Q8NFZ6 (VN1R2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vomeronasal type-1 receptor 2

Alternative name(s):
G-protein coupled receptor GPCR25
Short name=hGPCR25
V1r-like receptor 2

Gene names

Name:	VN1R2
Synonyms:	V1RL2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Putative pheromone receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Miscellaneous	The chimpanzee, gorilla and orangutan orthologous proteins do not exist, their genes are pseudogenes.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Pheromone response
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to pheromone Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	pheromone receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 395	395	Vomeronasal type-1 receptor 2		PRO_0000070214
Regions
	Transmembrane	12 – 32	21	Helical; Name=0; Potential
	Topological domain	33 – 51	19	Extracellular Potential
	Transmembrane	52 – 72	21	Helical; Name=1; Potential
	Topological domain	73 – 93	21	Cytoplasmic Potential
	Transmembrane	94 – 114	21	Helical; Name=2; Potential
	Topological domain	115 – 170	56	Extracellular Potential
	Transmembrane	171 – 191	21	Helical; Name=3; Potential
	Topological domain	192 – 208	17	Cytoplasmic Potential
	Transmembrane	209 – 229	21	Helical; Name=4; Potential
	Topological domain	230 – 267	38	Extracellular Potential
	Transmembrane	268 – 288	21	Helical; Name=5; Potential
	Topological domain	289 – 316	28	Cytoplasmic Potential
	Transmembrane	317 – 337	21	Helical; Name=6; Potential
	Topological domain	338 – 346	9	Extracellular Potential
	Transmembrane	347 – 367	21	Helical; Name=7; Potential
	Topological domain	368 – 395	28	Cytoplasmic Potential
	Compositional bias	50 – 55	6	Poly-Val
Amino acid modifications
	Glycosylation	239	1	N-linked (GlcNAc...) Potential
	Glycosylation	343	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	38	1	C → R. Ref.1 Ref.4 Ref.5 Corresponds to variant rs2965249 [ dbSNP | Ensembl ].		VAR_022798

Sequences

	Sequence		Length	Mass (Da)
	Q8NFZ6 [UniParc]. Last modified March 6, 2007. Version 2. Checksum: 0C32D3A611B2C4BD	FASTA	395	44,476
	10 20 30 40 50 60 MTHTLYPTPF ALYPINISAA WHLGPLPVSC FVSNKYQCSL AFGATTGLRV LVVVVPQTQL 70 80 90 100 110 120 SFLSSLCLVS LFLHSLVSAH GEKPTKPVGL DPTLFQVVVG ILGNFSLLYY YMFLYFRGYK 130 140 150 160 170 180 PRSTDLILRH LTVADSLVIL SKRIPETMAT FGLKHFDNYF GCKFLLYAHR VGRGVSIGST 190 200 210 220 230 240 CLLSVFQVIT INPRNSRWAE MKVKAPTYIG LSNILCWAFH MLVNAIFPIY TTGKWSNNNI 250 260 270 280 290 300 TKKGDLGYCS APLSDEVTKS VYAALTSFHD VLCLGLMLWA SSSIVLVLYR HKQQVQHICR 310 320 330 340 350 360 NNLYPNSSPG NRAIQSILAL VSTFALCYAL SFITYVYLAL FDNSSWWLVN TAALIIACFP 370 380 390 TISPFVLMCR DPSRSRLCSI CCRRNRRFFH DFRKM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel human vomeronasal receptor-like genes reveal species-specific families." Rodriguez I., Mombaerts P. Curr. Biol. 12:R409-R411(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-38.
[2]	"Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates." Zhang J., Webb D.M. Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Identification of G protein-coupled receptor genes from the human genome sequence." Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S. FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-38.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-38.

Web resources

Protein Spotlight

No one nose - Issue 61 of August 2005

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF370359 Genomic DNA. Translation: AAM83034.1. AY312480 Genomic DNA. Translation: AAP85615.1. AY312481 Genomic DNA. Translation: AAP85616.1. AY312482 Genomic DNA. Translation: AAP85617.1. AB083607 Genomic DNA. Translation: BAB89320.1. CH471135 Genomic DNA. Translation: EAW72126.1. BC130356 mRNA. Translation: AAI30357.1. BC130358 mRNA. Translation: AAI30359.1.
IPI	IPI00176426.
RefSeq	NP_776255.2. NM_173856.2.
UniGene	Hs.553684.
3D structure databases
ProteinModelPortal	Q8NFZ6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000351244.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	146337173.
Proteomic databases
PaxDb	Q8NFZ6.
PRIDE	Q8NFZ6.
Protocols and materials databases
DNASU	317701.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000341702; ENSP00000351244; ENSG00000196131.
GeneID	317701.
KEGG	hsa:317701.
UCSC	uc002qbi.2. human.
Organism-specific databases
CTD	317701.
GeneCards	GC19P053760.
HGNC	HGNC:19872. VN1R2.
HPA	HPA044551.
neXtProt	NX_Q8NFZ6.
PharmGKB	PA134969616.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG279967.
HOGENOM	HOG000231675.
HOVERGEN	HBG073430.
InParanoid	Q8NFZ6.
KO	K04614.
OMA	SPFVLMC.
PhylomeDB	Q8NFZ6.
Gene expression databases
Bgee	Q8NFZ6.
CleanEx	HS_VN1R2.
Genevestigator	Q8NFZ6.
GermOnline	ENSG00000196131. Homo sapiens.
Family and domain databases
InterPro	IPR017452. GPCR_Rhodpsn_7TM. IPR004072. Vmron_rcpt_1. [Graphical view]
Pfam	PF03402. V1R. 1 hit. [Graphical view]
PRINTS	PR01534. VOMERONASL1R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	317701.
NextBio	96362.

Entry information

Entry name

VN1R2_HUMAN

Accession

Primary (citable) accession number: Q8NFZ6
Secondary accession number(s): A1L411, Q8TDU4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	March 6, 2007
Last modified:	May 1, 2013
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.