Q8NFZ3 (NLGNY_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 93.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Neuroligin-4, Y-linked Short name=Neuroligin Y | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 816 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Putative neuronal cell surface protein involved in cell-cell-interactions. |
| Subunit structure | Homodimer. Interacts with NRXN1 in a calcium-dependent manner. Interacts through its C-terminus with DLG4/PSD-95 third PDZ domain By similarity. |
| Subcellular location | Cell membrane; Single-pass type I membrane protein. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density By similarity. |
| Tissue specificity | Expressed in fetal and adult brain, prostate and testis. Ref.5 |
| Sequence similarities | Belongs to the type-B carboxylesterase/lipase family. |
| Sequence caution | The sequence BAA76795.2 differs from that shown. Reason: Erroneous initiation. |
Ontologies
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q8NFZ3-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q8NFZ3-2) The sequence of this isoform differs from the canonical sequence as follows: 1-168: Missing. | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 43 | 43 | Potential | ||||||||
| Chain | 44 – 816 | 773 | Neuroligin-4, Y-linked | PRO_0000008649 | |||||||
Regions | |||||||||||
| Topological domain | 44 – 676 | 633 | Extracellular Potential | ||||||||
| Transmembrane | 677 – 697 | 21 | Helical; Potential | ||||||||
| Topological domain | 698 – 816 | 119 | Cytoplasmic Potential | ||||||||
| Region | 359 – 364 | 6 | Interaction with NRXN1 By similarity | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 102 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 511 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 110 ↔ 146 | By similarity | |||||||||
| Disulfide bond | 306 ↔ 317 | By similarity | |||||||||
| Disulfide bond | 476 ↔ 510 | By similarity | |||||||||
Natural variations | |||||||||||
| Alternative sequence | 1 – 168 | 168 | Missing in isoform 2. | VSP_007537 | |||||||
Experimental info | |||||||||||
| Sequence conflict | 203 | 1 | Y → C in CAD97670. Ref.3 | ||||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF376804 mRNA. Translation: AAM46113.1. AB023168 mRNA. Translation: BAA76795.2. Different initiation. BX537428 mRNA. Translation: CAD97670.1. BC113525 mRNA. Translation: AAI13526.1. BC113551 mRNA. Translation: AAI13552.1. |
| IPI | IPI00171705. IPI00240784. |
| RefSeq | NP_001157710.1. NM_001164238.1. NP_001193779.1. NM_001206850.1. NP_055708.3. NM_014893.4. |
| UniGene | Hs.439199. Hs.694600. |
3D structure databases | |
| ProteinModelPortal | Q8NFZ3. |
| SMR | Q8NFZ3. Positions 41-599. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q8NFZ3. |
Protein family/group databases | |
| MEROPS | S09.989. |
PTM databases | |
| PhosphoSite | Q8NFZ3. |
Polymorphism databases | |
| DMDM | 31076823. |
Proteomic databases | |
| PRIDE | Q8NFZ3. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000339174; ENSP00000342535; ENSG00000165246. ENST00000355905; ENSP00000348169; ENSG00000165246. |
| GeneID | 22829. |
| KEGG | hsa:22829. |
| UCSC | uc004fte.1. human. uc004ftg.1. human. |
Organism-specific databases | |
| CTD | 22829. |
| GeneCards | GC0YP016634. |
| H-InvDB | HIX0019056. |
| HGNC | HGNC:15529. NLGN4Y. |
| HPA | HPA001651. |
| MIM | 400028. gene. |
| neXtProt | NX_Q8NFZ3. |
| HUGE | Search... |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG19421. |
| GeneTree | ENSGT00600000084208. |
| HOVERGEN | HBG008839. |
| PhylomeDB | Q8NFZ3. |
Gene expression databases | |
| ArrayExpress | Q8NFZ3. |
| Bgee | Q8NFZ3. |
| CleanEx | HS_NLGN4Y. |
| Genevestigator | Q8NFZ3. |
| GermOnline | ENSG00000165246. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR002018. CarbesteraseB. IPR019819. Carboxylesterase_B_CS. IPR000460. Neuroligin. [Graphical view] |
| Pfam | PF00135. COesterase. 1 hit. [Graphical view] |
| PRINTS | PR01090. NEUROLIGIN. |
| PROSITE | PS00941. CARBOXYLESTERASE_B_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| SOURCE | Search... |
Entry information
| Entry name | NLGNY_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8NFZ3 Secondary accession number(s): Q14D08, Q7Z3T5, Q9Y2F8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome Y Human chromosome Y: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with