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Q8NFZ5

- TNIP2_HUMAN

UniProt

Q8NFZ5 - TNIP2_HUMAN

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Protein
TNFAIP3-interacting protein 2
Gene
TNIP2, ABIN2, FLIP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.6 Publications

GO - Molecular functioni

  1. polyubiquitin binding Source: UniProtKB
  2. protein binding Source: IntAct
  3. protein kinase binding Source: UniProtKB

GO - Biological processi

  1. CD40 signaling pathway Source: UniProtKB
  2. I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  3. apoptotic process Source: UniProtKB-KW
  4. cellular response to lipopolysaccharide Source: UniProtKB
  5. inflammatory response Source: UniProtKB-KW
  6. interleukin-1-mediated signaling pathway Source: UniProtKB
  7. negative regulation of endothelial cell apoptotic process Source: UniProtKB
  8. positive regulation of B cell activation Source: UniProtKB
  9. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  10. positive regulation of macrophage activation Source: UniProtKB
  11. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  12. protein stabilization Source: UniProtKB
  13. toll-like receptor 2 signaling pathway Source: UniProtKB
  14. toll-like receptor 3 signaling pathway Source: UniProtKB
  15. toll-like receptor 9 signaling pathway Source: UniProtKB
  16. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Inflammatory response, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_22442. Interleukin-1 signaling.
SignaLinkiQ8NFZ5.

Names & Taxonomyi

Protein namesi
Recommended name:
TNFAIP3-interacting protein 2
Alternative name(s):
A20-binding inhibitor of NF-kappa-B activation 2
Short name:
ABIN-2
Fetal liver LKB1-interacting protein
Gene namesi
Name:TNIP2
Synonyms:ABIN2, FLIP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:19118. TNIP2.

Subcellular locationi

Cytoplasm. Nucleus Inferred 3 Publications

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi62 – 621S → A: Reduces phosphorylation. 2 Publications
Mutagenesisi146 – 1461S → A: Reduces phosphorylation; reduces CHUK-mediated NF-kappa-B activation. 2 Publications
Mutagenesisi309 – 3102DF → NA: Abolishes ubiquitin binding. 1 Publication
Mutagenesisi313 – 3142ER → AA: Abolishes ubiquitin binding; loss of inhibitory activity on NF-kappa-B activation. 1 Publication

Organism-specific databases

PharmGKBiPA134957006.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 429429TNFAIP3-interacting protein 2
PRO_0000322583Add
BLAST

Post-translational modificationi

In vitro phosphorylated by CHUK.1 Publication
Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination probably leading to constitutive proteasomal degradation which can be impaired by IKK-A/CHUK or IKBKB probbaly involving deubiquitination.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8NFZ5.
PaxDbiQ8NFZ5.
PRIDEiQ8NFZ5.

PTM databases

PhosphoSiteiQ8NFZ5.

Expressioni

Tissue specificityi

Ubiquitously expressed in all tissues examined.1 Publication

Gene expression databases

ArrayExpressiQ8NFZ5.
BgeeiQ8NFZ5.
CleanExiHS_TNIP2.
GenevestigatoriQ8NFZ5.

Organism-specific databases

HPAiCAB020818.
HPA049886.

Interactioni

Subunit structurei

Interacts with STK11/LKB1, TNFAIP3, IKBKG, NFKB1, MAP3K8, TEK, RIPK1, CHUK, IKBKB and SMARCD1. Interacts with polyubiquitin.8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
IKBKGQ9Y6K96EBI-359372,EBI-81279
MAP3K8P412799EBI-359372,EBI-354900
NFKB1P19838-18EBI-359372,EBI-1452239
STK11Q158315EBI-359372,EBI-306838

Protein-protein interaction databases

BioGridi122573. 23 interactions.
DIPiDIP-27617N.
IntActiQ8NFZ5. 18 interactions.
MINTiMINT-97349.
STRINGi9606.ENSP00000321203.

Structurei

3D structure databases

ProteinModelPortaliQ8NFZ5.
SMRiQ8NFZ5. Positions 400-429.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni289 – 34759Ubiquitin-binding domain (UBD)
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili29 – 11789 Reviewed prediction
Add
BLAST
Coiled coili196 – 22631 Reviewed prediction
Add
BLAST
Coiled coili255 – 34086 Reviewed prediction
Add
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG47580.
HOGENOMiHOG000049046.
HOVERGENiHBG055553.
InParanoidiQ8NFZ5.
OMAiADETHQL.
OrthoDBiEOG7M0NRH.
PhylomeDBiQ8NFZ5.
TreeFamiTF332167.

