Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q8NFZ5 (TNIP2_HUMAN)

Last modified June 16, 2009. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    TNFAIP3-interacting protein 2
Alternative name(s):
    Fetal liver LKB1-interacting protein
    A20-binding inhibitor of NF-kappa-B activation 2
      Short name=ABIN-2
Gene names
Name: TNIP2
Synonyms: ABIN2, FLIP1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length429 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Ref.2 Ref.6 Ref.7

Subunit structure

Interacts with STK11, TNFAIP3, IKBKG, NFKB1, MAP3K8 and RIPK1. Ref.2 Ref.6 Ref.7

Subcellular location

Cytoplasm. Ref.2

Tissue specificity

Ubiquitously expressed in all tissues examined. Ref.2

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
   PTMPhosphoprotein
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionprotein binding Ref.2 Ref.6 Ref.7

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.2 Ref.5 Ref.1 (identifier: Q8NFZ5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.3 (identifier: Q8NFZ5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 429429TNFAIP3-interacting protein 2
PRO_0000322583

Regions

Coiled coil29 – 11789 Potential
Coiled coil196 – 22631 Potential
Coiled coil255 – 34086 Potential

Amino acid modifications

Modified residue1861Phosphoserine Ref.8

Natural variations

Alternative sequence1 – 107107Missing in isoform 2. Ref.3
VSP_052701
Natural variant3961A → V: dbSNP rs2269495. Ref.3 Ref.5
VAR_039463

Experimental info

Sequence conflict1531Q → H in CAC34835. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 0F6B049C2B3483DC

FASTA42948,700
        10         20         30         40         50         60 
MSRDPGSGGW EEAPRAAAAL CTLYHEAGQR LRRLQDQLAA RDALIARLRA RLAALEGDAA 

        70         80         90        100        110        120 
PSLVDALLEQ VARFREQLRR QEGGAAEAQM RQEIERLTER LEEKEREMQQ LLSQPQHERE 

       130        140        150        160        170        180 
KEVVLLRRSM AEGERARAAS DVLCRSLANE THQLRRTLTA TAHMCQHLAK CLDERQHAQR 

       190        200        210        220        230        240 
NVGERSPDQS EHTDGHTSVQ SVIEKLQEEN RLLKQKVTHV EDLNAKWQRY NASRDEYVRG 

       250        260        270        280        290        300 
LHAQLRGLQI PHEPELMRKE ISRLNRQLEE KINDCAEVKQ ELAASRTARD AALERVQMLE 

       310        320        330        340        350        360 
QQILAYKDDF MSERADRERA QSRIQELEEK VASLLHQVSW RQDSREPDAG RIHAGSKTAK 

       370        380        390        400        410        420 
YLAADALELM VPGGWRPGTG SQQPEPPAEG GHPGAAQRGQ GDLQCPHCLQ CFSDEQGEEL 


LRHVAECCQ 

« Hide

Isoform 2.

Checksum: 4B145A09A85133BE
Show »

FASTA32236,682

References

« Hide 'large scale' references
[1]"Identification of a novel A20-binding inhibitor of nuclear factor-kappaB activation termed ABIN-2."
Van Huffel S.C., Delaei F., Heyninck K., De Valck D., Beyaert R.
J. Biol. Chem. 276:30216-30223(2001) [PubMed: 11390377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation."
Liu W.-K., Chien C.-Y., Chou C.-K., Su J.-Y.
J. Biomed. Sci. 10:242-252(2003) [PubMed: 12595760] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH STK11.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-396.
Tissue: Kidney epithelium.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-396.
Tissue: Uterus.
[6]"The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis."
Liu W.-K., Yen P.-F., Chien C.-Y., Fann M.-J., Su J.-Y., Chou C.-K.
Biochem. J. 378:867-876(2004) [PubMed: 14653779] [Abstract]
Cited for: FUNCTION, INTERACTION WITH IKBKG.
[7]"ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability."
Lang V., Symons A., Watton S.J., Janzen J., Soneji Y., Beinke S., Howell S., Ley S.C.
Mol. Cell. Biol. 24:5235-5248(2004) [PubMed: 15169888] [Abstract]
Cited for: FUNCTION, INTERACTION WITH NFKB1; MAP3K8 AND TNFAIP3.
[8]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-186, MASS SPECTROMETRY.

Cross-references

Sequence databases

AJ304866 mRNA. Translation: CAC34835.1.
AF372839 mRNA. Translation: AAM21315.1.
AK026176 mRNA. Translation: BAB15382.1.
AK096296 mRNA. Translation: BAG53250.1.
CH471131 Genomic DNA. Translation: EAW82514.1.
BC002740 mRNA. Translation: AAH02740.2.
IPIIPI00168953.
IPI00884948.
RefSeqNP_077285.2.
UniGeneHs.368551

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ8NFZ5. 9 interactions.

Proteomic databases

PRIDEQ8NFZ5.

Genome annotation databases

EnsemblENSG00000168884. Homo sapiens. [Contig view]
GeneID79155.
KEGGhsa:79155.

Organism-specific databases

GeneCardsGC04M002780.
HGNCHGNC:19118. TNIP2.
MIM610669. gene.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ8NFZ5.
OMAQ8NFZ5. ASDVLCR.

Gene expression databases

ArrayExpressQ8NFZ5.
BgeeQ8NFZ5.
CleanExHS_TNIP2.

Family and domain databases

ProtoNetSearch...

Other Resources

NextBio68079.
SOURCESearch...

Entry information

Entry nameTNIP2_HUMAN
AccessionPrimary (citable) accession number: Q8NFZ5
Secondary accession number(s): B3KTY8 expand/collapse secondary AC list , Q7L5L2, Q9BQR6, Q9H682
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2002
Last modified: June 16, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents