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Protein

Rab effector MyRIP

Gene

MYRIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri63 – 10543FYVE-typeAdd
BLAST

GO - Molecular functioni

  • zinc ion binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Rab effector MyRIP
Alternative name(s):
Exophilin-8
Myosin-VIIa- and Rab-interacting protein
Synaptotagmin-like protein lacking C2 domains C
Short name:
SlaC2-c
Short name:
Slp homolog lacking C2 domains c
Gene namesi
Name:MYRIP
Synonyms:SLAC2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:19156. MYRIP.

Subcellular locationi

  • Cytoplasm By similarity
  • Cytoplasmperinuclear region By similarity
  • Cytoplasmic vesiclesecretory vesicle By similarity

  • Note: In presynaptic and postsynaptic areas in photoreceptor cells and in the basal microvilli of retinal pigment epithelium cells. Associated with melanosomes. Colocalizes with actin filaments.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38800.

Polymorphism and mutation databases

BioMutaiMYRIP.
DMDMi116242669.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 859859Rab effector MyRIPPRO_0000190224Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei298 – 2981PhosphoserineBy similarity
Modified residuei350 – 3501PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8NFW9.
PeptideAtlasiQ8NFW9.
PRIDEiQ8NFW9.

PTM databases

iPTMnetiQ8NFW9.
PhosphoSiteiQ8NFW9.

Expressioni

Tissue specificityi

Detected in brain, skin, heart, adrenal medulla, pancreas, intestine, liver, kidney, muscle and testis.

Gene expression databases

BgeeiENSG00000170011.
CleanExiHS_MYRIP.
ExpressionAtlasiQ8NFW9. baseline and differential.
GenevisibleiQ8NFW9. HS.

Organism-specific databases

HPAiHPA006433.

Interactioni

Subunit structurei

Binds MYO5A, MYO7A and F-actin (By similarity). Binds RAB27A that has been activated by GTP-binding via its N-terminus. Interacts with PRKAR2A. Interacts with components of the exocyst complex, including EXOC3 and EXOC4 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
C1orf216Q8TAB53EBI-1759414,EBI-747505

Protein-protein interaction databases

BioGridi117424. 3 interactions.
DIPiDIP-48949N.
IntActiQ8NFW9. 5 interactions.
MINTiMINT-7242301.
STRINGi9606.ENSP00000301972.

Structurei

3D structure databases

ProteinModelPortaliQ8NFW9.
SMRiQ8NFW9. Positions 4-141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 124121RabBDPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni143 – 560418Myosin-bindingAdd
BLAST
Regioni193 – 20917PKA-bindingBy similarityAdd
BLAST
Regioni232 – 24817Negative regulation of PKA-bindingBy similarityAdd
BLAST
Regioni495 – 856362Actin-bindingAdd
BLAST

