Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neuroligin-2

Gene

NLGN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-6794361. Interactions of neurexins and neuroligins at synapses.

Protein family/group databases

ESTHERihuman-NLGN2. Neuroligin.
MEROPSiS09.995.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroligin-2
Gene namesi
Name:NLGN2
Synonyms:KIAA1366
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:14290. NLGN2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini15 – 677ExtracellularSequence analysisAdd BLAST663
Transmembranei678 – 698HelicalSequence analysisAdd BLAST21
Topological domaini699 – 835CytoplasmicSequence analysisAdd BLAST137

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • cell surface Source: BHF-UCL
  • inhibitory synapse Source: BHF-UCL
  • integral component of plasma membrane Source: GO_Central
  • integral component of postsynaptic membrane Source: BHF-UCL
  • membrane Source: UniProtKB
  • postsynaptic membrane Source: UniProtKB
  • presynaptic membrane Source: UniProtKB-SubCell
  • synapse Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi57555.
OpenTargetsiENSG00000169992.
PharmGKBiPA31648.

Polymorphism and mutation databases

DMDMi31076824.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 14Sequence analysisAdd BLAST14
ChainiPRO_000000864315 – 835Neuroligin-2Add BLAST821

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi98N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi106 ↔ 141By similarity
Glycosylationi136N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi317 ↔ 328By similarity
Disulfide bondi487 ↔ 521By similarity
Glycosylationi522N-linked (GlcNAc...)Sequence analysis1
Modified residuei713PhosphoserineBy similarity1
Modified residuei718PhosphoserineBy similarity1
Modified residuei769PhosphotyrosineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8NFZ4.
PaxDbiQ8NFZ4.
PeptideAtlasiQ8NFZ4.
PRIDEiQ8NFZ4.

PTM databases

iPTMnetiQ8NFZ4.
PhosphoSitePlusiQ8NFZ4.

Expressioni

Tissue specificityi

Expressed in the blood vessel walls. Detected in colon, brain and pancreas islets of Langerhans (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells.2 Publications

Gene expression databases

BgeeiENSG00000169992.
CleanExiHS_NLGN2.
ExpressionAtlasiQ8NFZ4. baseline and differential.
GenevisibleiQ8NFZ4. HS.

Organism-specific databases

HPAiHPA055321.
HPA069278.

Interactioni

Subunit structurei

Interacts with NRXN1, NRXN2 and NRXN3 (By similarity). Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3) (PubMed:9278515). Interacts with PATJ (By similarity). Interacts with GPHN (By similarity). Interacts with MDGA1 and MDGA2 (By similarity). Found in a complex with MAGI2 and IGSF9B, where it interacts with MAGI2 (via WW 1, WW 2 and PDZ 2 domains) (PubMed:23751499).By similarity2 Publications

GO - Molecular functioni

  • cell adhesion molecule binding Source: BHF-UCL
  • neurexin family protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi121611. 17 interactors.
STRINGi9606.ENSP00000305288.

Structurei

3D structure databases

ProteinModelPortaliQ8NFZ4.
SMRiQ8NFZ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1516. Eukaryota.
COG2272. LUCA.
GeneTreeiENSGT00760000118946.
HOGENOMiHOG000231424.
HOVERGENiHBG008839.
InParanoidiQ8NFZ4.
KOiK07378.
OMAiFNAASHH.
OrthoDBiEOG091G0CHW.
PhylomeDBiQ8NFZ4.
TreeFamiTF326187.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019819. Carboxylesterase_B_CS.
IPR000460. Nlgn.
IPR030023. NLGN2.
[Graphical view]
PANTHERiPTHR11559:SF53. PTHR11559:SF53. 2 hits.
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
PRINTSiPR01090. NEUROLIGIN.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NFZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLLALCLVG LAGAQRGGGG PGGGAPGGPG LGLGSLGEER FPVVNTAYGR
60 70 80 90 100
VRGVRRELNN EILGPVVQFL GVPYATPPLG ARRFQPPEAP ASWPGVRNAT
110 120 130 140 150
TLPPACPQNL HGALPAIMLP VWFTDNLEAA ATYVQNQSED CLYLNLYVPT
160 170 180 190 200
EDGPLTKKRD EATLNPPDTD IRDPGKKPVM LFLHGGSYME GTGNMFDGSV
210 220 230 240 250
LAAYGNVIVA TLNYRLGVLG FLSTGDQAAK GNYGLLDQIQ ALRWLSENIA
260 270 280 290 300
HFGGDPERIT IFGSGAGASC VNLLILSHHS EGLFQKAIAQ SGTAISSWSV
310 320 330 340 350
NYQPLKYTRL LAAKVGCDRE DSAEAVECLR RKPSRELVDQ DVQPARYHIA
360 370 380 390 400
FGPVVDGDVV PDDPEILMQQ GEFLNYDMLI GVNQGEGLKF VEDSAESEDG
410 420 430 440 450
VSASAFDFTV SNFVDNLYGY PEGKDVLRET IKFMYTDWAD RDNGEMRRKT
460 470 480 490 500
LLALFTDHQW VAPAVATAKL HADYQSPVYF YTFYHHCQAE GRPEWADAAH
510 520 530 540 550
GDELPYVFGV PMVGATDLFP CNFSKNDVML SAVVMTYWTN FAKTGDPNQP
560 570 580 590 600
VPQDTKFIHT KPNRFEEVVW SKFNSKEKQY LHIGLKPRVR DNYRANKVAF
610 620 630 640 650
WLELVPHLHN LHTELFTTTT RLPPYATRWP PRPPAGAPGT RRPPPPATLP
660 670 680 690 700
PEPEPEPGPR AYDRFPGDSR DYSTELSVTV AVGASLLFLN ILAFAALYYK
710 720 730 740 750
RDRRQELRCR RLSPPGGSGS GVPGGGPLLP AAGRELPPEE ELVSLQLKRG
760 770 780 790 800
GGVGADPAEA LRPACPPDYT LALRRAPDDV PLLAPGALTL LPSGLGPPPP
810 820 830
PPPPSLHPFG PFPPPPPTAT SHNNTLPHPH STTRV
Length:835
Mass (Da):90,820
Last modified:October 1, 2002 - v1
Checksum:i359938630193EF87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF376802 mRNA. Translation: AAM46111.1.
AB037787 mRNA. Translation: BAA92604.1.
CCDSiCCDS11103.1.
RefSeqiNP_065846.1. NM_020795.3.
UniGeneiHs.26229.

Genome annotation databases

EnsembliENST00000302926; ENSP00000305288; ENSG00000169992.
ENST00000575301; ENSP00000461168; ENSG00000169992.
GeneIDi57555.
KEGGihsa:57555.
UCSCiuc002ggt.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF376802 mRNA. Translation: AAM46111.1.
AB037787 mRNA. Translation: BAA92604.1.
CCDSiCCDS11103.1.
RefSeqiNP_065846.1. NM_020795.3.
UniGeneiHs.26229.

3D structure databases

ProteinModelPortaliQ8NFZ4.
SMRiQ8NFZ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121611. 17 interactors.
STRINGi9606.ENSP00000305288.

Protein family/group databases

ESTHERihuman-NLGN2. Neuroligin.
MEROPSiS09.995.

PTM databases

iPTMnetiQ8NFZ4.
PhosphoSitePlusiQ8NFZ4.

Polymorphism and mutation databases

DMDMi31076824.

Proteomic databases

EPDiQ8NFZ4.
PaxDbiQ8NFZ4.
PeptideAtlasiQ8NFZ4.
PRIDEiQ8NFZ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302926; ENSP00000305288; ENSG00000169992.
ENST00000575301; ENSP00000461168; ENSG00000169992.
GeneIDi57555.
KEGGihsa:57555.
UCSCiuc002ggt.3. human.

Organism-specific databases

CTDi57555.
DisGeNETi57555.
GeneCardsiNLGN2.
HGNCiHGNC:14290. NLGN2.
HPAiHPA055321.
HPA069278.
MIMi606479. gene.
neXtProtiNX_Q8NFZ4.
OpenTargetsiENSG00000169992.
PharmGKBiPA31648.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1516. Eukaryota.
COG2272. LUCA.
GeneTreeiENSGT00760000118946.
HOGENOMiHOG000231424.
HOVERGENiHBG008839.
InParanoidiQ8NFZ4.
KOiK07378.
OMAiFNAASHH.
OrthoDBiEOG091G0CHW.
PhylomeDBiQ8NFZ4.
TreeFamiTF326187.

Enzyme and pathway databases

ReactomeiR-HSA-6794361. Interactions of neurexins and neuroligins at synapses.

Miscellaneous databases

ChiTaRSiNLGN2. human.
GeneWikiiNLGN2.
GenomeRNAii57555.
PROiQ8NFZ4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169992.
CleanExiHS_NLGN2.
ExpressionAtlasiQ8NFZ4. baseline and differential.
GenevisibleiQ8NFZ4. HS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019819. Carboxylesterase_B_CS.
IPR000460. Nlgn.
IPR030023. NLGN2.
[Graphical view]
PANTHERiPTHR11559:SF53. PTHR11559:SF53. 2 hits.
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
PRINTSiPR01090. NEUROLIGIN.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNLGN2_HUMAN
AccessioniPrimary (citable) accession number: Q8NFZ4
Secondary accession number(s): Q9P2I1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.