##gff-version 3
Q8NFY9	UniProtKB	Chain	1	601	.	.	.	ID=PRO_0000278220;Note=Kelch repeat and BTB domain-containing protein 8	
Q8NFY9	UniProtKB	Domain	49	117	.	.	.	Note=BTB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00037	
Q8NFY9	UniProtKB	Domain	153	252	.	.	.	Note=BACK;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q8NFY9	UniProtKB	Repeat	336	390	.	.	.	Note=Kelch 1;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q8NFY9	UniProtKB	Repeat	391	441	.	.	.	Note=Kelch 2;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q8NFY9	UniProtKB	Repeat	443	481	.	.	.	Note=Kelch 3;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q8NFY9	UniProtKB	Repeat	483	532	.	.	.	Note=Kelch 4;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q8NFY9	UniProtKB	Repeat	542	588	.	.	.	Note=Kelch 5;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q8NFY9	UniProtKB	Region	1	25	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q8NFY9	UniProtKB	Compositional bias	1	20	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q8NFY9	UniProtKB	Alternative sequence	6	447	.	.	.	ID=VSP_056107;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039	
Q8NFY9	UniProtKB	Natural variant	198	198	.	.	.	ID=VAR_036082;Note=In a breast cancer sample%3B somatic mutation. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974	
Q8NFY9	UniProtKB	Natural variant	405	405	.	.	.	ID=VAR_036083;Note=In a breast cancer sample%3B somatic mutation. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974	
Q8NFY9	UniProtKB	Natural variant	420	420	.	.	.	ID=VAR_030694;Note=C->R;Dbxref=dbSNP:rs13096789	
Q8NFY9	UniProtKB	Mutagenesis	74	74	.	.	.	Note=Abolishes CUL3-binding and ability to mediate monoubiquitination of NOLC1 and TCOF1. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26399832;Dbxref=PMID:26399832	
Q8NFY9	UniProtKB	Mutagenesis	579	579	.	.	.	Note=Abolishes substrate-binding and ability to mediate monoubiquitination of NOLC1 and TCOF1. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26399832;Dbxref=PMID:26399832