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Q8NFY4

- SEM6D_HUMAN

UniProt

Q8NFY4 - SEM6D_HUMAN

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Protein

Semaphorin-6D

Gene
SEMA6D, KIAA1479
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections.

GO - Molecular functioni

  1. receptor activity Source: InterPro

GO - Biological processi

  1. axon guidance Source: Reactome
  2. negative regulation of smooth muscle cell migration Source: Ensembl
  3. positive regulation of smooth muscle cell migration Source: Ensembl
  4. ventricular system development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiREACT_19200. Other semaphorin interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-6D
Gene namesi
Name:SEMA6D
Synonyms:KIAA1479
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:16770. SEMA6D.

Subcellular locationi

Isoform 1 : Cell membrane; Single-pass type I membrane protein 1 Publication
Isoform 2 : Cell membrane; Single-pass type I membrane protein 1 Publication
Isoform 3 : Cell membrane; Single-pass type I membrane protein 1 Publication
Isoform 4 : Cell membrane; Single-pass type I membrane protein 1 Publication
Isoform 5 : Cell membrane; Single-pass type I membrane protein 1 Publication
Isoform 7 : Cytoplasm 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 662642Extracellular Reviewed predictionAdd
BLAST
Transmembranei663 – 68321Helical; Reviewed predictionAdd
BLAST
Topological domaini684 – 1073390Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134951035.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 10731053Semaphorin-6DPRO_0000044615Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi51 – 511N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi108 ↔ 118 By similarity
Disulfide bondi136 ↔ 145 By similarity
Disulfide bondi259 ↔ 370 By similarity
Glycosylationi283 – 2831N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi284 ↔ 329 By similarity
Glycosylationi435 – 4351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi461 – 4611N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi477 ↔ 506 By similarity
Disulfide bondi515 ↔ 533 By similarity
Disulfide bondi521 ↔ 568 By similarity
Disulfide bondi525 ↔ 541 By similarity
Glycosylationi631 – 6311N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8NFY4.
PaxDbiQ8NFY4.
PRIDEiQ8NFY4.

PTM databases

PhosphoSiteiQ8NFY4.

Expressioni

Gene expression databases

ArrayExpressiQ8NFY4.
BgeeiQ8NFY4.
GenevestigatoriQ8NFY4.

Organism-specific databases

HPAiHPA043109.

Structurei

3D structure databases

ProteinModelPortaliQ8NFY4.
SMRiQ8NFY4. Positions 23-533.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 512486SemaAdd
BLAST
Domaini514 – 56956PSIAdd
BLAST

Sequence similaritiesi

Belongs to the semaphorin family.
Contains 1 PSI domain.
Contains 1 Sema domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG293968.
HOGENOMiHOG000232047.
HOVERGENiHBG072910.
InParanoidiQ8NFY4.
KOiK06842.
OMAiCVFAAFV.
OrthoDBiEOG7SV0TJ.
PhylomeDBiQ8NFY4.
TreeFamiTF316102.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative splicing. Align

