##gff-version 3 Q8NFU7 UniProtKB Chain 1 2136 . . . ID=PRO_0000251949;Note=Methylcytosine dioxygenase TET1 Q8NFU7 UniProtKB Zinc finger 584 625 . . . Note=CXXC-type;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00509,ECO:0000269|PubMed:29276034;Dbxref=PMID:29276034 Q8NFU7 UniProtKB Region 1 47 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8NFU7 UniProtKB Region 528 674 . . . Note=Sufficient for binding to genomic CpG islands Q8NFU7 UniProtKB Region 712 746 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8NFU7 UniProtKB Region 849 876 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8NFU7 UniProtKB Region 899 923 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8NFU7 UniProtKB Region 1119 1169 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8NFU7 UniProtKB Region 1580 1593 . . . Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6N021 Q8NFU7 UniProtKB Region 1774 1897 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8NFU7 UniProtKB Region 1919 1984 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8NFU7 UniProtKB Region 2074 2100 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8NFU7 UniProtKB Compositional bias 10 24 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8NFU7 UniProtKB Compositional bias 30 44 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8NFU7 UniProtKB Compositional bias 713 746 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8NFU7 UniProtKB Compositional bias 1119 1149 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8NFU7 UniProtKB Compositional bias 1783 1811 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8NFU7 UniProtKB Compositional bias 1849 1885 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8NFU7 UniProtKB Compositional bias 1924 1955 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8NFU7 UniProtKB Binding site 591 591 . . . Ontology_term=ECO:0000255,ECO:0000269,ECO:0007744;evidence=ECO:0000255|PROSITE-ProRule:PRU00509,ECO:0000269|PubMed:29276034,ECO:0007744|PDB:6ASD;Dbxref=PMID:29276034 Q8NFU7 UniProtKB Binding site 594 594 . . . Ontology_term=ECO:0000255,ECO:0000269,ECO:0007744;evidence=ECO:0000255|PROSITE-ProRule:PRU00509,ECO:0000269|PubMed:29276034,ECO:0007744|PDB:6ASD;Dbxref=PMID:29276034 Q8NFU7 UniProtKB Binding site 597 597 . . . Ontology_term=ECO:0000255,ECO:0000269,ECO:0007744;evidence=ECO:0000255|PROSITE-ProRule:PRU00509,ECO:0000269|PubMed:29276034,ECO:0007744|PDB:6ASD;Dbxref=PMID:29276034 Q8NFU7 UniProtKB Binding site 603 603 . . . Ontology_term=ECO:0000255,ECO:0000269,ECO:0007744;evidence=ECO:0000255|PROSITE-ProRule:PRU00509,ECO:0000269|PubMed:29276034,ECO:0007744|PDB:6ASD;Dbxref=PMID:29276034 Q8NFU7 UniProtKB Binding site 606 606 . . . Ontology_term=ECO:0000255,ECO:0000269,ECO:0007744;evidence=ECO:0000255|PROSITE-ProRule:PRU00509,ECO:0000269|PubMed:29276034,ECO:0007744|PDB:6ASD;Dbxref=PMID:29276034 Q8NFU7 UniProtKB Binding site 609 609 . . . Ontology_term=ECO:0000255,ECO:0000269,ECO:0007744;evidence=ECO:0000255|PROSITE-ProRule:PRU00509,ECO:0000269|PubMed:29276034,ECO:0007744|PDB:6ASD;Dbxref=PMID:29276034 Q8NFU7 UniProtKB Binding site 619 619 . . . Ontology_term=ECO:0000255,ECO:0000269,ECO:0007744;evidence=ECO:0000255|PROSITE-ProRule:PRU00509,ECO:0000269|PubMed:29276034,ECO:0007744|PDB:6ASD;Dbxref=PMID:29276034 Q8NFU7 UniProtKB Binding site 624 624 . . . Ontology_term=ECO:0000255,ECO:0000269,ECO:0007744;evidence=ECO:0000255|PROSITE-ProRule:PRU00509,ECO:0000269|PubMed:29276034,ECO:0007744|PDB:6ASD;Dbxref=PMID:29276034 Q8NFU7 UniProtKB Binding site 1422 1422 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6N021 Q8NFU7 UniProtKB Binding site 1424 1424 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6N021 Q8NFU7 UniProtKB Binding site 1482 1482 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6N021 Q8NFU7 UniProtKB Binding site 1508 1508 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6N021 Q8NFU7 UniProtKB Binding site 1510 1510 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6N021 Q8NFU7 UniProtKB Binding site 1551 1551 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6N021 Q8NFU7 UniProtKB Binding site 1561 1561 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6N021 Q8NFU7 UniProtKB Binding site 1563 1563 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6N021 Q8NFU7 UniProtKB Binding site 1579 1579 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6N021 Q8NFU7 UniProtKB Binding site 1588 1588 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6N021 Q8NFU7 UniProtKB