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Q8NFZ6

- VN1R2_HUMAN

UniProt

Q8NFZ6 - VN1R2_HUMAN

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Protein

Vomeronasal type-1 receptor 2

Gene
VN1R2, V1RL2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Putative pheromone receptor.

GO - Molecular functioni

  1. pheromone receptor activity Source: InterPro

GO - Biological processi

  1. response to pheromone Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Pheromone response

Names & Taxonomyi

Protein namesi
Recommended name:
Vomeronasal type-1 receptor 2
Alternative name(s):
G-protein coupled receptor GPCR25
Short name:
hGPCR25
V1r-like receptor 2
Gene namesi
Name:VN1R2
Synonyms:V1RL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:19872. VN1R2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221Helical; Name=0; Reviewed predictionAdd
BLAST
Topological domaini33 – 5119Extracellular Reviewed predictionAdd
BLAST
Transmembranei52 – 7221Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini73 – 9321Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei94 – 11421Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini115 – 17056Extracellular Reviewed predictionAdd
BLAST
Transmembranei171 – 19121Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini192 – 20817Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei209 – 22921Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini230 – 26738Extracellular Reviewed predictionAdd
BLAST
Transmembranei268 – 28821Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini289 – 31628Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei317 – 33721Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini338 – 3469Extracellular Reviewed prediction
Transmembranei347 – 36721Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini368 – 39528Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134969616.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395Vomeronasal type-1 receptor 2PRO_0000070214Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi239 – 2391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi343 – 3431N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NFZ6.
PRIDEiQ8NFZ6.

Expressioni

Gene expression databases

BgeeiQ8NFZ6.
CleanExiHS_VN1R2.
GenevestigatoriQ8NFZ6.

Organism-specific databases

HPAiHPA044551.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000351244.

Structurei

3D structure databases

ProteinModelPortaliQ8NFZ6.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi50 – 556Poly-Val

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG279967.
HOGENOMiHOG000231675.
HOVERGENiHBG073430.
InParanoidiQ8NFZ6.
KOiK04614.
OMAiSPFVLMC.
OrthoDBiEOG7CG70G.
PhylomeDBiQ8NFZ6.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view]
PfamiPF03402. V1R. 1 hit.
[Graphical view]
PRINTSiPR01534. VOMERONASL1R.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NFZ6-1 [UniParc]FASTAAdd to Basket

« Hide

MTHTLYPTPF ALYPINISAA WHLGPLPVSC FVSNKYQCSL AFGATTGLRV    50
LVVVVPQTQL SFLSSLCLVS LFLHSLVSAH GEKPTKPVGL DPTLFQVVVG 100
ILGNFSLLYY YMFLYFRGYK PRSTDLILRH LTVADSLVIL SKRIPETMAT 150
FGLKHFDNYF GCKFLLYAHR VGRGVSIGST CLLSVFQVIT INPRNSRWAE 200
MKVKAPTYIG LSNILCWAFH MLVNAIFPIY TTGKWSNNNI TKKGDLGYCS 250
APLSDEVTKS VYAALTSFHD VLCLGLMLWA SSSIVLVLYR HKQQVQHICR 300
NNLYPNSSPG NRAIQSILAL VSTFALCYAL SFITYVYLAL FDNSSWWLVN 350
TAALIIACFP TISPFVLMCR DPSRSRLCSI CCRRNRRFFH DFRKM 395
Length:395
Mass (Da):44,476
Last modified:March 6, 2007 - v2
Checksum:i0C32D3A611B2C4BD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti38 – 381C → R.3 Publications
Corresponds to variant rs2965249 [ dbSNP | Ensembl ].
VAR_022798

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF370359 Genomic DNA. Translation: AAM83034.1.
AY312480 Genomic DNA. Translation: AAP85615.1.
AY312481 Genomic DNA. Translation: AAP85616.1.
AY312482 Genomic DNA. Translation: AAP85617.1.
AB083607 Genomic DNA. Translation: BAB89320.1.
CH471135 Genomic DNA. Translation: EAW72126.1.
BC130356 mRNA. Translation: AAI30357.1.
BC130358 mRNA. Translation: AAI30359.1.
CCDSiCCDS12862.1.
RefSeqiNP_776255.2. NM_173856.2.
UniGeneiHs.553684.

Genome annotation databases

EnsembliENST00000341702; ENSP00000351244; ENSG00000196131.
GeneIDi317701.
KEGGihsa:317701.
UCSCiuc002qbi.2. human.

Polymorphism databases

DMDMi146337173.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

No one nose - Issue 61 of August 2005

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF370359 Genomic DNA. Translation: AAM83034.1 .
AY312480 Genomic DNA. Translation: AAP85615.1 .
AY312481 Genomic DNA. Translation: AAP85616.1 .
AY312482 Genomic DNA. Translation: AAP85617.1 .
AB083607 Genomic DNA. Translation: BAB89320.1 .
CH471135 Genomic DNA. Translation: EAW72126.1 .
BC130356 mRNA. Translation: AAI30357.1 .
BC130358 mRNA. Translation: AAI30359.1 .
CCDSi CCDS12862.1.
RefSeqi NP_776255.2. NM_173856.2.
UniGenei Hs.553684.

3D structure databases

ProteinModelPortali Q8NFZ6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000351244.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 146337173.

Proteomic databases

PaxDbi Q8NFZ6.
PRIDEi Q8NFZ6.

Protocols and materials databases

DNASUi 317701.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000341702 ; ENSP00000351244 ; ENSG00000196131 .
GeneIDi 317701.
KEGGi hsa:317701.
UCSCi uc002qbi.2. human.

Organism-specific databases

CTDi 317701.
GeneCardsi GC19P053760.
HGNCi HGNC:19872. VN1R2.
HPAi HPA044551.
neXtProti NX_Q8NFZ6.
PharmGKBi PA134969616.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG279967.
HOGENOMi HOG000231675.
HOVERGENi HBG073430.
InParanoidi Q8NFZ6.
KOi K04614.
OMAi SPFVLMC.
OrthoDBi EOG7CG70G.
PhylomeDBi Q8NFZ6.

Miscellaneous databases

GeneWikii VN1R2.
GenomeRNAii 317701.
NextBioi 96362.
PROi Q8NFZ6.

Gene expression databases

Bgeei Q8NFZ6.
CleanExi HS_VN1R2.
Genevestigatori Q8NFZ6.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view ]
Pfami PF03402. V1R. 1 hit.
[Graphical view ]
PRINTSi PR01534. VOMERONASL1R.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel human vomeronasal receptor-like genes reveal species-specific families."
    Rodriguez I., Mombaerts P.
    Curr. Biol. 12:R409-R411(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-38.
  2. "Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates."
    Zhang J., Webb D.M.
    Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Identification of G protein-coupled receptor genes from the human genome sequence."
    Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
    FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-38.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-38.

Entry informationi

Entry nameiVN1R2_HUMAN
AccessioniPrimary (citable) accession number: Q8NFZ6
Secondary accession number(s): A1L411, Q8TDU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: March 6, 2007
Last modified: July 9, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The chimpanzee, gorilla and orangutan orthologous proteins do not exist, their genes are pseudogenes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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