Sequence similaritiesi

Contains 1 FYVE-type zinc finger.Curated
Contains 1 RabBD (Rab-binding) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri63 – 10543FYVE-typeAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IHBX. Eukaryota.
ENOG41126RD. LUCA.
GeneTreeiENSGT00390000013933.
HOGENOMiHOG000113712.
HOVERGENiHBG052562.
InParanoidiQ8NFW9.
OMAiARCIHSG.
OrthoDBiEOG091G01RQ.
PhylomeDBiQ8NFW9.
TreeFamiTF331599.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR006788. Myrip/Melanophilin.
IPR010911. Rab_BD.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02318. FYVE_2. 1 hit.
PF04698. Rab_eff_C. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS50916. RABBD. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NFW9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRKLDLSGL TDDETEHVLQ VVQRDFNLRK KEEERLSELK QKLDEEGSKC
60 70 80 90 100
SILSKHQQFV EHCCMRCCSP FTFLVNTKRQ CGDCKFNVCK SCCSYQKHEK
110 120 130 140 150
AWVCCVCQQA RLLRAQSLEW FYNNVKSRFK RFGSAKVLKN LYRKHRLESG
160 170 180 190 200
ACFDILGGSL FESNLENEGS ISGSDSTFYR QSEGHSVMDT LAVALRVAEE
210 220 230 240 250
AIEEAISKAE AYGDSLDKQN EASYLRDHKE ELTEELATTI LQKIIRKQKS
260 270 280 290 300
KSEQQVEEEP GWPHPQSCST KVADEGTSAS PGGYRAPAAL WRSQSAFSIT
310 320 330 340 350
GEEALKTPPV EAPSRQPRDQ GQHPRAESAL PSWKSVDRLD ETNLAPVLQS
360 370 380 390 400
PDGNWVALKD GAPPPTRLLA KPKSGTFQAL EVASSVASAY DEMGSDSEED
410 420 430 440 450
FDWSEALSKL CPRSRALPRN PQPQPTQAQS SDQGPIAASP SSALSPNPEA
460 470 480 490 500
MCSDSETSSA GSSREVGHQA RLSWLQRKAP RNPAAEKMRL HGELDVNFNP
510 520 530 540 550
QLASRETSDS SEPEEAPHTT DRRARRWRRA RLGSEEPSKE PSSPSAQLRD
560 570 580 590 600
LDTHQVSDDL SETDISNEAR DPQTLTDTTE EKRRNRLYEL AMKMSEKETS
610 620 630 640 650
SGEDQESEPK TESENQKESL SSEDNSQSVQ EELKKKFSAV SLCNISTEVL
660 670 680 690 700
KVINATEELI AGSTGPWESP QVPPDRQKGM FPRGTDQVRL DEQLTSLEEN
710 720 730 740 750
VYLAAGTVYG LETQLTELED AARCIHSGTD ETHLADLEDQ VATAAAQVHH
760 770 780 790 800
AELQISDIES RISALTIAGL NIAPCVRFTR RRDQKQRTQV QTIDTSRQQR
810 820 830 840 850
RKLPAPPVKA EKIETSSVTT IKTFNHNFIL QGSSTNRTKE RKGTTKDLME

PALESAVMY
Length:859
Mass (Da):95,706
Last modified:October 17, 2006 - v2
Checksum:iC1087932C405DFDD
GO
Isoform 2 (identifier: Q8NFW9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     636-700: Missing.

Note: No experimental confirmation available.
Show »
Length:794
Mass (Da):88,565
Checksum:i2E76826EB1611C0A
GO
Isoform 3 (identifier: Q8NFW9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: MGRKLDLSGL...VCCVCQQARL → MQKSLRPIGL

Note: No experimental confirmation available.
Show »
Length:757
Mass (Da):83,766
Checksum:iFC56B17B4CEEB3B6
GO
Isoform 4 (identifier: Q8NFW9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-187: Missing.

Note: No experimental confirmation available.
Show »
Length:672
Mass (Da):74,108
Checksum:iB3B0FFAD3EAB9FE6
GO
Isoform 5 (identifier: Q8NFW9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     637-637: F → S
     638-859: Missing.

Note: No experimental confirmation available.
Show »
Length:637
Mass (Da):71,137
Checksum:i99D42DE8889A2D8D
GO
Isoform 6 (identifier: Q8NFW9-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: MGRKLDLSGL...QFVEHCCMRC → MRKAASAASS...PGSAASASKR
     68-156: Missing.