Isoform 4 (identifier: Q8NFY4-1) [UniParc]FASTAAdd to Basket

Also known as: SEMA6D.4

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRVFLLCAYI LLLMVSQLRA VSFPEDDEPL NTVDYHYSRQ YPVFRGRPSG     50
NESQHRLDFQ LMLKIRDTLY IAGRDQVYTV NLNEMPKTEV IPNKKLTWRS 100
RQQDRENCAM KGKHKDECHN FIKVFVPRND EMVFVCGTNA FNPMCRYYRL 150
STLEYDGEEI SGLARCPFDA RQTNVALFAD GKLYSATVAD FLASDAVIYR 200
SMGDGSALRT IKYDSKWIKE PHFLHAIEYG NYVYFFFREI AVEHNNLGKA 250
VYSRVARICK NDMGGSQRVL EKHWTSFLKA RLNCSVPGDS FFYFDVLQSI 300
TDIIQINGIP TVVGVFTTQL NSIPGSAVCA FSMDDIEKVF KGRFKEQKTP 350
DSVWTAVPED KVPKPRPGCC AKHGLAEAYK TSIDFPDETL SFIKSHPLMD 400
SAVPPIADEP WFTKTRVRYR LTAISVDHSA GPYQNYTVIF VGSEAGMVLK 450
VLAKTSPFSL NDSVLLEEIE AYNHAKCSAE NEEDKKVISL QLDKDHHALY 500
VAFSSCIIRI PLSRCERYGS CKKSCIASRD PYCGWLSQGS CGRVTPGMLA 550
EGYEQDTEFG NTAHLGDCHE ILPTSTTPDY KIFGGPTSDM EVSSSSVTTM 600
ASIPEITPKV IDTWRPKLTS SRKFVVQDDP NTSDFTDPLS GIPKGVRWEV 650
QSGESNQMVH MNVLITCVFA AFVLGAFIAG VAVYCYRDMF VRKNRKIHKD 700
AESAQSCTDS SGSFAKLNGL FDSPVKEYQQ NIDSPKLYSN LLTSRKELPP 750
NGDTKSMVMD HRGQPPELAA LPTPESTPVL HQKTLQAMKS HSEKAHGHGA 800
SRKETPQFFP SSPPPHSPLS HGHIPSAIVL PNATHDYNTS FSNSNAHKAE 850
KKLQNIDHPL TKSSSKRDHR RSVDSRNTLN DLLKHLNDPN SNPKAIMGDI 900
QMAHQNLMLD PMGSMSEVPP KVPNREASLY SPPSTLPRNS PTKRVDVPTT 950
PGVPMTSLER QRGYHKNSSQ RHSISAMPKN LNSPNGVLLS RQPSMNRGGY 1000
MPTPTGAKVD YIQGTPVSVH LQPSLSRQSS YTSNGTLPRT GLKRTPSLKP 1050
DVPPKPSFVP QTPSVRPLNK YTY 1073
Length:1,073
Mass (Da):119,872
Last modified:October 1, 2002 - v1
Checksum:i7DCE4DFC5BF70F9E
GO
Isoform 1 (identifier: Q8NFY4-2) [UniParc]FASTAAdd to Basket

Also known as: SEMA6D.1

The sequence of this isoform differs from the canonical sequence as follows:
     549-549: L → LLLTEDFFAFHNHS
     570-644: Missing.

Show »
Length:1,011
Mass (Da):113,290
Checksum:i9D6B8B3633941B89
GO
Isoform 2 (identifier: Q8NFY4-3) [UniParc]FASTAAdd to Basket

Also known as: SEMA6D.2

The sequence of this isoform differs from the canonical sequence as follows:
     570-644: Missing.

Show »
Length:998
Mass (Da):111,730
Checksum:i3F46D6872E8D5344
GO
Isoform 3 (identifier: Q8NFY4-4) [UniParc]FASTAAdd to Basket

Also known as: SEMA6D.3

The sequence of this isoform differs from the canonical sequence as follows:
     589-644: Missing.

Show »
Length:1,017
Mass (Da):113,736
Checksum:i4D639CEBADD9F2A0
GO
Isoform 5 (identifier: Q8NFY4-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     549-549: L → LLLTEDFFAFHNHS
     589-644: Missing.

Note: No experimental confirmation available.

Show »
Length:1,030
Mass (Da):115,296
Checksum:i659CF8EA114B048F
GO
Isoform 6 (identifier: Q8NFY4-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     570-588: Missing.

Note: No experimental confirmation available.

Show »
Length:1,054
Mass (Da):117,866
Checksum:iA888C403FFACEE8F
GO
Isoform 7 (identifier: Q8NFY4-7) [UniParc]FASTAAdd to Basket

Also known as: SEMA6Ds, Short

The sequence of this isoform differs from the canonical sequence as follows:
     477-1073: Missing.

Show »
Length:476
Mass (Da):54,217
Checksum:i3AAB6E77051D2D83
GO
Isoform 8 (identifier: Q8NFY4-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     570-588: Missing.
     601-1073: ASIPEITPKV...SVRPLNKYTY → VYDGKSSLESPTRWST

Note: No experimental confirmation available. Gene prediction based on mRNA data.

Show »
Length:597
Mass (Da):67,538
Checksum:i58D3EE7B6B68DB67
GO

Sequence cautioni

The sequence BAA96003.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti307 – 3071N → S.
Corresponds to variant rs3743279 [ dbSNP | Ensembl ].
VAR_051931
Natural varianti478 – 4781S → N.
Corresponds to variant rs532598 [ dbSNP | Ensembl ].
VAR_051932
Natural varianti969 – 9691S → T.
Corresponds to variant rs16960074 [ dbSNP | Ensembl ].
VAR_051933

