Q8NFY4 (SEM6D_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Semaphorin-6D

Gene names

Name:	SEMA6D
Synonyms:	KIAA1479

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1073 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections.
Subcellular location	Isoform 1: Cell membrane; Single-pass type I membrane protein Ref.1. Isoform 2: Cell membrane; Single-pass type I membrane protein Ref.1. Isoform 3: Cell membrane; Single-pass type I membrane protein Ref.1. Isoform 4: Cell membrane; Single-pass type I membrane protein Ref.1. Isoform 5: Cell membrane; Single-pass type I membrane protein Ref.1. Isoform 7: Cytoplasm Ref.1.
Sequence similarities	Belongs to the semaphorin family. Contains 1 PSI domain. Contains 1 Sema domain.
Sequence caution	The sequence BAA96003.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Cell membrane Cytoplasm Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Developmental protein
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Traceable author statement. Source: Reactome
Cellular_component	Golgi apparatus Inferred from direct assay. Source: HPA integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay. Source: HPA
Molecular_function	receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 4 (identifier: Q8NFY4-1)

Also known as: SEMA6D.4;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: Q8NFY4-2)

Also known as: SEMA6D.1;

The sequence of this isoform differs from the canonical sequence as follows:
     549-549: L → LLLTEDFFAFHNHS
     570-644: Missing.

Isoform 2 (identifier: Q8NFY4-3)

Also known as: SEMA6D.2;

The sequence of this isoform differs from the canonical sequence as follows:
     570-644: Missing.

Isoform 3 (identifier: Q8NFY4-4)

Also known as: SEMA6D.3;

The sequence of this isoform differs from the canonical sequence as follows:
     589-644: Missing.

Isoform 5 (identifier: Q8NFY4-5)

The sequence of this isoform differs from the canonical sequence as follows:
     549-549: L → LLLTEDFFAFHNHS
     589-644: Missing.

Note: No experimental confirmation available.

Isoform 6 (identifier: Q8NFY4-6)

The sequence of this isoform differs from the canonical sequence as follows:
     570-588: Missing.

Note: No experimental confirmation available.

Isoform 7 (identifier: Q8NFY4-7)

Also known as: SEMA6Ds; Short;

The sequence of this isoform differs from the canonical sequence as follows:
     477-1073: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 1073	1053	Semaphorin-6D		PRO_0000044615
Regions
	Topological domain	21 – 662	642	Extracellular Potential
	Transmembrane	663 – 683	21	Helical; Potential
	Topological domain	684 – 1073	390	Cytoplasmic Potential
	Domain	27 – 512	486	Sema
	Domain	514 – 569	56	PSI
Amino acid modifications
	Glycosylation	51	1	N-linked (GlcNAc...) Potential
	Glycosylation	283	1	N-linked (GlcNAc...) Potential
	Glycosylation	435	1	N-linked (GlcNAc...) Potential
	Glycosylation	461	1	N-linked (GlcNAc...) Potential
	Glycosylation	631	1	N-linked (GlcNAc...) Potential
	Disulfide bond	108 ↔ 118		By similarity
	Disulfide bond	136 ↔ 145		By similarity
	Disulfide bond	259 ↔ 370		By similarity
	Disulfide bond	284 ↔ 329		By similarity
	Disulfide bond	477 ↔ 506		By similarity
	Disulfide bond	515 ↔ 533		By similarity
	Disulfide bond	521 ↔ 568		By similarity
	Disulfide bond	525 ↔ 541		By similarity
Natural variations
	Alternative sequence	477 – 1073	597	Missing in isoform 7.		VSP_016564
	Alternative sequence	549	1	L → LLLTEDFFAFHNHS in isoform 1 and isoform 5.		VSP_016565
	Alternative sequence	570 – 644	75	Missing in isoform 1 and isoform 2.		VSP_016566
	Alternative sequence	570 – 588	19	Missing in isoform 6.		VSP_016572
	Alternative sequence	589 – 644	56	Missing in isoform 3 and isoform 5.		VSP_016567
	Natural variant	307	1	N → S. Corresponds to variant rs3743279 [ dbSNP | Ensembl ].		VAR_051931
	Natural variant	478	1	S → N. Corresponds to variant rs532598 [ dbSNP | Ensembl ].		VAR_051932
	Natural variant	969	1	S → T. Corresponds to variant rs16960074 [ dbSNP | Ensembl ].		VAR_051933

Sequences

	Sequence		Length	Mass (Da)
	Isoform 4 (SEMA6D.4) [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 7DCE4DFC5BF70F9E	FASTA	1,073	119,872
	10 20 30 40 50 60 MRVFLLCAYI LLLMVSQLRA VSFPEDDEPL NTVDYHYSRQ YPVFRGRPSG NESQHRLDFQ 70 80 90 100 110 120 LMLKIRDTLY IAGRDQVYTV NLNEMPKTEV IPNKKLTWRS RQQDRENCAM KGKHKDECHN 130 140 150 160 170 180 FIKVFVPRND EMVFVCGTNA FNPMCRYYRL STLEYDGEEI SGLARCPFDA RQTNVALFAD 190 200 210 220 230 240 GKLYSATVAD FLASDAVIYR SMGDGSALRT IKYDSKWIKE PHFLHAIEYG NYVYFFFREI 250 260 270 280 290 300 AVEHNNLGKA VYSRVARICK NDMGGSQRVL EKHWTSFLKA RLNCSVPGDS FFYFDVLQSI 310 320 330 340 350 360 TDIIQINGIP TVVGVFTTQL NSIPGSAVCA FSMDDIEKVF KGRFKEQKTP DSVWTAVPED 370 380 390 400 410 420 KVPKPRPGCC AKHGLAEAYK TSIDFPDETL SFIKSHPLMD SAVPPIADEP WFTKTRVRYR 430 440 450 460 470 480 LTAISVDHSA GPYQNYTVIF VGSEAGMVLK VLAKTSPFSL NDSVLLEEIE AYNHAKCSAE 490 500 510 520 530 540 NEEDKKVISL QLDKDHHALY VAFSSCIIRI PLSRCERYGS CKKSCIASRD PYCGWLSQGS 550 560 570 580 590 600 CGRVTPGMLA EGYEQDTEFG NTAHLGDCHE ILPTSTTPDY KIFGGPTSDM EVSSSSVTTM 610 620 630 640 650 660 ASIPEITPKV IDTWRPKLTS SRKFVVQDDP NTSDFTDPLS GIPKGVRWEV QSGESNQMVH 670 680 690 700 710 720 MNVLITCVFA AFVLGAFIAG VAVYCYRDMF VRKNRKIHKD AESAQSCTDS SGSFAKLNGL 730 740 750 760 770 780 FDSPVKEYQQ NIDSPKLYSN LLTSRKELPP NGDTKSMVMD HRGQPPELAA LPTPESTPVL 790 800 810 820 830 840 HQKTLQAMKS HSEKAHGHGA SRKETPQFFP SSPPPHSPLS HGHIPSAIVL PNATHDYNTS 850 860 870 880 890 900 FSNSNAHKAE KKLQNIDHPL TKSSSKRDHR RSVDSRNTLN DLLKHLNDPN SNPKAIMGDI 910 920 930 940 950 960 QMAHQNLMLD PMGSMSEVPP KVPNREASLY SPPSTLPRNS PTKRVDVPTT PGVPMTSLER 970 980 990 1000 1010 1020 QRGYHKNSSQ RHSISAMPKN LNSPNGVLLS RQPSMNRGGY MPTPTGAKVD YIQGTPVSVH 1030 1040 1050 1060 1070 LQPSLSRQSS YTSNGTLPRT GLKRTPSLKP DVPPKPSFVP QTPSVRPLNK YTY
	Isoform 1 (SEMA6D.1) [UniParc]. Checksum: 9D6B8B3633941B89	FASTA	1,011	113,290
	10 20 30 40 50 60 MRVFLLCAYI LLLMVSQLRA VSFPEDDEPL NTVDYHYSRQ YPVFRGRPSG NESQHRLDFQ 70 80 90 100 110 120 LMLKIRDTLY IAGRDQVYTV NLNEMPKTEV IPNKKLTWRS RQQDRENCAM KGKHKDECHN 130 140 150 160 170 180 FIKVFVPRND EMVFVCGTNA FNPMCRYYRL STLEYDGEEI SGLARCPFDA RQTNVALFAD 190 200 210 220 230 240 GKLYSATVAD FLASDAVIYR SMGDGSALRT IKYDSKWIKE PHFLHAIEYG NYVYFFFREI 250 260 270 280 290 300 AVEHNNLGKA VYSRVARICK NDMGGSQRVL EKHWTSFLKA RLNCSVPGDS FFYFDVLQSI 310 320 330 340 350 360 TDIIQINGIP TVVGVFTTQL