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Protein

Syntaxin-binding protein 6

Gene

STXBP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis.

GO - Molecular functioni

GO - Biological processi

  • exocyst localization Source: GO_Central
  • Golgi to plasma membrane transport Source: GO_Central
  • negative regulation of exocytosis Source: ParkinsonsUK-UCL
  • regulation of SNARE complex assembly Source: ParkinsonsUK-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-binding protein 6
Alternative name(s):
Amisyn
Gene namesi
Name:STXBP6
ORF Names:HSPC156
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19666. STXBP6.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • exocyst Source: GO_Central
  • integral component of membrane Source: InterPro
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134985567.

Polymorphism and mutation databases

BioMutaiSTXBP6.
DMDMi34222907.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 210209Syntaxin-binding protein 6PRO_0000206782Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8NFX7.
MaxQBiQ8NFX7.
PaxDbiQ8NFX7.
PeptideAtlasiQ8NFX7.
PRIDEiQ8NFX7.

PTM databases

iPTMnetiQ8NFX7.
PhosphoSiteiQ8NFX7.

Expressioni

Tissue specificityi

Detected at low levels in brain, and at very low levels in heart, adrenal gland, testis, liver and kidney.1 Publication

Gene expression databases

BgeeiENSG00000168952.
CleanExiHS_STXBP6.
ExpressionAtlasiQ8NFX7. baseline and differential.
GenevisibleiQ8NFX7. HS.

Organism-specific databases

HPAiHPA003552.

Interactioni

Subunit structurei

Part of a ternary complex containing SNAP25 and STX1A that can be dissociated by NAPA and NSF. Interacts with STX4A.1 Publication

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • GTP-Rho binding Source: GO_Central

Protein-protein interaction databases

BioGridi118860. 13 interactions.
STRINGi9606.ENSP00000324302.

Structurei

3D structure databases

ProteinModelPortaliQ8NFX7.
SMRiQ8NFX7. Positions 156-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini151 – 21060v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 v-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410KCU0. Eukaryota.
ENOG410ZU11. LUCA.
GeneTreeiENSGT00530000063494.
HOGENOMiHOG000132986.
HOVERGENiHBG059039.
InParanoidiQ8NFX7.
KOiK08519.
OMAiIFAPHDE.
OrthoDBiEOG091G0J6M.
PhylomeDBiQ8NFX7.

Family and domain databases

InterProiIPR028258. Sec3-PIP2_bind.
IPR001388. Synaptobrevin.
[Graphical view]
PfamiPF15277. Sec3-PIP2_bind. 1 hit.
PF00957. Synaptobrevin. 1 hit.
[Graphical view]
SMARTiSM01313. Sec3-PIP2_bind. 1 hit.
[Graphical view]
PROSITEiPS50892. V_SNARE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NFX7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAKSAISKE IFAPLDERML GAVQVKRRTK KKIPFLATGG QGEYLTYICL
60 70 80 90 100
SVTNKKPTQA SITKVKQFEG STSFVRRSQW MLEQLRQVNG IDPNGDSAEF
110 120 130 140 150
DLLFENAFDQ WVASTASEKC TFFQILHHTC QRYLTDRKPE FINCQSKIMG
160 170 180 190 200
GNSILHSAAD SVTSAVQKAS QALNERGERL GRAEEKTEDL KNSAQQFAET
210
AHKLAMKHKC
Length:210
Mass (Da):23,554
Last modified:August 22, 2003 - v2
Checksum:i7C046A90D4C4B2D8
GO
Isoform 2 (identifier: Q8NFX7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     204-210: LAMKHKC → VTFRGRK

Note: May be due to an intron retention.
Show »
Length:210
Mass (Da):23,587
Checksum:i71935317EB88D738
GO
Isoform 3 (identifier: Q8NFX7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-102: Missing.
     103-150: LFENAFDQWV...FINCQSKIMG → MSACFLDTRR...VSDAPALLLS

Note: May be due to an intron retention.
Show »
Length:108
Mass (Da):11,587
Checksum:i158A8019FE7D25C2
GO

Sequence cautioni

The sequence AAM46624 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti117 – 1171S → P in BAC04911 (PubMed:14702039).Curated
Sequence conflicti125 – 1251I → T in BAC04911 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 102102Missing in isoform 3. 1 PublicationVSP_008071Add
BLAST
Alternative sequencei103 – 15048LFENA…SKIMG → MSACFLDTRRAAFLQCDLPS SYRILTLPESGHCGSAEPVS DAPALLLS in isoform 3. 1 PublicationVSP_008072Add
BLAST
Alternative sequencei204 – 2107LAMKHKC → VTFRGRK in isoform 2. 1 PublicationVSP_008073

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF391153 mRNA. Translation: AAM46624.1. Different initiation.
AF161505 mRNA. Translation: AAF29120.1.
AK096957 mRNA. Translation: BAC04911.1.
AL834346 mRNA. Translation: CAD39012.2.
AL137164 Genomic DNA. No translation available.
AL161663 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65996.1.
CH471078 Genomic DNA. Translation: EAW65999.1.
CH471078 Genomic DNA. Translation: EAW66000.1.
CH471078 Genomic DNA. Translation: EAW66001.1.
BC009499 mRNA. Translation: AAH09499.1.
BC067278 mRNA. Translation: AAH67278.1.
CCDSiCCDS9634.1. [Q8NFX7-1]
RefSeqiNP_001291405.1. NM_001304476.1. [Q8NFX7-1]
NP_001291406.1. NM_001304477.1. [Q8NFX7-1]
NP_054897.4. NM_014178.7. [Q8NFX7-1]
UniGeneiHs.508958.