Note: No experimental confirmation available.
Show »
Length:770
Mass (Da):83,948
Checksum:i3ADC2EC7D733AD03
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti130 – 1301K → E in BAG54185 (PubMed:14702039).Curated
Sequence conflicti529 – 5291R → G in BAG54276 (PubMed:14702039).Curated
Sequence conflicti536 – 5361E → G in BAG54276 (PubMed:14702039).Curated
Sequence conflicti571 – 5711D → E in AAM43954 (PubMed:11964381).Curated
Sequence conflicti773 – 7731A → T in BAH14439 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti312 – 3121A → T.1 Publication
Corresponds to variant rs59923220 [ dbSNP | Ensembl ].
VAR_061755
Natural varianti365 – 3651P → L.
Corresponds to variant rs55785561 [ dbSNP | Ensembl ].
VAR_061756
Natural varianti673 – 6731P → S.
Corresponds to variant rs34800524 [ dbSNP | Ensembl ].
VAR_051717

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 187187Missing in isoform 4. 1 PublicationVSP_043539Add
BLAST
Alternative sequencei1 – 112112MGRKL…QQARL → MQKSLRPIGL in isoform 3. 1 PublicationVSP_043540Add
BLAST
Alternative sequencei1 – 6767MGRKL…CCMRC → MRKAASAASSRSTSSLWSTA ACAAARPSPSSSTPSASVEI ANSMSARAAAPTRSTKRPGS AASASKR in isoform 6. 1 PublicationVSP_054896Add
BLAST
Alternative sequencei68 – 15689Missing in isoform 6. 1 PublicationVSP_054897Add
BLAST
Alternative sequencei636 – 70065Missing in isoform 2. 1 PublicationVSP_043541Add
BLAST
Alternative sequencei637 – 6371F → S in isoform 5. 1 PublicationVSP_043542
Alternative sequencei638 – 859222Missing in isoform 5. 1 PublicationVSP_043543Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF396687 mRNA. Translation: AAM43954.1.
AB083783 mRNA. Translation: BAC15555.1.
AK125334 mRNA. Translation: BAG54185.1.
AK126013 mRNA. Translation: BAG54276.1.
AK294714 mRNA. Translation: BAH11857.1.
AK316068 mRNA. Translation: BAH14439.1.
AC099331 Genomic DNA. No translation available.
AC099557 Genomic DNA. No translation available.
AC104188 Genomic DNA. No translation available.
AC110718 Genomic DNA. No translation available.
AC130439 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64595.1.
BC092512 mRNA. Translation: AAH92512.1.
BC109311 mRNA. Translation: AAI09312.1.
BC109312 mRNA. Translation: AAI09313.1.
AL050090 mRNA. Translation: CAB43262.1.
CCDSiCCDS2689.1. [Q8NFW9-1]
CCDS68390.1. [Q8NFW9-2]
CCDS68391.1. [Q8NFW9-6]
CCDS68392.1. [Q8NFW9-4]
PIRiT08739.
RefSeqiNP_001271352.1. NM_001284423.1. [Q8NFW9-1]
NP_001271353.1. NM_001284424.1. [Q8NFW9-2]
NP_001271354.1. NM_001284425.1. [Q8NFW9-6]
NP_001271355.1. NM_001284426.1. [Q8NFW9-4]
NP_056275.2. NM_015460.3. [Q8NFW9-1]
XP_011531877.1. XM_011533575.1. [Q8NFW9-1]
UniGeneiHs.594535.