NSIPGSAVCA FSMDDIEKVF KGRFKEQKTP DSVWTAVPED 370 380 390 400 410 420 KVPKPRPGCC AKHGLAEAYK TSIDFPDETL SFIKSHPLMD SAVPPIADEP WFTKTRVRYR 430 440 450 460 470 480 LTAISVDHSA GPYQNYTVIF VGSEAGMVLK VLAKTSPFSL NDSVLLEEIE AYNHAKCSAE 490 500 510 520 530 540 NEEDKKVISL QLDKDHHALY VAFSSCIIRI PLSRCERYGS CKKSCIASRD PYCGWLSQGS 550 560 570 580 590 600 CGRVTPGMLL LTEDFFAFHN HSAEGYEQDT EFGNTAHLGD CHGVRWEVQS GESNQMVHMN 610 620 630 640 650 660 VLITCVFAAF VLGAFIAGVA VYCYRDMFVR KNRKIHKDAE SAQSCTDSSG SFAKLNGLFD 670 680 690 700 710 720 SPVKEYQQNI DSPKLYSNLL TSRKELPPNG DTKSMVMDHR GQPPELAALP TPESTPVLHQ 730 740 750 760 770 780 KTLQAMKSHS EKAHGHGASR KETPQFFPSS PPPHSPLSHG HIPSAIVLPN ATHDYNTSFS 790 800 810 820 830 840 NSNAHKAEKK LQNIDHPLTK SSSKRDHRRS VDSRNTLNDL LKHLNDPNSN PKAIMGDIQM 850 860 870 880 890 900 AHQNLMLDPM GSMSEVPPKV PNREASLYSP PSTLPRNSPT KRVDVPTTPG VPMTSLERQR 910 920 930 940 950 960 GYHKNSSQRH SISAMPKNLN SPNGVLLSRQ PSMNRGGYMP TPTGAKVDYI QGTPVSVHLQ 970 980 990 1000 1010 PSLSRQSSYT SNGTLPRTGL KRTPSLKPDV PPKPSFVPQT PSVRPLNKYT Y
	Isoform 2 (SEMA6D.2) [UniParc]. Checksum: 3F46D6872E8D5344	FASTA	998	111,730
	10 20 30 40 50 60 MRVFLLCAYI LLLMVSQLRA VSFPEDDEPL NTVDYHYSRQ YPVFRGRPSG NESQHRLDFQ 70 80 90 100 110 120 LMLKIRDTLY IAGRDQVYTV NLNEMPKTEV IPNKKLTWRS RQQDRENCAM KGKHKDECHN 130 140 150 160 170 180 FIKVFVPRND EMVFVCGTNA FNPMCRYYRL STLEYDGEEI SGLARCPFDA RQTNVALFAD 190 200 210 220 230 240 GKLYSATVAD FLASDAVIYR SMGDGSALRT IKYDSKWIKE PHFLHAIEYG NYVYFFFREI 250 260 270 280 290 300 AVEHNNLGKA VYSRVARICK NDMGGSQRVL EKHWTSFLKA RLNCSVPGDS FFYFDVLQSI 310 320 330 340 350 360 TDIIQINGIP TVVGVFTTQL NSIPGSAVCA FSMDDIEKVF KGRFKEQKTP DSVWTAVPED 370 380 390 400 410 420 KVPKPRPGCC AKHGLAEAYK TSIDFPDETL SFIKSHPLMD SAVPPIADEP WFTKTRVRYR 430 440 450 460 470 480 LTAISVDHSA GPYQNYTVIF VGSEAGMVLK VLAKTSPFSL NDSVLLEEIE AYNHAKCSAE 490 500 510 520 530 540 NEEDKKVISL QLDKDHHALY VAFSSCIIRI PLSRCERYGS CKKSCIASRD PYCGWLSQGS 550 560 570 580 590 600 CGRVTPGMLA EGYEQDTEFG NTAHLGDCHG VRWEVQSGES NQMVHMNVLI TCVFAAFVLG 610 620 630 640 650 660 AFIAGVAVYC YRDMFVRKNR KIHKDAESAQ SCTDSSGSFA KLNGLFDSPV KEYQQNIDSP 670 680 690 700 710 720 KLYSNLLTSR KELPPNGDTK SMVMDHRGQP PELAALPTPE STPVLHQKTL QAMKSHSEKA 730 740 750 760 770 780 HGHGASRKET PQFFPSSPPP HSPLSHGHIP SAIVLPNATH DYNTSFSNSN AHKAEKKLQN 790 800 810 820 830 840 IDHPLTKSSS KRDHRRSVDS RNTLNDLLKH LNDPNSNPKA IMGDIQMAHQ NLMLDPMGSM 850 860 870 880 890 900 SEVPPKVPNR EASLYSPPST LPRNSPTKRV DVPTTPGVPM TSLERQRGYH KNSSQRHSIS 910 920 930 940 950 960 AMPKNLNSPN GVLLSRQPSM NRGGYMPTPT GAKVDYIQGT PVSVHLQPSL SRQSSYTSNG 970 980 990 TLPRTGLKRT PSLKPDVPPK PSFVPQTPSV RPLNKYTY