Family and domain databases

InterProiIPR022008. EABR.
[Graphical view]
PfamiPF12180. EABR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 13 Publications (identifier: Q8NFZ5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSRDPGSGGW EEAPRAAAAL CTLYHEAGQR LRRLQDQLAA RDALIARLRA    50
RLAALEGDAA PSLVDALLEQ VARFREQLRR QEGGAAEAQM RQEIERLTER 100
LEEKEREMQQ LLSQPQHERE KEVVLLRRSM AEGERARAAS DVLCRSLANE 150
THQLRRTLTA TAHMCQHLAK CLDERQHAQR NVGERSPDQS EHTDGHTSVQ 200
SVIEKLQEEN RLLKQKVTHV EDLNAKWQRY NASRDEYVRG LHAQLRGLQI 250
PHEPELMRKE ISRLNRQLEE KINDCAEVKQ ELAASRTARD AALERVQMLE 300
QQILAYKDDF MSERADRERA QSRIQELEEK VASLLHQVSW RQDSREPDAG 350
RIHAGSKTAK YLAADALELM VPGGWRPGTG SQQPEPPAEG GHPGAAQRGQ 400
GDLQCPHCLQ CFSDEQGEEL LRHVAECCQ 429
Length:429
Mass (Da):48,700
Last modified:October 1, 2002 - v1
Checksum:i0F6B049C2B3483DC
GO
Isoform 21 Publication (identifier: Q8NFZ5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: Missing.

Note: No experimental confirmation available.

Show »
Length:322
Mass (Da):36,682
Checksum:i4B145A09A85133BE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti249 – 2491Q → H in patients with gastrointestinal diffuse large cell lymphoma; impairs inhibitory activity on CARD11-induced NF-kappa-B activation. 1 Publication
Corresponds to variant rs116129895 [ dbSNP | Ensembl ].
VAR_067969
Natural varianti255 – 2551E → K in patients with gastrointestinal diffuse large cell lymphoma; somatic mutation; impairs inhibitory activity on CARD11-induced NF-kappa-B activation and impairs interaction with TNFAIP3. 1 Publication
Corresponds to variant rs116412781 [ dbSNP | Ensembl ].
VAR_067970
Natural varianti396 – 3961A → V.2 Publications
Corresponds to variant rs2269495 [ dbSNP | Ensembl ].
VAR_039463

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 107107Missing in isoform 2. 1 Publication
VSP_052701Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti153 – 1531Q → H in CAC34835. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ304866 mRNA. Translation: CAC34835.1.
AF372839 mRNA. Translation: AAM21315.1.
AK026176 mRNA. Translation: BAB15382.1.
AK096296 mRNA. Translation: BAG53250.1.
CH471131 Genomic DNA. Translation: EAW82514.1.
AL121750, AL110117 Genomic DNA. Translation: CAM28233.1.
AL110117, AL121750 Genomic DNA. Translation: CAM28252.1.
CH471131 Genomic DNA. Translation: EAW82516.1.
BC002740 mRNA. Translation: AAH02740.2.
CCDSiCCDS3362.1. [Q8NFZ5-1]
CCDS54714.1. [Q8NFZ5-2]
RefSeqiNP_001154999.1. NM_001161527.1. [Q8NFZ5-2]
NP_077285.3. NM_024309.3. [Q8NFZ5-1]
UniGeneiHs.368551.

Genome annotation databases

EnsembliENST00000315423; ENSP00000321203; ENSG00000168884. [Q8NFZ5-1]
ENST00000510267; ENSP00000427613; ENSG00000168884. [Q8NFZ5-2]
GeneIDi79155.
KEGGihsa:79155.
UCSCiuc003gff.2. human. [Q8NFZ5-1]

Polymorphism databases

DMDMi74715616.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ304866 mRNA. Translation: CAC34835.1 .
AF372839 mRNA. Translation: AAM21315.1 .
AK026176 mRNA. Translation: BAB15382.1 .
AK096296 mRNA. Translation: BAG53250.1 .
CH471131 Genomic DNA. Translation: EAW82514.1 .
AL121750 , AL110117 Genomic DNA. Translation: CAM28233.1 .
AL110117 , AL121750 Genomic DNA. Translation: CAM28252.1 .
CH471131 Genomic DNA. Translation: EAW82516.1 .
BC002740 mRNA. Translation: AAH02740.2 .
CCDSi CCDS3362.1. [Q8NFZ5-1 ]
CCDS54714.1. [Q8NFZ5-2 ]
RefSeqi NP_001154999.1. NM_001161527.1. [Q8NFZ5-2 ]
NP_077285.3. NM_024309.3. [Q8NFZ5-1 ]
UniGenei Hs.368551.

3D structure databases

ProteinModelPortali Q8NFZ5.
SMRi Q8NFZ5. Positions 400-429.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122573. 23 interactions.
DIPi DIP-27617N.
IntActi Q8NFZ5. 18 interactions.
MINTi MINT-97349.
STRINGi 9606.ENSP00000321203.

PTM databases

PhosphoSitei Q8NFZ5.

Polymorphism databases

DMDMi 74715616.

