##gff-version 3
Q8NFZ5	UniProtKB	Chain	1	429	.	.	.	ID=PRO_0000322583;Note=TNFAIP3-interacting protein 2	
Q8NFZ5	UniProtKB	Zinc finger	397	429	.	.	.	Note=CCHC NOA-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01142	
Q8NFZ5	UniProtKB	Region	177	199	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q8NFZ5	UniProtKB	Region	289	347	.	.	.	Note=Ubiquitin-binding domain (UBD)	
Q8NFZ5	UniProtKB	Region	372	400	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q8NFZ5	UniProtKB	Coiled coil	29	117	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q8NFZ5	UniProtKB	Coiled coil	196	226	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q8NFZ5	UniProtKB	Coiled coil	255	340	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q8NFZ5	UniProtKB	Compositional bias	177	192	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q8NFZ5	UniProtKB	Binding site	405	405	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01142	
Q8NFZ5	UniProtKB	Binding site	408	408	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01142	
Q8NFZ5	UniProtKB	Binding site	423	423	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01142	
Q8NFZ5	UniProtKB	Binding site	427	427	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01142	
Q8NFZ5	UniProtKB	Modified residue	7	7	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569	
Q8NFZ5	UniProtKB	Alternative sequence	1	107	.	.	.	ID=VSP_052701;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039	
Q8NFZ5	UniProtKB	Natural variant	249	249	.	.	.	ID=VAR_067969;Note=Found in patients with gastrointestinal diffuse large cell lymphoma%3B impairs inhibitory activity on CARD11-induced NF-kappa-B activation. Q->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21266526;Dbxref=dbSNP:rs116129895,PMID:21266526	
Q8NFZ5	UniProtKB	Natural variant	255	255	.	.	.	ID=VAR_067970;Note=Found in patients with gastrointestinal diffuse large cell lymphoma%3B somatic mutation%3B impairs inhibitory activity on CARD11-induced NF-kappa-B activation and impairs interaction with TNFAIP3. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21266526;Dbxref=dbSNP:rs116412781,PMID:21266526	
Q8NFZ5	UniProtKB	Natural variant	396	396	.	.	.	ID=VAR_039463;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2269495,PMID:14702039,PMID:15489334	
Q8NFZ5	UniProtKB	Mutagenesis	62	62	.	.	.	Note=Reduces phosphorylation. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21784860;Dbxref=PMID:21784860	
Q8NFZ5	UniProtKB	Mutagenesis	146	146	.	.	.	Note=Reduces phosphorylation%3B reduces CHUK-mediated NF-kappa-B activation. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21784860;Dbxref=PMID:21784860	
Q8NFZ5	UniProtKB	Mutagenesis	309	310	.	.	.	Note=Abolishes ubiquitin binding. DF->NA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18212736;Dbxref=PMID:18212736	
Q8NFZ5	UniProtKB	Mutagenesis	313	314	.	.	.	Note=Abolishes ubiquitin binding%3B loss of inhibitory activity on NF-kappa-B activation. ER->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18212736;Dbxref=PMID:18212736	
Q8NFZ5	UniProtKB	Sequence conflict	153	153	.	.	.	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q8NFZ5	UniProtKB	Helix	263	273	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5H07	
Q8NFZ5	UniProtKB	Helix	276	336	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5H07