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Protein

TNFAIP3-interacting protein 2

Gene

TNIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.6 Publications

GO - Molecular functioni

  • polyubiquitin binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Inflammatory response, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_22442. Interleukin-1 signaling.
SignaLinkiQ8NFZ5.

Names & Taxonomyi

Protein namesi
Recommended name:
TNFAIP3-interacting protein 2
Alternative name(s):
A20-binding inhibitor of NF-kappa-B activation 2
Short name:
ABIN-2
Fetal liver LKB1-interacting protein
Gene namesi
Name:TNIP2Imported
Synonyms:ABIN2, FLIP1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:19118. TNIP2.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus Curated

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi62 – 621S → A: Reduces phosphorylation. 1 Publication
Mutagenesisi146 – 1461S → A: Reduces phosphorylation; reduces CHUK-mediated NF-kappa-B activation. 1 Publication
Mutagenesisi309 – 3102DF → NA: Abolishes ubiquitin binding. 1 Publication
Mutagenesisi313 – 3142ER → AA: Abolishes ubiquitin binding; loss of inhibitory activity on NF-kappa-B activation. 1 Publication

Organism-specific databases

PharmGKBiPA134957006.

Polymorphism and mutation databases

BioMutaiTNIP2.
DMDMi74715616.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 429429TNFAIP3-interacting protein 2PRO_0000322583Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71Phosphoserine1 Publication

Post-translational modificationi

In vitro phosphorylated by CHUK.1 Publication
Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination probably leading to constitutive proteasomal degradation which can be impaired by IKK-A/CHUK or IKBKB probbaly involving deubiquitination.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8NFZ5.
PaxDbiQ8NFZ5.
PRIDEiQ8NFZ5.

PTM databases

PhosphoSiteiQ8NFZ5.

Expressioni

Tissue specificityi

Ubiquitously expressed in all tissues examined.1 Publication

Gene expression databases

BgeeiQ8NFZ5.
CleanExiHS_TNIP2.
ExpressionAtlasiQ8NFZ5. baseline and differential.
GenevestigatoriQ8NFZ5.

Organism-specific databases

HPAiCAB020818.
HPA049886.
HPA063197.

Interactioni

Subunit structurei

Interacts with STK11/LKB1, TNFAIP3, IKBKG, NFKB1, MAP3K8, TEK, RIPK1, CHUK, IKBKB and SMARCD1. Interacts with polyubiquitin.8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
IKBKGQ9Y6K96EBI-359372,EBI-81279
MAP3K8P4127910EBI-359372,EBI-354900
NFKB1P19838-18EBI-359372,EBI-1452239
STK11Q158315EBI-359372,EBI-306838

Protein-protein interaction databases

BioGridi122573. 27 interactions.
DIPiDIP-27617N.
IntActiQ8NFZ5. 19 interactions.
MINTiMINT-97349.
STRINGi9606.ENSP00000321203.

Structurei

3D structure databases

ProteinModelPortaliQ8NFZ5.
SMRiQ8NFZ5. Positions 401-429.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni289 – 34759Ubiquitin-binding domain (UBD)Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili29 – 11789Sequence AnalysisAdd
BLAST
Coiled coili196 – 22631Sequence AnalysisAdd
BLAST
Coiled coili255 – 34086Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG47580.
GeneTreeiENSGT00390000009019.
HOGENOMiHOG000049046.
HOVERGENiHBG055553.
InParanoidiQ8NFZ5.
OMAiQKYDSSR.
OrthoDBiEOG7M0NRH.
PhylomeDBiQ8NFZ5.
TreeFamiTF332167.

Family and domain databases

InterProiIPR022008. EABR.
[Graphical view]
PfamiPF12180. EABR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 13 Publications (identifier: Q8NFZ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRDPGSGGW EEAPRAAAAL CTLYHEAGQR LRRLQDQLAA RDALIARLRA
60 70 80 90 100
RLAALEGDAA PSLVDALLEQ VARFREQLRR QEGGAAEAQM RQEIERLTER
110 120 130 140 150
LEEKEREMQQ LLSQPQHERE KEVVLLRRSM AEGERARAAS DVLCRSLANE
160 170 180 190 200
THQLRRTLTA TAHMCQHLAK CLDERQHAQR NVGERSPDQS EHTDGHTSVQ
210 220 230 240 250
SVIEKLQEEN RLLKQKVTHV EDLNAKWQRY NASRDEYVRG LHAQLRGLQI
260 270 280 290 300
PHEPELMRKE ISRLNRQLEE KINDCAEVKQ ELAASRTARD AALERVQMLE
310 320 330 340 350
QQILAYKDDF MSERADRERA QSRIQELEEK VASLLHQVSW RQDSREPDAG
360 370 380 390 400
RIHAGSKTAK YLAADALELM VPGGWRPGTG SQQPEPPAEG GHPGAAQRGQ
410 420
GDLQCPHCLQ CFSDEQGEEL LRHVAECCQ
Length:429
Mass (Da):48,700
Last modified:October 1, 2002 - v1
Checksum:i0F6B049C2B3483DC
GO
Isoform 21 Publication (identifier: Q8NFZ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: Missing.