	Isoform 3 (SEMA6D.3) [UniParc]. Checksum: 4D639CEBADD9F2A0	FASTA	1,017	113,736
	10 20 30 40 50 60 MRVFLLCAYI LLLMVSQLRA VSFPEDDEPL NTVDYHYSRQ YPVFRGRPSG NESQHRLDFQ 70 80 90 100 110 120 LMLKIRDTLY IAGRDQVYTV NLNEMPKTEV IPNKKLTWRS RQQDRENCAM KGKHKDECHN 130 140 150 160 170 180 FIKVFVPRND EMVFVCGTNA FNPMCRYYRL STLEYDGEEI SGLARCPFDA RQTNVALFAD 190 200 210 220 230 240 GKLYSATVAD FLASDAVIYR SMGDGSALRT IKYDSKWIKE PHFLHAIEYG NYVYFFFREI 250 260 270 280 290 300 AVEHNNLGKA VYSRVARICK NDMGGSQRVL EKHWTSFLKA RLNCSVPGDS FFYFDVLQSI 310 320 330 340 350 360 TDIIQINGIP TVVGVFTTQL NSIPGSAVCA FSMDDIEKVF KGRFKEQKTP DSVWTAVPED 370 380 390 400 410 420 KVPKPRPGCC AKHGLAEAYK TSIDFPDETL SFIKSHPLMD SAVPPIADEP WFTKTRVRYR 430 440 450 460 470 480 LTAISVDHSA GPYQNYTVIF VGSEAGMVLK VLAKTSPFSL NDSVLLEEIE AYNHAKCSAE 490 500 510 520 530 540 NEEDKKVISL QLDKDHHALY VAFSSCIIRI PLSRCERYGS CKKSCIASRD PYCGWLSQGS 550 560 570 580 590 600 CGRVTPGMLA EGYEQDTEFG NTAHLGDCHE ILPTSTTPDY KIFGGPTSGV RWEVQSGESN 610 620 630 640 650 660 QMVHMNVLIT CVFAAFVLGA FIAGVAVYCY RDMFVRKNRK IHKDAESAQS CTDSSGSFAK 670 680 690 700 710 720 LNGLFDSPVK EYQQNIDSPK LYSNLLTSRK ELPPNGDTKS MVMDHRGQPP ELAALPTPES 730 740 750 760 770 780 TPVLHQKTLQ AMKSHSEKAH GHGASRKETP QFFPSSPPPH SPLSHGHIPS AIVLPNATHD 790 800 810 820 830 840 YNTSFSNSNA HKAEKKLQNI DHPLTKSSSK RDHRRSVDSR NTLNDLLKHL NDPNSNPKAI 850 860 870 880 890 900 MGDIQMAHQN LMLDPMGSMS EVPPKVPNRE ASLYSPPSTL PRNSPTKRVD VPTTPGVPMT 910 920 930 940 950 960 SLERQRGYHK NSSQRHSISA MPKNLNSPNG VLLSRQPSMN RGGYMPTPTG AKVDYIQGTP 970 980 990 1000 1010 VSVHLQPSLS RQSSYTSNGT LPRTGLKRTP SLKPDVPPKP SFVPQTPSVR PLNKYTY
	Isoform 5 [UniParc]. Checksum: 659CF8EA114B048F	FASTA	1,030	115,296
	10 20 30 40 50 60 MRVFLLCAYI LLLMVSQLRA VSFPEDDEPL NTVDYHYSRQ YPVFRGRPSG NESQHRLDFQ 70 80 90 100 110 120 LMLKIRDTLY IAGRDQVYTV NLNEMPKTEV IPNKKLTWRS RQQDRENCAM KGKHKDECHN 130 140 150 160 170 180 FIKVFVPRND EMVFVCGTNA FNPMCRYYRL STLEYDGEEI SGLARCPFDA RQTNVALFAD 190 200 210 220 230 240 GKLYSATVAD FLASDAVIYR SMGDGSALRT IKYDSKWIKE PHFLHAIEYG NYVYFFFREI 250 260 270 280 290 300 AVEHNNLGKA VYSRVARICK NDMGGSQRVL EKHWTSFLKA