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Protein

Vomeronasal type-1 receptor 2

Gene

VN1R2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative pheromone receptor.

GO - Molecular functioni

  1. pheromone receptor activity Source: InterPro

GO - Biological processi

  1. response to pheromone Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Pheromone response

Names & Taxonomyi

Protein namesi
Recommended name:
Vomeronasal type-1 receptor 2
Alternative name(s):
G-protein coupled receptor GPCR25
Short name:
hGPCR25
V1r-like receptor 2
Gene namesi
Name:VN1R2
Synonyms:V1RL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:19872. VN1R2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221Helical; Name=0Sequence AnalysisAdd
BLAST
Topological domaini33 – 5119ExtracellularSequence AnalysisAdd
BLAST
Transmembranei52 – 7221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini73 – 9321CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei94 – 11421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini115 – 17056ExtracellularSequence AnalysisAdd
BLAST
Transmembranei171 – 19121Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini192 – 20817CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei209 – 22921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini230 – 26738ExtracellularSequence AnalysisAdd
BLAST
Transmembranei268 – 28821Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini289 – 31628CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei317 – 33721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini338 – 3469ExtracellularSequence Analysis
Transmembranei347 – 36721Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini368 – 39528CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134969616.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395Vomeronasal type-1 receptor 2PRO_0000070214Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi343 – 3431N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NFZ6.
PRIDEiQ8NFZ6.

Expressioni

Gene expression databases

BgeeiQ8NFZ6.
CleanExiHS_VN1R2.
GenevestigatoriQ8NFZ6.

Organism-specific databases

HPAiHPA044551.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000351244.

Structurei

3D structure databases

ProteinModelPortaliQ8NFZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi50 – 556Poly-Val

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG279967.
GeneTreeiENSGT00760000118911.
HOGENOMiHOG000231675.
HOVERGENiHBG073430.
InParanoidiQ8NFZ6.
KOiK04614.
OMAiSPFVLMC.
OrthoDBiEOG7CG70G.
PhylomeDBiQ8NFZ6.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view]
PfamiPF03402. V1R. 1 hit.
[Graphical view]
PRINTSiPR01534. VOMERONASL1R.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NFZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHTLYPTPF ALYPINISAA WHLGPLPVSC FVSNKYQCSL AFGATTGLRV
60 70 80 90 100
LVVVVPQTQL SFLSSLCLVS LFLHSLVSAH GEKPTKPVGL DPTLFQVVVG
110 120 130 140 150
ILGNFSLLYY YMFLYFRGYK PRSTDLILRH LTVADSLVIL SKRIPETMAT
160 170 180 190 200
FGLKHFDNYF GCKFLLYAHR VGRGVSIGST CLLSVFQVIT INPRNSRWAE
210 220 230 240 250
MKVKAPTYIG LSNILCWAFH MLVNAIFPIY TTGKWSNNNI TKKGDLGYCS
260 270 280 290 300
APLSDEVTKS VYAALTSFHD VLCLGLMLWA SSSIVLVLYR HKQQVQHICR
310 320 330 340 350
NNLYPNSSPG NRAIQSILAL VSTFALCYAL SFITYVYLAL FDNSSWWLVN
360 370 380 390
TAALIIACFP TISPFVLMCR DPSRSRLCSI CCRRNRRFFH DFRKM
Length:395
Mass (Da):44,476
Last modified:March 6, 2007 - v2
Checksum:i0C32D3A611B2C4BD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti38 – 381C → R.3 Publications
Corresponds to variant rs2965249 [ dbSNP | Ensembl ].
VAR_022798

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF370359 Genomic DNA. Translation: AAM83034.1.
AY312480 Genomic DNA. Translation: AAP85615.1.
AY312481 Genomic DNA. Translation: AAP85616.1.
AY312482 Genomic DNA. Translation: AAP85617.1.
AB083607 Genomic DNA. Translation: BAB89320.1.
CH471135 Genomic DNA. Translation: EAW72126.1.
BC130356 mRNA. Translation: AAI30357.1.
BC130358 mRNA. Translation: AAI30359.1.
CCDSiCCDS12862.1.
RefSeqiNP_776255.2. NM_173856.2.
UniGeneiHs.553684.

Genome annotation databases

EnsembliENST00000341702; ENSP00000351244; ENSG00000196131.
GeneIDi317701.
KEGGihsa:317701.
UCSCiuc002qbi.2. human.

Polymorphism databases

DMDMi146337173.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

No one nose - Issue 61 of August 2005

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF370359 Genomic DNA. Translation: AAM83034.1.
AY312480 Genomic DNA. Translation: AAP85615.1.
AY312481 Genomic DNA. Translation: AAP85616.1.
AY312482 Genomic DNA. Translation: AAP85617.1.
AB083607 Genomic DNA. Translation: BAB89320.1.
CH471135 Genomic DNA. Translation: EAW72126.1.
BC130356 mRNA. Translation: AAI30357.1.
BC130358 mRNA. Translation: AAI30359.1.
CCDSiCCDS12862.1.
RefSeqiNP_776255.2. NM_173856.2.
UniGeneiHs.553684.

3D structure databases

ProteinModelPortaliQ8NFZ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000351244.

Protein family/group databases

GPCRDBiSearch...

Polymorphism databases

DMDMi146337173.

Proteomic databases

PaxDbiQ8NFZ6.
PRIDEiQ8NFZ6.

Protocols and materials databases

DNASUi317701.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341702; ENSP00000351244; ENSG00000196131.
GeneIDi317701.
KEGGihsa:317701.
UCSCiuc002qbi.2. human.

Organism-specific databases

CTDi317701.
GeneCardsiGC19P053760.
HGNCiHGNC:19872. VN1R2.
HPAiHPA044551.
neXtProtiNX_Q8NFZ6.
PharmGKBiPA134969616.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG279967.
GeneTreeiENSGT00760000118911.
HOGENOMiHOG000231675.
HOVERGENiHBG073430.
InParanoidiQ8NFZ6.
KOiK04614.
OMAiSPFVLMC.
OrthoDBiEOG7CG70G.
PhylomeDBiQ8NFZ6.

Miscellaneous databases

GeneWikiiVN1R2.
GenomeRNAii317701.
NextBioi96362.
PROiQ8NFZ6.

Gene expression databases

BgeeiQ8NFZ6.
CleanExiHS_VN1R2.
GenevestigatoriQ8NFZ6.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view]
PfamiPF03402. V1R. 1 hit.
[Graphical view]
PRINTSiPR01534. VOMERONASL1R.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel human vomeronasal receptor-like genes reveal species-specific families."
    Rodriguez I., Mombaerts P.
    Curr. Biol. 12:R409-R411(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-38.
  2. "Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates."
    Zhang J., Webb D.M.
    Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Identification of G protein-coupled receptor genes from the human genome sequence."
    Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
    FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-38.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-38.

Entry informationi

Entry nameiVN1R2_HUMAN
AccessioniPrimary (citable) accession number: Q8NFZ6
Secondary accession number(s): A1L411, Q8TDU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: March 6, 2007
Last modified: January 7, 2015
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The chimpanzee, gorilla and orangutan orthologous proteins do not exist, their genes are pseudogenes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.