Note: No experimental confirmation available.Curated

Show »
Length:322
Mass (Da):36,682
Checksum:i4B145A09A85133BE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti153 – 1531Q → H in CAC34835 (PubMed:11390377).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti249 – 2491Q → H Found in patients with gastrointestinal diffuse large cell lymphoma; impairs inhibitory activity on CARD11-induced NF-kappa-B activation. 1 Publication
Corresponds to variant rs116129895 [ dbSNP | Ensembl ].
VAR_067969
Natural varianti255 – 2551E → K Found in patients with gastrointestinal diffuse large cell lymphoma; somatic mutation; impairs inhibitory activity on CARD11-induced NF-kappa-B activation and impairs interaction with TNFAIP3. 1 Publication
Corresponds to variant rs116412781 [ dbSNP | Ensembl ].
VAR_067970
Natural varianti396 – 3961A → V.2 Publications
Corresponds to variant rs2269495 [ dbSNP | Ensembl ].
VAR_039463

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 107107Missing in isoform 2. 1 PublicationVSP_052701Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ304866 mRNA. Translation: CAC34835.1.
AF372839 mRNA. Translation: AAM21315.1.
AK026176 mRNA. Translation: BAB15382.1.
AK096296 mRNA. Translation: BAG53250.1.
CH471131 Genomic DNA. Translation: EAW82514.1.
AL121750, AL110117 Genomic DNA. Translation: CAM28233.1.
AL110117, AL121750 Genomic DNA. Translation: CAM28252.1.
CH471131 Genomic DNA. Translation: EAW82516.1.
BC002740 mRNA. Translation: AAH02740.2.
CCDSiCCDS3362.1. [Q8NFZ5-1]
CCDS54714.1. [Q8NFZ5-2]
RefSeqiNP_001154999.1. NM_001161527.1. [Q8NFZ5-2]
NP_001278945.1. NM_001292016.1.
NP_077285.3. NM_024309.3. [Q8NFZ5-1]
UniGeneiHs.368551.

Genome annotation databases

EnsembliENST00000315423; ENSP00000321203; ENSG00000168884. [Q8NFZ5-1]
ENST00000510267; ENSP00000427613; ENSG00000168884. [Q8NFZ5-2]
GeneIDi79155.
KEGGihsa:79155.
UCSCiuc003gff.2. human. [Q8NFZ5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ304866 mRNA. Translation: CAC34835.1.
AF372839 mRNA. Translation: AAM21315.1.
AK026176 mRNA. Translation: BAB15382.1.
AK096296 mRNA. Translation: BAG53250.1.
CH471131 Genomic DNA. Translation: EAW82514.1.
AL121750, AL110117 Genomic DNA. Translation: CAM28233.1.
AL110117, AL121750 Genomic DNA. Translation: CAM28252.1.
CH471131 Genomic DNA. Translation: EAW82516.1.
BC002740 mRNA. Translation: AAH02740.2.
CCDSiCCDS3362.1. [Q8NFZ5-1]
CCDS54714.1. [Q8NFZ5-2]
RefSeqiNP_001154999.1. NM_001161527.1. [Q8NFZ5-2]
NP_001278945.1. NM_001292016.1.
NP_077285.3. NM_024309.3. [Q8NFZ5-1]
UniGeneiHs.368551.

3D structure databases

ProteinModelPortaliQ8NFZ5.
SMRiQ8NFZ5. Positions 401-429.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122573. 27 interactions.
DIPiDIP-27617N.
IntActiQ8NFZ5. 19 interactions.
MINTiMINT-97349.
STRINGi9606.ENSP00000321203.

PTM databases

PhosphoSiteiQ8NFZ5.

Polymorphism and mutation databases

BioMutaiTNIP2.
DMDMi74715616.