RLNCSVPGDS FFYFDVLQSI 310 320 330 340 350 360 TDIIQINGIP TVVGVFTTQL NSIPGSAVCA FSMDDIEKVF KGRFKEQKTP DSVWTAVPED 370 380 390 400 410 420 KVPKPRPGCC AKHGLAEAYK TSIDFPDETL SFIKSHPLMD SAVPPIADEP WFTKTRVRYR 430 440 450 460 470 480 LTAISVDHSA GPYQNYTVIF VGSEAGMVLK VLAKTSPFSL NDSVLLEEIE AYNHAKCSAE 490 500 510 520 530 540 NEEDKKVISL QLDKDHHALY VAFSSCIIRI PLSRCERYGS CKKSCIASRD PYCGWLSQGS 550 560 570 580 590 600 CGRVTPGMLL LTEDFFAFHN HSAEGYEQDT EFGNTAHLGD CHEILPTSTT PDYKIFGGPT 610 620 630 640 650 660 SGVRWEVQSG ESNQMVHMNV LITCVFAAFV LGAFIAGVAV YCYRDMFVRK NRKIHKDAES 670 680 690 700 710 720 AQSCTDSSGS FAKLNGLFDS PVKEYQQNID SPKLYSNLLT SRKELPPNGD TKSMVMDHRG 730 740 750 760 770 780 QPPELAALPT PESTPVLHQK TLQAMKSHSE KAHGHGASRK ETPQFFPSSP PPHSPLSHGH 790 800 810 820 830 840 IPSAIVLPNA THDYNTSFSN SNAHKAEKKL QNIDHPLTKS SSKRDHRRSV DSRNTLNDLL 850 860 870 880 890 900 KHLNDPNSNP KAIMGDIQMA HQNLMLDPMG SMSEVPPKVP NREASLYSPP STLPRNSPTK 910 920 930 940 950 960 RVDVPTTPGV PMTSLERQRG YHKNSSQRHS ISAMPKNLNS PNGVLLSRQP SMNRGGYMPT 970 980 990 1000 1010 1020 PTGAKVDYIQ GTPVSVHLQP SLSRQSSYTS NGTLPRTGLK RTPSLKPDVP PKPSFVPQTP 1030 SVRPLNKYTY
	Isoform 6 [UniParc]. Checksum: A888C403FFACEE8F	FASTA	1,054	117,866
	10 20 30 40 50 60 MRVFLLCAYI LLLMVSQLRA VSFPEDDEPL NTVDYHYSRQ YPVFRGRPSG NESQHRLDFQ 70 80 90 100 110 120 LMLKIRDTLY IAGRDQVYTV NLNEMPKTEV IPNKKLTWRS RQQDRENCAM KGKHKDECHN 130 140 150 160 170 180 FIKVFVPRND EMVFVCGTNA FNPMCRYYRL STLEYDGEEI SGLARCPFDA RQTNVALFAD 190 200 210 220 230 240 GKLYSATVAD FLASDAVIYR SMGDGSALRT IKYDSKWIKE PHFLHAIEYG NYVYFFFREI 250 260 270 280 290 300 AVEHNNLGKA VYSRVARICK NDMGGSQRVL EKHWTSFLKA RLNCSVPGDS FFYFDVLQSI 310 320 330 340 350 360 TDIIQINGIP TVVGVFTTQL NSIPGSAVCA FSMDDIEKVF KGRFKEQKTP DSVWTAVPED 370 380 390 400 410 420 KVPKPRPGCC AKHGLAEAYK TSIDFPDETL SFIKSHPLMD SAVPPIADEP WFTKTRVRYR 430 440 450 460 470 480 LTAISVDHSA GPYQNYTVIF VGSEAGMVLK VLAKTSPFSL NDSVLLEEIE AYNHAKCSAE 490 500 510 520 530 540 NEEDKKVISL QLDKDHHALY VAFSSCIIRI PLSRCERYGS CKKSCIASRD PYCGWLSQGS 550 560 570 580 590 600 CGRVTPGMLA EGYEQDTEFG NTAHLGDCHD MEVSSSSVTT MASIPEITPK VIDTWRPKLT 610 620 630 640 650 660 SSRKFVVQDD PNTSDFTDPL SGIPKGVRWE VQSGESNQMV HMNVLITCVF AAFVLGAFIA 670 680 690 700 710 720 GVAVYCYRDM FVRKNRKIHK DAESAQSCTD SSGSFAKLNG LFDSPVKEYQ QNIDSPKLYS 730 740 750 760 770 780 NLLTSRKELP PNGDTKSMVM DHRGQPPELA ALPTPESTPV