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei477 – 1073597Missing in isoform 7. VSP_016564Add
BLAST
Alternative sequencei549 – 5491L → LLLTEDFFAFHNHS in isoform 1 and isoform 5. VSP_016565
Alternative sequencei570 – 64475Missing in isoform 1 and isoform 2. VSP_016566Add
BLAST
Alternative sequencei570 – 58819Missing in isoform 6 and isoform 8. VSP_016572Add
BLAST
Alternative sequencei589 – 64456Missing in isoform 3 and isoform 5. VSP_016567Add
BLAST
Alternative sequencei601 – 1073473ASIPE…NKYTY → VYDGKSSLESPTRWST in isoform 8. VSP_054084Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF389426 mRNA. Translation: AAM69449.1.
AF389427 mRNA. Translation: AAM69450.1.
AF389428 mRNA. Translation: AAM69451.1.
AF389429 mRNA. Translation: AAM69452.1.
AF389430 mRNA. Translation: AAM69453.1.
AB040912 mRNA. Translation: BAA96003.2. Different initiation.
AC018900 Genomic DNA. No translation available.
AC044787 Genomic DNA. No translation available.
AC009558 Genomic DNA. No translation available.
AC012050 Genomic DNA. No translation available.
AC023905 Genomic DNA. No translation available.
AC066615 Genomic DNA. No translation available.
AC084882 Genomic DNA. No translation available.
BC150253 mRNA. Translation: AAI50254.1.
CCDSiCCDS32224.1. [Q8NFY4-2]
CCDS32225.1. [Q8NFY4-1]
CCDS32226.1. [Q8NFY4-4]
CCDS32227.1. [Q8NFY4-3]
CCDS32228.1. [Q8NFY4-8]
CCDS32229.1. [Q8NFY4-7]
RefSeqiNP_001185928.1. NM_001198999.1. [Q8NFY4-2]
NP_065909.1. NM_020858.1. [Q8NFY4-2]
NP_079242.2. NM_024966.2. [Q8NFY4-7]
NP_705869.1. NM_153616.1. [Q8NFY4-3]
NP_705870.1. NM_153617.1. [Q8NFY4-4]
NP_705871.1. NM_153618.1. [Q8NFY4-1]
NP_705872.1. NM_153619.1. [Q8NFY4-8]
XP_005254744.1. XM_005254687.1. [Q8NFY4-1]
XP_005254746.1. XM_005254689.1. [Q8NFY4-6]
XP_005254747.1. XM_005254690.1. [Q8NFY4-5]
UniGeneiHs.511265.

Genome annotation databases

EnsembliENST00000316364; ENSP00000324857; ENSG00000137872. [Q8NFY4-1]
ENST00000354744; ENSP00000346786; ENSG00000137872. [Q8NFY4-4]
ENST00000355997; ENSP00000348276; ENSG00000137872.
ENST00000358066; ENSP00000350770; ENSG00000137872. [Q8NFY4-2]
ENST00000389425; ENSP00000374076; ENSG00000137872. [Q8NFY4-7]
ENST00000389428; ENSP00000374079; ENSG00000137872. [Q8NFY4-3]
ENST00000389432; ENSP00000374083; ENSG00000137872. [Q8NFY4-5]
ENST00000389433; ENSP00000374084; ENSG00000137872. [Q8NFY4-6]
ENST00000536845; ENSP00000446152; ENSG00000137872. [Q8NFY4-1]
ENST00000537942; ENSP00000442040; ENSG00000137872. [Q8NFY4-2]
ENST00000558014; ENSP00000452815; ENSG00000137872. [Q8NFY4-2]
ENST00000558816; ENSP00000453661; ENSG00000137872.
GeneIDi80031.
KEGGihsa:80031.
UCSCiuc001zvw.3. human. [Q8NFY4-2]
uc001zvx.1. human. [Q8NFY4-7]
uc001zvy.3. human. [Q8NFY4-1]
uc001zvz.3. human. [Q8NFY4-4]
uc001zwc.3. human. [Q8NFY4-3]

Polymorphism databases

DMDMi74715611.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF389426 mRNA. Translation: AAM69449.1 .
AF389427 mRNA. Translation: AAM69450.1 .
AF389428 mRNA. Translation: AAM69451.1 .
AF389429 mRNA. Translation: AAM69452.1 .
AF389430 mRNA. Translation: AAM69453.1 .
AB040912 mRNA. Translation: BAA96003.2 . Different initiation.
AC018900 Genomic DNA. No translation available.
AC044787 Genomic DNA. No translation available.
AC009558 Genomic DNA. No translation available.
AC012050 Genomic DNA. No translation available.
AC023905 Genomic DNA. No translation available.
AC066615 Genomic DNA. No translation available.
AC084882 Genomic DNA. No translation available.
BC150253 mRNA. Translation: AAI50254.1 .
CCDSi CCDS32224.1. [Q8NFY4-2 ]
CCDS32225.1. [Q8NFY4-1 ]
CCDS32226.1. [Q8NFY4-4 ]
CCDS32227.1. [Q8NFY4-3 ]
CCDS32228.1. [Q8NFY4-8 ]
CCDS32229.1. [Q8NFY4-7 ]
RefSeqi NP_001185928.1. NM_001198999.1. [Q8NFY4-2 ]
NP_065909.1. NM_020858.1. [Q8NFY4-2 ]
NP_079242.2. NM_024966.2. [Q8NFY4-7 ]
NP_705869.1. NM_153616.1. [Q8NFY4-3 ]
NP_705870.1. NM_153617.1. [Q8NFY4-4 ]
NP_705871.1. NM_153618.1. [Q8NFY4-1 ]
NP_705872.1. NM_153619.1. [Q8NFY4-8 ]
XP_005254744.1. XM_005254687.1. [Q8NFY4-1 ]
XP_005254746.1. XM_005254689.1. [Q8NFY4-6 ]
XP_005254747.1. XM_005254690.1. [Q8NFY4-5 ]
UniGenei Hs.511265.