Genome annotation databases

EnsembliENST00000302541; ENSP00000301972; ENSG00000170011. [Q8NFW9-1]
ENST00000396217; ENSP00000379519; ENSG00000170011. [Q8NFW9-6]
ENST00000425621; ENSP00000389323; ENSG00000170011. [Q8NFW9-2]
ENST00000444716; ENSP00000398665; ENSG00000170011. [Q8NFW9-1]
ENST00000458292; ENSP00000413392; ENSG00000170011. [Q8NFW9-5]
ENST00000539167; ENSP00000438297; ENSG00000170011. [Q8NFW9-4]
GeneIDi25924.
KEGGihsa:25924.
UCSCiuc003cka.5. human. [Q8NFW9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF396687 mRNA. Translation: AAM43954.1.
AB083783 mRNA. Translation: BAC15555.1.
AK125334 mRNA. Translation: BAG54185.1.
AK126013 mRNA. Translation: BAG54276.1.
AK294714 mRNA. Translation: BAH11857.1.
AK316068 mRNA. Translation: BAH14439.1.
AC099331 Genomic DNA. No translation available.
AC099557 Genomic DNA. No translation available.
AC104188 Genomic DNA. No translation available.
AC110718 Genomic DNA. No translation available.
AC130439 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64595.1.
BC092512 mRNA. Translation: AAH92512.1.
BC109311 mRNA. Translation: AAI09312.1.
BC109312 mRNA. Translation: AAI09313.1.
AL050090 mRNA. Translation: CAB43262.1.
CCDSiCCDS2689.1. [Q8NFW9-1]
CCDS68390.1. [Q8NFW9-2]
CCDS68391.1. [Q8NFW9-6]
CCDS68392.1. [Q8NFW9-4]
PIRiT08739.
RefSeqiNP_001271352.1. NM_001284423.1. [Q8NFW9-1]
NP_001271353.1. NM_001284424.1. [Q8NFW9-2]
NP_001271354.1. NM_001284425.1. [Q8NFW9-6]
NP_001271355.1. NM_001284426.1. [Q8NFW9-4]
NP_056275.2. NM_015460.3. [Q8NFW9-1]
XP_011531877.1. XM_011533575.1. [Q8NFW9-1]
UniGeneiHs.594535.

3D structure databases

ProteinModelPortaliQ8NFW9.
SMRiQ8NFW9. Positions 4-141.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117424. 3 interactions.
DIPiDIP-48949N.
IntActiQ8NFW9. 5 interactions.
MINTiMINT-7242301.
STRINGi9606.ENSP00000301972.

PTM databases

iPTMnetiQ8NFW9.
PhosphoSiteiQ8NFW9.

Polymorphism and mutation databases

BioMutaiMYRIP.
DMDMi116242669.

Proteomic databases

PaxDbiQ8NFW9.
PeptideAtlasiQ8NFW9.
PRIDEiQ8NFW9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302541; ENSP00000301972; ENSG00000170011. [Q8NFW9-1]
ENST00000396217; ENSP00000379519; ENSG00000170011. [Q8NFW9-6]
ENST00000425621; ENSP00000389323; ENSG00000170011. [Q8NFW9-2]
ENST00000444716; ENSP00000398665; ENSG00000170011. [Q8NFW9-1]
ENST00000458292; ENSP00000413392; ENSG00000170011. [Q8NFW9-5]
ENST00000539167; ENSP00000438297; ENSG00000170011. [Q8NFW9-4]
GeneIDi25924.
KEGGihsa:25924.
UCSCiuc003cka.5. human. [Q8NFW9-1]

Organism-specific databases

CTDi25924.
GeneCardsiMYRIP.
HGNCiHGNC:19156. MYRIP.
HPAiHPA006433.
MIMi611790. gene.
neXtProtiNX_Q8NFW9.
PharmGKBiPA38800.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHBX. Eukaryota.
ENOG41126RD. LUCA.
GeneTreeiENSGT00390000013933.
HOGENOMiHOG000113712.
HOVERGENiHBG052562.
InParanoidiQ8NFW9.
OMAiARCIHSG.
OrthoDBiEOG091G01RQ.
PhylomeDBiQ8NFW9.
TreeFamiTF331599.

Miscellaneous databases

GenomeRNAii25924.
PROiQ8NFW9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170011.
CleanExiHS_MYRIP.
ExpressionAtlasiQ8NFW9. baseline and differential.
GenevisibleiQ8NFW9. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR006788. Myrip/Melanophilin.
IPR010911. Rab_BD.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02318. FYVE_2. 1 hit.
PF04698. Rab_eff_C. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS50916. RABBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYRIP_HUMAN
AccessioniPrimary (citable) accession number: Q8NFW9
Secondary accession number(s): B3KWM3
, B3KWW4, B7Z2H1, B7Z9V3, G3XAI8, Q32M41, Q32M42, Q569F7, Q8IUF5, Q9Y3V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: October 17, 2006
Last modified: September 7, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.