Q8NFZ3 (NLGNY_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuroligin-4, Y-linked
Short name=Neuroligin Y

Gene names

Name:	NLGN4Y
Synonyms:	KIAA0951

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	816 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Putative neuronal cell surface protein involved in cell-cell-interactions.
Subunit structure	Homodimer. Interacts with NRXN1 in a calcium-dependent manner. Interacts through its C-terminus with DLG4/PSD-95 third PDZ domain By similarity.
Subcellular location	Cell membrane; Single-pass type I membrane protein. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density By similarity.
Tissue specificity	Expressed in fetal and adult brain, prostate and testis. Ref.5
Sequence similarities	Belongs to the type-B carboxylesterase/lipase family.
Sequence caution	The sequence BAA76795.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Coding sequence diversity	Alternative splicing
Domain	Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW synapse assembly Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW cell surface Inferred from Biological aspect of Ancestor. Source: RefGenome integral to plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome postsynaptic density Inferred from electronic annotation. Source: UniProtKB-SubCell postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	neurexin family protein binding Inferred from Biological aspect of Ancestor. Source: RefGenome receptor activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NFZ3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NFZ3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-168: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 43	43	Potential
	Chain	44 – 816	773	Neuroligin-4, Y-linked		PRO_0000008649
Regions
	Topological domain	44 – 676	633	Extracellular Potential
	Transmembrane	677 – 697	21	Helical; Potential
	Topological domain	698 – 816	119	Cytoplasmic Potential
	Region	359 – 364	6	Interaction with NRXN1 By similarity
Amino acid modifications
	Glycosylation	102	1	N-linked (GlcNAc...) Potential
	Glycosylation	511	1	N-linked (GlcNAc...) Potential
	Disulfide bond	110 ↔ 146		By similarity
	Disulfide bond	306 ↔ 317		By similarity
	Disulfide bond	476 ↔ 510		By similarity
Natural variations
	Alternative sequence	1 – 168	168	Missing in isoform 2.		VSP_007537
Experimental info
	Sequence conflict	203	1	Y → C in CAD97670. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: FB68910773B1BBF6	FASTA	816	92,021
	10 20 30 40 50 60 MLRPQGLLWL PLLFTSVCVM LNSNVLLWIT ALAIKFTLID SQAQYPVVNT NYGKIQGLRT 70 80 90 100 110 120 PLPSEILGPV EQYLGVPYAS PPTGERRFQP PESPSSWTGI RNATQFSAVC PQHLDERFLL 130 140 150 160 170 180 HDMLPIWFTT SLDTLMTYVQ DQNEDCLYLN IYVPMEDDIH EQNSKKPVMV YIHGGSYMEG 190 200 210 220 230 240 TGNMIDGSIL ASYGNVIVIT INYRLGILGF LSTGDQAAKG NYGLLDQIQA LRWIEENVGA 250 260 270 280 290 300 FGGDPKRVTI FGSGAGASCV SLLTLSHYSE GLFQKAIIQS GTALSSWAVN YQPAKYTRIL 310 320 330 340 350 360 ADKVGCNMLD TTDMVECLKN KNYKELIQQT ITPATYHIAF GPVIDGDVIP DDPQILMEQG 370 380 390 400 410 420 EFLNYDIMLG VNQGEGLKFV DGIVDNEDGV TPNDFDFSVS NFVDNLYGYP EGKDTLRETI 430 440 450 460 470 480 KFMYTDWADK ENPETRRKTL VALFTDHQWV APAVATADLH AQYGSPTYFY AFYHHCQSEM 490 500 510 520 530 540 KPSWADSAHG DEVPYVFGIP MIGPTELFSC NFSKNDVMLS AVVMTYWTNF AKTGDPNQPV 550 560 570 580 590 600 PQDTKFIHTK PNRFEEVAWS KYNPKDQLYL HIGLKPRVRD HYRATKVAFW LELVPHLHNL 610 620 630 640 650 660 NEIFQYVSTT TKVPPPDMTS FPYGTRRSPA KIWPTTKRPA ITPANNPKHS KDPHKTGPED 670 680 690 700 710 720 TTVLIETKRD YSTELSVTIA VGASLLFLNI LAFAALYYKK DKRRHETHRH PSPQRNTTND 730 740 750 760 770 780 ITHIQNEEIM SLQMKQLEHD HECESLQAHD TLRLTCPPDY TLTLRRSPDD IPFMTPNTIT 790 800 810 MIPNTLMGMQ PLHTFKTFSG GQNSTNLPHG HSTTRV
	Isoform 2 [UniParc]. Checksum: 1A2E6727A709BFBC	FASTA	648	72,885
	10 20 30 40 50 60 MVYIHGGSYM EGTGNMIDGS ILASYGNVIV ITINYRLGIL GFLSTGDQAA KGNYGLLDQI 70 80 90 100 110 120 QALRWIEENV GAFGGDPKRV TIFGSGAGAS CVSLLTLSHY SEGLFQKAII QSGTALSSWA 130 140 150 160 170 180 VNYQPAKYTR ILADKVGCNM LDTTDMVECL KNKNYKELIQ QTITPATYHI AFGPVIDGDV 190 200 210 220 230 240 IPDDPQILME QGEFLNYDIM LGVNQGEGLK FVDGIVDNED GVTPNDFDFS VSNFVDNLYG 250 260 270 280 290 300 YPEGKDTLRE TIKFMYTDWA DKENPETRRK TLVALFTDHQ WVAPAVATAD LHAQYGSPTY 310 320 330 340 350 360 FYAFYHHCQS EMKPSWADSA HGDEVPYVFG IPMIGPTELF SCNFSKNDVM LSAVVMTYWT 370 380 390 400 410 420 NFAKTGDPNQ PVPQDTKFIH TKPNRFEEVA WSKYNPKDQL YLHIGLKPRV RDHYRATKVA 430 440 450 460 470 480 FWLELVPHLH NLNEIFQYVS TTTKVPPPDM TSFPYGTRRS PAKIWPTTKR PAITPANNPK 490 500 510 520 530 540 HSKDPHKTGP EDTTVLIETK RDYSTELSVT IAVGASLLFL NILAFAALYY KKDKRRHETH 550 560 570 580 590 600 RHPSPQRNTT NDITHIQNEE IMSLQMKQLE HDHECESLQA HDTLRLTCPP DYTLTLRRSP 610 620 630 640 DDIPFMTPNT ITMIPNTLMG MQPLHTFKTF SGGQNSTNLP HGHSTTRV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism." Jamain S., Quach H., Betancur C., Rastam M., Colineaux C., Gillberg I.C., Soderstrom H., Giros B., Leboyer M., Gillberg C., Bourgeron T., Nyden A., Philippe A., Cohen D., Chabane N., Mouren-Simeoni M.C., Brice A., Sponheim E. , Spurkland I., Skjeldal O.H., Coleman M., Pearl P.L., Cohen I.L., Tsiouris J., Zappella M., Menchetti G., Pompella A., Aschauer H., Van Maldergem L. Nat. Genet. 34:27-29(2003) [PubMed: 12669065] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed: 10231032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Fetal kidney.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[5]	"The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes." Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., Graves T.A. , Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R., McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S., Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P., Waterston R.H., Wilson R.K., Rozen S., Page D.C. Nature 423:825-837(2003) [PubMed: 12815422] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF376804 mRNA. Translation: AAM46113.1. AB023168 mRNA. Translation: BAA76795.2. Different initiation. BX537428 mRNA. Translation: CAD97670.1. BC113525 mRNA. Translation: AAI13526.1. BC113551 mRNA. Translation: AAI13552.1.
IPI	IPI00171705. IPI00240784.
RefSeq	NP_001157710.1. NM_001164238.1. NP_001193779.1. NM_001206850.1. NP_055708.3. NM_014893.4.
UniGene	Hs.439199. Hs.694600.
3D structure databases
ProteinModelPortal	Q8NFZ3.
SMR	Q8NFZ3. Positions 41-599.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8NFZ3.
Protein family/group databases
MEROPS	S09.989.
PTM databases
PhosphoSite	Q8NFZ3.
Polymorphism databases
DMDM	31076823.
Proteomic databases
PRIDE	Q8NFZ3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000339174; ENSP00000342535; ENSG00000165246. ENST00000355905; ENSP00000348169; ENSG00000165246.
GeneID	22829.
KEGG	hsa:22829.
UCSC	uc004fte.1. human. uc004ftg.1. human.
Organism-specific databases
CTD	22829.
GeneCards	GC0YP016634.
H-InvDB	HIX0019056.
HGNC	HGNC:15529. NLGN4Y.
HPA	HPA001651.
MIM	400028. gene.
neXtProt	NX_Q8NFZ3.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG19421.
GeneTree	ENSGT00600000084208.
HOVERGEN	HBG008839.
PhylomeDB	Q8NFZ3.
Gene expression databases
ArrayExpress	Q8NFZ3.
Bgee	Q8NFZ3.
CleanEx	HS_NLGN4Y.
Genevestigator	Q8NFZ3.
GermOnline	ENSG00000165246. Homo sapiens.
Family and domain databases
InterPro	IPR002018. CarbesteraseB. IPR019819. Carboxylesterase_B_CS. IPR000460. Neuroligin. [Graphical view]
Pfam	PF00135. COesterase. 1 hit. [Graphical view]
PRINTS	PR01090. NEUROLIGIN.
PROSITE	PS00941. CARBOXYLESTERASE_B_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

NLGNY_HUMAN

Accession

Primary (citable) accession number: Q8NFZ3
Secondary accession number(s): Q14D08, Q7Z3T5, Q9Y2F8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 23, 2003
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.