Proteomic databases

MaxQBiQ8NFZ5.
PaxDbiQ8NFZ5.
PRIDEiQ8NFZ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315423; ENSP00000321203; ENSG00000168884. [Q8NFZ5-1]
ENST00000510267; ENSP00000427613; ENSG00000168884. [Q8NFZ5-2]
GeneIDi79155.
KEGGihsa:79155.
UCSCiuc003gff.2. human. [Q8NFZ5-1]

Organism-specific databases

CTDi79155.
GeneCardsiGC04M002780.
H-InvDBHIX0164015.
HGNCiHGNC:19118. TNIP2.
HPAiCAB020818.
HPA049886.
HPA063197.
MIMi610669. gene.
neXtProtiNX_Q8NFZ5.
PharmGKBiPA134957006.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG47580.
GeneTreeiENSGT00390000009019.
HOGENOMiHOG000049046.
HOVERGENiHBG055553.
InParanoidiQ8NFZ5.
OMAiQKYDSSR.
OrthoDBiEOG7M0NRH.
PhylomeDBiQ8NFZ5.
TreeFamiTF332167.

Enzyme and pathway databases

ReactomeiREACT_22442. Interleukin-1 signaling.
SignaLinkiQ8NFZ5.

Miscellaneous databases

GeneWikiiTNIP2.
GenomeRNAii79155.
NextBioi68079.
PROiQ8NFZ5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NFZ5.
CleanExiHS_TNIP2.
ExpressionAtlasiQ8NFZ5. baseline and differential.
GenevestigatoriQ8NFZ5.

Family and domain databases

InterProiIPR022008. EABR.
[Graphical view]
PfamiPF12180. EABR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel A20-binding inhibitor of nuclear factor-kappaB activation termed ABIN-2."
    Van Huffel S.C., Delaei F., Heyninck K., De Valck D., Beyaert R.
    J. Biol. Chem. 276:30216-30223(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation."
    Liu W.-K., Chien C.-Y., Chou C.-K., Su J.-Y.
    J. Biomed. Sci. 10:242-252(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH STK11/LKB1.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-396.
    Tissue: Kidney epitheliumImported.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-396.
    Tissue: UterusImported.
  7. "Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions."
    Klinkenberg M., Van Huffel S., Heyninck K., Beyaert R.
    FEBS Lett. 498:93-97(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TNFAIP3.
  8. "ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1."
    Tadros A., Hughes D.P., Dunmore B.J., Brindle N.P.
    Blood 102:4407-4409(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2."
    Hughes D.P., Marron M.B., Brindle N.P.
    Circ. Res. 92:630-636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TEK.
  10. "The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation."
    Chien C.Y., Liu W.K., Chou C.K., Su J.Y.
    FEBS Lett. 543:55-60(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SMARCD1.
  11. "The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis."
    Liu W.-K., Yen P.-F., Chien C.-Y., Fann M.-J., Su J.-Y., Chou C.-K.
    Biochem. J. 378:867-876(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH IKBKG.
  12. "ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability."
    Lang V., Symons A., Watton S.J., Janzen J., Soneji Y., Beinke S., Howell S., Ley S.C.
    Mol. Cell. Biol. 24:5235-5248(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH NFKB1; MAP3K8 AND TNFAIP3.
  13. "Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins."
    Wagner S., Carpentier I., Rogov V., Kreike M., Ikeda F., Lohr F., Wu C.J., Ashwell J.D., Dotsch V., Dikic I., Beyaert R.
    Oncogene 27:3739-3745(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITIN-BINDING, MUTAGENESIS OF 309-ASP-PHE-310 AND 313-GLU-ARG-314.
  14. "A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2 (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase alpha (IKKalpha)-mediated NF-kappaB transcriptional activity."
    Leotoing L., Chereau F., Baron S., Hube F., Valencia H.J., Bordereaux D., Demmers J.A., Strouboulis J., Baud V.
    J. Biol. Chem. 286:32277-32288(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CHUK AND IKBKB, UBIQUITINATION, PHOSPHORYLATION, MUTAGENESIS OF SER-62 AND SER-146.
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  16. "A20, ABIN-1/2, and CARD11 mutations and their prognostic value in gastrointestinal diffuse large B-cell lymphoma."
    Dong G., Chanudet E., Zeng N., Appert A., Chen Y.W., Au W.Y., Hamoudi R.A., Watkins A.J., Ye H., Liu H., Gao Z., Chuang S.S., Srivastava G., Du M.Q.
    Clin. Cancer Res. 17:1440-1451(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS HIS-249 AND LYS-255, INTERACTION WITH TNFAIP3, CHARACTERIZATION OF VARIANT LYS-255.

Entry informationi

Entry nameiTNIP2_HUMAN
AccessioniPrimary (citable) accession number: Q8NFZ5
Secondary accession number(s): B1AKS4
, B3KTY8, D3DVQ9, Q7L5L2, Q9BQR6, Q9H682
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2002
Last modified: May 27, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.