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Q8NFZ5 (TNIP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
TNFAIP3-interacting protein 2
Alternative name(s):
A20-binding inhibitor of NF-kappa-B activation 2
Short name=ABIN-2
Fetal liver LKB1-interacting protein
Gene names
Name:TNIP2
Synonyms:ABIN2, FLIP1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length429 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. Ref.2 Ref.8 Ref.10 Ref.11 Ref.12 Ref.14

Subunit structure

Interacts with STK11/LKB1, TNFAIP3, IKBKG, NFKB1, MAP3K8, TEK, RIPK1, CHUK, IKBKB and SMARCD1. Interacts with polyubiquitin. Ref.2 Ref.7 Ref.9 Ref.10 Ref.11 Ref.12 Ref.14 Ref.15

Subcellular location

Cytoplasm. Nucleus Probable Ref.2 Ref.10 Ref.14.

Tissue specificity

Ubiquitously expressed in all tissues examined. Ref.2

Post-translational modification

In vitro phosphorylated by CHUK. Ref.14

Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination probably leading to constitutive proteasomal degradation which can be impaired by IKK-A/CHUK or IKBKB probbaly involving deubiquitination. Ref.14

Ontologies

Keywords
   Biological processApoptosis
Inflammatory response
Transcription
Transcription regulation
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
   PTMPhosphoprotein
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processCD40 signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

I-kappaB kinase/NF-kappaB signaling

Inferred from electronic annotation. Source: Ensembl

apoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

cellular response to lipopolysaccharide

Inferred from sequence or structural similarity. Source: UniProtKB

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

interleukin-1-mediated signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of endothelial cell apoptotic process

Inferred from direct assay Ref.8. Source: UniProtKB

positive regulation of B cell activation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of I-kappaB kinase/NF-kappaB signaling

Inferred from direct assay Ref.14. Source: UniProtKB

positive regulation of macrophage activation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay Ref.10. Source: UniProtKB

protein stabilization

Inferred from sequence or structural similarity. Source: UniProtKB

toll-like receptor 2 signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

toll-like receptor 3 signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

toll-like receptor 9 signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytosol

Traceable author statement. Source: Reactome

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionpolyubiquitin binding

Inferred from direct assay Ref.13. Source: UniProtKB

protein kinase binding

Inferred from direct assay Ref.14. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.1 Ref.2 Ref.6 (identifier: Q8NFZ5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.3 (identifier: Q8NFZ5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 429429TNFAIP3-interacting protein 2
PRO_0000322583

Regions

Region289 – 34759Ubiquitin-binding domain (UBD)
Coiled coil29 – 11789 Potential
Coiled coil196 – 22631 Potential
Coiled coil255 – 34086 Potential

Natural variations

Alternative sequence1 – 107107Missing in isoform 2. Ref.3
VSP_052701
Natural variant2491Q → H in patients with gastrointestinal diffuse large cell lymphoma; impairs inhibitory activity on CARD11-induced NF-kappa-B activation. Ref.15
Corresponds to variant rs116129895 [ dbSNP | Ensembl ].
VAR_067969
Natural variant2551E → K in patients with gastrointestinal diffuse large cell lymphoma; somatic mutation; impairs inhibitory activity on CARD11-induced NF-kappa-B activation and impairs interaction with TNFAIP3. Ref.15
Corresponds to variant rs116412781 [ dbSNP | Ensembl ].
VAR_067970
Natural variant3961A → V. Ref.3 Ref.6
Corresponds to variant rs2269495 [ dbSNP | Ensembl ].
VAR_039463

Experimental info

Mutagenesis621S → A: Reduces phosphorylation. Ref.13 Ref.14
Mutagenesis1461S → A: Reduces phosphorylation; reduces CHUK-mediated NF-kappa-B activation. Ref.13 Ref.14
Mutagenesis309 – 3102DF → NA: Abolishes ubiquitin binding. Ref.13
Mutagenesis313 – 3142ER → AA: Abolishes ubiquitin binding; loss of inhibitory activity on NF-kappa-B activation. Ref.13
Sequence conflict1531Q → H in CAC34835. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 0F6B049C2B3483DC

FASTA42948,700
        10         20         30         40         50         60 
MSRDPGSGGW EEAPRAAAAL CTLYHEAGQR LRRLQDQLAA RDALIARLRA RLAALEGDAA 

        70         80         90        100        110        120 
PSLVDALLEQ VARFREQLRR QEGGAAEAQM RQEIERLTER LEEKEREMQQ LLSQPQHERE 

       130        140        150        160        170        180 
KEVVLLRRSM AEGERARAAS DVLCRSLANE THQLRRTLTA TAHMCQHLAK CLDERQHAQR 

       190        200        210        220        230        240 
NVGERSPDQS EHTDGHTSVQ SVIEKLQEEN RLLKQKVTHV EDLNAKWQRY NASRDEYVRG 

       250        260        270        280        290        300 
LHAQLRGLQI PHEPELMRKE ISRLNRQLEE KINDCAEVKQ ELAASRTARD AALERVQMLE 

       310        320        330        340        350        360 
QQILAYKDDF MSERADRERA QSRIQELEEK VASLLHQVSW RQDSREPDAG RIHAGSKTAK 

       370        380        390        400        410        420 
YLAADALELM VPGGWRPGTG SQQPEPPAEG GHPGAAQRGQ GDLQCPHCLQ CFSDEQGEEL 


LRHVAECCQ 

« Hide

Isoform 2 [UniParc].

