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Protein

Neuroligin-2

Gene

NLGN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-6794361. Neurexins and neuroligins.

Protein family/group databases

ESTHERihuman-NLGN2. Neuroligin.
MEROPSiS09.995.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroligin-2
Gene namesi
Name:NLGN2
Synonyms:KIAA1366
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000169992.9.
HGNCiHGNC:14290. NLGN2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini15 – 677ExtracellularSequence analysisAdd BLAST663
Transmembranei678 – 698HelicalSequence analysisAdd BLAST21
Topological domaini699 – 835CytoplasmicSequence analysisAdd BLAST137

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi57555.
OpenTargetsiENSG00000169992.
PharmGKBiPA31648.

Polymorphism and mutation databases

DMDMi31076824.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 14Sequence analysisAdd BLAST14
ChainiPRO_000000864315 – 835Neuroligin-2Add BLAST821

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi106 ↔ 141By similarity
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi317 ↔ 328By similarity
Disulfide bondi487 ↔ 521By similarity
Glycosylationi522N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei713PhosphoserineBy similarity1
Modified residuei718PhosphoserineBy similarity1
Modified residuei769PhosphotyrosineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8NFZ4.
PaxDbiQ8NFZ4.
PeptideAtlasiQ8NFZ4.
PRIDEiQ8NFZ4.

PTM databases

iPTMnetiQ8NFZ4.
PhosphoSitePlusiQ8NFZ4.

Expressioni

Tissue specificityi

Expressed in the blood vessel walls. Detected in colon, brain and pancreas islets of Langerhans (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells.2 Publications

Gene expression databases

BgeeiENSG00000169992.
CleanExiHS_NLGN2.
ExpressionAtlasiQ8NFZ4. baseline and differential.
GenevisibleiQ8NFZ4. HS.

Organism-specific databases

HPAiHPA055321.
HPA069278.

Interactioni

Subunit structurei

Interacts with NRXN1, NRXN2 and NRXN3 (By similarity). Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3) (PubMed:9278515). Interacts with PATJ (By similarity). Interacts with GPHN (By similarity). Interacts with MDGA1 and MDGA2 (By similarity). Found in a complex with MAGI2 and IGSF9B, where it interacts with MAGI2 (via WW 1, WW 2 and PDZ 2 domains) (PubMed:23751499).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121611. 25 interactors.
STRINGi9606.ENSP00000305288.

