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Protein

Vomeronasal type-1 receptor 2

Gene

VN1R2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative pheromone receptor.

Miscellaneous

The chimpanzee, gorilla and orangutan orthologous proteins do not exist, their genes are pseudogenes.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processPheromone response

Names & Taxonomyi

Protein namesi
Recommended name:
Vomeronasal type-1 receptor 2
Alternative name(s):
G-protein coupled receptor GPCR25
Short name:
hGPCR25
V1r-like receptor 2
Gene namesi
Name:VN1R2
Synonyms:V1RL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:19872. VN1R2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32Helical; Name=0Sequence analysisAdd BLAST21
Topological domaini33 – 51ExtracellularSequence analysisAdd BLAST19
Transmembranei52 – 72Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini73 – 93CytoplasmicSequence analysisAdd BLAST21
Transmembranei94 – 114Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini115 – 170ExtracellularSequence analysisAdd BLAST56
Transmembranei171 – 191Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini192 – 208CytoplasmicSequence analysisAdd BLAST17
Transmembranei209 – 229Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini230 – 267ExtracellularSequence analysisAdd BLAST38
Transmembranei268 – 288Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini289 – 316CytoplasmicSequence analysisAdd BLAST28
Transmembranei317 – 337Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini338 – 346ExtracellularSequence analysis9
Transmembranei347 – 367Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini368 – 395CytoplasmicSequence analysisAdd BLAST28

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi317701.
PharmGKBiPA134969616.

Polymorphism and mutation databases

BioMutaiVN1R2.
DMDMi146337173.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000702141 – 395Vomeronasal type-1 receptor 2Add BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi239N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi343N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NFZ6.
PeptideAtlasiQ8NFZ6.
PRIDEiQ8NFZ6.

Expressioni

Gene expression databases

BgeeiENSG00000196131.
CleanExiHS_VN1R2.
GenevisibleiQ8NFZ6. HS.

Organism-specific databases

HPAiHPA044551.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000351244.

Structurei

3D structure databases

ProteinModelPortaliQ8NFZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi50 – 55Poly-Val6

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKIB. Eukaryota.
ENOG4111F74. LUCA.
GeneTreeiENSGT00760000118911.
HOGENOMiHOG000231675.
HOVERGENiHBG073430.
InParanoidiQ8NFZ6.
KOiK04614.
OMAiFHDVLCL.
OrthoDBiEOG091G0D1J.
PhylomeDBiQ8NFZ6.

Family and domain databases

InterProiView protein in InterPro
IPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
PfamiView protein in Pfam
PF03402. V1R. 1 hit.
PRINTSiPR01534. VOMERONASL1R.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NFZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHTLYPTPF ALYPINISAA WHLGPLPVSC FVSNKYQCSL AFGATTGLRV
60 70 80 90 100
LVVVVPQTQL SFLSSLCLVS LFLHSLVSAH GEKPTKPVGL DPTLFQVVVG
110 120 130 140 150
ILGNFSLLYY YMFLYFRGYK PRSTDLILRH LTVADSLVIL SKRIPETMAT
160 170 180 190 200
FGLKHFDNYF GCKFLLYAHR VGRGVSIGST CLLSVFQVIT INPRNSRWAE
210 220 230 240 250
MKVKAPTYIG LSNILCWAFH MLVNAIFPIY TTGKWSNNNI TKKGDLGYCS
260 270 280 290 300
APLSDEVTKS VYAALTSFHD VLCLGLMLWA SSSIVLVLYR HKQQVQHICR
310 320 330 340 350
NNLYPNSSPG NRAIQSILAL VSTFALCYAL SFITYVYLAL FDNSSWWLVN
360 370 380 390
TAALIIACFP TISPFVLMCR DPSRSRLCSI CCRRNRRFFH DFRKM
Length:395
Mass (Da):44,476
Last modified:March 6, 2007 - v2
Checksum:i0C32D3A611B2C4BD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02279838C → R3 PublicationsCorresponds to variant dbSNP:rs2965249Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF370359 Genomic DNA. Translation: AAM83034.1.
AY312480 Genomic DNA. Translation: AAP85615.1.
AY312481 Genomic DNA. Translation: AAP85616.1.
AY312482 Genomic DNA. Translation: AAP85617.1.
AB083607 Genomic DNA. Translation: BAB89320.1.
CH471135 Genomic DNA. Translation: EAW72126.1.
BC130356 mRNA. Translation: AAI30357.1.
BC130358 mRNA. Translation: AAI30359.1.
CCDSiCCDS12862.1.
RefSeqiNP_776255.2. NM_173856.2.
UniGeneiHs.553684.

Genome annotation databases

EnsembliENST00000341702; ENSP00000351244; ENSG00000196131.
GeneIDi317701.
KEGGihsa:317701.
UCSCiuc002qbi.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiVN1R2_HUMAN
AccessioniPrimary (citable) accession number: Q8NFZ6
Secondary accession number(s): A1L411, Q8TDU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: March 6, 2007
Last modified: June 7, 2017
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  6. SIMILARITY comments
    Index of protein domains and families