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Q8NFZ4

- NLGN2_HUMAN

UniProt

Q8NFZ4 - NLGN2_HUMAN

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Protein

Neuroligin-2

Gene

NLGN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity).By similarity

GO - Molecular functioni

  1. cell adhesion molecule binding Source: BHF-UCL
  2. neurexin family protein binding Source: UniProtKB
  3. receptor activity Source: RefGenome

GO - Biological processi

  1. cell-cell junction maintenance Source: UniProtKB
  2. gephyrin clustering Source: BHF-UCL
  3. locomotory exploration behavior Source: Ensembl
  4. neuromuscular process controlling balance Source: Ensembl
  5. neuron cell-cell adhesion Source: BHF-UCL
  6. positive regulation of excitatory postsynaptic membrane potential Source: BHF-UCL
  7. positive regulation of inhibitory postsynaptic membrane potential Source: BHF-UCL
  8. positive regulation of synapse assembly Source: BHF-UCL
  9. positive regulation of synaptic transmission, GABAergic Source: BHF-UCL
  10. positive regulation of synaptic transmission, glutamatergic Source: BHF-UCL
  11. postsynaptic density protein 95 clustering Source: BHF-UCL
  12. postsynaptic membrane assembly Source: BHF-UCL
  13. presynaptic membrane assembly Source: BHF-UCL
  14. protein localization to synapse Source: BHF-UCL
  15. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: BHF-UCL
  16. regulation of respiratory gaseous exchange by neurological system process Source: BHF-UCL
  17. regulation of synaptic transmission Source: BHF-UCL
  18. sensory perception of pain Source: Ensembl
  19. single organismal cell-cell adhesion Source: UniProtKB
  20. synapse assembly Source: UniProtKB
  21. synapse organization Source: BHF-UCL
  22. terminal button organization Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Protein family/group databases

MEROPSiS09.995.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroligin-2
Gene namesi
Name:NLGN2
Synonyms:KIAA1366
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:14290. NLGN2.

Subcellular locationi

Cell membrane By similarity; Single-pass type I membrane protein By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity. Cell junctionsynapsepresynaptic cell membrane By similarity
Note: Detected at postsynaptic membranes in brain. Detected at dendritic spines in cultured neurons. Colocalizes with GPHN and ARHGEF9 at neuronal cell membranes (By similarity). Localized at presynaptic membranes in retina. Colocalizes with GABRG2 at inhibitory synapses in the retina (By similarity).By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cell surface Source: BHF-UCL
  3. inhibitory synapse Source: BHF-UCL
  4. integral component of plasma membrane Source: BHF-UCL
  5. membrane Source: UniProtKB
  6. postsynaptic membrane Source: UniProtKB
  7. synapse Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31648.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1414Sequence AnalysisAdd
BLAST
Chaini15 – 835821Neuroligin-2PRO_0000008643Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi106 ↔ 141By similarity
Glycosylationi136 – 1361N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi317 ↔ 328By similarity
Disulfide bondi487 ↔ 521By similarity
Glycosylationi522 – 5221N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NFZ4.
PRIDEiQ8NFZ4.

PTM databases

PhosphoSiteiQ8NFZ4.

Expressioni

Tissue specificityi

Expressed in the blood vessel walls. Detected in colon, brain and pancreas islets of Langerhans (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells.2 Publications

Gene expression databases

BgeeiQ8NFZ4.
CleanExiHS_NLGN2.
GenevestigatoriQ8NFZ4.

Organism-specific databases

HPAiHPA055321.

Interactioni

Subunit structurei

Interacts with NRXN1, NRXN2 and NRXN3. Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3). Interacts with INADL. Interacts with GPHN (By similarity). Interacts with MDGA1 and MDGA2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi121611. 9 interactions.
STRINGi9606.ENSP00000305288.