LHQKTLQAMK SHSEKAHGHG 790 800 810 820 830 840 ASRKETPQFF PSSPPPHSPL SHGHIPSAIV LPNATHDYNT SFSNSNAHKA EKKLQNIDHP 850 860 870 880 890 900 LTKSSSKRDH RRSVDSRNTL NDLLKHLNDP NSNPKAIMGD IQMAHQNLML DPMGSMSEVP 910 920 930 940 950 960 PKVPNREASL YSPPSTLPRN SPTKRVDVPT TPGVPMTSLE RQRGYHKNSS QRHSISAMPK 970 980 990 1000 1010 1020 NLNSPNGVLL SRQPSMNRGG YMPTPTGAKV DYIQGTPVSV HLQPSLSRQS SYTSNGTLPR 1030 1040 1050 TGLKRTPSLK PDVPPKPSFV PQTPSVRPLN KYTY
	Isoform 7 (SEMA6Ds) (Short) [UniParc]. Checksum: 3AAB6E77051D2D83	FASTA	476	54,217
	10 20 30 40 50 60 MRVFLLCAYI LLLMVSQLRA VSFPEDDEPL NTVDYHYSRQ YPVFRGRPSG NESQHRLDFQ 70 80 90 100 110 120 LMLKIRDTLY IAGRDQVYTV NLNEMPKTEV IPNKKLTWRS RQQDRENCAM KGKHKDECHN 130 140 150 160 170 180 FIKVFVPRND EMVFVCGTNA FNPMCRYYRL STLEYDGEEI SGLARCPFDA RQTNVALFAD 190 200 210 220 230 240 GKLYSATVAD FLASDAVIYR SMGDGSALRT IKYDSKWIKE PHFLHAIEYG NYVYFFFREI 250 260 270 280 290 300 AVEHNNLGKA VYSRVARICK NDMGGSQRVL EKHWTSFLKA RLNCSVPGDS FFYFDVLQSI 310 320 330 340 350 360 TDIIQINGIP TVVGVFTTQL NSIPGSAVCA FSMDDIEKVF KGRFKEQKTP DSVWTAVPED 370 380 390 400 410 420 KVPKPRPGCC AKHGLAEAYK TSIDFPDETL SFIKSHPLMD SAVPPIADEP WFTKTRVRYR 430 440 450 460 470 LTAISVDHSA GPYQNYTVIF VGSEAGMVLK VLAKTSPFSL NDSVLLEEIE AYNHAK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification, characterization, and functional study of the two novel human members of the semaphorin gene family." Qu X., Wei H., Zhai Y., Que H., Chen Q., Tang F., Wu Y., Xing G., Zhu Y., Liu S., Fan M., He F. J. Biol. Chem. 277:35574-35585(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 7), SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Brain.
[2]	"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[4]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF389426 mRNA. Translation: AAM69449.1. AF389427 mRNA. Translation: AAM69450.1. AF389428 mRNA. Translation: AAM69451.1. AF389429 mRNA. Translation: AAM69452.1. AF389430 mRNA. Translation: AAM69453.1. AB040912 mRNA. Translation: BAA96003.2. Different initiation. AC018900 Genomic DNA. No translation available. AC044787 Genomic DNA. No translation available. BC150253 mRNA. Translation: AAI50254.1.
IPI	IPI00170551. IPI00170617. IPI00178302. IPI00332846. IPI00374169. IPI00465042. IPI00657834.