Checksum: 4B145A09A85133BE
Show »

FASTA32236,682

References

« Hide 'large scale' references
[1]"Identification of a novel A20-binding inhibitor of nuclear factor-kappaB activation termed ABIN-2."
Van Huffel S.C., Delaei F., Heyninck K., De Valck D., Beyaert R.
J. Biol. Chem. 276:30216-30223(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation."
Liu W.-K., Chien C.-Y., Chou C.-K., Su J.-Y.
J. Biomed. Sci. 10:242-252(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH STK11/LKB1.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-396.
Tissue: Kidney epithelium.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-396.
Tissue: Uterus.
[7]"Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions."
Klinkenberg M., Van Huffel S., Heyninck K., Beyaert R.
FEBS Lett. 498:93-97(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TNFAIP3.
[8]"ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1."
Tadros A., Hughes D.P., Dunmore B.J., Brindle N.P.
Blood 102:4407-4409(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[9]"The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2."
Hughes D.P., Marron M.B., Brindle N.P.
Circ. Res. 92:630-636(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TEK.
[10]"The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation."
Chien C.Y., Liu W.K., Chou C.K., Su J.Y.
FEBS Lett. 543:55-60(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SMARCD1.
[11]"The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis."
Liu W.-K., Yen P.-F., Chien C.-Y., Fann M.-J., Su J.-Y., Chou C.-K.
Biochem. J. 378:867-876(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH IKBKG.
[12]"ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability."
Lang V., Symons A., Watton S.J., Janzen J., Soneji Y., Beinke S., Howell S., Ley S.C.
Mol. Cell. Biol. 24:5235-5248(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH NFKB1; MAP3K8 AND TNFAIP3.
[13]"Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins."
Wagner S., Carpentier I., Rogov V., Kreike M., Ikeda F., Lohr F., Wu C.J., Ashwell J.D., Dotsch V., Dikic I., Beyaert R.
Oncogene 27:3739-3745(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITIN-BINDING, MUTAGENESIS OF 309-ASP-PHE-310 AND 313-GLU-ARG-314.
[14]"A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2 (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase alpha (IKKalpha)-mediated NF-kappaB transcriptional activity."
Leotoing L., Chereau F., Baron S., Hube F., Valencia H.J., Bordereaux D., Demmers J.A., Strouboulis J., Baud V.
J. Biol. Chem. 286:32277-32288(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CHUK AND IKBKB, UBIQUITINATION, PHOSPHORYLATION, MUTAGENESIS OF SER-62 AND SER-146.
[15]"A20, ABIN-1/2, and CARD11 mutations and their prognostic value in gastrointestinal diffuse large B-cell lymphoma."
Dong G., Chanudet E., Zeng N., Appert A., Chen Y.W., Au W.Y., Hamoudi R.A., Watkins A.J., Ye H., Liu H., Gao Z., Chuang S.S., Srivastava G., Du M.Q.
Clin. Cancer Res. 17:1440-1451(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS HIS-249 AND LYS-255, INTERACTION WITH TNFAIP3, CHARACTERIZATION OF VARIANT LYS-255.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ304866 mRNA. Translation: CAC34835.1.
AF372839 mRNA. Translation: AAM21315.1.
AK026176 mRNA. Translation: BAB15382.1.
AK096296 mRNA. Translation: BAG53250.1.
CH471131 Genomic DNA. Translation: EAW82514.1.
AL121750, AL110117 Genomic DNA. Translation: CAM28233.1.
AL110117, AL121750 Genomic DNA. Translation: CAM28252.1.
CH471131 Genomic DNA. Translation: EAW82516.1.
BC002740 mRNA. Translation: AAH02740.2.
RefSeqNP_001154999.1. NM_001161527.1.
NP_077285.3. NM_024309.3.
UniGeneHs.368551.

3D structure databases

ProteinModelPortalQ8NFZ5.
SMRQ8NFZ5. Positions 400-429.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122573. 23 interactions.
DIPDIP-27617N.
IntActQ8NFZ5. 18 interactions.
MINTMINT-97349.
STRING9606.ENSP00000321203.

PTM databases

PhosphoSiteQ8NFZ5.

Polymorphism databases

DMDM74715616.

Proteomic databases

PaxDbQ8NFZ5.
PRIDEQ8NFZ5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000315423; ENSP00000321203; ENSG00000168884. [Q8NFZ5-1]
ENST00000510267; ENSP00000427613; ENSG00000168884. [Q8NFZ5-2]
GeneID79155.
KEGGhsa:79155.
UCSCuc003gff.2. human. [Q8NFZ5-1]

Organism-specific databases

CTD79155.
GeneCardsGC04M002780.
H-InvDBHIX0164015.
HGNCHGNC:19118. TNIP2.
HPACAB020818.
HPA049886.
MIM610669. gene.
neXtProtNX_Q8NFZ5.
PharmGKBPA134957006.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47580.
HOGENOMHOG000049046.
HOVERGENHBG055553.
InParanoidQ8NFZ5.
OMAADETHQL.
OrthoDBEOG7M0NRH.
PhylomeDBQ8NFZ5.
TreeFamTF332167.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.
SignaLinkQ8NFZ5.

Gene expression databases

ArrayExpressQ8NFZ5.
BgeeQ8NFZ5.
CleanExHS_TNIP2.
GenevestigatorQ8NFZ5.

Family and domain databases

InterProIPR022008. EABR.
[Graphical view]
PfamPF12180. EABR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTNIP2.
GenomeRNAi79155.
NextBio68079.
PROQ8NFZ5.
SOURCESearch...

Entry information

Entry nameTNIP2_HUMAN
AccessionPrimary (citable) accession number: Q8NFZ5
Secondary accession number(s): B1AKS4 expand/collapse secondary AC list , B3KTY8, D3DVQ9, Q7L5L2, Q9BQR6, Q9H682
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM