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Q8NFZ5

- TNIP2_HUMAN

UniProt

Q8NFZ5 - TNIP2_HUMAN

Protein

TNFAIP3-interacting protein 2

Gene

TNIP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.6 Publications

    GO - Molecular functioni

    1. polyubiquitin binding Source: UniProtKB
    2. protein binding Source: IntAct
    3. protein kinase binding Source: UniProtKB

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. CD40 signaling pathway Source: UniProtKB
    3. cellular response to lipopolysaccharide Source: UniProtKB
    4. I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    5. inflammatory response Source: UniProtKB-KW
    6. interleukin-1-mediated signaling pathway Source: UniProtKB
    7. negative regulation of endothelial cell apoptotic process Source: UniProtKB
    8. positive regulation of B cell activation Source: UniProtKB
    9. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
    10. positive regulation of macrophage activation Source: UniProtKB
    11. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    12. protein stabilization Source: UniProtKB
    13. toll-like receptor 2 signaling pathway Source: UniProtKB
    14. toll-like receptor 3 signaling pathway Source: UniProtKB
    15. toll-like receptor 9 signaling pathway Source: UniProtKB
    16. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Apoptosis, Inflammatory response, Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_22442. Interleukin-1 signaling.
    SignaLinkiQ8NFZ5.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TNFAIP3-interacting protein 2
    Alternative name(s):
    A20-binding inhibitor of NF-kappa-B activation 2
    Short name:
    ABIN-2
    Fetal liver LKB1-interacting protein
    Gene namesi
    Name:TNIP2Imported
    Synonyms:ABIN2, FLIP1Imported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:19118. TNIP2.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus Curated

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi62 – 621S → A: Reduces phosphorylation. 2 Publications
    Mutagenesisi146 – 1461S → A: Reduces phosphorylation; reduces CHUK-mediated NF-kappa-B activation. 2 Publications
    Mutagenesisi309 – 3102DF → NA: Abolishes ubiquitin binding. 1 Publication
    Mutagenesisi313 – 3142ER → AA: Abolishes ubiquitin binding; loss of inhibitory activity on NF-kappa-B activation. 1 Publication

    Organism-specific databases

    PharmGKBiPA134957006.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 429429TNFAIP3-interacting protein 2PRO_0000322583Add
    BLAST

    Post-translational modificationi

    In vitro phosphorylated by CHUK.1 Publication
    Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination probably leading to constitutive proteasomal degradation which can be impaired by IKK-A/CHUK or IKBKB probbaly involving deubiquitination.1 Publication

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ8NFZ5.
    PaxDbiQ8NFZ5.
    PRIDEiQ8NFZ5.

    PTM databases

    PhosphoSiteiQ8NFZ5.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed in all tissues examined.1 Publication

    Gene expression databases

    ArrayExpressiQ8NFZ5.
    BgeeiQ8NFZ5.
    CleanExiHS_TNIP2.
    GenevestigatoriQ8NFZ5.

    Organism-specific databases

    HPAiCAB020818.
    HPA049886.

    Interactioni

    Subunit structurei

    Interacts with STK11/LKB1, TNFAIP3, IKBKG, NFKB1, MAP3K8, TEK, RIPK1, CHUK, IKBKB and SMARCD1. Interacts with polyubiquitin.8 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    IKBKGQ9Y6K96EBI-359372,EBI-81279
    MAP3K8P412799EBI-359372,EBI-354900
    NFKB1P19838-18EBI-359372,EBI-1452239
    STK11Q158315EBI-359372,EBI-306838

    Protein-protein interaction databases

    BioGridi122573. 23 interactions.
    DIPiDIP-27617N.
    IntActiQ8NFZ5. 18 interactions.
    MINTiMINT-97349.
    STRINGi9606.ENSP00000321203.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NFZ5.
    SMRiQ8NFZ5. Positions 400-429.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni289 – 34759Ubiquitin-binding domain (UBD)Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili29 – 11789Sequence AnalysisAdd
    BLAST
    Coiled coili196 – 22631Sequence AnalysisAdd
    BLAST
    Coiled coili255 – 34086Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG47580.
    HOGENOMiHOG000049046.
    HOVERGENiHBG055553.
    InParanoidiQ8NFZ5.
    OMAiADETHQL.
    OrthoDBiEOG7M0NRH.
    PhylomeDBiQ8NFZ5.
    TreeFamiTF332167.

    Family and domain databases

    InterProiIPR022008. EABR.
    [Graphical view]
    PfamiPF12180. EABR. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 13 Publications (identifier: Q8NFZ5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSRDPGSGGW EEAPRAAAAL CTLYHEAGQR LRRLQDQLAA RDALIARLRA    50
    RLAALEGDAA PSLVDALLEQ VARFREQLRR QEGGAAEAQM RQEIERLTER 100
    LEEKEREMQQ LLSQPQHERE KEVVLLRRSM AEGERARAAS DVLCRSLANE 150
    THQLRRTLTA TAHMCQHLAK CLDERQHAQR NVGERSPDQS EHTDGHTSVQ 200
    SVIEKLQEEN RLLKQKVTHV EDLNAKWQRY NASRDEYVRG LHAQLRGLQI 250
    PHEPELMRKE ISRLNRQLEE KINDCAEVKQ ELAASRTARD AALERVQMLE 300
    QQILAYKDDF MSERADRERA QSRIQELEEK VASLLHQVSW RQDSREPDAG 350
    RIHAGSKTAK YLAADALELM VPGGWRPGTG SQQPEPPAEG GHPGAAQRGQ 400
    GDLQCPHCLQ CFSDEQGEEL LRHVAECCQ 429
    Length:429
    Mass (Da):48,700
    Last modified:October 1, 2002 - v1
    Checksum:i0F6B049C2B3483DC
    GO
    Isoform 21 Publication (identifier: Q8NFZ5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-107: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:322
    Mass (Da):36,682
    Checksum:i4B145A09A85133BE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti153 – 1531Q → H in CAC34835. (PubMed:11390377)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti249 – 2491Q → H in patients with gastrointestinal diffuse large cell lymphoma; impairs inhibitory activity on CARD11-induced NF-kappa-B activation. 1 Publication
    Corresponds to variant rs116129895 [ dbSNP | Ensembl ].
    VAR_067969
    Natural varianti255 – 2551E → K in patients with gastrointestinal diffuse large cell lymphoma; somatic mutation; impairs inhibitory activity on CARD11-induced NF-kappa-B activation and impairs interaction with TNFAIP3. 1 Publication
    Corresponds to variant rs116412781 [ dbSNP | Ensembl ].
    VAR_067970
    Natural varianti396 – 3961A → V.2 Publications
    Corresponds to variant rs2269495 [ dbSNP | Ensembl ].
    VAR_039463

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 107107Missing in isoform 2. 1 PublicationVSP_052701Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ304866 mRNA. Translation: CAC34835.1.
    AF372839 mRNA. Translation: AAM21315.1.
    AK026176 mRNA. Translation: BAB15382.1.
    AK096296 mRNA. Translation: BAG53250.1.
    CH471131 Genomic DNA. Translation: EAW82514.1.
    AL121750, AL110117 Genomic DNA. Translation: CAM28233.1.
    AL110117, AL121750 Genomic DNA. Translation: CAM28252.1.
    CH471131 Genomic DNA. Translation: EAW82516.1.
    BC002740 mRNA. Translation: AAH02740.2.
    CCDSiCCDS3362.1. [Q8NFZ5-1]
    CCDS54714.1. [Q8NFZ5-2]
    RefSeqiNP_001154999.1. NM_001161527.1. [Q8NFZ5-2]
    NP_077285.3. NM_024309.3. [Q8NFZ5-1]
    UniGeneiHs.368551.

    Genome annotation databases

    EnsembliENST00000315423; ENSP00000321203; ENSG00000168884. [Q8NFZ5-1]
    ENST00000510267; ENSP00000427613; ENSG00000168884. [Q8NFZ5-2]
    GeneIDi79155.
    KEGGihsa:79155.
    UCSCiuc003gff.2. human. [Q8NFZ5-1]

    Polymorphism databases

    DMDMi74715616.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ304866 mRNA. Translation: CAC34835.1 .
    AF372839 mRNA. Translation: AAM21315.1 .
    AK026176 mRNA. Translation: BAB15382.1 .
    AK096296 mRNA. Translation: BAG53250.1 .
    CH471131 Genomic DNA. Translation: EAW82514.1 .
    AL121750 , AL110117 Genomic DNA. Translation: CAM28233.1 .
    AL110117 , AL121750 Genomic DNA. Translation: CAM28252.1 .
    CH471131 Genomic DNA. Translation: EAW82516.1 .
    BC002740 mRNA. Translation: AAH02740.2 .
    CCDSi CCDS3362.1. [Q8NFZ5-1 ]
    CCDS54714.1. [Q8NFZ5-2 ]
    RefSeqi NP_001154999.1. NM_001161527.1. [Q8NFZ5-2 ]
    NP_077285.3. NM_024309.3. [Q8NFZ5-1 ]
    UniGenei Hs.368551.

    3D structure databases

    ProteinModelPortali Q8NFZ5.
    SMRi Q8NFZ5. Positions 400-429.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122573. 23 interactions.
    DIPi DIP-27617N.
    IntActi Q8NFZ5. 18 interactions.
    MINTi MINT-97349.
    STRINGi 9606.ENSP00000321203.

    PTM databases

    PhosphoSitei Q8NFZ5.

    Polymorphism databases

    DMDMi 74715616.