3D structure databases

ProteinModelPortali Q8NFY4.
SMRi Q8NFY4. Positions 23-533.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8NFY4.

Polymorphism databases

DMDMi 74715611.

Proteomic databases

MaxQBi Q8NFY4.
PaxDbi Q8NFY4.
PRIDEi Q8NFY4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000316364 ; ENSP00000324857 ; ENSG00000137872 . [Q8NFY4-1 ]
ENST00000354744 ; ENSP00000346786 ; ENSG00000137872 . [Q8NFY4-4 ]
ENST00000355997 ; ENSP00000348276 ; ENSG00000137872 .
ENST00000358066 ; ENSP00000350770 ; ENSG00000137872 . [Q8NFY4-2 ]
ENST00000389425 ; ENSP00000374076 ; ENSG00000137872 . [Q8NFY4-7 ]
ENST00000389428 ; ENSP00000374079 ; ENSG00000137872 . [Q8NFY4-3 ]
ENST00000389432 ; ENSP00000374083 ; ENSG00000137872 . [Q8NFY4-5 ]
ENST00000389433 ; ENSP00000374084 ; ENSG00000137872 . [Q8NFY4-6 ]
ENST00000536845 ; ENSP00000446152 ; ENSG00000137872 . [Q8NFY4-1 ]
ENST00000537942 ; ENSP00000442040 ; ENSG00000137872 . [Q8NFY4-2 ]
ENST00000558014 ; ENSP00000452815 ; ENSG00000137872 . [Q8NFY4-2 ]
ENST00000558816 ; ENSP00000453661 ; ENSG00000137872 .
GeneIDi 80031.
KEGGi hsa:80031.
UCSCi uc001zvw.3. human. [Q8NFY4-2 ]
uc001zvx.1. human. [Q8NFY4-7 ]
uc001zvy.3. human. [Q8NFY4-1 ]
uc001zvz.3. human. [Q8NFY4-4 ]
uc001zwc.3. human. [Q8NFY4-3 ]

Organism-specific databases

CTDi 80031.
GeneCardsi GC15P047476.
HGNCi HGNC:16770. SEMA6D.
HPAi HPA043109.
MIMi 609295. gene.
neXtProti NX_Q8NFY4.
PharmGKBi PA134951035.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG293968.
HOGENOMi HOG000232047.
HOVERGENi HBG072910.
InParanoidi Q8NFY4.
KOi K06842.
OMAi CVFAAFV.
OrthoDBi EOG7SV0TJ.
PhylomeDBi Q8NFY4.
TreeFami TF316102.

Enzyme and pathway databases

Reactomei REACT_19200. Other semaphorin interactions.

Miscellaneous databases

GenomeRNAii 80031.
NextBioi 70190.
PROi Q8NFY4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8NFY4.
Bgeei Q8NFY4.
Genevestigatori Q8NFY4.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR016201. Plexin-like_fold.
IPR002165. Plexin_repeat.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
PANTHERi PTHR11036. PTHR11036. 1 hit.
Pfami PF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view ]
SMARTi SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view ]
SUPFAMi SSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEi PS51004. SEMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification, characterization, and functional study of the two novel human members of the semaphorin gene family."
    Qu X., Wei H., Zhai Y., Que H., Chen Q., Tang F., Wu Y., Xing G., Zhu Y., Liu S., Fan M., He F.
    J. Biol. Chem. 277:35574-35585(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 7), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Entry informationi

Entry nameiSEM6D_HUMAN
AccessioniPrimary (citable) accession number: Q8NFY4
Secondary accession number(s): A6NF10
, A6NM95, A6NNK1, A7E2A0, Q8NFY3, Q8NFY5, Q8NFY6, Q8NFY7, Q9P249
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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