RefSeq	NP_001185928.1. NM_001198999.1. NP_065909.1. NM_020858.1. NP_079242.2. NM_024966.2. NP_705869.1. NM_153616.1. NP_705870.1. NM_153617.1. NP_705871.1. NM_153618.1. NP_705872.1. NM_153619.1.
UniGene	Hs.511265.
3D structure databases
ProteinModelPortal	Q8NFY4.
ModBase	Search...
PTM databases
PhosphoSite	Q8NFY4.
Polymorphism databases
DMDM	74715611.
Proteomic databases
PaxDb	Q8NFY4.
PRIDE	Q8NFY4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000316364; ENSP00000324857; ENSG00000137872. ENST00000354744; ENSP00000346786; ENSG00000137872. ENST00000358066; ENSP00000350770; ENSG00000137872. ENST00000389425; ENSP00000374076; ENSG00000137872. ENST00000389428; ENSP00000374079; ENSG00000137872. ENST00000389432; ENSP00000374083; ENSG00000137872. ENST00000389433; ENSP00000374084; ENSG00000137872. ENST00000536845; ENSP00000446152; ENSG00000137872. ENST00000537942; ENSP00000442040; ENSG00000137872. ENST00000558014; ENSP00000452815; ENSG00000137872.
GeneID	80031.
KEGG	hsa:80031.
UCSC	uc001zvw.3. human. uc001zvx.1. human. uc001zvy.3. human. uc001zvz.3. human. uc001zwc.3. human.
Organism-specific databases
CTD	80031.
GeneCards	GC15P047476.
HGNC	HGNC:16770. SEMA6D.
HPA	HPA043109.
MIM	609295. gene.
neXtProt	NX_Q8NFY4.
PharmGKB	PA134951035.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG293968.
HOVERGEN	HBG072910.
InParanoid	Q8NFY4.
KO	K06842.
OMA	YIAGRDQ.
Enzyme and pathway databases
Reactome	REACT_111045. Developmental Biology.
Gene expression databases
ArrayExpress	Q8NFY4.
Bgee	Q8NFY4.
Genevestigator	Q8NFY4.
GermOnline	ENSG00000137872. Homo sapiens.
Family and domain databases
Gene3D	2.130.10.10. 1 hit.
InterPro	IPR003659. Plexin-like. IPR016201. Plexin-like_fold. IPR002165. Plexin_repeat. IPR027231. Semaphorin. IPR001627. Semaphorin/CD100_Ag. IPR015943. WD40/YVTN_repeat-like_dom. [Graphical view]
PANTHER	PTHR11036. PTHR11036. 1 hit.
Pfam	PF01437. PSI. 1 hit. PF01403. Sema. 1 hit. [Graphical view]
SMART	SM00423. PSI. 1 hit. SM00630. Sema. 1 hit. [Graphical view]
SUPFAM	SSF103575. Plexin-like_fold. 1 hit. SSF101912. Sema. 1 hit.
PROSITE	PS51004. SEMA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	80031.
NextBio	70190.
SOURCE	Search...

Entry information

Entry name

SEM6D_HUMAN

Accession

Primary (citable) accession number: Q8NFY4
Secondary accession number(s): A6NF10 , A6NNK1, A7E2A0, Q8NFY3, Q8NFY5, Q8NFY6, Q8NFY7, Q9P249

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.