Structurei

Secondary structure

1835
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi43 – 45Combined sources3
Beta strandi50 – 52Combined sources3
Beta strandi54 – 57Combined sources4
Beta strandi61 – 63Combined sources3
Beta strandi65 – 73Combined sources9
Turni81 – 84Combined sources4
Beta strandi94 – 98Combined sources5
Turni116 – 118Combined sources3
Helixi121 – 125Combined sources5
Helixi127 – 131Combined sources5
Helixi132 – 134Combined sources3
Beta strandi135 – 137Combined sources3
Beta strandi143 – 148Combined sources6
Beta strandi177 – 183Combined sources7
Beta strandi186 – 190Combined sources5
Helixi193 – 195Combined sources3
Helixi199 – 205Combined sources7
Beta strandi208 – 212Combined sources5
Helixi217 – 221Combined sources5
Beta strandi225 – 228Combined sources4
Helixi233 – 246Combined sources14
Helixi249 – 252Combined sources4
Beta strandi254 – 264Combined sources11
Helixi266 – 276Combined sources11
Turni279 – 283Combined sources5
Beta strandi285 – 291Combined sources7
Beta strandi294 – 296Combined sources3
Turni297 – 299Combined sources3
Beta strandi300 – 302Combined sources3
Helixi304 – 314Combined sources11
Helixi322 – 329Combined sources8
Helixi334 – 338Combined sources5
Beta strandi350 – 352Combined sources3
Beta strandi357 – 360Combined sources4
Helixi364 – 369Combined sources6
Beta strandi377 – 383Combined sources7
Helixi388 – 391Combined sources4
Helixi403 – 417Combined sources15
Helixi424 – 434Combined sources11
Helixi444 – 459Combined sources16
Helixi461 – 473Combined sources13
Beta strandi478 – 483Combined sources6
Turni500 – 503Combined sources4
Helixi504 – 507Combined sources4
Helixi510 – 512Combined sources3
Beta strandi517 – 519Combined sources3
Helixi525 – 544Combined sources20
Turni575 – 577Combined sources3
Beta strandi580 – 586Combined sources7
Beta strandi588 – 591Combined sources4
Helixi595 – 603Combined sources9
Turni604 – 607Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XEQX-ray3.14A42-611[»]
ProteinModelPortaliQ8NFZ4.
SMRiQ8NFZ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1516. Eukaryota.
COG2272. LUCA.
GeneTreeiENSGT00760000118946.
HOGENOMiHOG000231424.
HOVERGENiHBG008839.
InParanoidiQ8NFZ4.
KOiK07378.
OMAiGCNQEEN.
OrthoDBiEOG091G0CHW.
PhylomeDBiQ8NFZ4.
TreeFamiTF326187.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019819. Carboxylesterase_B_CS.
IPR000460. Nlgn.
IPR030023. NLGN2.
PANTHERiPTHR43903:SF3. PTHR43903:SF3. 1 hit.
PfamiView protein in Pfam
PF00135. COesterase. 1 hit.
PRINTSiPR01090. NEUROLIGIN.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiView protein in PROSITE
PS00941. CARBOXYLESTERASE_B_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NFZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLLALCLVG LAGAQRGGGG PGGGAPGGPG LGLGSLGEER FPVVNTAYGR
60 70 80 90 100
VRGVRRELNN EILGPVVQFL GVPYATPPLG ARRFQPPEAP ASWPGVRNAT
110 120 130 140 150
TLPPACPQNL HGALPAIMLP VWFTDNLEAA ATYVQNQSED CLYLNLYVPT
160 170 180 190 200
EDGPLTKKRD EATLNPPDTD IRDPGKKPVM LFLHGGSYME GTGNMFDGSV
210 220 230 240 250
LAAYGNVIVA TLNYRLGVLG FLSTGDQAAK GNYGLLDQIQ ALRWLSENIA
260 270 280 290 300
HFGGDPERIT IFGSGAGASC VNLLILSHHS EGLFQKAIAQ SGTAISSWSV
310 320 330 340 350
NYQPLKYTRL LAAKVGCDRE DSAEAVECLR RKPSRELVDQ DVQPARYHIA
360 370 380 390 400
FGPVVDGDVV PDDPEILMQQ GEFLNYDMLI GVNQGEGLKF VEDSAESEDG
410 420 430 440 450
VSASAFDFTV SNFVDNLYGY PEGKDVLRET IKFMYTDWAD RDNGEMRRKT
460 470 480 490 500
LLALFTDHQW VAPAVATAKL HADYQSPVYF YTFYHHCQAE GRPEWADAAH
510 520 530 540 550
GDELPYVFGV PMVGATDLFP CNFSKNDVML SAVVMTYWTN FAKTGDPNQP
560 570 580 590 600
VPQDTKFIHT KPNRFEEVVW SKFNSKEKQY LHIGLKPRVR DNYRANKVAF
610 620 630 640 650
WLELVPHLHN LHTELFTTTT RLPPYATRWP PRPPAGAPGT RRPPPPATLP
660 670 680 690 700
PEPEPEPGPR AYDRFPGDSR DYSTELSVTV AVGASLLFLN ILAFAALYYK
710 720 730 740 750
RDRRQELRCR RLSPPGGSGS GVPGGGPLLP AAGRELPPEE ELVSLQLKRG
760 770 780 790 800
GGVGADPAEA LRPACPPDYT LALRRAPDDV PLLAPGALTL LPSGLGPPPP
810 820 830
PPPPSLHPFG PFPPPPPTAT SHNNTLPHPH STTRV
Length:835
Mass (Da):90,820
Last modified:October 1, 2002 - v1
Checksum:i359938630193EF87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF376802 mRNA. Translation: AAM46111.1.
AB037787 mRNA. Translation: BAA92604.1.
CCDSiCCDS11103.1.
RefSeqiNP_065846.1. NM_020795.3.
UniGeneiHs.26229.

Genome annotation databases

EnsembliENST00000302926; ENSP00000305288; ENSG00000169992.
ENST00000575301; ENSP00000461168; ENSG00000169992.
ENST00000639647; ENSP00000492323; ENSG00000283859.
ENST00000640620; ENSP00000492198; ENSG00000283859.
GeneIDi57555.
KEGGihsa:57555.
UCSCiuc002ggt.3. human.

Similar proteinsi

Entry informationi

Entry nameiNLGN2_HUMAN
AccessioniPrimary (citable) accession number: Q8NFZ4
Secondary accession number(s): Q9P2I1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: October 1, 2002
Last modified: November 22, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families