Structurei

3D structure databases

ProteinModelPortaliQ8NFZ4.
SMRiQ8NFZ4. Positions 42-609.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini15 – 677663ExtracellularSequence AnalysisAdd
BLAST
Topological domaini699 – 835137CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei678 – 69821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2272.
GeneTreeiENSGT00760000118946.
HOGENOMiHOG000231424.
HOVERGENiHBG008839.
InParanoidiQ8NFZ4.
KOiK07378.
OMAiDIRDPGK.
OrthoDBiEOG7RBZ7R.
PhylomeDBiQ8NFZ4.
TreeFamiTF326187.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019819. Carboxylesterase_B_CS.
IPR000460. Neuroligin.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
PRINTSiPR01090. NEUROLIGIN.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NFZ4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWLLALCLVG LAGAQRGGGG PGGGAPGGPG LGLGSLGEER FPVVNTAYGR
60 70 80 90 100
VRGVRRELNN EILGPVVQFL GVPYATPPLG ARRFQPPEAP ASWPGVRNAT
110 120 130 140 150
TLPPACPQNL HGALPAIMLP VWFTDNLEAA ATYVQNQSED CLYLNLYVPT
160 170 180 190 200
EDGPLTKKRD EATLNPPDTD IRDPGKKPVM LFLHGGSYME GTGNMFDGSV
210 220 230 240 250
LAAYGNVIVA TLNYRLGVLG FLSTGDQAAK GNYGLLDQIQ ALRWLSENIA
260 270 280 290 300
HFGGDPERIT IFGSGAGASC VNLLILSHHS EGLFQKAIAQ SGTAISSWSV
310 320 330 340 350
NYQPLKYTRL LAAKVGCDRE DSAEAVECLR RKPSRELVDQ DVQPARYHIA
360 370 380 390 400
FGPVVDGDVV PDDPEILMQQ GEFLNYDMLI GVNQGEGLKF VEDSAESEDG
410 420 430 440 450
VSASAFDFTV SNFVDNLYGY PEGKDVLRET IKFMYTDWAD RDNGEMRRKT
460 470 480 490 500
LLALFTDHQW VAPAVATAKL HADYQSPVYF YTFYHHCQAE GRPEWADAAH
510 520 530 540 550
GDELPYVFGV PMVGATDLFP CNFSKNDVML SAVVMTYWTN FAKTGDPNQP
560 570 580 590 600
VPQDTKFIHT KPNRFEEVVW SKFNSKEKQY LHIGLKPRVR DNYRANKVAF
610 620 630 640 650
WLELVPHLHN LHTELFTTTT RLPPYATRWP PRPPAGAPGT RRPPPPATLP
660 670 680 690 700
PEPEPEPGPR AYDRFPGDSR DYSTELSVTV AVGASLLFLN ILAFAALYYK
710 720 730 740 750
RDRRQELRCR RLSPPGGSGS GVPGGGPLLP AAGRELPPEE ELVSLQLKRG
760 770 780 790 800
GGVGADPAEA LRPACPPDYT LALRRAPDDV PLLAPGALTL LPSGLGPPPP
810 820 830
PPPPSLHPFG PFPPPPPTAT SHNNTLPHPH STTRV
Length:835
Mass (Da):90,820
Last modified:October 1, 2002 - v1
Checksum:i359938630193EF87
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF376802 mRNA. Translation: AAM46111.1.
AB037787 mRNA. Translation: BAA92604.1.
CCDSiCCDS11103.1.
RefSeqiNP_065846.1. NM_020795.3.
UniGeneiHs.26229.

Genome annotation databases

EnsembliENST00000302926; ENSP00000305288; ENSG00000169992.
ENST00000575301; ENSP00000461168; ENSG00000169992.
GeneIDi57555.
KEGGihsa:57555.
UCSCiuc002ggt.1. human.

Polymorphism databases

DMDMi31076824.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF376802 mRNA. Translation: AAM46111.1 .
AB037787 mRNA. Translation: BAA92604.1 .
CCDSi CCDS11103.1.
RefSeqi NP_065846.1. NM_020795.3.
UniGenei Hs.26229.

3D structure databases

ProteinModelPortali Q8NFZ4.
SMRi Q8NFZ4. Positions 42-609.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121611. 9 interactions.
STRINGi 9606.ENSP00000305288.

Protein family/group databases

MEROPSi S09.995.

PTM databases

PhosphoSitei Q8NFZ4.

Polymorphism databases

DMDMi 31076824.

Proteomic databases

PaxDbi Q8NFZ4.
PRIDEi Q8NFZ4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000302926 ; ENSP00000305288 ; ENSG00000169992 .
ENST00000575301 ; ENSP00000461168 ; ENSG00000169992 .
GeneIDi 57555.
KEGGi hsa:57555.
UCSCi uc002ggt.1. human.

Organism-specific databases

CTDi 57555.
GeneCardsi GC17P007311.
HGNCi HGNC:14290. NLGN2.
HPAi HPA055321.
MIMi 606479. gene.
neXtProti NX_Q8NFZ4.
PharmGKBi PA31648.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2272.
GeneTreei ENSGT00760000118946.
HOGENOMi HOG000231424.
HOVERGENi HBG008839.
InParanoidi Q8NFZ4.
KOi K07378.
OMAi DIRDPGK.
OrthoDBi EOG7RBZ7R.
PhylomeDBi Q8NFZ4.
TreeFami TF326187.

Miscellaneous databases

GeneWikii NLGN2.
GenomeRNAii 57555.
NextBioi 64034.
PROi Q8NFZ4.
SOURCEi Search...

Gene expression databases

Bgeei Q8NFZ4.
CleanExi HS_NLGN2.
Genevestigatori Q8NFZ4.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019819. Carboxylesterase_B_CS.
IPR000460. Neuroligin.
[Graphical view ]
Pfami PF00135. COesterase. 1 hit.
[Graphical view ]
PRINTSi PR01090. NEUROLIGIN.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 286-835.
    Tissue: Brain.
  3. Cited for: INTERACTION WITH DLG4.
  4. "Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion."
    Suckow A.T., Comoletti D., Waldrop M.A., Mosedale M., Egodage S., Taylor P., Chessler S.D.
    Endocrinology 149:6006-6017(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
  5. "The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions."
    Bottos A., Destro E., Rissone A., Graziano S., Cordara G., Assenzio B., Cera M.R., Mascia L., Bussolino F., Arese M.
    Proc. Natl. Acad. Sci. U.S.A. 106:20782-20787(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiNLGN2_HUMAN
AccessioniPrimary (citable) accession number: Q8NFZ4
Secondary accession number(s): Q9P2I1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3