Genome annotation databases

EnsembliENST00000323944; ENSP00000324302; ENSG00000168952. [Q8NFX7-1]
ENST00000396700; ENSP00000379928; ENSG00000168952. [Q8NFX7-1]
ENST00000419632; ENSP00000397212; ENSG00000168952. [Q8NFX7-1]
ENST00000546511; ENSP00000449536; ENSG00000168952. [Q8NFX7-1]
ENST00000548369; ENSP00000447655; ENSG00000168952. [Q8NFX7-3]
ENST00000550887; ENSP00000449379; ENSG00000168952. [Q8NFX7-1]
GeneIDi29091.
KEGGihsa:29091.
UCSCiuc001wpt.5. human. [Q8NFX7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF391153 mRNA. Translation: AAM46624.1. Different initiation.
AF161505 mRNA. Translation: AAF29120.1.
AK096957 mRNA. Translation: BAC04911.1.
AL834346 mRNA. Translation: CAD39012.2.
AL137164 Genomic DNA. No translation available.
AL161663 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65996.1.
CH471078 Genomic DNA. Translation: EAW65999.1.
CH471078 Genomic DNA. Translation: EAW66000.1.
CH471078 Genomic DNA. Translation: EAW66001.1.
BC009499 mRNA. Translation: AAH09499.1.
BC067278 mRNA. Translation: AAH67278.1.
CCDSiCCDS9634.1. [Q8NFX7-1]
RefSeqiNP_001291405.1. NM_001304476.1. [Q8NFX7-1]
NP_001291406.1. NM_001304477.1. [Q8NFX7-1]
NP_054897.4. NM_014178.7. [Q8NFX7-1]
UniGeneiHs.508958.

3D structure databases

ProteinModelPortaliQ8NFX7.
SMRiQ8NFX7. Positions 156-208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118860. 13 interactions.
STRINGi9606.ENSP00000324302.

PTM databases

iPTMnetiQ8NFX7.
PhosphoSiteiQ8NFX7.

Polymorphism and mutation databases

BioMutaiSTXBP6.
DMDMi34222907.

Proteomic databases

EPDiQ8NFX7.
MaxQBiQ8NFX7.
PaxDbiQ8NFX7.
PeptideAtlasiQ8NFX7.
PRIDEiQ8NFX7.

Protocols and materials databases

DNASUi29091.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323944; ENSP00000324302; ENSG00000168952. [Q8NFX7-1]
ENST00000396700; ENSP00000379928; ENSG00000168952. [Q8NFX7-1]
ENST00000419632; ENSP00000397212; ENSG00000168952. [Q8NFX7-1]
ENST00000546511; ENSP00000449536; ENSG00000168952. [Q8NFX7-1]
ENST00000548369; ENSP00000447655; ENSG00000168952. [Q8NFX7-3]
ENST00000550887; ENSP00000449379; ENSG00000168952. [Q8NFX7-1]
GeneIDi29091.
KEGGihsa:29091.
UCSCiuc001wpt.5. human. [Q8NFX7-1]

Organism-specific databases

CTDi29091.
GeneCardsiSTXBP6.
HGNCiHGNC:19666. STXBP6.
HPAiHPA003552.
MIMi607958. gene.
neXtProtiNX_Q8NFX7.
PharmGKBiPA134985567.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KCU0. Eukaryota.
ENOG410ZU11. LUCA.
GeneTreeiENSGT00530000063494.
HOGENOMiHOG000132986.
HOVERGENiHBG059039.
InParanoidiQ8NFX7.
KOiK08519.
OMAiIFAPHDE.
OrthoDBiEOG091G0J6M.
PhylomeDBiQ8NFX7.

Miscellaneous databases

GenomeRNAii29091.
PROiQ8NFX7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168952.
CleanExiHS_STXBP6.
ExpressionAtlasiQ8NFX7. baseline and differential.
GenevisibleiQ8NFX7. HS.

Family and domain databases

InterProiIPR028258. Sec3-PIP2_bind.
IPR001388. Synaptobrevin.
[Graphical view]
PfamiPF15277. Sec3-PIP2_bind. 1 hit.
PF00957. Synaptobrevin. 1 hit.
[Graphical view]
SMARTiSM01313. Sec3-PIP2_bind. 1 hit.
[Graphical view]
PROSITEiPS50892. V_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTXB6_HUMAN
AccessioniPrimary (citable) accession number: Q8NFX7
Secondary accession number(s): D3DS78
, Q8N3H1, Q8N8D5, Q96GF3, Q9P008
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: August 22, 2003
Last modified: September 7, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.