Binding site 1648 1648 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6N021 Q8NFU7 UniProtKB Binding site 1664 1664 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6N021 Q8NFU7 UniProtKB Binding site 1670 1670 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6N021 Q8NFU7 UniProtKB Binding site 1672 1672 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21496894;Dbxref=PMID:21496894 Q8NFU7 UniProtKB Binding site 1674 1674 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21496894;Dbxref=PMID:21496894 Q8NFU7 UniProtKB Binding site 1677 1677 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6N021 Q8NFU7 UniProtKB Binding site 1706 1706 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6N021 Q8NFU7 UniProtKB Binding site 2028 2028 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6N021 Q8NFU7 UniProtKB Binding site 2043 2045 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6N021 Q8NFU7 UniProtKB Binding site 2049 2051 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6N021 Q8NFU7 UniProtKB Binding site 2059 2059 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6N021 Q8NFU7 UniProtKB Site 1608 1609 . . . Note=Breakpoint for translocation to form KMT2A/MLL1-TET1 oncogene;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12124344;Dbxref=PMID:12124344 Q8NFU7 UniProtKB Modified residue 871 871 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q8NFU7 UniProtKB Cross-link 1589 1589 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:36056023;Dbxref=PMID:36056023 Q8NFU7 UniProtKB Alternative sequence 1 671 . . . ID=VSP_061826;Note=In isoform 2. Missing Q8NFU7 UniProtKB Alternative sequence 657 1487 . . . ID=VSP_061827;Note=In isoform 3. Missing Q8NFU7 UniProtKB Alternative sequence 657 694 . . . ID=VSP_061828;Note=In isoform 4. ADFDNKPVNGPKSESMDYSRCGHGEEQKLELNPHTVEN->IELYKKTKAHIIHTLGQDQVLLLSGKSWRIGMVKKETQ Q8NFU7 UniProtKB Alternative sequence 695 2136 . . . ID=VSP_061829;Note=In isoform 4. Missing Q8NFU7 UniProtKB Natural variant 162 162 . . . ID=VAR_027734;Note=D->G;Dbxref=dbSNP:rs10823229 Q8NFU7 UniProtKB Natural variant 193 193 . . . ID=VAR_027735;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs12773594 Q8NFU7 UniProtKB Natural variant 256 256 . . . ID=VAR_027736;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs12221107 Q8NFU7 UniProtKB Natural variant 1018 1018 . . . ID=VAR_027737;Note=N->S;Dbxref=dbSNP:rs16925541 Q8NFU7 UniProtKB Natural variant 1123 1123 . . . ID=VAR_027738;Note=I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12124344;Dbxref=dbSNP:rs3998860,PMID:12124344 Q8NFU7 UniProtKB Natural variant 2056 2056 . . . ID=VAR_080763;Note=Found in a consanguineous family with intellectual disability%3B uncertain significance. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28397838;Dbxref=PMID:28397838 Q8NFU7 UniProtKB Mutagenesis 1672 1672 . . . Note=Loss of catalytic activity and loss of the ability to induce DNA demethylation%3B when associated with A-1674. When transfected in knockout cells%2C fails to restore pancreatic beta-cell specification%2C as shown by impaired NKX6.1%2C PAX6%2C PDX1 and INS expression%3B when associated with A-1674. H->Y;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19372391,ECO:0000269|PubMed:21496894,ECO:0000269|PubMed:35798741;Dbxref=PMID:19372391,PMID:21496894,PMID:35798741 Q8NFU7 UniProtKB Mutagenesis 1674 1674 . . . Note=Loss of catalytic activity and loss of the ability to induce DNA demethylation%3B when associated with Y-1672. When transfected in knockout cells%2C fails to restore pancreatic beta-cell specification%2C as shown by impaired NKX6.1%2C PAX6%2C PDX1 and INS expression%3B when associated with Y-1672. D->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19372391,ECO:0000269|PubMed:21496894,ECO:0000269|PubMed:35798741;Dbxref=PMID:19372391,PMID:21496894,PMID:35798741 Q8NFU7 UniProtKB Sequence conflict 2001 2001 . . . Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8NFU7 UniProtKB Helix 595 598 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6ASD Q8NFU7 UniProtKB Beta strand 604 606 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6ASD Q8NFU7 UniProtKB Helix 607 610 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6ASD Q8NFU7 UniProtKB Turn 611 614 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6ASD Q8NFU7 UniProtKB Turn 620 622 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6ASD Q8NFU7 UniProtKB Helix 625 628 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6ASD