Proteomic databases

MaxQBi Q8NFZ5.
PaxDbi Q8NFZ5.
PRIDEi Q8NFZ5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000315423 ; ENSP00000321203 ; ENSG00000168884 . [Q8NFZ5-1 ]
ENST00000510267 ; ENSP00000427613 ; ENSG00000168884 . [Q8NFZ5-2 ]
GeneIDi 79155.
KEGGi hsa:79155.
UCSCi uc003gff.2. human. [Q8NFZ5-1 ]

Organism-specific databases

CTDi 79155.
GeneCardsi GC04M002780.
H-InvDB HIX0164015.
HGNCi HGNC:19118. TNIP2.
HPAi CAB020818.
HPA049886.
MIMi 610669. gene.
neXtProti NX_Q8NFZ5.
PharmGKBi PA134957006.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47580.
HOGENOMi HOG000049046.
HOVERGENi HBG055553.
InParanoidi Q8NFZ5.
OMAi ADETHQL.
OrthoDBi EOG7M0NRH.
PhylomeDBi Q8NFZ5.
TreeFami TF332167.

Enzyme and pathway databases

Reactomei REACT_22442. Interleukin-1 signaling.
SignaLinki Q8NFZ5.

Miscellaneous databases

GeneWikii TNIP2.
GenomeRNAii 79155.
NextBioi 68079.
PROi Q8NFZ5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8NFZ5.
Bgeei Q8NFZ5.
CleanExi HS_TNIP2.
Genevestigatori Q8NFZ5.

Family and domain databases

InterProi IPR022008. EABR.
[Graphical view ]
Pfami PF12180. EABR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel A20-binding inhibitor of nuclear factor-kappaB activation termed ABIN-2."
    Van Huffel S.C., Delaei F., Heyninck K., De Valck D., Beyaert R.
    J. Biol. Chem. 276:30216-30223(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation."
    Liu W.-K., Chien C.-Y., Chou C.-K., Su J.-Y.
    J. Biomed. Sci. 10:242-252(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH STK11/LKB1.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-396.
    Tissue: Kidney epithelium.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-396.
    Tissue: Uterus.
  7. "Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions."
    Klinkenberg M., Van Huffel S., Heyninck K., Beyaert R.
    FEBS Lett. 498:93-97(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TNFAIP3.
  8. "ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1."
    Tadros A., Hughes D.P., Dunmore B.J., Brindle N.P.
    Blood 102:4407-4409(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2."
    Hughes D.P., Marron M.B., Brindle N.P.
    Circ. Res. 92:630-636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TEK.
  10. "The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation."
    Chien C.Y., Liu W.K., Chou C.K., Su J.Y.
    FEBS Lett. 543:55-60(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SMARCD1.
  11. "The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis."
    Liu W.-K., Yen P.-F., Chien C.-Y., Fann M.-J., Su J.-Y., Chou C.-K.
    Biochem. J. 378:867-876(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH IKBKG.
  12. "ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability."
    Lang V., Symons A., Watton S.J., Janzen J., Soneji Y., Beinke S., Howell S., Ley S.C.
    Mol. Cell. Biol. 24:5235-5248(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH NFKB1; MAP3K8 AND TNFAIP3.
  13. "Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins."
    Wagner S., Carpentier I., Rogov V., Kreike M., Ikeda F., Lohr F., Wu C.J., Ashwell J.D., Dotsch V., Dikic I., Beyaert R.
    Oncogene 27:3739-3745(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITIN-BINDING, MUTAGENESIS OF 309-ASP-PHE-310 AND 313-GLU-ARG-314.
  14. "A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2 (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase alpha (IKKalpha)-mediated NF-kappaB transcriptional activity."
    Leotoing L., Chereau F., Baron S., Hube F., Valencia H.J., Bordereaux D., Demmers J.A., Strouboulis J., Baud V.
    J. Biol. Chem. 286:32277-32288(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CHUK AND IKBKB, UBIQUITINATION, PHOSPHORYLATION, MUTAGENESIS OF SER-62 AND SER-146.
  15. "A20, ABIN-1/2, and CARD11 mutations and their prognostic value in gastrointestinal diffuse large B-cell lymphoma."
    Dong G., Chanudet E., Zeng N., Appert A., Chen Y.W., Au W.Y., Hamoudi R.A., Watkins A.J., Ye H., Liu H., Gao Z., Chuang S.S., Srivastava G., Du M.Q.
    Clin. Cancer Res. 17:1440-1451(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS HIS-249 AND LYS-255, INTERACTION WITH TNFAIP3, CHARACTERIZATION OF VARIANT LYS-255.

Entry informationi

Entry nameiTNIP2_HUMAN
AccessioniPrimary (citable) accession number: Q8NFZ5
Secondary accession number(s): B1AKS4
, B3KTY8, D3DVQ9, Q7L5L2, Q9BQR6, Q9H682
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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