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-38.

Web resources

Protein Spotlight

No one nose - Issue 61 of August 2005

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF370359 Genomic DNA. Translation: AAM83034.1.
AY312480 Genomic DNA. Translation: AAP85615.1.
AY312481 Genomic DNA. Translation: AAP85616.1.
AY312482 Genomic DNA. Translation: AAP85617.1.
AB083607 Genomic DNA. Translation: BAB89320.1.
CH471135 Genomic DNA. Translation: EAW72126.1.
BC130356 mRNA. Translation: AAI30357.1.
BC130358 mRNA. Translation: AAI30359.1.
CCDSCCDS12862.1.
RefSeqNP_776255.2. NM_173856.2.
UniGeneHs.553684.

3D structure databases

ProteinModelPortalQ8NFZ6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000351244.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM146337173.

Proteomic databases

PaxDbQ8NFZ6.
PRIDEQ8NFZ6.

Protocols and materials databases

DNASU317701.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000341702; ENSP00000351244; ENSG00000196131.
GeneID317701.
KEGGhsa:317701.
UCSCuc002qbi.2. human.

Organism-specific databases

CTD317701.
GeneCardsGC19P053760.
HGNCHGNC:19872. VN1R2.
HPAHPA044551.
neXtProtNX_Q8NFZ6.
PharmGKBPA134969616.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG279967.
HOGENOMHOG000231675.
HOVERGENHBG073430.
InParanoidQ8NFZ6.
KOK04614.
OMASPFVLMC.
OrthoDBEOG7CG70G.
PhylomeDBQ8NFZ6.

Gene expression databases

BgeeQ8NFZ6.
CleanExHS_VN1R2.
GenevestigatorQ8NFZ6.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view]
PfamPF03402. V1R. 1 hit.
[Graphical view]
PRINTSPR01534. VOMERONASL1R.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiVN1R2.
GenomeRNAi317701.
NextBio96362.
PROQ8NFZ6.

Entry information

Entry nameVN1R2_HUMAN
AccessionPrimary (citable) accession number: Q8NFZ6
Secondary accession number(s): A1L411, Q8TDU4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: March 6, 2007
Last modified: July 9, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries