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Q8NFZ4

- NLGN2_HUMAN

UniProt

Q8NFZ4 - NLGN2_HUMAN

Protein

Neuroligin-2

Gene

NLGN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion By similarity.By similarity

    GO - Molecular functioni

    1. cell adhesion molecule binding Source: BHF-UCL
    2. neurexin family protein binding Source: UniProtKB
    3. receptor activity Source: RefGenome

    GO - Biological processi

    1. cell-cell junction maintenance Source: UniProtKB
    2. gephyrin clustering Source: BHF-UCL
    3. locomotory exploration behavior Source: Ensembl
    4. neuromuscular process controlling balance Source: Ensembl
    5. neuron cell-cell adhesion Source: BHF-UCL
    6. positive regulation of excitatory postsynaptic membrane potential Source: BHF-UCL
    7. positive regulation of inhibitory postsynaptic membrane potential Source: BHF-UCL
    8. positive regulation of synapse assembly Source: BHF-UCL
    9. positive regulation of synaptic transmission, GABAergic Source: BHF-UCL
    10. positive regulation of synaptic transmission, glutamatergic Source: BHF-UCL
    11. postsynaptic density protein 95 clustering Source: BHF-UCL
    12. postsynaptic membrane assembly Source: BHF-UCL
    13. presynaptic membrane assembly Source: BHF-UCL
    14. protein localization to synapse Source: BHF-UCL
    15. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: BHF-UCL
    16. regulation of respiratory gaseous exchange by neurological system process Source: BHF-UCL
    17. regulation of synaptic transmission Source: BHF-UCL
    18. sensory perception of pain Source: Ensembl
    19. single organismal cell-cell adhesion Source: UniProtKB
    20. synapse assembly Source: UniProtKB
    21. synapse organization Source: BHF-UCL
    22. terminal button organization Source: BHF-UCL

    Keywords - Biological processi

    Cell adhesion

    Protein family/group databases

    MEROPSiS09.995.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuroligin-2
    Gene namesi
    Name:NLGN2
    Synonyms:KIAA1366
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:14290. NLGN2.

    Subcellular locationi

    Cell membrane By similarity; Single-pass type I membrane protein By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity. Cell junctionsynapsepresynaptic cell membrane By similarity
    Note: Detected at postsynaptic membranes in brain. Detected at dendritic spines in cultured neurons. Colocalizes with GPHN and ARHGEF9 at neuronal cell membranes By similarity. Localized at presynaptic membranes in retina. Colocalizes with GABRG2 at inhibitory synapses in the retina By similarity.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cell surface Source: BHF-UCL
    3. inhibitory synapse Source: BHF-UCL
    4. integral component of plasma membrane Source: BHF-UCL
    5. membrane Source: UniProtKB
    6. postsynaptic membrane Source: UniProtKB
    7. presynaptic membrane Source: UniProtKB-SubCell
    8. synapse Source: BHF-UCL

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31648.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1414Sequence AnalysisAdd
    BLAST
    Chaini15 – 835821Neuroligin-2PRO_0000008643Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi106 ↔ 141By similarity
    Glycosylationi136 – 1361N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi317 ↔ 328By similarity
    Disulfide bondi487 ↔ 521By similarity
    Glycosylationi522 – 5221N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NFZ4.
    PRIDEiQ8NFZ4.

    PTM databases

    PhosphoSiteiQ8NFZ4.

    Expressioni

    Tissue specificityi

    Expressed in the blood vessel walls. Detected in colon, brain and pancreas islets of Langerhans (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells.2 Publications

    Gene expression databases

    BgeeiQ8NFZ4.
    CleanExiHS_NLGN2.
    GenevestigatoriQ8NFZ4.

    Organism-specific databases

    HPAiHPA055321.

    Interactioni

    Subunit structurei

    Interacts with NRXN1, NRXN2 and NRXN3. Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3). Interacts with INADL. Interacts with GPHN By similarity. Interacts with MDGA1 and MDGA2 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi121611. 7 interactions.
    STRINGi9606.ENSP00000305288.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NFZ4.
    SMRiQ8NFZ4. Positions 42-609.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini15 – 677663ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini699 – 835137CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei678 – 69821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2272.
    HOGENOMiHOG000231424.
    HOVERGENiHBG008839.
    InParanoidiQ8NFZ4.
    KOiK07378.
    OMAiDIRDPGK.
    OrthoDBiEOG7RBZ7R.
    PhylomeDBiQ8NFZ4.
    TreeFamiTF326187.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR002018. CarbesteraseB.
    IPR019819. Carboxylesterase_B_CS.
    IPR000460. Neuroligin.
    [Graphical view]
    PfamiPF00135. COesterase. 1 hit.
    [Graphical view]
    PRINTSiPR01090. NEUROLIGIN.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00941. CARBOXYLESTERASE_B_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8NFZ4-1 [UniParc]FASTAAdd to Basket

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    MWLLALCLVG LAGAQRGGGG PGGGAPGGPG LGLGSLGEER FPVVNTAYGR    50
    VRGVRRELNN EILGPVVQFL GVPYATPPLG ARRFQPPEAP ASWPGVRNAT 100
    TLPPACPQNL HGALPAIMLP VWFTDNLEAA ATYVQNQSED CLYLNLYVPT 150
    EDGPLTKKRD EATLNPPDTD IRDPGKKPVM LFLHGGSYME GTGNMFDGSV 200
    LAAYGNVIVA TLNYRLGVLG FLSTGDQAAK GNYGLLDQIQ ALRWLSENIA 250
    HFGGDPERIT IFGSGAGASC VNLLILSHHS EGLFQKAIAQ SGTAISSWSV 300
    NYQPLKYTRL LAAKVGCDRE DSAEAVECLR RKPSRELVDQ DVQPARYHIA 350
    FGPVVDGDVV PDDPEILMQQ GEFLNYDMLI GVNQGEGLKF VEDSAESEDG 400
    VSASAFDFTV SNFVDNLYGY PEGKDVLRET IKFMYTDWAD RDNGEMRRKT 450
    LLALFTDHQW VAPAVATAKL HADYQSPVYF YTFYHHCQAE GRPEWADAAH 500
    GDELPYVFGV PMVGATDLFP CNFSKNDVML SAVVMTYWTN FAKTGDPNQP 550
    VPQDTKFIHT KPNRFEEVVW SKFNSKEKQY LHIGLKPRVR DNYRANKVAF 600
    WLELVPHLHN LHTELFTTTT RLPPYATRWP PRPPAGAPGT RRPPPPATLP 650
    PEPEPEPGPR AYDRFPGDSR DYSTELSVTV AVGASLLFLN ILAFAALYYK 700
    RDRRQELRCR RLSPPGGSGS GVPGGGPLLP AAGRELPPEE ELVSLQLKRG 750
    GGVGADPAEA LRPACPPDYT LALRRAPDDV PLLAPGALTL LPSGLGPPPP 800
    PPPPSLHPFG PFPPPPPTAT SHNNTLPHPH STTRV 835
    Length:835
    Mass (Da):90,820
    Last modified:October 1, 2002 - v1
    Checksum:i359938630193EF87
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF376802 mRNA. Translation: AAM46111.1.
    AB037787 mRNA. Translation: BAA92604.1.
    CCDSiCCDS11103.1.
    RefSeqiNP_065846.1. NM_020795.3.
    UniGeneiHs.26229.

    Genome annotation databases

    EnsembliENST00000302926; ENSP00000305288; ENSG00000169992.
    ENST00000575301; ENSP00000461168; ENSG00000169992.
    GeneIDi57555.
    KEGGihsa:57555.
    UCSCiuc002ggt.1. human.

    Polymorphism databases

    DMDMi31076824.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF376802 mRNA. Translation: AAM46111.1 .
    AB037787 mRNA. Translation: BAA92604.1 .
    CCDSi CCDS11103.1.
    RefSeqi NP_065846.1. NM_020795.3.
    UniGenei Hs.26229.

    3D structure databases

    ProteinModelPortali Q8NFZ4.
    SMRi Q8NFZ4. Positions 42-609.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121611. 7 interactions.
    STRINGi 9606.ENSP00000305288.

    Protein family/group databases

    MEROPSi S09.995.

    PTM databases

    PhosphoSitei Q8NFZ4.

    Polymorphism databases

    DMDMi 31076824.

    Proteomic databases

    PaxDbi Q8NFZ4.
    PRIDEi Q8NFZ4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302926 ; ENSP00000305288 ; ENSG00000169992 .
    ENST00000575301 ; ENSP00000461168 ; ENSG00000169992 .
    GeneIDi 57555.
    KEGGi hsa:57555.
    UCSCi uc002ggt.1. human.

    Organism-specific databases

    CTDi 57555.
    GeneCardsi GC17P007311.
    HGNCi HGNC:14290. NLGN2.
    HPAi HPA055321.
    MIMi 606479. gene.
    neXtProti NX_Q8NFZ4.
    PharmGKBi PA31648.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2272.
    HOGENOMi HOG000231424.
    HOVERGENi HBG008839.
    InParanoidi Q8NFZ4.
    KOi K07378.
    OMAi DIRDPGK.
    OrthoDBi EOG7RBZ7R.
    PhylomeDBi Q8NFZ4.
    TreeFami TF326187.

    Miscellaneous databases

    GeneWikii NLGN2.
    GenomeRNAii 57555.
    NextBioi 64034.
    PROi Q8NFZ4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8NFZ4.
    CleanExi HS_NLGN2.
    Genevestigatori Q8NFZ4.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR002018. CarbesteraseB.
    IPR019819. Carboxylesterase_B_CS.
    IPR000460. Neuroligin.
    [Graphical view ]
    Pfami PF00135. COesterase. 1 hit.
    [Graphical view ]
    PRINTSi PR01090. NEUROLIGIN.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00941. CARBOXYLESTERASE_B_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 286-835.
      Tissue: Brain.
    3. Cited for: INTERACTION WITH DLG4.
    4. "Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion."
      Suckow A.T., Comoletti D., Waldrop M.A., Mosedale M., Egodage S., Taylor P., Chessler S.D.
      Endocrinology 149:6006-6017(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
    5. "The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions."
      Bottos A., Destro E., Rissone A., Graziano S., Cordara G., Assenzio B., Cera M.R., Mascia L., Bussolino F., Arese M.
      Proc. Natl. Acad. Sci. U.S.A. 106:20782-20787(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiNLGN2_HUMAN
    AccessioniPrimary (citable) accession number: Q8NFZ4
    Secondary accession number(s): Q9P2I1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 23, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3