    Proteomic databases

    MaxQBi Q8NFZ5.
    PaxDbi Q8NFZ5.
    PRIDEi Q8NFZ5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000315423 ; ENSP00000321203 ; ENSG00000168884 . [Q8NFZ5-1 ]
    ENST00000510267 ; ENSP00000427613 ; ENSG00000168884 . [Q8NFZ5-2 ]
    GeneIDi 79155.
    KEGGi hsa:79155.
    UCSCi uc003gff.2. human. [Q8NFZ5-1 ]

    Organism-specific databases

    CTDi 79155.
    GeneCardsi GC04M002780.
    H-InvDB HIX0164015.
    HGNCi HGNC:19118. TNIP2.
    HPAi CAB020818.
    HPA049886.
    MIMi 610669. gene.
    neXtProti NX_Q8NFZ5.
    PharmGKBi PA134957006.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47580.
    HOGENOMi HOG000049046.
    HOVERGENi HBG055553.
    InParanoidi Q8NFZ5.
    OMAi ADETHQL.
    OrthoDBi EOG7M0NRH.
    PhylomeDBi Q8NFZ5.
    TreeFami TF332167.

    Enzyme and pathway databases

    Reactomei REACT_22442. Interleukin-1 signaling.
    SignaLinki Q8NFZ5.

    Miscellaneous databases

    GeneWikii TNIP2.
    GenomeRNAii 79155.
    NextBioi 68079.
    PROi Q8NFZ5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8NFZ5.
    Bgeei Q8NFZ5.
    CleanExi HS_TNIP2.
    Genevestigatori Q8NFZ5.

    Family and domain databases

    InterProi IPR022008. EABR.
    [Graphical view ]
    Pfami PF12180. EABR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel A20-binding inhibitor of nuclear factor-kappaB activation termed ABIN-2."
      Van Huffel S.C., Delaei F., Heyninck K., De Valck D., Beyaert R.
      J. Biol. Chem. 276:30216-30223(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation."
      Liu W.-K., Chien C.-Y., Chou C.-K., Su J.-Y.
      J. Biomed. Sci. 10:242-252(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH STK11/LKB1.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-396.
      Tissue: Kidney epitheliumImported.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-396.
      Tissue: UterusImported.
    7. "Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions."
      Klinkenberg M., Van Huffel S., Heyninck K., Beyaert R.
      FEBS Lett. 498:93-97(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TNFAIP3.
    8. "ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1."
      Tadros A., Hughes D.P., Dunmore B.J., Brindle N.P.
      Blood 102:4407-4409(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2."
      Hughes D.P., Marron M.B., Brindle N.P.
      Circ. Res. 92:630-636(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TEK.
    10. "The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation."
      Chien C.Y., Liu W.K., Chou C.K., Su J.Y.
      FEBS Lett. 543:55-60(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SMARCD1.
    11. "The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis."
      Liu W.-K., Yen P.-F., Chien C.-Y., Fann M.-J., Su J.-Y., Chou C.-K.
      Biochem. J. 378:867-876(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH IKBKG.
    12. "ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability."
      Lang V., Symons A., Watton S.J., Janzen J., Soneji Y., Beinke S., Howell S., Ley S.C.
      Mol. Cell. Biol. 24:5235-5248(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH NFKB1; MAP3K8 AND TNFAIP3.
    13. "Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins."
      Wagner S., Carpentier I., Rogov V., Kreike M., Ikeda F., Lohr F., Wu C.J., Ashwell J.D., Dotsch V., Dikic I., Beyaert R.
      Oncogene 27:3739-3745(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITIN-BINDING, MUTAGENESIS OF 309-ASP-PHE-310 AND 313-GLU-ARG-314.
    14. "A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2 (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase alpha (IKKalpha)-mediated NF-kappaB transcriptional activity."
      Leotoing L., Chereau F., Baron S., Hube F., Valencia H.J., Bordereaux D., Demmers J.A., Strouboulis J., Baud V.
      J. Biol. Chem. 286:32277-32288(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CHUK AND IKBKB, UBIQUITINATION, PHOSPHORYLATION, MUTAGENESIS OF SER-62 AND SER-146.
    15. "A20, ABIN-1/2, and CARD11 mutations and their prognostic value in gastrointestinal diffuse large B-cell lymphoma."
      Dong G., Chanudet E., Zeng N., Appert A., Chen Y.W., Au W.Y., Hamoudi R.A., Watkins A.J., Ye H., Liu H., Gao Z., Chuang S.S., Srivastava G., Du M.Q.
      Clin. Cancer Res. 17:1440-1451(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS HIS-249 AND LYS-255, INTERACTION WITH TNFAIP3, CHARACTERIZATION OF VARIANT LYS-255.

    Entry informationi

    Entry nameiTNIP2_HUMAN
    AccessioniPrimary (citable) accession number: Q8NFZ5
    Secondary accession number(s): B1AKS4
    , B3KTY8, D3DVQ9, Q7L5L2, Q9BQR6, Q9H682
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

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